Resistance and resilience to tau pathology in Alzheimer's disease: Effects of age, sex, and APOE alleles by Yury Loika, Stephanie Webster, Elena Loiko, Alexander M. Kulminski

“…METHODS We studied resistance and resilience to tau pathology by assessing Braak stages based on apolipoprotein E (APOE) alleles, sex, and age in a sample of 1932 cognitively intact individuals of European ancestry from the Alzheimer's Disease Sequencing Project (ADSP). …”
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Decommissioning and post-irradiation examination of the LHC beam dumps by N. Solieri, A. Lund, A.-P. Bernardes, L. R. Buonocore, A. Cherif, S. De Man, M. Di Castro, S. Di Giovannantonio, G. Dumont, S. El-Idrissi, E. Farina, D. Grenier, E. Grenier-Boley, M. Himmerlich, A. Infantino, A. Lechner, R. Mouret, D. Pazem, A. T. Perez-Fontenla, E. Romagnoli, S. Sgobba, C. Tromel, C. Veiga Almagro, M. Calviani

“…Endoscopic inspections of these beam dumps and experimental high-intensity proton-beam irradiation of material samples raised concerns about the structural integrity of the carbon-based materials in their cores. …”
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ChildDiffusion: Unlocking the Potential of Generative AI and Controllable Augmentations for Child Facial Data Using Stable Diffusion and Large Language Models by Muhammad Ali Farooq, Wang Yao, Peter Corcoran

“…To exemplify its potential, we open-sourced a dataset of 2.5k child facial samples across five ethnic classes, which underwent rigorous qualitative and quantitative evaluations. …”
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Application and Validation of Semiautomatic Quantification of Immunohistochemically Stained Sections for Low Cellular Tissue Such as Intervertebral Disc Using QuPath by Andrea Nüesch, Maria Paola Ferri, Christine L. Le Maitre

“…ABSTRACT Background Immunohistochemistry (IHC) is a widely used method for localizing and semi‐quantifying proteins in tissue samples. Traditional IHC analysis often relies on manually counting 200 cells within a designated area, a time‐intensive and subjective process that can compromise reproducibility and accuracy. …”
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Integrating human biomonitoring exposure data into a primary care morbidity database: a feasibility study by Pieter Jansen, Elly Den Hond, Katleen De Brouwere, Endale Alemayehu Ali, Hamid Yimam Hassen, Ilona Gabaret, Gijs Van Pottelbergh

“…Because of the modest sample size used in this feasibility study, no conclusions about the impact of PFAS on health endpoints can be drawn. …”
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Visual inspection after acetic acid (VIA) is highly heterogeneous in primary cervical screening in Amazonian Peru. by Maribel Almonte, Catterina Ferreccio, Silvana Luciani, Miguel Gonzales, Jose M Delgado, Carlos Santos, Manuel Alvarez, Jack Cuzick, Peter Sasieni

“…<h4>Methods</h4>At the screening visit, midwives collected three cervical samples for Pap, LBC and HC2 before performing VIA. …”
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COVID-19 Coronavirus Infection and Trimesters: Is There a Link? by Gulbanu Ganikyzy Shaimerdenova, Gulzhan Abuova, Dana Bekaryssova

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Acceptance of Driverless Vehicles: Results from a Large Cross-National Questionnaire Study by Sina Nordhoff, Joost de Winter, Miltos Kyriakidis, Bart van Arem, Riender Happee

“…Shuttles that operate without an onboard driver are currently being developed and tested in various projects worldwide. However, there is a paucity of knowledge on the determinants of acceptance of driverless shuttles in large cross-national samples. …”
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The Effectiveness of Geographic Information Systems in Sustainable Urban Planning in Iraq: An Analytical Study of Experts’ Opinions by Nawshirwan Mahmood Rahim

“…The study aims to gather and analyze the opinions of specialists and experts in urban planning, environmental management, and GIS across various cities in Iraq. A sample of 100 experts from Baghdad, Basra, Erbil, Mosul, and Najaf was selected based on their experience and competence in projects utilizing GIS. …”
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Investigating factors influencing utilization of trauma-focused cognitive behavioral therapy among unaccompanied young refugees: an exploratory analysis by Barbara Kasparik, Madina Farani, Elisa Pfeiffer, Cedric Sachser, Rita Rosner

“…Method This study is part of the multi-site project BETTER CARE which aims to implement a stepped and collaborative care approach. …”
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Lasting lockdown love? Problem behaviour and pandemic and non-pandemic related risk factors influencing the owner-dog relationship in a UK cohort of dogs reaching early adulthood. by Bree L Merritt, Dan G O'Neill, Claire L Brand, Zoe Belshaw, Fiona C Dale, Camilla L Pegram, Rowena M A Packer

“…The Pandemic Puppies project longitudinally studied dogs bought as puppies aged < 16-weeks old during the 2020 phase of the COVID-19 pandemic by collecting owner-completed data during puppyhood and as adults. …”
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Comparison of sub-canopy topsoil properties between three woody plant species, a case study of the Baladeh Watershed, Mazandaran Province, Iran by Alireza Mohebali, Reza Erfanzadeh, Mohammad Jafari

“…The results of this study indicated that in sub-alpine grasslands, the presence and maintaining of woody species is important due to its positive role on substratum soil, considering in the rangeland improvement projects.…”
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Where taxonomy based on subtle morphological differences is perfectly mirrored by huge genetic distances: DNA barcoding in Protura (Hexapoda). by Monika Carol Resch, Julia Shrubovych, Daniela Bartel, Nikolaus U Szucsich, Gerald Timelthaler, Yun Bu, Manfred Walzl, Günther Pass

“…Aim of the present pilot project was to examine if DNA barcoding can be a useful additional approach for delimiting and determining proturan species.…”
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IMPLEMENTATION OF THE CASE STUDY METHOD IN DISTANCE LEARNING OF ENTREPRENEURSHIP FUNDAMENTALS by O. R. Chepyuk, A. I. Gorylev

“…These practical problems were solved within implementation of the project Tempus «Acquisition of Professional and Entrepreneurial Skills by means of Education of Entrepreneurial Spirit and Consultation of the Beginning Entrepreneurs». …”
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High ELF4 expression in human cancers is associated with worse disease outcomes and increased resistance to anticancer drugs. by Doris Kafita, Victor Daka, Panji Nkhoma, Mildred Zulu, Ephraim Zulu, Rabecca Tembo, Zifa Ngwira, Florence Mwaba, Musalula Sinkala, Sody Munsaka

“…Here, using ELF4 mRNA expression data of 9,350 samples from the Cancer Genome Atlas pan-cancer project, we identify two groups of patient's tumours: those that expressed high ELF4 transcripts and those that expressed low ELF4 transcripts across 32 different human cancers. …”
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Predicting patent challenges for small-molecule drugs: A cross-sectional study. by Ally Memedovich, Brian Steele, Taylor Orr, Shanzeh Chaudhry, Mina Tadrous, Aaron S Kesselheim, Aidan Hollis, Reed F Beall

“…Of the 210 new small-molecule drugs included in the sample, 55% experienced initiation of patent challenge within the first year of eligibility. …”
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Design differences and variation in results between randomised trials and non-randomised emulations: meta-analysis of RCT-DUPLICATE data by Sebastian Schneeweiss, Shirley V Wang, Rachel Heyard, Leonhard Held

“…Most of the heterogeneity in effect estimates between the RCT-RWE study pairs in this sample could be explained by three emulation differences in the meta-regression model: treatment started in hospital (which does not appear in health insurance claims data), discontinuation of some baseline treatments at randomisation (which would have been an unusual care decision in clinical practice), and delayed onset of drug effects (which would be under-reported in real world clinical practice because of the relatively short persistence of the treatment). …”
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Piloting the informed health choices resources in Barcelona primary schools: A mixed methods study. by Laura Samsó Jofra, Pablo Alonso-Coello, Esther Cánovas Martínez, Carol de Britos Marsal, Ana Gallego Iborra, Ena Pery Niño de Guzman Quispe, Giordano Pérez-Gaxiola, Carolina Requeijo, Marta Roqué I Figuls, Sarah Rosenbaum, Karla Salas-Gama, Iratxe Urreta-Barallobre, Laura Martínez García

“…<h4>Introduction</h4>The main objective of the Informed Health Choices (IHC) project is to teach people to assess treatment claims and make informed health choices. …”
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Characterisation and validation of insertions and deletions in 173 patient exomes. by Francesco Lescai, Silvia Bonfiglio, Chiara Bacchelli, Estelle Chanudet, Aoife Waters, Sanjay M Sisodiya, Dalia Kasperavičiūtė, Julie Williams, Denise Harold, John Hardy, Robert Kleta, Sebahattin Cirak, Richard Williams, John C Achermann, John Anderson, David Kelsell, Tom Vulliamy, Henry Houlden, Nicholas Wood, Una Sheerin, Gian Paolo Tonini, Donna Mackay, Khalid Hussain, Jane Sowden, Veronica Kinsler, Justyna Osinska, Tony Brooks, Mike Hubank, Philip Beales, Elia Stupka

“…Although the 1,000 genome project has clearly highlighted the prevalence of rare variants and more complex variants (e.g. insertions, deletions), their role in disease is as yet far from elucidated.We set out to analyse the properties of sequence variants identified in a comprehensive collection of exome re-sequencing studies performed on samples from patients affected by a broad range of complex and rare diseases (N = 173). …”
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SWOT Technology Application on Tikrit University Engineering Consulting Bureau by Saif Saad Mohammed Khuder, Abdulrahman Adnan Ibrahim, Sinan Noori Faihan

“… Iraqi engineering consultancy bureaus have significantly contributed to resolving obstacles and issues encountered in various engineering projects, leading to their successful completion within the designated timeframe. …”
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