Early mechanisms of pathobiology are revealed by transcriptional temporal dynamics in hippocampal CA1 neurons of prion infected mice. by Anna Majer, Sarah J Medina, Yulian Niu, Bernard Abrenica, Kathy J Manguiat, Kathy L Frost, Clark S Philipson, Debra L Sorensen, Stephanie A Booth

“…Our findings suggest that prion replication results in the persistent stimulation of a programmed response that is mediated, at least in part, by synaptic NMDA receptor activity that initially promotes cell survival and neurite remodelling. …”
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Bioprinted hydrogels in bone regeneration: a bibliometric analysis by Huijie Zhang, Xiaoyu Li, Zhenyu Jia, Kun Jiao, Kun Jiao, Chen Liu, Chen Liu, Zixiang Deng, Yushu Bai, Xianzhao Wei, Xiaoyi Zhou

“…Our bibliometric-based visualization analysis revealed that the mechanical properties and osteogenic differentiation capacity of biomaterials have been a focal research topic over the past decade, while emerging research has also concentrated on the in vitro fabrication of stem cells for bone regeneration and osteogenic differentiation, particularly the precise application of in situ stem cell-loaded bioprinted organoids.ConclusionThis study provides an in-depth analysis of the research trajectory in the application of bioprinted hydrogels for bone regeneration. …”
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Dual threat: Susceptibility mechanisms and treatment strategies for COVID-19 and bacterial co-infections by Keda Chen, Ruiqi Weng, Jiaxuan Li, Hao Wu, Xiaotian Tie, Hongyu Li, Yuanyuan Zhang

“…Emerging therapeutic strategies include antiviral agents, immunomodulators, artificial liver support systems, and cell-based therapies. Public health policy recommendations focus on antimicrobial stewardship programs, biomarker-guided antibiotic use, and investment in rapid diagnostic technologies. …”
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Association of salivary Interleukin-6 levels in smokers with periodontitis by Alhussein M Ali, Ayser N Mohammed, Haider A Al-Waeli, Hadeer A Al-Ani

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Exploring the Structural Diversity and Biotechnological Potential of the Rhodophyte Phycolectome by Éllen F. Rodrigues, Flavia Alves Verza, Felipe Garcia Nishimura, Renê Oliveira Beleboni, Cedric Hermans, Kaat Janssens, Maarten Lieven De Mol, Paco Hulpiau, Mozart Marins

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Determination of reference values for TREC and KREC in circulating blood of the persons over 18 years by M. A. Saitgalina, N. E. Liubimova, Yu. V. Ostankova, R. N. Kuznetzova, A. A. Totolian

“…Increasing attention is being paid to methods for detecting primary and secondary T and/or B cell immunodeficiencies. Their implementation into laboratory diagnostics would contribute to the early diagnostics of immunodeficiencies. …”
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Pyroptosis regulation by Salmonella effectors by Yuan Meng, Yuan Meng, Qianjin Zhang, Qianjin Zhang, Mengen Xu, Mengen Xu, Ke Ding, Ke Ding, Ke Ding, Zuhua Yu, Zuhua Yu, Jing Li, Jing Li

“…Pyroptosis, a proinflammatory form of programmed cell death, is involved in many disease processes. …”
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Translational randomized phase II trial of cabozantinib in combination with nivolumab in advanced, recurrent, or metastatic endometrial cancer by John Wright, Stephanie Lheureux, Ilaria Colombo, Ramy Gadalla, Pamela S Ohashi, Xuan Li, Lisa Wang, Matthew S Block, David G Brooks, Andrea Jewell, Carolyn McCourt, Eugenia Girda, Sarah Temkin, Gini F Fleming, Linda Duska, Daniela E Matei, Panagiotis A Konstantinopoulos, Ben X Wang, Stephanie L Gaillard, Michael McHale, Floor J Backes, Theresa L Werner, Siobhan Kehoe, Rachel Wildman, Shirin Soleimani, Scott Lien, Trevor Pugh

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Using Active and Passive Smartphone Data to Enhance Adolescents’ Emotional Awareness in Forensic Outpatient Setting: A Qualitative Feasibility and Usability Study by Merel M L Leijse, Levi van Dam, Tijs Jambroes, Amber Timmerman, Arne Popma

“…App usage included completing a brief emoji survey 3 times a day (active data) and allowing Feelee to track the call logs, Bluetooth devices in proximity, cell tower IDs, app usage, and phone status (passive data). …”
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Unraveling the immunological landscape and gut microbiome in sepsis: a comprehensive approach to diagnosis and prognosisResearch in context by Yali Luo, Jian Gao, Xinliang Su, Helian Li, Yingcen Li, Wenhao Qi, Xuling Han, Jingxuan Han, Yiran Zhao, Alin Zhang, Yan Zheng, Feng Qian, Hongyu He

“…Findings: Septic patients exhibited decreased proportions of natural killer (NK) cells and plasmacytoid dendritic cells (pDCs) in CD45+ leukocytes compared with non-septic ICU patients and healthy controls. …”
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Chronic Inflammation and Cytokines in the Tumor Microenvironment by Glauben Landskron, Marjorie De la Fuente, Peti Thuwajit, Chanitra Thuwajit, Marcela A. Hermoso

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The Study of Coastal Vulnerability in North Insana District, North Central Timor Regency, East Nusa Tenggara Province (Indonesia) by Ludgardis Ledheng, Blasius Atini, Emanuel Maria Yosef Hano’e

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Predictive biomarkers for targeted therapy in daily anatomic pathology for ovarian tumors by Niti Sureka, Sufian Zaheer

“…This review provides an in-depth exploration of the current and emerging predictive biomarkers in ovarian cancer, emphasizing their clinical implications and potential to improve patient outcomes.…”
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Evaluating the Effectiveness of Various Small RNA Alignment Techniques in Transcriptomic Analysis by Examining Different Sources of Variability Through a Multi-Alignment Approach by Xinwei Zhao, Eberhard Korsching

“…DNA and RNA nucleotide sequences are ubiquitous in all biological cells, serving as both a comprehensive library of capabilities for the cells and as an impressive regulatory system to control cellular function. …”
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Epigenetic regulation of cancer stemness by Claudia Galassi, Gwenola Manic, Manel Esteller, Lorenzo Galluzzi, Ilio Vitale

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Study of water quality in ex-mining pits for fish cultivation in Gunung Mas regency, Central Kalimantan by Lukas Inel, Infa Minggawati, Tania Serezova Augusta, Frid Agustinus, Fenky Wirada

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MS-DIAL 5 multimodal mass spectrometry data mining unveils lipidome complexities by Hiroaki Takeda, Yuki Matsuzawa, Manami Takeuchi, Mikiko Takahashi, Kozo Nishida, Takeshi Harayama, Yoshimasa Todoroki, Kuniyoshi Shimizu, Nami Sakamoto, Takaki Oka, Masashi Maekawa, Mi Hwa Chung, Yuto Kurizaki, Saki Kiuchi, Kanako Tokiyoshi, Bujinlkham Buyantogtokh, Misaki Kurata, Aleš Kvasnička, Ushio Takeda, Haruki Uchino, Mayu Hasegawa, Junki Miyamoto, Kana Tanabe, Shigenori Takeda, Tetsuya Mori, Ryota Kumakubo, Tsuyoshi Tanaka, Tomoko Yoshino, Mami Okamoto, Hidenori Takahashi, Makoto Arita, Hiroshi Tsugawa

“…Using MSI data from the eye and n-3-VLC-PUFA-supplemented HeLa cells, we identified glycerol 3-phosphate acyltransferase as an enzyme candidate responsible for incorporating n-3 VLC-PUFAs into the sn1 position of phospholipids in mammalian cells, which was confirmed using EAD-MS/MS and recombinant proteins in a cell-free system. …”
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Endoscopic and immunohistochemical aspects in an inverted papilloma with unilateral total obstruction of the nasal fossa by Irina Enache, Florin Anghelina, Mircea-Sorin Ciolofan, Carmen Aurelia Mogoantă, Alex Emilian Stepan, Ioana-Cristina Vîlcea, Cosmin Vasile Obleagă, Andrei Osman

“…An inverted papilloma is a medical condition in which epithelial cells placed on the surface grow in depth into the underlying supporting tissue. …”
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Knowledge, attitudes and strategies on contraceptive utilization among adolescents: views from beneficiaries and parents in City of Kigali by Jean Baptiste Hategekimana, Adolphe Ndikubwimana, Justin Ndayisenga, Fidele Niyitegeka, Daniel Ukwishatse, Serieux Cyubahiro, Bivegete Kenny Ntwali, Absolomon Gashaija, Alice Nyirazigama, Noel Korukire, Felix K. Rubuga, Patrick Karakwende, Celestin Banamwana, Pierre Dukuziyaturemye, Jean Muhire, Marie Josee Mwiseneza, Theoneste Ntakirutimana, Deborah Oluwaseun Shomuyiwa, Don Eliseo Lucero-Prisno III

“…For the quantitative phase, convenience sampling facilitated by the in charge of Health at the sector level and community health workers at the cell level ensured effective access to the study’s target demographic. …”
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A lattice-mechanical metamaterial with tunable two-step deformation, tunable stiffness, tunable energy absorption and programmable properties by Chenyang Liu, Zexin Gao, Jiahui Chang, Jianan Zhao, Song Qiu, Peiran Yu, Xi Zhang

“…Metamaterials built from these unit cells can also achieve the same properties. These properties can exist in multiple directions and are not affected by the number of unit cells. …”
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