Integrated promoter-capture Hi-C and Hi-C analysis reveals fine-tuned regulation of the 3D chromatin architecture in colorectal cancer by Ajay Kumar Saw, Ayush Madhok, Anupam Bhattacharya, Anupam Bhattacharya, Soumyadeep Nandi, Sanjeev Galande, Sanjeev Galande

“…The analysis focused on identifying fine-scale interactions within topologically associated domains (TADs) while incorporating histone modification landscapes (H3K27ac, H3K4me3) and transcriptomic signatures from CRC cell lines and the TCGA database. For experimental validation, ChIP-quantitative PCR was performed at the promoters of target genes using the highly malignant colorectal cell line HT29 and compared it to an embryonic cell line NT2D1.Results:Our integrated analysis revealed significant genomic structural instability in CRC cells, closely associated with tumor-suppressive transcriptional programs. …”
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Research Progress on Cancer Risk and Its Pathogenesis of Gastric Precancerous Conditions by WANG Yuxin, PENG Wenwan, ZHOU Zheng, HUANG Haiyang, LU Xiaomin, DONG Mingguo

“…In the microenvironment of gastric mucosa, imbalance and disorder of oxidation and antioxidant effect, energy metabolism, immune homeostasis, cell proliferation and death are the pathogenesis of gastric precancerous conditions. …”
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Effects of targeted care using a risk warning model on burn site infection by Chenchen Sun, Xiaowu Wang, Dong Wu

“…This study aimed to establish an infection risk warning model based on the clinical characteristics of burn patients, by formulating targeted care programs according to the risk warning factors, and analyzing the effects of these programs on wound infection in burn patients. …”
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Application of marine bacterial alginate lyases in wastewater treatment, biofilm removal and green technology by M.U.K. Anjung, H. Nursyam, A.A. Prihanto, E. Chasanah

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Deciphering molecular and cellular ex vivo responses to bispecific antibodies PD1-TIM3 and PD1-LAG3 in human tumors by Alfred Zippelius, Petra Herzig, Pratiksha Gulati, Christian Klein, Marta Trüb, Kirsten D Mertz, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Marina Natoli, Klas Hatje, Fabian Junker, Zhiwen Jiang, Iakov I Davydov, Markus Germann, Daniel Marbach, Adrian Zwick, Patrick Weber, Stefan Seeber, Lothar Tietze, Laura Codarri-Deak, Henry Kao

“…Similarly, little is known on the differential effects of dual, compared with single, checkpoint inhibition.Methods We here performed in-depth characterization, including multicolor flow cytometry, single cell RNA sequencing and multiplex supernatant analysis, using tumor single cell suspensions from patients with cancer treated ex vivo with novel bispecific antibodies targeting programmed cell death protein 1 (PD-1) and TIM-3 (PD1-TIM3), PD-1 and LAG-3 (PD1-LAG3), or with anti-PD-1.Results We identified patient samples which were responsive to PD1-TIM3, PD1-LAG3 or anti-PD-1 using an in vitro approach, validated by the analysis of 659 soluble proteins and enrichment for an anti-PD-1 responder signature. …”
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Molecular analysis of immune checkpoint inhibitor associated erythema nodosum-like toxicity by Xiaopeng Sun, Margaret L. Axelrod, Paula I. Gonzalez-Ericsson, Violeta Sanchez, Violeta Sanchez, Yu Wang, Jonathan L. Curry, Elizabeth J. Phillips, Yaomin Xu, Douglas B. Johnson, Justin M. Balko

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Research Progress in the Study of Traditional Chinese Herbal Medicine Extracts Regulating Ferroptosis thus Improving the Symptom of Alzheimer's Disease by PEI Jinying, SONG Jinzhou, MA Daofeng, LUO Xiaoting, LIU Bin, DONG Xiaohong, CONG Shuyuan

“…Ferroptosis, rising as a new research direction on AD biological mechanism in recent years, mainly studies on iron-dependent programmed cell death. A large amount of evidence has shown that AD is closely related to ferroptosis in the brain. …”
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Virseqimprover: an integrated pipeline for viral contig error correction, extension, and annotation by Haoqiu Song, Saima Sultana Tithi, Connor Brown, Frank O. Aylward, Roderick Jensen, Liqing Zhang

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Machine learning modeling and analysis of prognostic hub genes in cervical adenocarcinoma: a multi target therapy for enhancement in immunosurveillance by Madiha Jabeen Abbasi, Rashid Abbasi, ShuPeng Wu, Md Belal Bin Heyat, Ding Xianfeng, Huijie Jia, Aiwen Zheng

“…Results indicate high binding affinity of Imatinib compound into active pockets of BIRC5 which is confirmed by cell viability lab experiment. Current study demonstrates novel biomarkers and therapeutic drugs for in depth understanding of endocervical carcinogensis.…”
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Lipid metabolic reprogramming and associated ferroptosis in osteosarcoma: From molecular mechanisms to potential targets by Zhiyang Yin, Guanlu Shen, Minjie Fan, Pengfei Zheng

“…Ferroptosis is an iron-dependent form of programmed cell death associated with lipid peroxidation. …”
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Research progress of ferroptosis in the occurrence and development of periodontitis by SUN Ruiman, QIN Xu, ZHU Guangxun

“…Ferroptosis, an iron-dependent form of programmed cell death, is primarily characterized by altered iron homeostasis, weak antioxidant defense, and accumulation of lipid peroxides and plays an important role in a variety of diseases. …”
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Alum-anchored IL-12 combined with cytotoxic chemotherapy and immune checkpoint blockade enhanced antitumor immune responses in head and neck cancer models by James W Hodge, Howard Kaufman, Michelle R Padget, Kellsye P Fabian, Sailaja Battula, Wiem Lassoued, Ginette Santiago-Sanchez, Clint Tanner Allen

“…Background First-line treatment with pembrolizumab plus chemotherapy in recurrent and metastatic head and neck squamous cell carcinomas (HNSCC) has improved survival. However, the overall response rate with this standard of care regimen (SOC) remains limited. …”
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Application of [18F]FLT‐PET in pulmonary arterial hypertension: a clinical study in pulmonary arterial hypertension patients and unaffected bone morphogenetic protein receptor type... by Liza Botros, Samara M.A. Jansen, Ali Ashek, Onno A. Spruijt, Jelco Tramper, Anton Vonk Noordegraaf, Jurjan Aman, Hans Harms, Frances S. deMan, Marc C. Huisman, Lan Zhao, Harm J. Bogaard

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Estimation of noncanonical pyroptosis biomarkers gasdermin D and caspase 4 in gingiva of periodontitis and diabetes patients: An observational cross-sectional study by Lalitha Tanjore Arunachalam, Snophia Suresh, Vamsi Lavu, Shankarram Vedamanickam, John Ebinezer, Bhavishya Balachandran

“…Pyroptosis, an inflammatory form of programmed cell death, is implicated in periodontitis and diabetes. …”
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The outcast of medicine: metals in medicine--from traditional mineral medicine to metallodrugs by Donghan Bai, Michal Nowak, Dajun Lu, Qiaochu Wang, Martin Fitzgerald, Hui Zhang, Remy MacDonald, Ziwen Xu, Lu Luo

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High expression of nucleobindin 2 is associated with poor prognosis in gastric cancer by Bolag Altan, Kyoichi Kaira, Shuichi Okada, Tsugumichi Saito, Eijiro Yamada, Halin Bao, Pinjie Bao, Kengo Takahashi, Takehiko Yokobori, Oyama Tetsunari, Masahiko Nishiyama, Masanobu Yamada

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Atomic-level investigation of KCNJ2 mutations associated with ventricular arrhythmic syndrome phenotypes by Saba Munawar, Corey L. Anderson, Louise Reilly, Ryan Woltz, Yusra Sajid Kiani, Nipavan Chiamvimonvat, Lee L. Eckhardt

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Predictability of tropical Pacific decadal variability is dominated by oceanic Rossby waves by Xian Wu, Stephen G. Yeager, Clara Deser, Antonietta Capotondi, Andrew T. Wittenberg, Michael J. McPhaden

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DETERMINATION OF REFERENCE VALUES FOR TREC AND KREC IN DRY BLOOD SPOTS OF NEWBORNS FROM DIFFERENT GESTATION AGES IN SVERDLOVSK REGION by S. S. Deryabina, I. A. Tuzankina, V. N. Shershnev

“…As a preparatory stage for implementation of genetic testing for severe combined immunodeficiency under a neonatal screening program, a study was performed in Sverdlovsk Region which concerned quantitative determination of T and B cell neogenesis markers (TREC and KREC, respectively) in blood of conditionally healthy newborns. …”
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A two-decade bibliometric analysis of tumor-associated macrophages in colorectal cancer research by Yadi Gao, Weichen Yuan, Jiexiang Zhang, Zhiwei Wang, Wenwen Cui, Zhongan Guan

“…Keyword co-occurrence and literature co-citation analysis identified nuclear factor kappa-B, endothelial growth factor, angiogenesis, polarization, TME, immune response, programmed cell death protein 1 blockade, and metabolism as current research hotspots and trends in this field. …”
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