Building digital histology models of transcriptional tumor programs with generative deep learning for pathology-based precision medicine by Hanna M. Hieromnimon, James Dolezal, Kristina Doytcheva, Frederick M. Howard, Sara Kochanny, Zhenyu Zhang, Robert L. Grossman, Kevin Tanager, Cindy Wang, Jakob Nikolas Kather, Evgeny Izumchenko, Nicole A. Cipriani, Elana J. Fertig, Alexander T. Pearson, Samantha J. Riesenfeld

“…Then, we used deep learning techniques to train a computational model to predict the activity levels of the transcriptional programs directly from histology images. We exploited that predictive capability to generate synthetic digital models of the cellular histology of each transcriptional program, using generative adversarial networks to isolate image features supporting specific transcriptional predictions and pathologist review to interpret the images. …”
Get full text

Evaluation of direct 16S rRNA PCR from clinical samples for bacterial detection in normally sterile body sites by Serife Satilmis, Nurver Ulger Toprak, Can Ilgın, Guner Soyletir

Get full text

Path coefficient analysis unraveled nutrient factors directly impacted the textural characteristics of cooked whole-grain purple rice by Ekawat Chaichoompu, Ekawat Chaichoompu, Siriluck Wattanavanitchakorn, Rungtiva Wansuksri, Wintai Kamolsukyeunyong, Siriphat Ruengphayak, Apichart Vanavichit

Get full text

Torque and speed prediction of a brushless direct current motor using nonlinear autoregressive with exogenous inputs and neural network by Muhammad Aseer Khan, Dur-e-Zehra Baig, Husan Ali, Fahad R. Albogamy

Get full text

Pre-treatment direct costs for people with tuberculosis during the COVID-19 pandemic in different healthcare settings in Bandung, Indonesia. by Bony Wiem Lestari, Eka Saptiningrum, Lavanya Huria, Auliya Ramanda Fikri, Benjamin Daniels, Nathaly Aguilera Vasquez, Angelina Sassi, Jishnu Das, Charity Oga-Omenka, Susan M McAllister, Madhukar Pai, Bachti Alisjahbana

Get full text

Spread and Scale of the Integrated Nutrition Pathway for Acute Care Across Canada: Protocol for the Advancing Malnutrition Care Program by Katherine L Ford, Celia Laur, Rupinder Dhaliwal, Roseann Nasser, Leah Gramlich, Johane P Allard, Heather Keller

“…ConclusionsEvaluation of the AMC program will strengthen decision-making, future programming, and will inform program changes that reflect implementation of best practices in nutrition care while supporting regional mentors and hospital champions. …”
Get full text

Presenting the Model of Aligning the Individual Development Program (IDP) with the Career Path, Based on the Foundation's data-theorizing Approach by Ali Kafami Ladani, Abdolali Keshtegar, Aleme Keikha

“…Increasing job satisfaction, increasing the capabilities and capacity of individuals and organizations, aligning individuals and organizations, improving organizational performance indicators, moving in the direction of a learning organization, and transparency and justice in the process of appointment and promotion were the consequences of aligning the individual development program with the career pathIntroduction The most important factor in economic, social, and cultural development and transformation, and the main factor in advancing society, is undoubtedly the human factor, and to achieve social and economic progress, special attention to the human factor is of great importance (Kumar et al., 2018). …”
Get full text

Contextual barriers to infection prevention and control program implementation in hospitals in Latin America: a mixed methods evaluation by Valeria Fabre, Clara Secaira, Carolyn Herzig, Elizabeth Bancroft, Maria Paula Bernachea, Lucy Anchiraico Galarza, Bowen Aquiles, Ana Belén Arauz, Maria Del Carmen Bangher, Marisa Liliana Bernan, Sol Burokas, Alfredo Canton, Iris L. Cazali, Angel Colque, Marisabel Comas, Rosa Verónica Contreras, Wanda Cornistein, Maria Gabriela Cordoba, Silvia Mabel Correa, Gustavo Costilla Campero, Marta Isabel Chamorro Ayala, Nuria Chavez, Gabriela De Ascencao, Carlos Cruz García, Clara Esquivel, Cecilia Ezcurra, Leonardo Fabbro, Leandro Falleroni, Johana Fernandez, Sandra Ferrari, Veronica Freire, Maria Isabel Garzón, José Anel Gonzales, Lucrecia Guaymas, Fausto Guerrero-Toapanta, Diego Laplume, Sandra Lambert, César Guillermo Lemir, Paola Romina Lazarte, Itzel L. Lopez, Herberth Maldonado, Guadalupe Martínez, Diego M. Maurizi, Florencia Mesplet, Cristina Moreno Izquierdo, Gabriela Luciana Moya, Mariela Nájera, Yanina Nuccetelli, Argelis Olmedo, Belén Palacio, Florencia Pellice, Carla Lorena Raffo, Carolina Ramos, Fanny Reino, Viviana Rodriguez, Federico Romero, Juan José Romero, Graciela Sadino, Nancy Sandoval, Mariana Suarez, Maria Victoria Suayter, Maria Alejandra Ureña, Marisol Valle, Ligia Vence Reyes, Silvia Vera Amate Perez, Hugo Videla, Silvina Villamandos, Olmedo Villarreal, Maria Alejandra Viteri, Eduardo Warley, Rodolfo E. Quiros

“…Additionally, we conducted semi-structured interviews among IPC personnel and microbiologists using the Systems Engineering Initiative for Patient Safety model to evaluate barriers and facilitators for IPC program implementation. We performed directed content analysis of interview transcripts to identify themes that focused on barriers and facilitators of IPC program implementation which are summarized descriptively. …”
Get full text

Advancing sustainability in low-resource settings: development and validation of a sustainability tool for evidence-based interventions and programs by Chisom Obiezu-Umeh, Divya S. Subramaniam, Ucheoma Nwaozuru, Titilola Gbaja-biamila, Titilola Gbaja-biamila, Lateef Akeem Blessing, Thembekile Shato, David Oladele, David Oladele, Lisa R. Hirschhorn, Enbal Shacham, Hong Xian, Oliver Chukwujekwu Ezechi, Juliet Iwelunmor

“…Subsequently, we piloted STEPS among 256 healthcare workers in Nigeria directly involved in implementing evidence-based programs and/or interventions. …”
Get full text

A Process Evaluation of the Isoniazid Preventive Therapy Program in Sanyati District, Mashonaland West Province, Zimbabwe 2019 by Chamunorwa Mhembe, Daniel Chirundu, Cleophas Chimbetete, Notion Tafara Gombe, Tsitsi Patience Juru, Addmore Chadambuka, Gerald Shambira, Mufuta Tshimanga

“…A review of the 2019 Sanyati District IPT program data indicated that not all clients eligible for the IPT were initiated on the IPT program. …”
Get full text

Electronic control of directional properties of reconfigurable plasmonic graphene-based antenna arrays with frequency scanning in the mid-IR range by G.S. Makeeva

“…To solve the electrodynamic problem using the CST MWS 2023 program, designed for numerical modeling of high-frequency antennas and devices, the Perfect Boundary Approximation (PBA) method is used, complementing the Finite Integration Technique (FIT) method, which works in the time domain. …”

Prediscussion and Postdiscussion Assessment Scores in a Self-Directed Learning Module Implemented in the Department of Biochemistry: A Comparative Study by Poonam Agrawal, Niket Verma

“…Background: Self-directed learning (SDL) is an important tool for transforming medical students into lifelong learners so that they are competent to identify their learning needs, allocate resources, and evaluate the learning process throughout their career. …”
Get full text

Salicylate-Elicited Activation of AMP-Activated Protein Kinase Directly Triggers Degradation of C-Myc in Colorectal Cancer Cells by Ana Laura S. A. Matos, Ashley J. Ovens, Emil Jakobsen, Diego Iglesias-Gato, Jacob M. Bech, Stine Friis, Lasse Kristoffer Bak, Gunvor I. Madsen, Jonathan S. Oakhill, Pietri Puustinen, José M. A. Moreira

Get full text

Digital modeling by biomedical informatics analysis predicts suppression of COVID-19 infectivity via ‘targeting oligonucleotide-directed devolution’ by Frank-Un Hong, Miguel Marciano Castro, Klaus D. Linse

“…Thus, through ‘targeting oligonucleotides directed devolution’ of S1/S2 site, the infectivity of SARS-CoV-2 may be attenuated. …”
Get full text

Effect of transcranial direct current stimulation over the primary motor cortex on short-term balance acquisition in healthy individuals by Ömer Burak Tor, Michael A. Nitsche, Edmund Wascher, Nevin A. Guzel, Charles S. Layne

“…N1 latency was reduced across all participants in both perturbation directions after training. However, only the anodal stimulation group showed a significant reduction in backward perturbations compared to baseline values. …”
Get full text

Hybrid Functions Direct Approach and State Feedback Optimal Solutions for a Class of Nonlinear Polynomial Time Delay Systems by Mohamed Karim Bouafoura, Naceur Benhadj Braiek

Get full text

RIS-assisted anti-spatial aliasing direct localization in NLOS scenarios via spatio-temporal-frequency information fusion by Jingjing Li, Jianhui Wang, Lihao Liu, Weijia Cui, Chunxiao Jian

“…Our proposed approach addresses these challenges through a cost-effective system and proposes a spatio-temporal-frequency information fusion (STFIF) direct localization algorithm that effectively resolves spatial aliasing issues in high-frequency applications. …”
Get full text

Evaluating the Pattern of Use and Direct Cost of Injectable Antibiotics Before and After Health Transformation Plan at Namazi Hospital in Shiraz by Shokooh Behdadian, Sakhajoo Nikoo, Fatemeh Soleymani, Afsaneh Vazin, Laleh Mahmoudi, Faezeh Abdizadeh, Iman Karimzadeh

“… Background: The inappropriate use of antimicrobials in outpatient and inpatient settings has led to the spread of microbial resistance, reduced clinical effectiveness of antimicrobial drugs, and significant direct and indirect costs. Various programs have been implemented to improve antimicrobial usage patterns. …”
Get full text

Change in stability direction induced by temporal interventions: a case study of a tuberculosis transmission model with relapse and reinfection by Dipo Aldila

Get full text

Optimizing Healthcare Expenditure for Spinal Cord Stimulation in Italy: The Value of Battery Longevity Improvement and a Direct-to-Implant Approach by Federica Tito, Gianfranco Sindaco, Simon Eggington, Elisa Tacconi, Francesca Borghetti, Mara Corbo, Gilberto Pari

“…With novel devices and specific programming settings, the lifetime cost per patient to a payer can be decreased without compromising the patient’s safety and positive clinical outcome…”
Get full text