Effect of Direct-Acting Antiviral Therapy on Thrombocytopenic Patients with Hepatitis C Virus-Related Chronic Liver Disease by Mahmoud Saif-Al-Islam, Usama M. Abdelaal, Mustafa Adel Younis, Hisham A. Alghany Algahlan, Safaa Khalaf

“…We aimed to analyze the hematologic effects of the new direct-acting antiviral (DAA) therapy, particularly on the platelet count in chronic HCV-infected patients with thrombocytopenia. …”
Get full text

Macro-Mesoscopic Failure Mechanism Based on a Direct Shear Test of a Cemented Sand and Gravel Layer by Long Qian, Xingwen Guo, Qinghui Liu, Xin Cai, Xiaochuan Zhang

“…In order to explore the influence of different layer treatment methods on the macro- and meso-mechanical properties of cemented sand and gravel (CSG), in this paper, the shear behavior of CSG material was simulated by a three-dimensional particle flow program (PFC3D) based on the results of direct shear test in the laboratory. …”
Get full text

Success of a second treatment of direct-acting antiviral therapy in patients with chronic Hepatitis C Virus infection. by Daniela L. Andrade-González, Aleida Bautista-Santos, Rosalba Moreno-Alcántar

“…Introduction and Objectives: Direct-acting antivirals (DAAs) are associated with a high sustained viral response (>95%) at 12 weeks (SVR12) in patients with chronic hepatitis C virus (HCV) infection.There is a low percentage of patients who have treatment failure or reinfection in the presence of persistent risk factors. …”
Get full text

Doctors’ perspectives on adhering to advance care directives when making medical decisions for patients: an Australian interview study by Karen M Detering, Marcus Sellars, Linda Nolte, Scott Fraser, Nadia Moore, Tessa Low

Get full text

Automation of the Formation of a Mathematical Formulation of Kinetics for Multistage Chemical Reactions and Numerical Solution to a Direct Problem by N. A. Lysenko, K. F. Koledina

“…The program results were presented by the example of catalytic reforming of gasoline. …”
Get full text

Assessment of Optimal Seeding Rate for Fine and Coarse Rice Varieties Using the Direct Seeded Rice (DSR) Method by Atif Naeem, Madad Ali, Ahmad Jawad, Asif Ameen, Mehwish, Talha Liaqat, Samreen Nazeer, Muhammad Zubair Akram, Shahbaz Hussain

“…Based on these findings, it is concluded that using an optimal seeding rate of 27 kg/ha for direct-seeded fine and coarse rice varieties is beneficial in terms of tillers and higher yield.…”
Get full text

Perbandingan Hukum Pertanggungjawaban Pidana Korporasi Tentang Perlindungan Dan Pengelolaan Lingkungan Hidup : Analisis Antara Amerika Dan Indonesia by Rozeli Rozeli, Endrio Susila

Get full text

Integrating artificial intelligence into medical education: a narrative systematic review of current applications, challenges, and future directions by Zeeshan Ahsan

Get full text

Microglial pyroptosis as a therapeutic target after traumatic spinal cord injury: current progress and future directions by Lei Shi, Lei Shi, Lei Shi, Qiheng Qian, Jiding Xie, Taoshuo Yang, Xinyu Zhao, Xiangqi Meng, Jingang Dai, Qiguan Jin

Get full text

Opportunities, Challenges, and Future Directions for Generative Artificial Intelligence in Library Information Literacy Education: A Scoping Review by Fan YUAN, Jia LI

“…To address these challenges, the research proposes a comprehensive framework that includes: 1) robust ethical guidelines for the implementation of GenAI, 2) systematic assessment mechanisms to monitor learning outcomes, 3) critical thinking training programs, and 4) strategies to maintain academic integrity and intellectual autonomy. …”
Get full text

Immunotherapy and the Tumor Microenvironment in Brain Metastases from Non-Small Cell Lung Cancer: Challenges and Future Directions by Meng Wang, Jihua Yang, Shuai Wang, Harjot Gill, Haiying Cheng

Get full text

Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12 by Selina Troester, Thomas Eder, Nadja Wukowits, Martin Piontek, Pablo Fernández-Pernas, Johannes Schmoellerl, Ben Haladik, Gabriele Manhart, Melanie Allram, Margarita Maurer-Granofszky, Nastassja Scheidegger, Karin Nebral, Giulio Superti-Furga, Roland Meisel, Beat Bornhauser, Peter Valent, Michael N. Dworzak, Johannes Zuber, Kaan Boztug, Florian Grebien

“…We employ an AML model for ligand-induced degradation of the NUP98::KDM5A fusion oncoprotein to identify epigenetic programs and transcriptional targets that are directly regulated by NUP98::KDM5A through CUT&Tag and nascent RNA-seq. …”
Get full text

Ticks (Acari: Ixodidae) and tick-borne diseases in Cameroon: Current understanding and future directions for more comprehensive surveillance by Yannick Ngnindji-Youdje, Michel Lontsi-Demano, Adama Zan Diarra, Juluis Foyet, Timolèon Tchuinkam, Philippe Parola

Get full text

A new approach for detecting HPV DNA in cervical swabs: comparison of nucleic acid extraction with direct PCR by Fatih Çubuk, Muhammet Çağrı Yıldız, Fikrican Balcı, Ahmet İrgin, Savaş Aşkın, Ekrem Sağtaş, Sedat kaygusuz

“…Results PharmaDirect provided 88.1% sensitivity compared to nucleic acid extraction. …”
Get full text

Effects of direction and gender on lower limb biomechanics during forward lunges in badminton players: a preliminary analysis by Li Huang, Yan Zhang, Shunxiang Gao, Junxia Lin, Fei Zheng, Yaodong Gu

“…Conclusions Gender-specific biomechanical strategies influence knee loading patterns during badminton lunges, contributing to direction-dependent variations in injury risk. These findings underscore the importance of incorporating directional biomechanical demands and sex-specific neuromuscular adaptations into training and injury prevention programs to mitigate injury risks.…”
Get full text

Survival analysis of patients with metastatic head and neck squamous cell carcinoma treated with metastasis-directed radiotherapy and immunotherapy by Peng Xu, Dongmei Liu, Jie Zhou, Zhengyi Tang, Shuo Wang, Yecai Huang, Mei Feng, Shun Lu, Jinyi Lang, Lucia Clara Orlandini

“…This study aims to evaluate whether adding metastasis-directed radiotherapy (MDRT) to immunotherapy and chemotherapy could improve the survival rate of patients with metastatic HNSCC. …”
Get full text

Against the background of global climate changes, the current ecological situation of Azerbaijan's water resources and the directions of efficient use by Ільгар Халілов, Фархад Емінов

“…Azerbaijan's water resources, their modern ecological condition and directions for effective use. The purpose of the study. …”
Get full text

Advancing the deployment and information management of direct air capture: A solution enabled by integrating consortium blockchain system by Zihan Chen, Yiyu Liu, Eryu Wang, Huajie You, Qi Gao, Fan David Yeung, Jia Li

“…Direct air capture (DAC) is a critical and emerging Negative Emissions Technology (NET) that directly removes CO2 from the atmosphere, significantly contributing to climate change. …”
Get full text

Social policy of the early 1990^s in the conditions of economic reform: directions and ways of solution (Southern Ural). by N. V. Baryshnikova, O. V. Kuznetsova

“…The result of each is the transition from active criticism and analysis of the impact of reforms on the social sphere of society to attempts to study methods and directions for changing social policy at federal and regional levels.   …”
Get full text

Mapping Connection and Direction Among Symptoms of Sleep Disturbance and Perceived Stress in Firefighters: Embracing the Network Analysis Perspective by Liu B, Zou M, Liu L, Wu Z, Jin Y, Feng Y, Jia Q, Li M, Ren L, Yang Q

“…Future intervention programs should prioritize these potential targets. …”
Get full text