PET in neurotherapeutic discovery and development by Melissa Chassé, Neil Vasdev

“…As such, PET imaging has long been used as a tool to aid drug discovery programs from preclinical biomarker validation all the way through to clinical trials. …”
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Intrinsic PD‐L1 Degradation Induced by a Novel Self‐Assembling Hexapeptide for Enhanced Cancer Immunotherapy by Hongxia Zhang, Ming Ji, Yamei Wang, Mengmeng Jiang, Zongyu Lv, Gongyu Li, Lulu Wang, Zhen Zheng

“…Abstract Programmed death‐ligand 1 (PD‐L1) is a critical immune checkpoint protein that facilitates tumor immune evasion. …”
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Quadruple Deep Q-Network-Based Energy Management Strategy for Plug-In Hybrid Electric Vehicles by Dingyi Guo, Guangyin Lei, Huichao Zhao, Fang Yang, Qiang Zhang

“…This approach provides a promising direction for real-time energy optimization in hybrid and electric vehicles.…”
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Deep Reinforcement Learning Based Joint Allocation Scheme in a TWDM-PON-Based mMIMO Fronthaul Network by Yuansen Cheng, Yingjie Shao, Shifeng Ding, Chun-Kit Chan

“…In this paper, we formulate the joint allocation problem into an integer linear programming mathematical model and propose a deep reinforcement learning (RL)-based joint allocation scheme with an energy-efficient architecture for the TWDM-PON-based mMIMO fronthaul network. …”
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Finding and following: a deep learning-based pipeline for tracking platelets during thrombus formation in vivo and ex vivo by Abigail S. McGovern, Pia Larsson, Volga Tarlac, Natasha Setiabakti, Leila Shabani Mashcool, Justin R. Hamilton, Niklas Boknäs, Juan Nunez-Iglesias

“…Furthermore, platelets in vivo exhibit less passive movement in the direction of blood flow. Our tools are free and open source and written in the popular and user-friendly Python programming language. …”
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Do College Freshmen Who Engage More in Online Social Comparison Tend to Be More Confused About Themselves? The Roles of Rumination and Self-Compassion by Sujie Kang, Qian Gu, Wen Qin, Sanming Liu, Yukang Xue, Qishan Zheng, Chuanhua Gu, Yuqi Cao

“…The results indicated that among college freshmen, online social comparisons can negatively impact self-concept clarity both directly and indirectly through rumination. Self-compassion moderated the effect of rumination on self-concept clarity. …”
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A lattice-mechanical metamaterial with tunable two-step deformation, tunable stiffness, tunable energy absorption and programmable properties by Chenyang Liu, Zexin Gao, Jiahui Chang, Jianan Zhao, Song Qiu, Peiran Yu, Xi Zhang

“…These properties can exist in multiple directions and are not affected by the number of unit cells. …”
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Subverting <i>Attachment</i> to Prevent <i>Attacking</i>: Alteration of Effector Immune Cell Migration and Adhesion as a Key Mechanism of Tumor Immune Evasion by Marta Mastrogiovanni, Emmanuel Donnadieu, Rajiv Pathak, Vincenzo Di Bartolo

“…We discuss the mechanisms by which tumors directly modulate immune cell adhesion and migration patterns to affect anti-tumor immunity and favor tumor evasion. …”
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ISLAMIC SOCIAL FINANCE AND SDG 2: MEASURING THE SOCIAL IMPACT OF ISLAMIC RELIGIOUS AND MALAY TRADITION COUNCIL IN PERAK STATE by Mohamed Fairooz Abdul Khir, Hainnuraqma Rahim, Faaza Fakhrunnas, Shamimi Mohd Zulkarnaini

“…The study adopts in-depth interviews with the stakeholders of MAIPk and performs a survey of Islamic social finance recipients in Perak State, focusing on the monthly financial and food bank assistance programs, which the number of recipients is 11,769 and 25,144 recipients. …”
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Gender and rural transformation: A systematic literature review by Maria Fay ROLA-RUBZEN, Hue T. VUONG, Claire DOLL, Curtis ROLLINS, Jon Marx SARMIENTO, Mohammad Jahangir ALAM, Ismat Ara BEGUM

“…Tailoring future development policies and programs to explicitly account for gender inclusiveness can lead to more successful rural transformation.…”
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Impact of teaching style on perceived mathematics achievement of elementary education preservice teachers: the mediating roles of attitude and math self-concept by Teresa Mae Awado, Tom Jefferson Abalos, Honey Rose Pelago, Vincent Morales, Jean Gindy Torres, Masza Lyn Milano, Danica Kaye Hallarte, Roselyn Gonzales, Gamaliel Gonzales

“…Implications for teacher training programs for elementary education are discussed, and future research directions are suggested.…”
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Connecting bone metastasis, adipose tissue and adipokines: How does physical activity fit? by Paola Maroni, Marta Gomarasca, Michela Signo, Giovanni Lombardi

“…Adipokines can act systemically or directly on tissues to drive cancer initiation, progression and metastasis. …”
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Enhancer regulatory networks globally connect non-coding breast cancer loci to cancer genes by Yihan Wang, Daniel A. Armendariz, Lei Wang, Huan Zhao, Shiqi Xie, Gary C. Hon

“…Analysis of > 500,000 single-cell transcriptomes in two breast cancer cell lines shows that perturbation of BC-associated enhancers disrupts breast cancer gene programs. We observe BC-associated enhancers that directly or indirectly regulate the expression of cancer genes. …”
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Comparison of the Accuracy Between Naive Bayes Classifier and Support Vector Machine Algorithms for Sentiment Analysis in Mobile JKN Application Reviews by Erni Septiani, Tubagus M. Akhriza, Mochamad Husni

“…This algorithm is implemented directly in sentiment analysis and combined with the Synthetic Minority Over-Sampling Technique (SMOTE) technique to overcome data imbalance. …”
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Institute of Mentoring in the Socio-Cultural Space of the Russian North and the Russian Arctic: Traditions and Innovations by Nikolay N. Terebikhin, Marina N. Melyutina, Aleksandra V. Yakovleva

“…The central place in the article is given to the presentation of the scientific results of the analysis of the forms, methods and directions of the mentoring activities of the Kenozerskiy National Park, which, relying on the ethno-cultural heritage of the traditional societies of the Ozernyy district, acts as a reference methodological school-laboratory, implementing a wide range of mentoring research and educational practices aimed at transformation of local territories into a socio-cultural space of creative dialogue and cooperation between the Park and local communities, training of leaders and activists of territorial public self-government (TPS), elaboration of regional strategy and local programs of spatial development of the Northern macro-region.…”
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Differential ER stress responses during lactation and postpartum outcomes in mice depending on their mitochondrial genotype by Mrittika Chattopadhyay, Edmund Charles Jenkins, William Janssen, Thelma Mashaka, Doris Germain

“…We show that in female mice that share the same nuclear genome (BL/6) but differ in mitochondrial genomes (C57 or NZB), lactation engages different transcriptional programs resulting in anti-tumorigenic lactation in BL/6C57 females and pro-tumorigenic lactation in BL/6NZB females. …”
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Ginkgetin from Ginkgo biloba: mechanistic insights into anticancer efficacy by Bei Xiong, Jin-Jian Lu, Hongwei Guo, Mingqing Huang, Ting Li

“…Furthermore, target identification, research limitations, future directions, and application prospects are comprehensively outlined, aiming to facilitate the clinical translation of ginkgetin. …”
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Tracking HIV persistence across T cell lineages during early ART-treated HIV-1-infection using a reservoir-marking humanized mouse model by Namita Satija, Foramben Patel, Gerrit Schmidt, Donald V. Doanman, Manav Kapoor, Annalena La Porte, Ying-Chih Wang, Kenneth M. Law, Anthony M. Esposito, Kimaada Allette, Kristin G. Beaumont, Robert P. Sebra, Benjamin K. Chen

“…Critical regulators of these pathways, including JUN, BCL2, and MDM2, change to opposite directions in the two states, highlighting gene expression programs that may support HIV persistence across T-cell lineages and states.…”
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Vaccination Strategies and Research Gaps in Hepatitis E Virus for Special Populations by Meng Wang, Binwei Duan, Mengcheng Liu, Yuxuan Zhang, Feng Wu, Guangming Li, Yabo Ouyang

“…Additionally, potential advancements in vaccine technology, including the development of broad-spectrum vaccines and innovative delivery systems, are discussed as future directions. Strategies: Addressing regulatory, economic, and logistical barriers remains crucial for effective HEV vaccination programs. …”
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The dual role of PGAM5 in inflammation by Yuxin Qi, Bhavana Rajbanshi, Ruihan Hao, Yifan Dang, Churong Xu, Wei Lu, Liming Dai, Bingjun Zhang, Xiaoling Zhang

“…Finally, the challenges and future directions of the use of PGAM5, which has dual properties, as a target molecule in the clinic are discussed. …”
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