Long-term mortality in mothers of infants with neonatal abstinence syndrome: A population-based parallel-cohort study in England and Ontario, Canada. by Astrid Guttmann, Ruth Blackburn, Abby Amartey, Limei Zhou, Linda Wijlaars, Natasha Saunders, Katie Harron, Maria Chiu, Ruth Gilbert

“…Limitations included lack of direct measures of maternal opioid use, other substance misuse, and treatments or supports received.…”
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Spontaneous and activation-induced apoptosis of peripheral blood mononuclear cells in the pathogenesis of type 1 diabetes mellitus by A. V. Lugovaya, N. M. Kalinina, V. Ph. Mitreikin, Yu. V. Emanuel, Yu. P. Kovalchuk, A. V. Artyomova

“…Assessment of activation apoptosis in response to stimulation with mitogen or a specific antigen is considered more significant when studying apoptosis markers in peripheral blood mononuclear cells to clarify the role of programmed cell death in pathogenesis of various diseases, since the role of apoptosis in immune response is increased in activated cells. …”
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Search for molecular descriptors and computer prediction of biological activity in a series of S-derivatives (1,2,4-triazole-3(2H)-yl)methyl)thiopyrimidines by Yu. V. Karpenko, O. I. Panasenko, A. P. Litun

“…Much attention is directed towards nitrogen-containing heterocycles, particularly derivatives of 1,2,4-triazole, due to their substantial medical and biological potential. …”
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The Impact of Exercise Training on the Brain and Cognition in Type 2 Diabetes, and its Physiological Mediators: A Systematic Review by Jitske Vandersmissen, Ilse Dewachter, Koen Cuypers, Dominique Hansen

“…In addition, BDNF, lactate, leptin, adiponectin, GSK3β, GLP-1, the AMPK/SIRT1 pathway, and the PI3K/Akt pathway were identified as plausible mediators directly from studies investigating the effect of exercise training on brain structure and function in T2DM. …”
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Using the Smath Computer Package in School Mathematics Lessons by Valery F. Ochkov, Inna E. Vasileva, Yuliya V. Shatskikh

“…When solving equations, the schoolchildren directly implemented the visualization method using SMath graphical tools. …”
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Lipid metabolism reprograming by SREBP1‐PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapy by Mengyi Lao, Xiaozhen Zhang, Zejun Li, Kang Sun, Hanshen Yang, Sicheng Wang, Lihong He, Yan Chen, Hanjia Zhang, Jiatao Shi, Daqian Xu, Tingbo Liang, Xueli Bai

“…Mechanistically, SREBP1 directly bound the PD‐L1 promoter, suppressing its transcription. …”
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Daurisoline Modulates the TBK1-Dependent Type I Interferon Pathway to Boost Anti-tumor Immunity via Targeting of LRP1 by Borui Tang, Yuting Wang, Liping Li, Cuicui Sun, Jingwen Dong, Ruoqi Li, Jianfeng Wang, Yu Long, Mingxiao Yin, Fei Xie, Dian Xiao, Xinbo Zhou, Na Zhang, Xiuli Zhao, Yanchun Feng, Hongbin Deng

“…Furthermore, DS demonstrated synergistic effects with anti-programmed death 1 therapy and a stimulator of interferon genes agonist by remodeling the immunosuppressive microenvironment. …”
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The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development by Pablo Gómez-del Arco, Joan Isern, Daniel Jimenez-Carretero, Dolores López-Maderuelo, Rebeca Piñeiro-Sabarís, Fadoua El Abdellaoui-Soussi, Carlos Torroja, María Linarejos Vera-Pedrosa, Mercedes Grima-Terrén, Alberto Benguria, Ana Simón-Chica, Antonio Queiro-Palou, Ana Dopazo, Fátima Sánchez-Cabo, José Jalife, José Luis de la Pompa, David Filgueiras-Rama, Pura Muñoz-Cánoves, Juan Miguel Redondo

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exoALMA. XII. Weighing and Sizing exoALMA Disks with Rotation Curve Modelling by Cristiano Longarini, Giuseppe Lodato, Giovanni Rosotti, Sean Andrews, Andrew Winter, Jochen Stadler, Andrés Izquierdo, Maria Galloway-Sprietsma, Stefano Facchini, Pietro Curone, Myriam Benisty, Richard Teague, Jaehan Bae, Marcelo Barraza-Alfaro, Gianni Cataldi, Ian Czekala, Nicolás Cuello, Daniele Fasano, Mario Flock, Misato Fukagawa, Himanshi Garg, Cassandra Hall, Iain Hammond, Caitlyn Hardiman, Thomas Hilder, Jane Huang, John D. Ilee, Andrea Isella, Kazuhiro Kanagawa, Geoffroy Lesur, Ryan A. Loomis, Francois Ménard, Ryuta Orihara, Christophe Pinte, Daniel Price, Leonardo Testi, Gaylor Wafflard- Fernandez, Lisa Wölfer, Hsi-Wei Yen, Tomohiro C. Yoshida, Brianna Zawadzki

“…The exoALMA large program offers a unique opportunity to investigate the fundamental properties of protoplanetary disks, such as their masses and sizes, providing important insights into the mechanism responsible for the transport of angular momentum. …”
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Detection of frictional meltwater on snow surface using a humidity indicator by Shiraz Ahmed Siddiqui, Michael Hasler, Martin Mössner, Joost van Putten, Kurt Schindelwig, Werner Nachbauer

“…After the test, the images captured before, and after the runs were systematically analysed using a self-developed program in LABVIEW (National Instruments Corporation, Austin, Texas, USA). …”
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Exploring protein–protein ligation approaches for the cytosolic delivery of antigens using AIP56 by Bruno Pinheiro, Bruno Pinheiro, Bruno Pinheiro, Ana C. Moura, Ana C. Moura, Pedro Oliveira, Jorge E. Azevedo, Jorge E. Azevedo, Jorge E. Azevedo, Ana do Vale, Ana do Vale, Nuno M. S. dos Santos, Nuno M. S. dos Santos

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Mahakala: A Python-based Modular Ray-tracing and Radiative Transfer Algorithm for Curved Spacetimes by Aniket Sharma, Lia Medeiros, George N. Wong, Chi-kwan Chan, Goni Halevi, Patrick D. Mullen, James M. Stone

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No significant association between self-reported physical activity and brain volumes in women and men from five European cohorts by Naiara Demnitz, William F. C. Baaré, Julia Binnewies, Andreas M. Brandmaier, Anders M. Fjell, Anne T. Gates, Rogier Kievit, Michael Kjaer, Kathrine Skak Madsen, Lars Nyberg, Sara Pudas, Hartwig R. Siebner, Sana Suri, Øystein Sørensen, Kristine Beate Walhovd, Klaus P. Ebmeier, Carl-Johan Boraxbekk

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HBV-driven host chromatin accessibility changes affect liver metabolic pathways, iron homeostasis and promote a preneoplastic phenotype by Vincenzo Alfano, Giuseppe Rubens Pascucci, Giacomo Corleone, Massimiliano Cocca, Francesca De Nicola, Océane Floriot, Alexia Paturel, Francesca Casuscelli Di Tocco, Claude Caron de Fromentel, Philippe Merle, Michel Rivoire, Massimo Levrero, Francesca Guerrieri

“…Abstract Backround and aims Complex host-virus interactions account for adaptive and innate immunity dysfunctions and viral cccDNA mini-chromosome persistence, key features of HBV chronicity and challenges for HBV cure. The extent of HBV direct impact on liver transcriptome remains controversial. …”
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Bio-functional hydrogel coated membranes to decrease T-cell exhaustion in manufacturing of CAR T-cells by Aida López Ruiz, Eric Slaughter, Kartik Bomb, Samantha L. Swedzinski, Paige J. LeValley, Zaining Yun, Jacob McCoskey, Kara Levine, Jonathan Steen, Joseph Almasian, Aparajita Chatterjee, Christina Carbrello, Dustin S. Chang, Hubaida Fuseini, Yama A. Abassi, Abraham M. Lenhoff, Catherine A. Fromen, April M. Kloxin, April M. Kloxin

“…To address this need, in this work, we utilized a bioinspired, scalable, tunable platform to direct T-cell activation and decrease exhaustion during CAR T production.MethodsHydrogel-coated membranes (HCMs) were designed with different co-stimulatory ligands and a physiologically-relevant substrate modulus inspired by the native microenvironment in which T cells are programmed. …”
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Sustained and specific multiplexed immune checkpoint modulation in CAR T cells induced by targeted epigenome editing by Maria Silvia Roman Azcona, Gianni Monaco, Melissa Whitehead, Masako Monika Kaufmann, Jamal Alzubi, Toni Cathomen, Claudio Mussolino

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RANKL blockade inhibits cancer growth through reversing the tolerogenic profile of tumor-infiltrating (plasmacytoid) dendritic cells by Pascale Hubert, Patrick Roncarati, Charlotte Pilard, Marie Ancion, Celia Reynders, Thomas Lerho, Diane Bruyere, Alizee Lebeau, Marie-Julie Nokin, Elodie Hendrick, Olivier Peulen, Philippe Delvenne, Michael Herfs, Margaux Luyckx, Michael Renard, Florian Poulain, Rebekah Crake, Raphael Peiffer

“…Regarding its role in carcinogenesis, while direct effects on tumor cell behavior have been precisely characterized, the impact of the RANKL/RANK system (and its inhibition) on the intratumoral immune landscape remains unclear.Methods After various in silico/in situ/in vitro analyses, the immunotherapeutic efficacy of RANKL blockade (alone and in combination with immune checkpoint inhibitors (anti-programmed cell death protein-1 (PD-1)) or doxorubicin/paclitaxel-based chemotherapy) was investigated using different syngeneic mouse models of triple-negative breast cancer (4T1, 67NR and E0771). …”
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Cost-savings and health impact of strategies for prevention of Respiratory Syncytial Virus with nirsevimab in Chile based on the integrated analysis of 2019–2023 national databases... by Denis Sauré, Miguel O’Ryan, Juan Pablo Torres, Natalia Trigo, Gonzalo Diaz, Marcel Goic, Charles Thraves, Jorge Pacheco, Patricio Aguilera, Andrea Caro, Leonardo J. Basso

“…Methods: Leveraging comprehensive inpatient, outpatient, and sentinel programs data, we conduct a simulation-based retrospective analysis to evaluate the net cost savings of various immunization strategies based on nirsevimab. …”
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Validating psychometric properties of generic quality-of-life instruments (WHOQOL-BREF (TW) and EQ-5D) among non-dialysis chronic kidney disease: Rasch and confirmatory factor anal... by Chih-Hen Yu, Ching-Chun Lin, Zheng-Zhe Wu, An-Bang Wu, Yu-Tzu Chang, Chung-Ying Lin, Jung-Der Wang, Junne-Ming Sung

“…Methods: Patients who were in CKD care programs at a medical center in Taiwan were recruited and self-filled WHOQOL-BREF Taiwan version (TW) and EQ-5D questionnaires. …”
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SP140 inhibits STAT1 signaling, induces IFN-γ in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response by Richard Carvajal, Akiva Mintz, Fatemeh Momen-Heravi, Alison Taylor, Kranthi Kiran Kishore Tanagala, Joshua Morin-Baxter, Maryum Cheema, Sunil Dubey, Angela Yoon, Yi-Shing L Cheng, Jeffrey Nickerson

“…Chromatin immunoprecipitation and analysis of assay of transposase accessible chromatin sequencing data were used to demonstrate the direct binding of SP140 on the promoters of STAT1. …”
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