Real-World Persistence and Effectiveness of Upadacitinib versus Other Janus Kinase Inhibitors and Tumor Necrosis Factor Inhibitors in Australian Patients with Rheumatoid Arthritis by Peter Youssef, Sabina Ciciriello, Talib Tahir, Joanna Leadbetter, Belinda Butcher, Miriam Calao, Nicole Walsh, Catherine O’Sullivan, Tegan Smith, Geoffrey Littlejohn

“…Abstract Introduction This study sought to describe treatment patterns, persistence, and effectiveness of upadacitinib (UPA) alone and compared to other Janus kinase inhibitors (JAKis) or tumor necrosis factor inhibitors (TNFis) in patients with rheumatoid arthritis (RA). …”
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Mass Casualty Incident Training in Immersive Virtual Reality: Quasi-Experimental Evaluation of Multimethod Performance Indicators by Anke Sabine Baetzner, Yannick Hill, Benjamin Roszipal, Solène Gerwann, Matthias Beutel, Tanja Birrenbach, Markus Karlseder, Stefan Mohr, Gabriel Alexander Salg, Helmut Schrom-Feiertag, Marie Ottilie Frenkel, Cornelia Wrzus

“…While the examined visual attention indicators did not function as valid performance indicators in this study, future research could further explore visual attention in MCI training and examine other indicators, such as holistic gaze patterns. Overall, the results underscore the importance of integrating objective indicators to enhance trainers’ feedback and provide trainees with guidance on evaluating and reflecting on their own performance.…”
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Daily home monitoring of potassium, creatinine, and estimated plasma volume in heart failure post‐discharge by Patrick Rossignol, Renaud Fay, Nicolas Girerd, Faiez Zannad

“…It was possible to document a number of episodes of hyperkalaemia (>5: mean ± standard deviation: 2.2 ± 2.2 or 5.5: 1.7 ± 1.6 mmol/L), hypokalaemia (<4: 1.9 ± 2.4 or 3.5: 0.5 ± 1.2 mmol/L), worsening renal function (drop in estimated glomerular filtration rate > 20%: 1.3 ± 1.8 or 30%: 0.7 ± 1.2) and recongestion (ePV rise above 10%: 1.4 ± 1.5, 15%: 2.3 ± 2.4, 5.5 mL/g Hb: 1.8 ± 2.6) episodes indicative of clinically relevant and potentially actionable cardiorenal and electrolytic patterns. Conclusions Our findings demonstrate that a 5‐day‐a‐week home monitoring combining haemoglobin/haematocrit, potassium, and creatinine measurements was able to capture a substantial number of clinically relevant cardiorenal and electrolyte events which are frequently overlooked and potentially actionable. …”
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Identifikasi Bakteri Infeksi Saluran Pernafasan Bawah Non Tuberkulosis (Non TB) dan Pola Resistensinya pada Penderita Diabetes Melitus di RSUP M. Djamil by Virgi Anggia Lubis, Yusticia Katar, Elizabeth Bahar

“…The objective of this study was to indentify the causal bacteria of lower respiratory infection non tuberculous infection and the  bacterial resistance patterns in patients with diabetes mellitus in RSUP M. …”
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Risk barriers and sustainability in payment for ecosystem service implementation in smallholder forestry by A. Ibrahim, S. Withaningsih, R. Kinseng, Parikesit ., D. Muhamad

“…Biophysical conditions like rainfall patterns and soil health further influence program success, demanding tailored approaches for effective implementation. …”
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Translation and Validation of the Edinburgh Postnatal Depression Scale for Eritrea: A Screening Tool for Postpartum Depression in Primary Health Care Facilities by Gebregziabher NK, Netsereab TB, Alazar FA, Fessaha YG, Sium AH, Ghebrehiwet NK

“…Nahom Kiros Gebregziabher,1,2 Tesfit Brhane Netsereab,1,3 Feven Andebrhan Alazar,4 Yerusalem Gebremeskel Fessaha,4 Aman Hadish Sium,4 Nardos Kidane Ghebrehiwet4 1Department of Community Medicine, Orotta College of Medicine and Health Sciences, Asmara, Eritrea; 2Department of Epidemiology & Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, People’s Republic of China; 3Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, People’s Republic of China; 4Ministry of Health, Asmara, EritreaCorrespondence: Nahom Kiros Gebregziabher, Department of Community Medicine, Orotta College of Medicine and Health Sciences, Asmara, Eritrea, Email nahomkiros21@gmail.comIntroduction: Postpartum depression (PPD) is a mood disorder characterized by symptoms such as changes in sleep and eating patterns, fatigue, sadness, crying, anxiety, and guilt. …”
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Which patients received a ReSPECT form, what was documented and what were the patient outcomes? A protocol for a retrospective observational study investigating the impact of the C... by Lucy Selman, Charlotte Chamberlain, Adam McDermott, Claire A Woodall, Lucy Victoria Pocock

“…It is unclear what impact the pandemic had on the implementation of ReSPECT and if this affected the type of patients who underwent the ReSPECT process, such as those with specific diagnoses or living in care homes. Patterns of clinical recommendations documented on ReSPECT forms during the first year of its implementation may also have changed, particularly with reference to the pandemic.To determine the equity and potential benefits of implementation of the ReSPECT form process in BNSSG and contribute to the ACP evidence base, this study will describe the characteristics of patients in the BNSSG area who had a completed ReSPECT form recorded in their primary care medical records before, during and after the first wave of the COVID-19 pandemic; describe the content of ReSPECT forms; and analyse outcomes for those patients who died with a ReSPECT form.Methods and analysis We will perform an observational retrospective study on data, collected from October 2019 for 12 months. …”
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Overall Survival of Patients with Metastatic Renal Cell Carcinoma Following the Introduction of Targeted and Immunotherapies: A Norwegian Retrospective, Real-World Registry Data St... by Puco K, Notland CS, Szulkin R, Jonasson C, Beisland C, Johannesen TB, Solli O, Oldenburg J, Heinrich D

“…Secondary endpoints included further analysis of treatment patterns and possible impact on OS. Secondary endpoint analysis was performed in patients diagnosed with mRCC between 1 January 2008 and 31 December 2018, as complete data on systemic therapies were available from 2008 and onwards.Results: In total, 4078 patients were diagnosed with mRCC in the period from 1995 to 2018. …”
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Pemanfaatan Aplikasi Pengiriman Makanan Pasca Penurunan Level Pembatasan Kegiatan Masyarakat Akibat Covid-19 Di Indonesia by Wan Ahmad Gazali Kodri, Dwiza Riana, Sri Hadianti

“…Restaurants can use this assessment to see shifts in food purchasing patterns.   …”
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Variations and anomalies in the structure and branching of lumbosacral spinal nerve roots: a case report and global insights by O. S. Nekhlopochyn, V. V. Verbov, M. M. Leshko, Ye. V. Cheshuk, I. M. Ivanovych, T. A. Malysheva

“…The lumbosacral nerve root anomalies (LSNRA) demonstrate a variety of structural variations and branching patterns, which are reflected in different classifications. …”
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Comparative Analysis of Multiple Hydrological Models in Assessing Climate Change Impacts on the Mille Watershed, Awash Basin, Ethiopia by Asmare Belay Nigussie, Mihiretie Ayana, Dessalegn Worku Ayalew, Gerawork Feleke, Asnake Enawgaw Amognehegn, Anteneh Yayeh Adamu, Andualem Endalew, Tewodrose Desale Meselaw, Shankar Karuppannan

“…As industrial and economic growth intensifies, greenhouse gases are released into the atmosphere, leading to a shift in global warming and climate change patterns. The Mille watershed faces significant challenges such as flooding, drought, irrigation, and water supply scarcity, as well as health issues stemming from climate change within the community. …”
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Glioma Image-Level and Slide-Level Gene Predictor (GLISP) for Molecular Diagnosis and Predicting Genetic Events of Adult Diffuse Glioma by Minh-Khang Le, Masataka Kawai, Kenta Masui, Takashi Komori, Takakazu Kawamata, Yoshihiro Muragaki, Tomohiro Inoue, Ippei Tahara, Kazunari Kasai, Tetsuo Kondo

“…Therefore, an artificial intelligence (AI) framework for learning histological patterns and predicting important genetic events would be useful for future studies and applications. …”
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Machine learning models for dementia screening to classify brain amyloid positivity on positron emission tomography using blood markers and demographic characteristics: a retrospec... by Noriyuki Kimura, Kotaro Sasaki, Teruaki Masuda, Takuya Ataka, Mariko Matsumoto, Mika Kitamura, Yosuke Nakamura, Etsuro Matsubara

“…., five combinations of variables), each constructed with three classification algorithms, resulting in a total of 15 patterns. L2-regularized logistic regression, and kernel Support Vector Machine (SVM) and Elastic Net algorithms were used to construct the classification models using 34 pre-selected variables (12 demographic characteristics, 11 blood test results, 11 cognitive test results). …”
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Integrated Impacts of Urban Spatial Form on Thermal Environment and Zonal Regulation under the Perspective of Spatial Heterogeneity by Yan Jinlong, Yin Chaohui, An Zihao, Zhang Simin, Wen Qian, Chen Weiqiang

“…Analyzing the spatial relationship between urban spatial patterns and the thermal environment and quantifying zoning to regulate the urban thermal environment according to local conditions is essential. …”
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Soil chemical factors contributing to differences in bacterial communities among tea field soils and their relationships with tea quality by Shuning Zhang, Shuning Zhang, Naoki Yanagisawa, Mio Asahina, Hiroto Yamashita, Hiroto Yamashita, Hiroto Yamashita, Takashi Ikka, Takashi Ikka, Takashi Ikka, Takashi Ikka

“…We conducted pot cultivation of tea plant ‘Yabukita’ to investigate how soil chemical factors affect bacterial communities and their influences on the nutrient status and quality of tea plants, and finally explored the complex relationships between soil bacterial features and tea quality.Results and discussionThe results showed that soil bacterial α-diversity was higher level in soils D and E, with distinct β-diversity patterns separating higher pH soils (D and E) from lower pH soils (A, B, and C). …”
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Integrated bioinformatics analysis and experimental validation of exosome-related gene signature in steroid-induced osteonecrosis of the femoral head by Renqun Mao, Wen Bi, Mengyue Yang, Lei Qin, Wenqing Li

“…Two SIONFH subtypes related to ERGs were identified, and distinctions in pathways and immune cell infiltration patterns were compared. SIONFH's high-risk subpopulation exhibited enriched immune-related pathways and high immune cell infiltration, such as M0 macrophages, resting mast cells, and neutrophils. …”
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Leveraging Local Community Capacities for Sustainable Security: A Case Study of the Border Villages in Darmiyan and Sarbisheh Counties by Javad Mikaniki

“…Social institutions are relatively stable patterns of behavior or a set of relationships, trends, and tools that are built around social interests and needs. …”
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Seasonal Variations in the Structure and Function of the Gut Flora in Adult Male Rhesus Macaques Reared in Outdoor Colonies by Longbao Lv, Feiyan Zhang, Haimei Zhou, Wenxian Xiao, Yingzhou Hu, Wenchao Wang, Zhu Zhu, Fangming Zhu, Dongdong Qin, Xintian Hu

“…The seasonal variations that occur in the gut microbiota of healthy adult rhesus monkeys kept in outdoor groups under conventional rearing patterns and how these variations are affected by environmental variables are relatively poorly understood. …”
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Elucidating metabolite and pH variations in stroke through guanidino, amine and amide CEST MRI: A comparative multi-field study at 9.4T and 3T by Kexin Wang, Licheng Ju, Guanda Qiao, Yajie Liang, Yihan Wu, Chengyan Chu, Joshua Rogers, Yuguo Li, Suyi Cao, Valina L. Dawson, Ted M Dawson, Piotr Walczak, Jiadi Xu

“…Both pMCAO and tMCAO models were utilized to examine the B1-dependence patterns and pH sensitivity of the different CEST contrasts in ischemic lesions compared to contralateral region. …”
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Urinary System Manifestation of IgG4-Related Disease: Clinical, Laboratory, Radiological, and Pathological Spectra of a Chinese Single-Centre Study by Fei Teng, Hui Lu, Ke Zheng, Gang Chen, Yubing Wen, Zheng Liu, Linyi Peng, Li Huo, Xiaofeng Zeng, Wen Zhang, Xuemei Li

“…Renal cortex low-density areas, parenchyma or pelvis nodular mass, bilateral enlargement of the kidney, and renal pelvis and ureter mass/wall thickening were specific image patterns of IgG4-RUD. Infiltration of plasma lymphocytes and storiform fibrosis were histopathological features of IgG4-RUD. …”
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