Integrating RNA-seq and scRNA-seq to explore the prognostic features and immune landscape of exosome-related genes in breast cancer metastasis by Guanyou Huang, Yong Yu, Heng Su, Hongchuan Gan, Liangzhao Chu

“…Compared to the low-risk group, the high-risk group exhibits increased immune cell infiltration and higher levels of immune evasion. scRNA-seq data reveal that high-risk cells have significantly higher risk scores and exhibit notable differences in signalling pathways and intercellular communication patterns.Conclusions This study presents a novel risk score model based on exosome-related genes, validated by comprehensive analyses including differential expression, survival analysis and external dataset validation. …”
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Joint trajectories of physical activity, health, and income before and after statutory retirement: A 22-year follow-up. by Tea Lallukka, Petteri Kolmonen, Ossi Rahkonen, Eero Lahelma, Jouni Lahti

“…We examined five repeated questionnaire surveys to identify any joint developmental patterns in the key indicators of healthy aging and well-being-leisure-time physical activity, health measured by general health perceptions, and household income, over a follow-up of 22 years. …”
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Treatment of a mutant KRAS lung cancer cell line with polyisoprenylated cysteinyl amide inhibitors activates the MAPK pathway, inhibits cell migration and induces apoptosis. by Matthew D Gregory, Kweku Ofosu-Asante, Jassy Mary S Lazarte, Pablo E Puente, Nada Tawfeeq, Nadine Belony, Yong Huang, Ite A Offringa, Nazarius S Lamango

“…However, CRAF/RAF1 phosphorylation decreased by 40%, suggesting significant changes in the KRAS/MAPK signaling patterns. Furthermore, 5 μM of NSL-YHJ-2-27 depleted the singly polyisoprenylated monomeric G-proteins RAC 1/2/3 and CDC42 by 77 and 76%, respectively. …”
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Biomechanical Basis of Interval Throwing Programs for Baseball Pitchers: A Systematic Review by Travis Dias, Benjamin G. Lerch, Jonathan S. Slowik, Kevin E. Wilk, James R. Andrews, E. Lyle Cain, Glenn S. Fleisig

“…While differences exist between interval throwing kinematics and pitching kinematics, the patterns are similar in general. # Level of Evidence 2…”
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Long-Term Safety and Effectiveness of Canakinumab in Patients with MKD/HIDS: Interim Analysis of the RELIANCE Registry by Prasad T. Oommen, Tilmann Kallinich, Juergen Rech, Norbert Blank, Julia Weber-Arden, Jasmin B. Kuemmerle-Deschner

“…Safety, physician- and patient-reported measures of disease activity and dosing patterns were evaluated at baseline and every 6 months until end-of-study visit. …”
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Anterior Endocrowns as An Alternative to Core Crown restorations: A Systematic Review by Hisham A. Mously, Ghada H. Naguib, Ahmed O. Abougazia, Afaf A. Almabadi, Osama A. Qutub, Mohamed T. Hamed

“…Conversely, post core-crown restorations demonstrated higher fracture resistance with the presence of ferrule, but were associated with more catastrophic failure patterns. Additionally, endocrowns generated lower stress levels in both the restorative material and the luting material compared to post core-crown restorations. …”
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Rotavirus infections in the pediatric population: a comparative study of pre-COVID and COVID-19 pandemic periods by Bahar Öztelcan Gündüz, Kazım Kutlutürk, Bülent Ünay

“…Statistical comparisons were made to evaluate changes in rotavirus infection patterns between the two examined periods.ResultsThe data of a total of 3,915 pediatric patients with diarrhea were included, with 468 (6.8%) testing positive for rotavirus. …”
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Atypical early neural responses to native and non-native language in infants at high likelihood for developing autism by Lauren Wagner, Megan Banchik, Tawny Tsang, Nana J. Okada, Rebecca Altshuler, Nicole McDonald, Susan Y. Bookheimer, Shafali S. Jeste, Shulamite Green, Mirella Dapretto

“…Importantly, we also demonstrate that HL infants show distinctly atypical patterns of lateralization for speech processing, particularly during native speech processing, suggesting a failure to left-lateralize. …”
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Spatiotemporal dynamics and prevention strategies of cervical cancer incidence in Addis Ababa, Ethiopia: an ecological study by Mathewos Assefa, Eva Johanna Kantelhardt, Teferi Gedif Fenta, Tariku Shimels

“…Objective This study analysed the spatial and temporal patterns of cervical cancer incidence in Addis Ababa from 2012 to 2021.Design An ecological study was conducted from 1 September to 30 November 2023 to examine the spatiotemporal trends of cervical cancer incidence.Setting The research was conducted in Addis Ababa, the capital city of Ethiopia.Participants Included were all patients with clinically and/or histopathologically confirmed diagnoses of cervical cancer.Data analysis The study employed advanced analytical tools including R programming, Quantum Geographic Information System V.3.36.0, GeoDa V.1.2.2 and System for Automated Geoscientific Analyses GIS V.9.3.2. …”
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HBV DNA integration and somatic mutations in HCC patients with HBV-HCV dual infection reveals profiles intermediate between HBV- and HCV-related HCC by Chiao-Ling Li, Chia-Lang Hsu, You-Yu Lin, Ming-Chih Ho, Rey-Heng Hu, Sheng-Tai Tzeng, Ya-Chun Wang, Yasuhito Tanaka, Pei-Jer Chen, Shiou-Hwei Yeh

“…Results Next generation sequencing revealed that 55% of HBCV-HCCs exhibited clonal HBV integration, which falls between the rates observed in HBV-HCCs (88%) and HCV-HCCs (7%), with similar integration patterns to HBV-HCCs. Common HCC somatic mutation analysis indicated HCV superinfection in HBCV-HCCs correlated with increased mutation rates in the telomerase reverse transcriptase (TERT) promoter and beta-catenin genes. …”
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Impedance mapping with high-density microelectrode array chips reveals dynamic heterogeneity of in vitro epithelial barriers by Alessandra Venz, Bastien Duckert, Liesbet Lagae, Saeedeh Ebrahimi Takalloo, Dries Braeken

“…Here, we used 16,384 CMOS-integrated HD-MEA chip with subcellular-sized electrodes (8 μm diameter, 15 μm pitch, patterned in 16 clusters each consisting of 1024 electrodes in a 32 × 32 matrix) and impedance sensing capability to monitor dynamic evolution of Caco-2 cells, such as their proliferation, barrier formation, and 3D structure development on the chip. …”
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WIMUSim: simulating realistic variabilities in wearable IMUs for human activity recognition by Nobuyuki Oishi, Phil Birch, Daniel Roggen, Paula Lago

“…WIMUSim models IMUs in wearable sensing using four key parameters: Body (skeletal model), Dynamics (movement patterns), Placement (device positioning), and Hardware (IMU characteristics). …”
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Post-Trial Feedback Alters Landing Performance in Adolescent Female Athletes Using a Portable Feedback System by Thomas W Kernozek, Drew Rutherford, Becky Heinert, Jessica Onsager, Maria Lee, Jeremie Schiedermayer, Stephanie Dietrich, Renee Dade, Thomas Gus Almonroeder

“…# Background Post-performance verbal and visual feedback based on data collected via lab-based instruments have been shown to improve landing patterns related to non-contact ACL injury. Biomechanical methods are often complex, difficult to transport and utilize in field settings, and costly, which limits their use for injury prevention. …”
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Perceptions and Motivations of Japanese Medical Students Regarding Course Evaluations: A Cultural Perspective by Suzuki S, Imafuku R, Kawakami C, Abe Y, Jego EH, Hidai C, Saiki T

“…Data on Japanese students’ evaluation practices may reveal diverse behavioral patterns in Asian countries, highlighting the value of country-specific studies to uncover unique educational contexts. …”
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Factors influencing choice of residency program among medical intern doctors and medical students: a cross-sectional survey by Ali Al Ajmi, Masoud Kashoub, Ibrahim S. Al-Busaidi, Mohammed Al Rashdi, Moza AlHussaini, Arwa Alsaidi, Mohammed Al Rawahi, Abdullah M. Al Alawi

“…Methods A cross-sectional survey using a validated, context-specific questionnaire was distributed to medical interns and clinical clerkship students at Sultan Qaboos University and the National University.Descriptive statistics and univariate analyses were used to explore demographic patterns and factors influencing specialty choices, including internal medicine. …”
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Global, regional, and national esophageal cancer deaths and DALYs attributable to diet low in vegetables and fruits, 1990–2019: analysis for the global burden of disease study by Bing Cui, Aqin Chen, Chengcheng Xu

“…Temporal trends were assessed using linear regression models, and cluster analysis was employed to explore burden patterns across different GBD regions. Decomposition analysis quantified the contributions of aging, population dynamics, and epidemiological changes to deaths and disability-adjusted life years (DALYs). …”
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Evaluation of Rainfall-Induced Accumulation Landslide Susceptibility Based on Remote Sensing Interpretation by Zhen Wu, Runqing Ye, Jue Huang, Xiaolin Fu, Yao Chen

“…The findings indicate that the complex geological conditions and the unique tectonic erosion landform patterns in the northeastern region of Chongqing not only make this area a center of heavy rainfall but also lead to frequent and recurrent rainfall-induced landslides. …”
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Genome wide identification of Dof transcription factors in Carmine radish reveals RsDof33 role in cadmium stress and anthocyanin biosynthesis by Caiming Gou, Jia Li, Bo Chen, Guoting Cheng, Zhangfei Zheng, Hua Peng, Ahmed H. El-Sappah

“…Cd stress-induced RsDof expression patterns were studied using an RNA-seq atlas and qRT-PCR. …”
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Determinants of health seeking behaviour in South Sudan: a cross-sectional household survey by Ilja Obels, Harry Laurence Selby Coleman, Masja Straetemans, Margo van Gurp, George William Lutwama, Eelco Jacobs

“…Our results suggest differences in patterns of HSB between states, but studies with larger sample sizes are needed to analyse this. …”
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Machine learning-driven identification of critical gene programs and key transcription factors in migraine by Lei Zhang, Yujie Li, Yunhao Xu, Wei Wang, Guangyu Guo

“…Although genetic factors have been implicated, the precise molecular mechanisms, particularly gene expression patterns in migraine-associated brain regions, remain unclear. …”
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