Application of large language models in disease diagnosis and treatment by Xintian Yang, Tongxin Li, Qin Su, Yaling Liu, Chenxi Kang, Yong Lyu, Lina Zhao, Yongzhan Nie, Yanglin Pan, Yuanyuan Ji

“…They can enhance diagnostic accuracy by processing vast amounts of patient data and medical literature and have demonstrated their utility in diagnosing common diseases and facilitating the identification of rare diseases by recognizing subtle patterns in symptoms and test results. Building on their image-recognition abilities, multimodal LLMs (MLLMs) show promising potential for diagnosis based on radiography, chest computed tomography (CT), electrocardiography (ECG), and common pathological images. …”
Get full text

3D Printed Swordfish‐Like Wireless Millirobot by Xingcheng Ou, Yu Sheng, Jiaqi Huang, Dantong Huang, Xiaohong Li, Ran Bi, Guoliang Chen, Weijie Hu, Shuang‐Zhuang Guo

“…This 20 mm long robot features a streamlined form and magnetically programmable movements, enabling biomimetic locomotion patterns such as straight‐line swimming and turning swimming. …”
Get full text

Modeling dynamics on the dance floor with directional swarmalators by Petri Toiviainen, Petri Toiviainen, Joshua S. Bamford, Joshua S. Bamford, Joshua S. Bamford, Marc R. Thompson, Marc R. Thompson

“…It establishes a quantitative framework to dissect how individuals on dance floors self-organize and generate emergent patterns in response to both musical stimuli and visual perception of other dancers. …”
Get full text

Complete Mitochondrial Genome of <i>Niphon spinosus</i> (Perciformes: Niphonidae): Genome Characterization and Phylogenetic Analysis by Maheshkumar Prakash Patil, Jong-Oh Kim, Seung Hyun Yoo, Jiyoung Shin, Ji-Young Yang, Kyunghoi Kim, Gun-Do Kim

“…Its nucleotide composition, gene arrangement, codon usage patterns, and tRNA secondary structures are identical with other members of the Percoidei suborder. …”
Get full text

DNA Methylation Is Involved in the Expression of miR-142-3p in Fibroblasts and Induced Pluripotent Stem Cells by Siti Razila Abdul Razak, Yukihiro Baba, Hiromitsu Nakauchi, Makoto Otsu, Sumiko Watanabe

“…We have been analyzing comprehensive expression patterns of microRNA in human and mouse embryonic stem and induced pluripotent stem cells. …”
Get full text

Identification of the sucrose phosphate synthase (SPS) gene family reveals the positive role of NtSPS5 and NtSPS6 in drought stress tolerance of tobacco by Bingyu Li, Huan Su, Shuaibin Wang, Junping Gao, Zhong Wang, Jun Yang, Xin Xu

“…Expression profiling demonstrated that NtSPS genes exhibit distinct expression patterns across different tissues and under various stress conditions. …”
Get full text

A minimal gene set characterizes TIL specific for diverse tumor antigens across different cancer types by Zhen Zeng, Tianbei Zhang, Jiajia Zhang, Shuai Li, Sydney Connor, Boyang Zhang, Yimin Zhao, Jordan Wilson, Dipika Singh, Rima Kulikauskas, Candice D. Church, Thomas H. Pulliam, Saumya Jani, Paul Nghiem, Suzanne L. Topalian, Patrick M. Forde, Drew M. Pardoll, Hongkai Ji, Kellie N. Smith

“…Putative tumor-reactive cells (pTRC) identified via MANAscore in anti-PD-1-treated lung tumors had higher expression of checkpoint and cytotoxicity-related genes relative to putative non-tumor-reactive cells. pTRC in pathologically responding tumors showed distinguished gene expression patterns and trajectories. Collectively, we show that MANAscore is a robust tool that can greatly enrich candidate tumor-specific T cells and be used to understand the functional programming of tumor-reactive TIL.…”
Get full text

Oncogenic PIK3CA corrupts growth factor signaling specificity by Ralitsa R Madsen, Alix Le Marois, Oliwia N Mruk, Margaritis Voliotis, Shaozhen Yin, Jahangir Sufi, Xiao Qin, Salome J Zhao, Julia Gorczynska, Daniele Morelli, Lindsay Davidson, Erik Sahai, Viktor I Korolchuk, Christopher J Tape, Bart Vanhaesebroeck

“…Abstract Technical limitations have prevented understanding of how growth factor signals are encoded in distinct activity patterns of the phosphoinositide 3-kinase (PI3K)/AKT pathway, and how this is altered by oncogenic pathway mutations. …”
Get full text

Multilevel and Spatially Heterogeneous Factors Influencing Poor Households’ Income in a Frontier Minority Area in Northeast China by Binyan Wang, Mark W. Rosenberg, Shijun Wang, Peifeng Yang, Junfeng Tian

“…We conducted a case study of Wangqing County, a frontier minority area in Northeast China to examine spatial patterns and income differentials among poor rural households in this area. …”
Get full text

A bibliometric analysis of optic atrophy from 2003 to 2023: research trends and hot spots by Liyuan Wang, Liyuan Wang, Liyuan Wang, Tianyang Yu, Tianyang Yu, Runze Wang, Lijuan Fu, Lijuan Fu, Feixue Dong, Feixue Dong, Shuang Zhao, Shuang Zhao, He Sun, He Sun, Yang Gao

“…We conducted a bibliometric analysis using tools such as CiteSpace, VOSviewer, and SCImago Graphica to examine annual publication trends, co-occurrence patterns, collaborative networks among countries and institutions, and the evolution of research hotspots of OA.ResultsA total of 5,274 publications were included in the bibliometric analysis, comprising 4,561 research articles and 713 review articles. …”
Get full text

Application of the Box–Behnken Design in the Development of Amorphous PVP K30–Phosphatidylcholine Dispersions for the Co-Delivery of Curcumin and Hesperetin Prepared by Hot-Melt Ex... by Kamil Wdowiak, Lidia Tajber, Andrzej Miklaszewski, Judyta Cielecka-Piontek

“…Notably, a significant improvement in solubility was observed, with formulations exhibiting distinct release patterns for the active compounds. Furthermore, the in vitro permeability through the gastrointestinal tract and blood–brain barrier was enhanced. …”
Get full text

Membrana preformativa: Unveiling the unexplored facets of dental development by Sakshi Sikaria, Suganya Panneer Selvam, Ramya Ramadoss, Sandhya Sundar

“…This study aims to provide detailed insights into the expression patterns and functional significance of Ki67 and Cyclin D1 in tooth development. …”
Get full text

A two-step machine learning approach for predictive maintenance and anomaly detection in environmental sensor systems by Saiprasad Potharaju, Ravi Kumar Tirandasu, Swapnali N. Tambe, Devyani Bhamare Jadhav, Dudla Anil Kumar, Shanmuk Srinivas Amiripalli

“…. • Provides actionable insights through anomaly visualization, revealing patterns in sensor performance.…”
Get full text

Quantifying intratumoral biomarker heterogeneity in tubo-ovarian high-grade serous carcinoma to optimize clinical translation by Aline Talhouk, Derek S. Chiu, Liliane Meunier, Kurosh Rahimi, Cécile Le Page, Monique Bernard, Diane Provencher, David G. Huntsman, Anne Marie Mes Masson, Martin Köbel

“…Markers were stained on tissue microarrays and scored using a continuous or categorical interpretation of staining patterns. Two-way random effect and nested intraclass correlation were used to assess continuous markers, and Gwet’s AC1 was used for categorical markers. …”
Get full text

Extreme migratory connectivity and apparent mirroring of non-breeding grounds conditions in a severely declining breeding population of an Afro-Palearctic migratory bird by Máire Kirkland, Nathaniel N. D. Annorbah, Lee Barber, John Black, Jeremy Blackburn, Michael Colley, Gary Clewley, Colin Cross, Mike Drew, Oliver J. L. Fox, Vicky Gilson, Steffen Hahn, Chas Holt, Mark F. Hulme, John Jarjou, Dembo Jatta, Emmanuel Jatta, Kevin Leighton, Ernestina Mensah-Pebi, Chris Orsman, Naffie Sarr, Roger Walsh, Leo Zwarts, Robert J. Fuller, Philip W. Atkinson, Chris M. Hewson

“…Extremely low levels of population mixing were also detected, so any impacts on this population on the non-breeding grounds are unlikely to be shared with more distant breeding populations, corresponding to the observed patterns of European population change. According to a species distribution model using independent field data, this population’s non-breeding grounds had lower suitability than others and likely declined before the period we were able to assess. …”
Get full text

Enhancing Disaster Situation Awareness Through Multimodal Social Media Data: Evidence from Typhoon Haikui by Songfeng Gao, Tengfei Yang, Yuning Xu, Naixia Mou, Xiaodong Wang, Hao Huang

“…This approach allowed us to analyze the spatiotemporal patterns of disaster evolution, enabling rapid disaster damage assessment and facilitating emergency response efforts. …”
Get full text

Genome biology of long non-coding RNAs in humans: A virtual karyotype by Alessandro Palma, Giulia Buonaiuto, Monica Ballarino, Pietro Laneve

“…Additionally, we observed that lncRNAs generally exhibit shorter gene lengths and fewer splicing variants compared to protein-coding transcripts, with a subset displaying pronounced clustering patterns that may indicate functional relevance. Finally, we identified several clinically associated and experimentally validated SNPs impacting lncRNA genes (lncGs). …”
Get full text

Wavenumber-dependent transmission of subthreshold waves on electrical synapses network model of Caenorhabditis elegans by Iksoo Chang, Taegon Chung, Sangyeol Kim

“…Also, we unraveled that (1) the transmission of all cell-pairs disappeared beyond a threshold wavenumber, (2) long distance and regular patterned transmission existed in the body-wall muscles part of the model network, and (3) major hub cell-pairs of the transmission were identified for many wavenumber conditions. …”
Get full text

Synergistic effects of CO2 sequestration on mechanical, microstructural, and environmental performance in carbonated MgO-based ECC by Zihao Song, Rui Chen, Tianyu Wang, Haoliang Wu

“…Specifically, the effects of varying MgO content on mechanical properties, crack patterns, and microstructure were investigated across six mix designs, with MgO dosages ranging from 40 % to 70 % of the binder, under both standard and accelerated carbonation curing conditions. …”
Get full text

Fine-scale forest classification with multi-temporal sentinel-1/2 imagery using a temporal convolutional neural network by Rongfei Duan, Chunlin Huang, Peng Dou, Jinliang Hou, Ying Zhang, Juan Gu

“…A Temporal Convolutional Neural Network (TempCNN), which excels in handling temporal data and adapting to complex patterns, was constructed using TensorFlow with 133.8k parameters. …”
Get full text