Enhanced Biomechanical Stability in Proximal Humeral Fractures: Finite Element Analysis of a Novel Endosteal Anatomical Support Nail for Improved Fixation in Elderly Patients by Jiawen Chen, Zhonghe Wang, Changda Li, Peiyu He, Zhongxuan Chen, Lijun Sun, Xiaoyan Cao, Na Tian, Xiang Dong, Peifu Tang, Hua Chen

“…Conclusions This study introduces a novel EAS concept to enhance the anti‐varus and anti‐rotational capabilities of the humeral head and distribute stress at the bone–implant interface in treating elderly PHFs. This strategy shows promise based on our limited analysis.…”
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Exogenous diethyl aminoethyl hexanoate alleviates the damage caused by low-temperature stress in Phaseolus vulgaris L. seedlings through photosynthetic and antioxidant systems by Yu Bai, Qiya Dai, Yanheng He, Li Yan, Jianpo Niu, Xuan Wang, Yongdong Xie, Xuena Yu, Wen Tang, Huanxiu Li, Zhi Huang, Bo Sun, Guochao Sun, Xun Wang, Yi Tang

“…These findings suggest that DA-6 treatment could serve as a promising approach for improving the resilience of P. vulgaris to low temperatures.…”
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NOX4 modulates breast cancer progression through cancer cell metabolic reprogramming and CD8+ T cell antitumor activity by Yingying Xiong, Yiming Weng, Shan Zhu, Jian Qin, Jia Feng, Xiaopeng Jing, Chao Luo, Wei Gong, Rui Sun, Min Peng

“…Therapeutically targeting the NOX4–MYC axis and leveraging NOX4’s immunomodulatory capacity could offer promising strategies for breast cancer management.…”
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Utilisation of the Innovative [18F]-Labelled Radiotracer [18F]-BIBD-071 Within HR+ Breast Cancer Xenograft Mouse Models by Di Fan, Xin Wang, Xueyuan Ling, Hongbin Li, Lu Zhang, Wei Zheng, Zehui Wu, Lin Ai

“…<b>Conclusions:</b> [18F]BIBD-071 is a promising PET tracer for diagnosing and monitoring HR+ breast cancer, warranting further research into hormone-dependent cancers.…”
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Segmentation of Dynamic Total-Body [18F]-FDG PET Images Using Unsupervised Clustering by Maria K. Jaakkola, Maria Rantala, Anna Jalo, Teemu Saari, Jaakko Hentilä, Jatta S. Helin, Tuuli A. Nissinen, Olli Eskola, Johan Rajander, Kirsi A. Virtanen, Jarna C. Hannukainen, Francisco López-Picón, Riku Klén

“…While GMM performed sufficiently, it was by far the slowest one among the tested approaches, making k-means combined with PCA the most promising candidate for further development. However, even with the best methods, the mean Jaccard index was slightly below 0.5 for the easiest tested organ and below 0.2 for the most challenging organ. …”
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Serum Pharmacochemistry and Network Pharmacology Reveal Active Compounds and Mechanisms of the Huaxian Formula in Alleviating Radiation-Induced Pulmonary Fibrosis by Gong C, Chen J, Zou P, Fang Z, Quan L, Wang J, Yin J, Lin B, Lang J, Chen M

“…The Huaxian formula (HXF), a traditional Chinese herbal remedy, shows promise in alleviating RIPF; however, its active ingredients and underlying mechanisms remain poorly understood.Methods: Through serum pharmacochemistry, network pharmacology, molecular docking, and experimental validation, we investigate the potential mechanisms of HXF in the prevention and treatment of radiation-induced pulmonary fibrosis (RIPF).Results: Histological examination and non-invasive computed tomography (CT) scans in animal experiments revealed that HXF improved extracellular matrix collagen deposition in the lung tissue of irradiated mice and reduced fibrosis manifestations on CT images. …”
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Magnesium ions regulate the Warburg effect to promote the differentiation of enteric neural crest cells into neurons by Qiongqian Xu, Xixi He, Yaru Mou, Dong Sun, Xintao Zhang, Jichang Han, Xiaoyang Liu, Xingjian Liu, Xue Ren, Dongming Wang, Jian Wang, Chuncan Ma, Qiangye Zhang, Aiwu Li

“…The double-cross-linked hydrogel gelatin methacryloyl—alginate (gelMA—ALMA), cross-linked with magnesium ions, showed promise in enhancing ENCCs differentiation in vivo without causing systemic hypermagnesemia. …”
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Composite Sorbents Based on Chitosan Polymer Matrix and Derivatives of 4-Amino-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide for Uranium Removal from Liquid Mineralized Media by Anna I. Matskevich, Konstantin V. Maslov, Veronika A. Prokudina, Daria D. Churakova, Oleg Yu. Slabko, Dmitry K. Patrushev, Nikita S. Markin, Eduard A. Tokar’

“…These results indicate that the synthesized sorbents are promising materials for uranium removal from liquid media, suitable for both purification and the recovery of radionuclides as valuable raw materials.…”
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Fermented sugarcane juice-derived probiotic Levilactobacillus brevis RAMULAB54 enhances lipid metabolism and glucose homeostasis through PPAR-γ activation by V. B. Chandana Kumari, Ramith Ramu, Sujay S. Huligere, Shashank M. Patil, Shivasharanappa Nayakvadi, Sharath Bijoor, Uma Venkateswaran Manjappara, Mohammad Z. Ahmed, Ling Shing Wong

“…LB13243's modulation of PPAR-γ suggests it as a promising natural option for managing diabetes and hyperlipidemia. …”
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Examining the Use of Machine Learning Algorithms to Enhance the Pediatric Triaging Approach by Aljubran HJ, Aljubran MJ, AlAwami AM, Aljubran MJ, Alkhalifah MA, Alkhalifah MM, Alkhalifah AS, Alabdullah TS

“…The model, tailored to the specific needs of pediatric patients, shows promise in improving triage accuracy and patient care in pediatric emergency departments. …”
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Spinally targeted paired associative stimulation with high-frequency peripheral component induces spinal level plasticity in healthy subjects by Anna Nätkynmäki, Leena Lauronen, Piia Haakana, Erika Kirveskari, Janne Avela, Anastasia Shulga

“…High-PAS is a novel PAS variant that has shown promising results in motor rehabilitation of individuals with SCI and these new findings contribute to the understanding of its mechanism of action. …”
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The suppression of the SPHK1/S1P/S1PR3 signaling pathway diminishes EGFR activation and increases the sensitivity of non-small cell lung cancer to gefitinib by Jing Zhang, Zequn Wang, Xihua Wei, Mengyuan Han, Ribai Yan, Lijie Ma, Yan Pan

“…Overall, targeting the SPHK1/S1P/S1PR3 signaling pathway represents a promising therapeutic strategy to enhance gefitinib sensitivity in NSCLC.…”
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PLL-g-HPA Hydrogel Loaded Human Umbilical Cord Mesenchymal Stem Cells Promote Burn Wound Healing in Rat Model by Regulating Inflammation Response by Tian L, Wang Z, Lei T, Feng L, Li Y, Wang K, Zhang Y, Zhang C, Liu J, Xing H, Ren W

“…Compared to the control group, treatment with PLL-g-HPA hydrogel in conjunction with hUC-MSCs significantly enhanced wound healing, modulated inflammatory responses, and promoted angiogenesis as well as re-epithelialization in rat models.Conclusion: The PLL-g-HPA hydrogel in conjunction with hUC-MSCs represents a promising therapeutic approach for the management of burn wounds.Keywords: rat burn model, wound healing, human umbilical cord mesenchymal stem cells, p-hydroxyphenylacetic acid grafted poly-l-ysine hydrogel…”
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The prognostic value of systemic immune-inflammation index in patients with unresectable hepatocellular carcinoma treated with immune-based therapy by Tian He, Bin Xu, Lu-Na Wang, Zi-Yi Wang, Huan-Chen Shi, Cheng-Jie Zhong, Xiao-Dong Zhu, Ying-Hao Shen, Jian Zhou, Jia Fan, Hui-Chuan Sun, Bo Hu, Cheng Huang

“…Conclusion SII is a promising predictor of both therapeutic efficacy and prognosis in HCC patients undergoing immune-based treatments. …”
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The Utility of Neutrophil CD64 and Presepsin as Diagnostic, Prognostic, and Monitoring Biomarkers in Neonatal Sepsis by Heba E. Hashem, Rania M. Abdel Halim, Sherin A. El Masry, Amira M. Mokhtar, Noureldin M. Abdelaal

“…Either of CD64 or presepsin combined with hs-CRP associated with better performance than any of them alone. nCD64 carries an additional promising role in reflecting sepsis prognosis.…”
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Immunoregulatory Effects of Subcutaneous Immunotherapy on Lymphocyte Subgroups and Cytokines in Children with Asthma by Yu-ting He, Ying Zhou, Qi Shao, Cong Gan, Meng Chen, Yu-ling Bao, Hai-yan Gu, Shu-lan Zhang, Yubao Cui, Man Tian

“…Conclusion. SCIT is a promising option to reduce the percentage of ILC2 and regulate Th1/Th2 and Th17/Treg immune balance in the peripheral blood of children with asthma.…”
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Le lymphosarcome fausse les résultats du test de la tuberculose effectué sur le sang by Cheick Coulibaly, Julia Seidl, Bettina Bernhard, Roland Plesker

“…La tumeur fut extraite le lendemain et soumise à un examen histopathologique. Nous supposions avoir affaire à une tumeur cancéreuse du sein. …”
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Advancements in Hyaluronic Acid Effect in Alveolar Ridge Preservation: A Narrative Review by Paul Andrei Nistor, Andreea Cândea, Iulia Cristina Micu, Andrada Soancă, Carmen Silvia Caloian, Alina Bârdea, Alexandra Roman

“…Hyaluronic acid (HYA) has emerged as a promising biological agent for ARP due to its osteoinductive, antimicrobial, and anti-inflammatory properties. …”
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Rescue of Mutant CFTR Channel Activity by Investigational Co-Potentiator Therapy by Mafalda Bacalhau, Filipa C. Ferreira, Marcelo Folhadella M. F. Azevedo, Talita P. Rosa, Camilla D. Buarque, Miquéias Lopes-Pacheco

“…After validation by electrophysiological assays, the most promising hits were also assessed in cells expressing other variants with defective gating/conductance, namely p.Pro205Ser, p.Ser549Arg, p.Gly551Asp, p.Ser945Leu, and p.Gly1349Asp. …”
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INTERNATIONAL AND NATIONAL LEGAL MECHANISMS OF JUDICIAL LIABILITY IN THE CONDITIONS OF ECONOMIC GLOBALISATION OF MODERN SOCIETY by Konul Akhundova

“…The results of the study show that the existing international legal mechanism of judicial liability developed by international institutions is quite effective and promising for implementation within the framework of national legal regimes, and the national mechanism of judicial liability needs to be improved both in terms of procedure and means of its implementation in connection with the economic development of society. …”
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