Deletion of sphingosine 1-phosphate receptor 1 in myeloid cells reduces hepatic inflammatory macrophages and attenuates MASH by Gopanandan Parthasarathy, Nanditha Venkatesan, Guneet Singh Sidhu, Myeong Jun Song, Chieh-Yu Liao, Fanta Barrow, Amy Mauer, Tejasav Sehrawat, Yasuhiko Nakao, P. Vineeth Daniel, Debanjali Dasgupta, Kevin Pavelko, Xavier S. Revelo, Harmeet Malhi

“…Although S1P receptors are expressed on several immune cell types, given the prominent role of monocyte-derived recruited macrophages in the sterile inflammation of MASH, we hypothesized that deletion of S1P receptor 1 (S1P1) on myeloid cells may ameliorate MASH by reducing the accumulation of proinflammatory monocyte-derived macrophages in the liver. …”
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Supplementation of Parachlorella sp. in feed promote the gut microbiome colonization and fecal IgA response of broiler in both early and late period by Woonhak Ji, Tae-Yong Kim, Chae Won Lee, Z-Hun Kim, Ji Young Jung, Byeong Cheol Ban, Changsu Kong, Myunghoo Kim

“…However, PA supplementation altered the cecal microbiome, with Clostridiaceae and Clostridium exhibiting prominent and consistent changes. In terms of intestinal immunity, PA supplementation significantly increased the number of CD3+ and CD4+ T cells when administered only during the early period. …”
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Information and Communication Technologies for Development: Evolution of International Discourse by Z. E. Gomboin

“…The final section summarizes the key provisions of critical approaches to ICT4D, which have gained prominence over the last decade. In each section the author examines both conceptual frameworks of the key donors’ policies, and concrete initiatives of international organizations, as well as their financing parameters and modalities. …”
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Association between adolescent obesity and early adulthood healthcare utilization—a two-cohort prospective study by Emilia Hagman, Vidar Halsteinli, Resthie R. Putri, Christina Hansen Edwards, Gudrun Waaler Bjørnelv, Claude Marcus, Rønnaug A. Ødegård

“…Among males, the association between obesity and healthcare utilization/annual specialized visits was less prominent. Annual excess costs for females with a history of adolescent obesity ranged from €578 to €835, while males showed minimal or no annual excess costs. …”
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The impact of mobile health interventions on service users' health outcomes and the role of health professions: a systematic review of systematic reviews by Fathiya Alkhuzaimi, Deborah Rainey, Christine Brown Wilson, Jacqueline Bloomfield

“…Abstract Background Mobile health (mHealth) tools have gained prominence in global healthcare in recent years, with demonstrated impacts on managing service users' health. …”
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Nature and Origin of Mineralizing Fluids in Hyperextensional Systems: The Case of Cretaceous Mg Metasomatism in the Pyrenees by Benoît Quesnel, Marie-Christine Boiron, Michel Cathelineau, Laurent Truche, Thomas Rigaudier, Gérard Bardoux, Pierre Agrinier, Michel de Saint Blanquat, Emmanuel Masini, Eric C. Gaucher

“…The giant Trimouns talc-chlorite deposit represents the most prominent occurrence of Albian metasomatism in the Pyrenees, with the occurrence of the largest talc deposit worldwide. …”
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Agribusiness strategy and Rural Development: A case Study of Ihunga Sub county-Ntungamo District. by Denis Simpson T.K, Singahache

“…The conclusion of the study was that agribusiness strategy has a prominent role to play in advancing rural development in Ihunga Sub County, Ntungamo District. …”
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Agribusiness strategy and rural development: A case study of Ihunga Sub County, Ntungamo District by Denis, Simpson Singahache

“…The conclusion of the study was that agribusiness strategy has a prominent role to play in advancing rural development in Ihunga Sub County, Ntungamo District. …”
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Influence of Exposure to Different Green Rooftop Spaces on Stress Restoration of College Students by Zhixiong ZHUO, Liang DONG

“…Although urbanization can offer people many conveniences, a large number of people also face different degrees of health risks in their daily lives, such as the increasing spread of various diseases, the growing prominence of psychological problems and the increasing health risks in cities. …”
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Antimicrobial susceptibility, biofilm formation, and virulence genes among atypical enteropathogenic Escherichia coli stool isolates in Tehran, Iran by Shahnaz Halimi, Akram Rezaei, Shirin Mohebi, Farhad Bonakdar Hashemi

“…Conclusion: Preventive measures by public health authorities can thwart the imminent crisis of widespread zoonotic contamination of the food chain in Iran. …”
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Beneficial haemodynamic effect of indomethacin during endotoxin shock in anaesthetized pigsputative involvement of nitric oxide? by T. Mózes, E. M. van Gelderen, E. J. Mylecharane, P. R. Saxena

“…In a group of nine pigs indomethacin (2 mg/kg, i.v.)was inected 20–25 rain after the start of LPS infusion at which time mean arterial blood pressure (MABP) had decreased below 40 mmHg indicating imminent death. Indomethacin immediately reversed the hypotension. …”
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Distinct expression profile reveals glia involvement in the trigeminal system attributing to post-traumatic headache by Gurueswar Nagarajan, Yumin Zhang

“…In situ assays also revealed that gliosis of satellite glial cells in the TG and astrocytes in the Sp5C were prominent days after injury. Furthermore, immunohistochemical study revealed a close interaction between activated microglia and reactive astrocytes correlating with increased calretinin interneurons in the Sp5C. …”
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Characterizing the regulatory effects of H2A.Z and SWR1-C on gene expression during hydroxyurea exposure in Saccharomyces cerevisiae. by Hilary T Brewis, Peter C Stirling, Michael S Kobor

“…Our data showed that H2A.Z played a more prominent role in gene activation than repression during HU exposure, and its incorporation was important for proper upregulation of several HU-induced genes. …”
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Comparing the performance of ChatGPT and ERNIE Bot in answering questions regarding liver cancer interventional radiology in Chinese and English contexts: A comparative study by Xue-ting Yuan, Chen-ye Shao, Zhen-zhen Zhang, Duo Qian

“…Introduction This study aims to critically assess the appropriateness and limitations of two prominent large language models (LLMs), enhanced representation through knowledge integration (ERNIE Bot) and chat generative pre-trained transformer (ChatGPT), in answering questions about liver cancer interventional radiology. …”
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A flood resilience assessment method of green-grey-blue coupled urban drainage system considering backwater effects by Yue Liu, Xiang Zhang, Jie Liu, Yao Wang, Haifeng Jia, Shiyong Tao

“…Among these approaches, green-grey-blue coupling measures have emerged as one of the prominent technical solutions. Several studies have demonstrated the effectiveness of blue-green infrastructure and integrated green-grey-blue systems in mitigating flood disasters. …”
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Is surgery superior for distal ulna fractures? a comprehensive systematic review and meta-analysis by Zakaria Chabihi, Brahim Demnati, Mohamed Moussadiq, Tariq Aalil, Yassine Fath El Khir, El Mehdi Boumediane, Mohamed Amine Benhima, Imad Abkari

“…Conclusions While surgical management may offer a higher union rate, the choice of treatment should be individualized, balancing the potential benefits against the risks of surgery, as ORIF implants are typically associated with higher ulnar-sided pain rates and limited ulnar deviation due to implant prominence. Future research should focus on standardizing study designs to improve the quality of evidence in the management of distal ulna fractures. …”
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Assessing hemorrhagic risks in combination therapy: implications of angiogenesis inhibitors and immune checkpoint inhibitors by Yuhui Yang, Yuhui Yang, Yuhui Yang, Pingping Long, Pingping Long, Ying Tuo, Ying Tuo, Xiaoxiao Wang

“…Gingival hemorrhage (ROR 3, PRR 418.9) and tumor hemorrhage (ROR 9.65, PRR 1893.36) were most common in the AGI group, while tumor hemorrhage (ROR 9.49, PRR 1350.78) and pulmonary hemorrhage (ROR 2.6, PRR 98.97) were prominent in the ICI group. In the combination group, esophageal variceal hemorrhage (ROR 40.72, PRR 2344.72) and tumor hemorrhage (ROR 19.31, PRR 1056.63) exhibited significantly increased risks Additive and multiplicative models indicated that the excess risk (RDAB = 0.01025, P<0.001) and relative risk (RRAB = 1.99277, P<0.001) of combination therapy were significantly higher than those of monotherapy, suggesting a positive interaction between the drugs that further increases the risk of hemorrhage.ConclusionOur study demonstrates that the combination of AGIs and ICIs significantly raises the risk of hemorrhage, underscoring the urgent need for enhanced monitoring protocols in clinical practice to improve treatment efficacy and safety.…”
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Economic Studies by A. V. Kholopov

“…Its establishment is associated with the prominent economist N.N. Lyubimov. In 1957 he with his colleagues published the first textbook on the subject which went through multiple republications. …”
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Exploring the antibacterial and anti-biofilm activity of two Iranian medical-grade kinds of honey on multidrug-resistant Pseudomonas aeruginosa by Mustafa Riyadh Alshaybawee, Shahrzad Asgari, Paria Ghadersoltani, Ahmadreza Mehrabian, Parastoo Saniee

“…Abstract Introduction Pseudomonas aeruginosa is a prominent multidrug-resistant and biofilm-forming bacteria. …”
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Accelerated pseudo-transient method for elastic, viscoelastic, and coupled hydromechanical problems with applications by Y. Alkhimenkov, Y. Y. Podladchikov

“…With the advent of the memory-wall phenomenon around 2005, where memory access speed overtook floating-point operations as the bottleneck in high-performance computing, the APT method has gained prominence as a powerful tool for tackling various PDEs in geosciences. …”
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