Incremental Value of Genotype Bins over the HAS-BLED Score for the Prediction of Bleeding Risk in Warfarin-Treated Patients with Atrial Fibrillation by Jia Liu, Guanyun Wang, Liu’an Qin, Yangxun Wu, Yuting Zou, Xuyun Wang, Ziqian Wang, Yuyan Wang, Shizhao Zhang, Yuxiao Zhang, Tong Yin

“…For each patient, CYP2C9∗3 and VKORC1-1639 A/G genotyping was performed to create 3 genotype functional bins. …”
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Prevalence of Gastric and Small-Intestinal Mucosal Injury in Elderly Patients Taking Enteric-Coated Aspirin by Magnetically Controlled Capsule Endoscopy by Feng Gao, Xue Chen, Jie Zhang

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Survival Status and Predictors of Mortality among Multidrug-Resistant Tuberculosis Patients in Saint Peter’s Specialized Hospital, Addis Ababa, Ethiopia by Mikyas Arega Muluneh, Abayneh Birlie Zeru, Behailu Tariku Derseh, Abebaw Molla Kebede

“…Result. A total of 484 patients were followed up for 5,078 person-months. …”
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Subcutaneous sarilumab for the treatment of hospitalized patients with moderate to severe COVID19 disease: A pragmatic, embedded randomized clinical trial. by Westyn Branch-Elliman, Ryan Ferguson, Gheorghe Doros, Patricia Woods, Sarah Leatherman, Judith Strymish, Rupak Datta, Rekha Goswami, Matthew D Jankowich, Nishant R Shah, Thomas H Taylor, Sarah T Page, Sara J Schiller, Colleen Shannon, Cynthia Hau, Maura Flynn, Erika Holmberg, Karen Visnaw, Rupali Dhond, Mary Brophy, Paul A Monach

“…The numbers of patients and events were too low to allow definitive conclusions to be drawn, but this study contributes valuable information about the role of subcutaneous IL-6R inhibition in the treatment of hospitalized COVID-19 patients. …”
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Association Between Vaso-Occlusive Crises and Opioid Prescriptions Among Patients with Sickle Cell Disease: A Retrospective Claims-Based Study by Hyeun Ah Kang, Jamie C. Barner, Kristin M. Richards, Menaka Bhor, Jincy Paulose, Abdullah Kutlar

“…Overall, 2071 (61.5%) had at least one VOC event with an average of 2.9 (SD=4.4). The results from the negative binomial regression showed that for every increase in VOC events, the number of opioid prescriptions increased by 9.5% (Incidence rate ratio=1.095, 95% CI: 1.078–1.111; _P_ ≤ 0.0001). …”
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Vegetal and Animal Food Proteins Have a Different Impact in the First Postprandial Hour of Impedance-pH Analysis in Patients with Heartburn by Irene Martinucci, Giada Guidi, Edoardo V. Savarino, Marzio Frazzoni, Salvatore Tolone, Leonardo Frazzoni, Lorenzo Fuccio, Lorenzo Bertani, Giorgia Bodini, Linda Ceccarelli, Vincenzo Savarino, Santino Marchi, Nicola de Bortoli

“…The male/female ratio was 80/85. Mean age was 51.9 ± 12.1 years. Impedance-pH analysis showed that 55/165 patients had pathological AET or a number of refluxes (nonerosive reflux disease (NERD)), 49/165 had normal AET and a number of refluxes but positive symptom-reflux association (hypersensitive esophagus (HE)), and 61/165 had normal AET and a number of refluxes with negative symptom-reflux association (functional heartburn (FH)). …”
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Assessment of the Effect of Oral Health on Quality of Life and Oral-Health Indicators among ESRD Patients in Southwest Florida: A Pilot Study by Payal Kahar, Carol Chapman, Jayanta Gupta

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ICU Length of Stay and Factors Associated with Longer Stay of Major Trauma Patients with Multiple Rib Fractures: A Retrospective Observational Study by Hesham S. Abdelwahed, F. Eduardo Martinez

“…The median ICU LOS was 4 (IQR: 2–7) days and the average ICU LOS was 6.5 (SD 8.5; 95% CI 5.3–7.6) days. The median number of rib fractures was 6 (IQR: 5–9) and 76 (35.3%) patients had a flail chest. …”
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Prospective study of change in liver function and fat in patients with colorectal liver metastases undergoing preoperative chemotherapy: protocol for the CLiFF Study by Katharine Cresswell, Juan W Valle, Michael Braun, Kat L Parmar, Derek O'Reilly, Jo H Naish, Steve R Williams, William K Lloyd, Lee Malcomson, Colin Bamford, Andrew G Renehan

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Comparison of fibreoptic-guided tracheal intubation through LMA Protector and i-gel in adult paralysed patients – A randomised comparative study by Mamta Bhardwaj, Karthik Manoharan, Kirti Kshetrapal, Karishma Dhankhar, Amit Singh, Susheela Taxak

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Positive hepatitis B surface antigen leads to a decrease in ovarian reserve in infertile patients receiving first in vitro fertilization treatment by Yutao Li, Xuejiao Wang, Ye Jiang, Qun Lv, Yi Zhang, Yu Wang

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Retrospective Analysis of Healthcare Resource Use, Treatment Patterns, and Treatment-related Events in Patients with Huntington’s Disease–associated Chorea Initiated on Tetrabenazi... by Victor W. Sung, Sanjay K. Gandhi, Victor Abler, Brian Davis, Debra E. Irwin, Karen E. Anderson, Ravi G. Iyer

“…**Methods:** Patients with a claim for HD-associated chorea (ICD-9-CM code 333.4) between 1/1/08 and 9/30/15 were selected from the MarketScan® Commercial and Medicare Supplemental databases. …”
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Characteristics, Mortality, and Clinical Outcomes of Hospitalized Patients with COVID-19 and Diabetes: A Reference Single-Center Cohort Study from Poland by Michał Kania, Konrad Mazur, Michał Terlecki, Bartłomiej Matejko, Jerzy Hohendorff, Zlata Chaykivska, Mateusz Fiema, Marianna Kopka, Małgorzata Kostrzycka, Magdalena Wilk, Tomasz Klupa, Przemysław Witek, Barbara Katra, Marek Klocek, Marek Rajzer, Maciej T. Malecki

“…The data were gathered from their medical records. Results. A total number of 5191 patients were included, of which 2348 (45.2%) were women. …”
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Russian Non-Interventional Study of the Efficacy and Tolerability of Rifaximin-α Therapy in Patients with Uncomplicated Diverticular Disease under the Conditions of Outpatient Prac... by O. S. Shifrin, E. A. Poluektova, A. V. Korolev, T. I. Semenova, M. V. Shein, G. N. Leksikova, O. A. Tokareva, O. E. Davydova, P. S. Andreev, S. E. Katorkin, A. A. Chernov, A. V. Zhuravlev, O. S. Sek, A. A. Kopina, N. Yu. Samokhina, Yu. V. Gorozhankina, M. F. Samigullin, V. S. Groshilin, E. N. Borisova, T. A. Petrova, I. Yu. Pirogova, S. V. Mednikov, N. V. Smagin, A. S. Sarsenbaeva, N. V. Smirnova, L. G. Kirsanova, N. M. Malyutina, M. A. Smirnova, E. N. Shleikova, V. T. Ivashkin

“…Physicians’ prescription of rifaximin-α (dose, duration of administration, number of prescribed courses) was evaluated, as well as patients’ compliance expressed as the ratio of the actual number of taken pills to the number of prescribed pills during each course according to the MMAS-4 scale. …”
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Study of the effectiveness of vacuum-aspiration breast biopsy in patients with complete clinical response after neoadjuvant polychemotherapy in complex treatment of breast cancer by K. V. Maksimov, D. V. Bagdasarova, A. D. Zikiryakhodzhaev, A. A. Kolomeytseva, M. L. Mazo, V. S. Surkova, F. N. Usov, I. A. Eremeeva, A. N. Gerasimov

“…However, further research is required with the inclusion of a larger number of patients.…”
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Single postoperative infusion of zoledronic acid to improve patient-reported outcome after hip or knee replacement: study protocol for a randomised, controlled, double-blinded clin... by Jonas Ranstam, Jörg Schilcher, Ewa Roos, Jonathan Brandt, Håkan Ledin, Per Aspenberg

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The impact of neuroscience education therapy, behavioral economics, and digital navigators on patient migraine treatment adherence to a mobile health application: a prospective pil... by Mia T. Minen, Erin K. Waire, John Torous, Jessica Fishman, Richard B. Lipton, Scott W. Powers

“…Abstract Mobile health (mHealth) tools can be used to deliver nonpharmacologic therapies to patients with migraine. However, mHealth studies often report poor treatment adherence. …”
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Anxiety as a mediator between symptom distress and quality of life in peritoneal dialysis patients: insights from mediation analysis and nonlinear models by Sixia Chen, Yun Wang, Sheng Feng, Mingli Shen, Fan Zhang, Kai Song, Wenwen Li, Yun- Wang

“…Anxiety mediated these relationships significantly, explaining 38.9% (95%CI: 18%–62%) and 33.3% (95%CI: 19%–49%) of the total effects for symptom number and distress, respectively. …”
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Behavior of SD-OCT Detectable Hyperreflective Foci in Diabetic Macular Edema Patients after Therapy with Anti-VEGF Agents and Dexamethasone Implants by Anne Rübsam, Laura Wernecke, Saskia Rau, Dominika Pohlmann, Bert Müller, Oliver Zeitz, Antonia M. Joussen

“…The number of foci decreased in 62.5% of patients after anti-VEGF (130.6 vs. 111.1, p=0.07) and in 68% of patients after dexamethasone injection ((123.4 vs. 94.9, p=0.02) 5.1). …”
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Is the Use of Tourniquets More Advantageous than Other Bleeding Control Techniques in Patients with Limb Hemorrhage? A Systematic Review and Meta-Analysis by Roberto Cirocchi, Dominica Prigorschi, Luca Properzi, Matteo Matteucci, Francesca Duro, Giovanni Domenico Tebala, Bruno Cirillo, Paolo Sapienza, Gioia Brachini, Sara Lauricella, Diletta Cassini, Antonia Rizzuto, Andrea Mingoli

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