Number 2: Chronic Obstructive Pulmonary Disease: The Importance of Exercise by Norman L Jones

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Analysis of changes in PCSK9 and TNF-α concentrations in response to physical exercises using virtual reality in patients in the fifth stage of chronic kidney disease undergoing he... by Agnieszka Turoń-Skrzypińska, Alicja Mińko, Aleksandra Rył, Aneta Cymbaluk-Płoska, Maciej Domański, Kazimierz Ciechanowski, Iwona Rotter

“…The aim of this study was to comprehensively assess the impact of regular physical activity using virtual reality on the concentration of plasma PCSK9 protein and TNF-α in patients with stage 5 CKD treated with hemodialysis. …”
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Epidemiological pattern of trauma among children 0-9 years in Cameroon. by Odette Dzemo Kibu, Sithombo Maqungo, Georges Nguefack-Tsague, Dickson Shey Nsagha, Nicholas Tendongfor, Fanny Nadia Dissak Delon, Darwin Touko, Elvis Asangbeng Tanue, Rasheedat Oke, Sandra Irene McCoy, Sabrinah Ariane Christie, Catherine Juillard, Alain Chichom-Mefire

“…<h4>Results</h4>Of the 5,439 patients captured in the trauma registry, 267 (4.9%) were children aged 0-9 years. …”
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Clinimetrics of the 9- and 19-Item Wearing-Off Questionnaire: A Systematic Review by Carlos E. Mantese, Artur Schumacher-Schuh, Carlos R. M. Rieder

“…WOQ-19 has variable specificity (0.39–0.8), depending on the number of positive items, while WOQ-9 lacks specificity (0.1–0.69). …”
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Instruments for assessing patient-reported experience measures among patients with diabetes mellitus: a scoping review by Soe Sandi Tint, Myo Zin Oo, Nida Buawangpong, Wichuda Jiraporncharoen, Nutchar Wiwatkunupakarn, Kittipan Rerkasem, Kanokwan Kulprachakarn, Hataichanok Chuljerm, Timothy E. O’Brien, Rohini Mathur, Chaisiri Angkurawaranon

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Correlation between Phase Angle and the Number of Medications in Older Inpatients: A Cross-Sectional Study by Toshiyuki Moriyama, Mizuki Tokunaga, Ryoko Hori, Akiko Hachisuka, Hideaki Itoh, Mitsuhiro Ochi, Yasuyuki Matsushima, Satoru Saeki

“…PhA was measured using bioelectrical impedance analysis. The number of medications taken by each patient was recorded at admission. …”
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Comparison between Real-Time Quantitative PCR Detection of HER2 mRNA Copy Number in Peripheral Blood and ELISA of Serum HER2 Protein for Determining HER2 Status in Breast Cancer Pa... by Maria Savino, Paola Parrella, Massimiliano Copetti, Raffaela Barbano, Roberto Murgo, Vito Michele Fazio, Vanna Maria Valori, Massimo Carella, Maria Garrubba, Stefano Angelo Santini

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Impact of the Number of Administered Systemic Treatment Lines on Local Response to Radiation Therapy for Multiple Myeloma by Andrea Emanuele Guerini, MD, Eneida Mataj, MD, Paolo Borghetti, MD, Luca Triggiani, Ludovica Pegurri, MD, Stefania Nici, Stefano Riga, Alessandra Tucci, MD, Angelo Belotti, MD, Marco Lorenzo Bonù, MD, Giorgio Facheris, MD, Stefano Maria Magrini, Luigi Spiazzi, Michela Buglione

“…The toxicity profile was optimal, as grade > 2 events during RT were reported only in 0.9% of cases. Conclusions: In this large retrospective cohort of MM patients, the number of systemic treatment lines administered before RT had no impact on the local response, confuting concerns of cross-resistance raised by multiple preclinical studies. …”
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Adiposity is associated with a higher number of thyroid nodules and worse fine-needle aspiration outcomes by Elpida Demetriou, Aliki Economides, Maria Fokou, Demetris Lamnisos, Stavroula A Paschou, Panagiotis Papageorgis, Panayiotis A Economides

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Effects of PCSK9 inhibitors on metabolic-associated fatty liver disease: a short review by Ewelina Jakielska, Paweł Głuszak, Marta Walczak, Wiesław Bryl

“…Recent studies have highlighted the relationship between MAFLD and proprotein convertase subtilisin/kexin type 9 (PCSK9). Based on the available data, PCSK9 inhibitors appear to have beneficial effects in patients with MAFLD, and they may be a treatment option in the future. …”
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S100A9 protein activates microglia and stimulates phagocytosis, resulting in synaptic and neuronal loss by Katryna Pampuscenko, Silvija Jankeviciute, Ramune Morkuniene, Darius Sulskis, Vytautas Smirnovas, Guy C. Brown, Vilmante Borutaite

“…There is a large increase in S100A9 expression in the brains of patients with neurodegenerative diseases, such as Alzheimer's disease, and S100A9 has been suggested to contribute to neurodegeneration, but the mechanisms are unclear. …”
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Correlation Between Number of Retrieved Oocytes and Pregnancy Rate After In Vitro Fertilization/IntraCytoplasmic Sperm Infection by Tanya Timeva, Tanya Milachich, Irena Antonova, Tanya Arabaji, Atanas Shterev, Hatim A. Omar

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Impact of Number and Placement of High-dose Vertices on Equivalent Uniform Dose and Peak-to-valley Ratio for Lattice Radiotherapy by A. T. Bhagyalakshmi, Velayudham Ramasubramanian

“…Aims: This study evaluated the influence of high dose (HD) vertex numbers and its placement on equivalent uniform dose (EUD) and peak-to-valley dose ratio (PVDR) in lattice radiotherapy (LRT). …”
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A new insight into the impact of copy number variations on cell cycle deregulation of luminal-type breast cancer by Amir Mahdi Khamaneh, Davoud Jafari-Gharabaghlou, Khalil Ansarin, Khalil Ansarin, Khalil Ansarin, Pouya Pazooki, Zahra Akbarpour, Behrooz Naghili, Behrooz Naghili, Nosratollah Zarghami, Nosratollah Zarghami

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Application of copy number variation sequencing combined with whole exome sequencing in prenatal left–right asymmetry disorders by Yu Qin, Muon Senglong, Koksear Touch, Juan Xiao, Ruijie Fang, Qingling kang, Lei Fan, Shufang Li, Jing Liu, Jianli Wu, Yuanyuan Wu, Xinwei Shi, Haiyi Liu, Xun Gong, Xingguang Lin, Ling Feng, Suhua Chen, Wei Li

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The Identification of Molecular Ploidy Status of Abnormal Pronuclear Zygotes Reveals a Significant Number of Euploid Blastocysts Available for Conception by Blair R. McCallie, Mary E. Haywood, Lauren N. Henry, Rachel M. Lee, William B. Schoolcraft, Mandy G. Katz-Jaffe

“…The objective of this study was to determine if pronuclear numeration (PN) observed at fertilization check is representative of the true ploidy status of the subsequent developing blastocyst in order to maximize the number of viable embryos available for infertility patients and increase their chances of conception. …”
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Development of a PROM to measure patient-centredness in chronic care consultations in primary care by Anne Holm, Anna Bernhardt Lyhnebeck, Sussi Friis Buhl, Kristine Bissenbakker, Jette Kolding Kristensen, Anne Møller, Anders Prior, Zaza Kamper-Jørgensen, Sidsel Böcher, Mads Aage Toft Kristensen, Asger Waagepetersen, Anders Hye Dalsgaard, Volkert Siersma, Ann Dorrit Guassora, John Brandt Brodersen, on behalf MM600 trial group

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No Evidence of Abnormal Expression of Beta-Catenin and Bcl-2 Proteins in Pilomatricoma as One Clinical Feature of Tetrasomy 9p Syndrome by Chariyawan Charalsawadi, Sasipong Trongnit, Kanoot Jaruthamsophon, Juthamas Wirojanan, Somchit Jaruratanasirikul, Anupong Nitiruangjaras, Pornprot Limprasert

“…Pilomatricoma has been reported in patients with chromosome 9 rearrangements, including 4 patients with tetrasomy 9p syndrome and one patient with partial trisomy 9. …”
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Prediction and verification of the influence of the rs367781716 SN P on the interaction of ТАТА -binding protein with the promoter of the human АВСА9 gene by O. V. Arkova, I. A. Drachkova, T. V. Arshinova, D. A. Rasskazov, V. V. Suslov, P. M. Ponomarenko, M. P. Ponomarenko, N. A. Kolchanov, L. K. Savinkova

“…On the other hand, tens of millions of unannotated SNPs correspond to a gigantic number of false positive (false negative) candidate SNP markers that are selected by computer methods for comparison of their frequency in patients with that in healthy people. …”
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Personalized optimization of systematic prostate biopsy core number based on mpMRI radiomics features: a large-sample retrospective analysis by Zhenlin Chen, Zhihao Li, Ruiling Dou, Shaoqin Jiang, Shaoshan Lin, Zequn Lin, Yue Xu, Ciquan Liu, Zijie Zheng, Yewen Lin, Mengqiang Li

“…This method, however, can increase the risk of urinary retention, infection and bleeding due to the excessive number of biopsy cores. Methods We retrospectively analyzed 622 patients who underwent SBx with prostate multiparametric MRI (mpMRI) from two centers between January 2014 to June 2022. …”
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