Quantifying tumor morphological complexity based on pretreatment MRI fractal analysis for predicting pathologic complete response and survival in breast cancer: a retrospective, multicenter study by Yao Huang, Ying Cao, Huifang Chen, Xiaosong Lan, Sun Tang, Zhitao Zhang, Ting Yin, Xiaoxia Wang, Jiuquan Zhang

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Urinary Immune Complexes Reflect Renal Pathology in Lupus Nephritis by Chenling Tang, Aygun Teymur, Tianfu Wu

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Immune digital twins for complex human pathologies: applications, limitations, and challenges by Anna Niarakis, Reinhard Laubenbacher, Gary An, Yaron Ilan, Jasmin Fisher, Åsmund Flobak, Kristin Reiche, María Rodríguez Martínez, Liesbet Geris, Luiz Ladeira, Lorenzo Veschini, Michael L. Blinov, Francesco Messina, Luis L. Fonseca, Sandra Ferreira, Arnau Montagud, Vincent Noël, Malvina Marku, Eirini Tsirvouli, Marcella M. Torres, Leonard A. Harris, T. J. Sego, Chase Cockrell, Amanda E. Shick, Hasan Balci, Albin Salazar, Kinza Rian, Ahmed Abdelmonem Hemedan, Marina Esteban-Medina, Bernard Staumont, Esteban Hernandez-Vargas, Shiny Martis B, Alejandro Madrid-Valiente, Panagiotis Karampelesis, Luis Sordo Vieira, Pradyumna Harlapur, Alexander Kulesza, Niloofar Nikaein, Winston Garira, Rahuman S. Malik Sheriff, Juilee Thakar, Van Du T. Tran, Jose Carbonell-Caballero, Soroush Safaei, Alfonso Valencia, Andrei Zinovyev, James A. Glazier

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Gastric Mixed Adenoneuroendocrine Carcinoma with Revised Diagnosis after Retrospective Pathologic Review by Bo Seok Jeong, Hye Won Hwang, Jong Won Kim, In Gyu Hwang, Jae Yong Park

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Multi-omics approaches to deciphering complex pathological mechanisms of migraine: a systematic review by Jiaojiao Liu, Qiaosheng Ren, Boxuan Du, Xian Liu, Yuqiu An, Peichi Zhang, Lexi Li, Zhenhong Liu, Zhenhong Liu, Kegang Cao, Kegang Cao

“…BackgroundMigraine represents a chronic neurological disorder characterized by high prevalence, substantial disability rates, and significant economic burden. Its pathogenesis is complex, and there is currently no cure. The rapid progress in multi-omics technologies has provided new tools to uncover the intricate pathological mechanisms underlying migraine. …”
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The janus face of astrocytes in multiple sclerosis: Balancing protection and pathology by Ahmad A. Abulaban, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Ali K. Albuhadily, Mustafa M. Shokr, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batiha

“…While the pathogenesis of MS involves complex interactions between peripheral immune cells and CNS glia, astrocytes—the most abundant glial cells—play a dual role in disease progression. …”
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Artificial Intelligence‐Based Pathology to Assist Prediction of Neoadjuvant Therapy Responses for Breast Cancer by Juan Ji, Fanglei Duan, Qiong Liao, Hao Wang, Shiwei Liu, Yang Liu, Zongyao Huang

“…Conclusion AI‐based pathology represents a prospective and powerful decision‐support tool for predicting breast cancer NAT response. …”
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Pathological complete response of locally advanced triple-negative breast cancer: case report by V. V. Konstantinova, G. A. Dashyan, R. M. Ahmedov, A. M. Belousov

“…The histological examination revealed a complete pathological response of the primary tumor and regional lymph nodes. …”
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Measurement of Intratumor Heterogeneity and Its Changing Pattern to Predict Response and Recurrence Risk After Neoadjuvant Chemotherapy in Breast Cancer by Mingxi Zhu, Qiong Wu, Xiaochuan Geng, Huaying Xie, Yan Wang, Ziping Wu, Yanping Lin, Liheng Zhou, Shuguang Xu, Yumei Ye, Wenjin Yin, Jia Hua, Jingsong Lu, Yaohui Wang

“…This study aimed to construct a model based on tumor heterogeneity in magnetic resonance imaging (MRI) for predicting the pathological complete response (pCR) to neoadjuvant chemotherapy (NAC). …”
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The influence of combined antioxidants usage on periodontal pathology in women with polycystic ovarian syndrome by Yu. G. Romanova, S. V. Dizik

“…The oral fluid biochemical parameters dynamics in women with moderate severity chronic generalized periodontitis associated with polycystic ovarian syndrome evidences the high efficiency of the prophylactic and therapeutic complex. Positive changes in the periodontal status of patients can be explained by a decrease in the intensity of lipid peroxidation, an inflammatory response, and activation of antioxidant protection in the oral cavity.…”
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Spatial relationships and interactions of immune cell niches are linked to the pathologic response of muscle-invasive bladder cancer to neoadjuvant therapy by Wasilijiang Wahafu, Quan Zhou, Xihua Yang, Yongming Yang, Yuanyuan Zhao, Zhu Wang, Xiangpeng Kang, Xiongjun Ye, Nianzeng Xing

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CTLA-4 blockade and interferon-α induce proinflammatory transcriptional changes in the tumor immune landscape that correlate with pathologic response in melanoma. by Arjun Khunger, Erin Piazza, Sarah Warren, Thomas H Smith, Xing Ren, Andrew White, Nathan Elliott, Alessandra Cesano, Joseph M Beechem, John M Kirkwood, Ahmad A Tarhini

“…In conclusion, we identified numerous genes that play roles in multiple biological pathways involved in immune activation, immune suppression and cell proliferation correlating with pathological/radiological responses following neoadjuvant immunotherapy highlighting the complexity of immune responses modulated by immunotherapy. …”
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FcRγIIA attenuates pathology of cutaneous leishmaniasis and modulates ITAMa/i balance by Ikram Hammi, Julien Giron-Michel, Myriam Riyad, Khadija Akarid, Damien Arnoult

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The dynamics of immunological parameters in early stages after bilateral lung transplantation in patients with various pulmonary pathology by M. Sh. Khubutiya, E. A. Tarabrin, E. I. Pervakova, V. P. Nikulina, M. A. Godkov

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Radiomic Study for Objectification of Diagnostics and Complex Treatment of Glioblastoma by Ya. O. Nikulshina, A. N. Redkin, A. V. Kolpakov, M. A. Zakharov

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Mitochondrial Unfolded Protein Response (mtUPR) Activation Improves Pathological Alterations in Cellular Models of Ethylmalonic Encephalopathy by José Manuel Romero-Domínguez, Paula Cilleros-Holgado, David Gómez-Fernández, Rocío Piñero-Pérez, Diana Reche-López, Ana Romero-González, Mónica Álvarez-Córdoba, Alejandra López-Cabrera, Marta Castro De Oliveira, Andrés Rodríguez-Sacristán, Susana González-Granero, José Manuel García-Verdugo, Angeles Aroca, José A. Sánchez-Alcázar

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Refractory Premature Ventricular Complex Triggered Ventricular Fibrillation Responsive to Cardiac Sympathetic Denervation by Natalie S. Rosen, Rishi Trivedi, Merve Gurakar, Michael Chilazi, Rachit M. Vakil, Ethan Tumarkin, Klitos Konstantinidis, Garima Sharma, Jonathan Chrispin

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Solving the Amyloid Paradox: Unveiling the Complex Pathogenicity of Amyloid Fibrils by Maksim I. Sulatsky, Olesya V. Stepanenko, Olga V. Stepanenko, Anna I. Sulatskaya

“…This review encompasses amyloids' disruptive effects on cellular processes and ability to trigger inflammatory responses, their resistance to degradation, capacity to regenerate after apparent destruction, tendency to propagate throughout the organism, propensity to cytotoxicity‐increasing transformation, and ability to sequester and pathologically modify essential biomolecules. …”
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Homogeneity in immune features between colorectal liver metastases better identifies patients with good prognosis compared to pathological response to preoperative chemotherapy by David Henault, David Stephen, Pierre-Antoine St-Hilaire, Nouredin Messaoudi, Franck Vandenbroucke-Menu, Eve Simoneau, Zhixia Rong, Marylène Plasse, Richard Létourneau, André Roy, Michel Dagenais, Réal Lapointe, Bich Nguyen, Anne-Marie Mes-Masson, G. Soucy, Simon Turcotte

“…In colorectal cancer liver metastases (CRLM), the density of tumor-infiltrating lymphocytes, the expression of class I major histocompatibility complex (MHC-I), and the pathological response to preoperative chemotherapy have been associated with oncological outcomes after complete resection. …”
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The Evolution of Anatomic Pathology by Stanley Cohen, Frederick Coffman

“…This commentary discusses some of the factors responsible for this, and suggests that pathology and radiology are converging towards a more holistic approach to diagnostic imaging.…”
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