Sex-specific associations between estimated glucose disposal rate and cognitive decline in middle-aged and older adults in China: a longitudinal cohort study by Chun Luo, Shuang Han, Xiaoying Shen, Hao Wu, Jianqing Zhou, Bingyang Liu

“…Estimated glucose disposal rate (eGDR) was used to assess IR and was calculated using waist circumference, hypertension status, and HbA1c levels. Participants were categorized into tertiles based on eGDR levels (Tertile 1: lowest; Tertile 3: highest). …”
Get full text

Nilai Perjuangan dalam Novel Arus Balik Karya Pramoedya Ananta Toer by Sabjan Badio, Burhan Nurgiyantoro, Hartono Hartono

“…The value of nationalism consists of love for the flag itself, loyal to the leader, thinking about the safety of the country, supporting the struggle to defend the country, and participating in defending the country. The value of the unyielding struggle consists of fighting to the death and believing in your abilities. …”
Get full text

Immunolipid magnetic bead-based circulating tumor cell sorting: a novel approach for pathological staging of colorectal cancer by Qingyan Deng, Weidong Li, Yueming Huang, Haitao Wang, Xinhao Zhou, Zhifen Guan, Bohao Cheng, Yao Wang

“…The consistency of gene mutations was as follows: TP53 (91.31%), PIK3CA (76.00%), KRAS (85.36%), BRAF (51.00%), APC (65.67%), and EGFR (74.00%), with an overall gene mutation consistency of 85.06%.ConclusionOur CTC sorting system, which is based on Ep-IMBs and Vi-IMBs, effectively captures CTCs in the peripheral blood of CRC patients and enables clinical hotspot gene mutation testing via these enriched CTCs. This system partially solves the problem of difficult tumor tissue sample collection and provides a reference for gene mutation testing in early diagnosis, therapeutic efficacy evaluation, prognosis assessment, and minimal metastasis detection in CRC patients, showing significant potential for clinical application, especially in targeted therapy gene testing for CRC.…”
Get full text

An Experience of Jigsaw as a New Educational Method in Dentistry by Atekeh Movaghari pour, Mostafa Sadeghi, Foad Iranmanesh, Fatemeh Sadat Emami, Faezeh Esmaeili Ranjbar

“…Students had all taken a course on Oral Medicine and we decided to evaluate their knowledge regarding pigmented oral lesions. Participants were randomly divided to two groups. Each group received a teaching session, one using the Jigsaw method (experimental group) and the other one using a lecture-based approach (control group). …”
Get full text

Study protocol of a pilot randomised controlled trial assessing the feasibility and acceptability of RecoverEsupport: a digital health intervention to enhance recovery in women und... by Christopher Oldmeadow, Mitch J Duncan, Penny Reeves, Priscilla Viana da Silva, Rebecca Wyse, Helen Moore, Alison Zucca, Sancha Robinson, Stephen Ridley Smith, Emma Sansalone, Owen Morris, Rebecca Chenery, Lara Riley, Anna Palazzi-Parsons

“…This pilot trial aims to assess the feasibility of conducting a trial of RecoverEsupport and the acceptability of the RecoverEsupport intervention to support patients to recover from breast cancer surgery.Methods and analysis Participants will be recruited from the perioperative clinic and breast surgery units at a major cancer hospital in New South Wales, Australia and randomised (1:1) to receive (1) control: usual care or (2) intervention: usual care plus RecoverEsupport. …”
Get full text

A Retrospective, Single-Center Assessment of Changes in Pain, Agitation, and Delirium Management Before and During the COVID-19 Pandemic by Rachel L. Winner, PharmD, BCCCP, Lydia R. Ware, PharmD, BCPS, BCCCP, Kevin M. Dube, PharmD, BCPS, BCCCP, Mary P. Kovacevic, PharmD, BCPS, BCCCP, Kenneth E. Lupi, PharmD, BCPS, BCCCP, Paul M. Szumita, PharmD, FCCM, FASHP, BCCCP, BCPS, Jeremy R. DeGrado, PharmD, BCCCP

“…DESIGN, SETTING, AND PARTICIPANTS:. This was a single-center, retrospective, pre-/post-cohort analysis of mechanically ventilated adult patients without COVID-19 infection admitted to an ICU in Boston, MA. …”
Get full text

Association of Asthma Control and Metered-Dose Inhaler Use Technique among Adult Asthmatic Patients Attending Outpatient Clinic, in Resource-Limited Country: A Prospective Study by Bezie Kebede, Girma Mamo, Abebaw Molla

“…Among these, 26 (18.4%) patients were controlled, 65 (46.1%) partially controlled, and 35% uncontrolled. Proportion of patients with uncontrolled asthma were higher among inefficient as compared to efficient, whereas patients with controlled asthma were higher among efficient as compared to inefficient. …”
Get full text

Genetic parameters for milk production traits of Simmental cows with random regression test-day model by A. Otwinowska-Mindur, E. Ptak, W. Jagusiak, A. Zarnecki

“…Precise genetic parameter estimates can allow the breeding value evaluation to be adjusted to meet European requirements and to enable participation in the international evaluation of Simmental bulls conducted by Interbull. …”
Get full text

The Effect of Diacerein on Type 2 Diabetic Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis by Shizhe Guo, Xianshan Guo, Hongya Zhang, Xuan’e Zhang, Zhen Li

“…Five RCTs with 278 participants were included. Compared with control, diacerein provided significant improvement on FBG (MD -0.52; 95% CI (-0.89~-0.14); P=0.007), but TSA showed that this positive effect required more support. …”
Get full text

Accuracy of screening tests for cervical precancer in women living with HIV in low-resource settings: a paired prospective study in Lusaka, Zambia by Nicola Low, Partha Basu, Andreas Limacher, Katayoun Taghavi, Misinzo Moono, Mulindi Mwanahamuntu, Herbert Kapesa, Albert Manasyan, Julia Bohlius, Marie Roumet, Thamsanqa Madliwa, Anne Rutjes

“…A sensitivity analysis considered disease when only visible lesions were biopsied.Results Women included in the study had well-controlled HIV infection (median CD4 count=542 cells/mm3) and all except one were on antiretroviral therapy. Among 371 participants with histopathological results, 27% (101/371) women had CIN2+ and 23% (23/101) were not detected by any index test. …”
Get full text

Multiple Myeloma and B Cell Lymphoma. Investigation of IL-6, IL-6 Receptor Antagonist (IL-6RA), and GP130 Antagonist (GP130A) Using Various Parameters in an In Vitro Model by Eva Kovacs

“…Our results showed that (1) all five MM cell lines (OPM-2, RPMI-8226, U-266, KMS-12-BM, MOLP-8) expressed surface IL-6R and gp130, the B cell lymphomas (WSU-1, DOHH-2, U-698) expressed only gp130; (2) exogenous IL-6 markedly up-regulated the expression of membrane IL-6R (up to 186%) and down-regulated the gp130 receptor (down to 4%) in MM cell lines, the membrane expression of gp130 in B cell lymphomas was not altered; (3) IL-6 markedly increased the spontaneous proliferation (up to 151%) in all MM cell lines, that of B cell lymphomas was not affected; (4) IL-6 increased the DNA synthesis in the S cell cycle phase of MM cells and arrested the stage G2/M, IL-6 was ineffective in any cell cycle phase of B cell lymphoma; (5) IL-6RA inhibited the membrane IL-6R partially, the proliferation was decreased only slightly; and (6) although gp130A inhibited the membrane gp130 completely, the proliferation was decreased 81—78% in MM and B cell lymphoma cell lines. …”
Get full text

“The Founder and Father of his Empire”: Voltaire on the Peace of Nystad and the Imperial Status of Russia by S. A. Mezin

“…The author finds out, why Voltaire, condemning fascination with the history of wars and kings, in his two works: «The History of Charles XII» and «The History of the Russian Empire under Peter the Great» paid great attention to the Northern War and Peter I’s participation in it.The reasons of the French historian interest to the named subject are viewed in terms of the modern methods of historical analysis, «philosophical» basis of his views on war and civilization, features of historical presentation.The paper shows Voltaire’s change in attitude on interpretation of the military historical subjects, first covered in «The History of Charles XII» and then in «The History of the Russian Empire under Peter the Great». …”
Get full text

Exosomal miR-141-3p from PDLSCs Alleviates High Glucose-Induced Senescence of PDLSCs by Activating the KEAP1-NRF2 Signaling Pathway by Min Liu, Rui Chen, Yunxuan Xu, Jiawen Zheng, Min Wang, Ping Wang

“…Stem cell-derived exosomes are important participants in intercellular information exchange and can help ameliorate senescence. …”
Get full text

Crisis response strategies of universities during the ongoing war: Beyond experience and responsibilities by Oleksandr Spivakovsky, Serhii Omelchuk, Daria Malchykova

“…The opinions expressed herein are the authors’ own and do not necessarily express the views of either the Bridge USA or American Councils.The authors express their gratitude to the vice-presidents, deans of faculties, and academic and non-academic staff of Kherson State University who participated in the development of institutional documents that implement crisis management decisions presented in this paper and form a crisis response strategy for the university during martial law.…”
Get full text

Association of sleep duration and sleep disorders with post-stroke depression and all-cause and cardiovascular disease mortality in US stroke survivors: results from NHANES 2005–20... by Weirong Chen, Yingying Shen, Shina Song, Xiaofeng Li

“…Results A total of 1101 stroke participants were included. In the fully adjusted model, sleep disorders were associated with increased odds of post-stroke depression (OR 2.689, p = 0.0146). …”
Get full text

Incidence of chronic wounds in Singapore, a multiethnic Asian country, between 2000 and 2017: a retrospective cohort study using a nationwide claims database by Nicholas Graves, Kelvin Bryan Tan, Orlanda Q Goh, Ganga Ganesan, Yi Zhen Ng, Keith Harding

“…We aimed to estimate the incidence trend of a multiethnic Asian population.Design Retrospective cohort study.Setting Singapore’s nationwide claims database.Participants Singaporeans and permanent residents.Outcomes Patients were identified by International Classification of Disease, Ninth Revision, Australian Modification (ICD-9-AM) and ICD-10-AM codes from all admissions between 2000 and 2017, and categorised according to aetiology: venous, arterial, diabetic and pressure. …”
Get full text

Is middle East pain syndrome (MEPS) a variant of fibromyalgia syndrome or a distinct disease? by Mona H. Elhamamy, Adel A. Elbeialy, Maha S. Mohamed, Sabah E. Abdelraheem, Hala M. Elzomor

“…Conclusion Elevated IL-17 levels, non-scleroderma pattern capillaroscopic and enthesopathy findings in both MEPS and FMS patients are strongly supportive that inflammatory mechanisms participate in the pathogenesis of both diseases. The significant increase of these findings in MEPS than FMS patients as well as the presence of hand tufts spur-like excrescences, confirm that the newly discovered MEPS is a different disease although it involves fibromyalgia symptoms and signs.…”
Get full text

Altered brain functional network connectivity and topology in type 2 diabetes mellitus by Weiwei Ni, Weiyin Vivian Liu, Mingrui Li, Shouchao Wei, Xuanzi Xu, Shutong Huang, Lanhui Zhu, Jieru Wang, Fengling Wen, Hailing Zhou

“…This study aimed to investigate T2DM-driven alterations in brain functional network connectivity and topology.MethodsEighty-five T2DM patients and 67 healthy controls (HCs) were included. All participants underwent clinical, neuropsychological, and laboratory tests, followed by MRI examinations, including resting-state functional magnetic resonance imaging (rs-fMRI) and three-dimensional high-resolution T1-weighted imaging (3D-T1WI) on a 3.0 T MRI scanner. …”
Get full text

Development and effectiveness evaluation of an interactive e-learning environment to enhance digital health literacy in cancer patients: study protocol for a randomized controlled... by Lukas Lange-Drenth, Hellena Willemer, Mirjam Banse, Anke Ernst, Anne Daubmann, Anja Holz, Christiane Bleich, Susanne Weg-Remers, Holger Schulz

“…Two thirds of the 660 participants will be recruited through the German Cancer Information Service (CIS) and one third through non-CIS routes. …”
Get full text

Clinico-spirometrical correlation of newly detected COPD patients with known tobacco smoking exposure or biomass smoke exposure presenting to a teaching institution in Vadodara, Gu... by Bhavesh Patel, G Mothiganesh, Arti D. Shah, Chirag H. Chakravarti, Parshwa Naik, Princee Patel

“…The study comprised records of 50 participants, from September 2022 to January 2024. Along with the spirometry results, pertinent clinical data were gathered. …”
Get full text