Safety and effectiveness of appropriately and inappropriately dosed rivaroxaban or apixaban versus warfarin in patients with atrial fibrillation: a cohort study with nested case–co... by Luis Alberto García Rodríguez, Pareen Vora, Luke Roberts, Gunnar Brobert, Samuel Fatoba, María Eugenia Sáez, Antonio González-Pérez

“…Objectives To investigate effects of appropriately and inappropriately dosed apixaban/rivaroxaban versus warfarin on effectiveness and safety outcomes in patients with non-valvular atrial fibrillation (NVAF).Design Cohort study with nested case–control analyses using primary care electronic health records (IQVIA Medical Research Data UK database).Setting UK primary care.Participants Patients aged ≥18 years with NVAF newly prescribed apixaban (N=14 701), rivaroxaban (N=14 288) or warfarin (N=16 175) between 1 January 2012 and 30 June 2018, and followed up to 31 December 2018.Primary and secondary outcome measures Incident cases of ischaemic stroke/systemic embolism (IS/SE) and intracranial bleeding (ICB). …”
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Assessing medical students’ beliefs about the opioid crisis and their post-graduation plans: a cross-sectional study by Samuel Borgemenke, Nicholas Durstock, Elizabeth A. Beverly

“…Qualitative data was also analyzed from participants’ comments pertaining to the opioid crisis. …”
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Relationships between multiple patient safety outcomes and healthcare and hospital-related risk factors in colorectal resection cases: cross-sectional evidence from a nationwide sa... by Ralf Kuhlen, Jochen Schmitt, Felix Walther, Martin Roessler, Peter Scriba, Maria Eberlein-Gonska, Olaf Schoffer

“…Therefore the aim of this analysis was to investigate consistent relationships between multiple patient safety outcomes, healthcare and hospital risk factors in colorectal resection cases.Design Cross-sectional study.Setting German inpatient routine care data of colorectal resections between 2016 and 2018.Participants We analysed 54 168 colon resection and 20 395 rectum resection cases treated in German hospitals. …”
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Association between D-dimer to lymphocyte ratio and in hospital all-cause mortality in elderly patients with sepsis: a cohort of 1123 patients by Xinguang Long, Zhenkui Hu, Chao Song, Jinhui Zhang

“…The association between DLR and all-cause mortality in patients with sepsis was further elucidated using the receiver operating characteristic (ROC) curve and Cox proportional hazards regression analysis.ResultsThe study included participants with a median age of 75 (65-84) years, with 707 (63.0%) being male. …”
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Influence of low-level laser radiation on the physico-chemical indicators of biomembranes by Л. В. Січевська, Т. M. Овсяннікова, А. О. Коваленко, І. А. Забєліна, О. М. Левченко, О. В. Гурін, В. П. Берест

“…Irradiation of samples of model lipid membranes with a helium-neon laser leads to a change in the surface characteristics of liposomes, which affects the kinetic parameters of the formation of protein-lipid complexes with the participation of cytochrome c. Conclusions: The target of laser photomodulation processes is the surface of the biological membrane of both natural cells, for example yeast cells, and model lipid membranes made of a mixture of phospholipids with different content of components. …”
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COVID-19-related stress, anxiety and vaccine hesitancy among healthcare workers in a tertiary hospital in South-Western Nigeria by Temitope Olumuyiwa Ojo, Tajudin Adesegun Adetunji, Stanley Chinedu Eneh, Baderinwa Opeyemi Akanji, Olusola Fajobi, Olanrewaju Elugbaju, Olanrewaju Ibikunle Ibigbami, Temilola Oladunmomi Owojuyigbe, Samuel Anu Olowookere, Olusegun Temitope Afolabi, Adedeji Ayodeji Onayade

“…Also, the WHO-5 index was used to assess the perceived mental wellbeing among study participants. Data analysis was conducted using SPSS 25 at univariate, bivariate and multivariate levels. …”
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Self-selected vs. prescribed aerobic exercise intensity: impacts on pleasure in women with obesity by Carlos Eduardo Rosa Da Silva, Wilian Jesus Santana, Gustavo Almeida, Adriano Verame, Antonio Roberto Doro, Eduardo Barbosa, Leonardo Lima, Helton Magalhães Dias, Marcelo Callegari Zanetti, Aylton Figueira Junior

“…The aim of the present study was to compare the effect of three aerobic training protocols on psychophysiological responses in physically inactive adult obese women.MethodsThe sample consisted of 90 women with a mean age of 48.3 ± 5.5 years and BMI of 31.2 ± 4.8 kg/m2, who participated in three treadmill aerobic training protocols: 1- Control group (IPI) with individually prescribed intensity (64 to 76% of HRmax), 2- Small group (SGS) with self-selected intensity, and 3- Individual with self-selected intensity (ISS). …”
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Factors Associated with Midterm Visual Field Variability in Patients with Stable Glaucoma by Maria Emília V. Guimarães, Carolina P. B. Gracitelli, Syril Dorairaj, Fábio N. Kanadani, Tiago S. Prata

“…GEE models were used to compare the CV and demographic and clinical parameters of all participants. Results. Mean age of all subjects was 65.8 ± 10.1 years. 54.0% were women. …”
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Effect of conservative treatment on greater trochanteric pain syndrome: a systematic review and network meta-analysis of randomized controlled trials by Si-Qi Wang, Ning-Yi Guo, Wei Liu, Hong-jie Huang, Bing-bing Xu, Jian-quan Wang

“…Results Nineteen RCTs involving 1701 participants were included. The risk of bias was assessed using Cochrane ROB2. …”
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Elucidating the expression and role of cGAS in pan-cancer using integrated bioinformatics and experimental approaches by Zhen Lian, Xue Liu, Xue Li

“…In conclusions, cGAS is wildly activated in human cancers, which might participate in regulating cancer immunity and DNA damage repair. cGAS could be used as an effective target for cancer treatment and might be a potential predictive immune marker.…”
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Association of vaginal oestradiol and the rate of breast cancer in Denmark: registry based, case-control study, nested in a nationwide cohort by Christian Torp-Pedersen, Lina Steinrud Mørch, Nelsan Pourhadi, Amani Meaidi, Ellen Christine Løkkegaard

“…Objective To estimate the rate of breast cancer associated with use of vaginal oestradiol tablets according to duration and intensity of their use.Design Registry based, case-control study, nested in a nationwide cohort.Setting Based in Denmark using the civil registration system, the national registry of medicinal product statistics, the Danish cancer registry, the Danish birth registry, and statistics Denmark.Participants Women aged 50-60 years in year 2000 or turning 50 years during the study period of 1 January 2000 to 31 December 2018 were included. …”
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Assessing the Inter-Rater and Inter-Trial Reliability of the NeurOptics Pupillary Light Response-3000 Pupillometer by Deborah A Jehu, Lori A Bolgla, Samantha Armas, Forest Dutton

“… # Study Design: Observational, reliability study Methods: Forty-eight healthy adults (age 18-40 years) without a history of neurological injury, optical surgery, or cognitive impairment participated. Two independent raters used the NeurOptics PLR-3000 to measure PLR parameters in the left and right eyes of each subject. …”
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Body mass index change and estimated glomerular filtration rate decline in a middle-aged population: health check-based cohort in Japan by Rajiv Saran, Yukari Yamada, Tatsuyoshi Ikenoue, Shingo Fukuma, Jennifer Bragg-Gresham, Edward Norton, Daichi Kohmoto

“…The primary outcome was combined 30% decline in eGFR, eGFR <15 mL/min/1.73 m2 and end-stage renal disease.Results During 245 147 person-years’ follow-up among 50 604 participants (mean eGFR, 83.7 mL/min/1.73 m2; mean BMI, 24.1 kg/m2), 645 demonstrated eGFR decline (incidence rate 2.6/1000 person-years, 95% CI: 2.4 to 2.8). …”
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Automated method of bronchus and artery dimension measurement in an adult bronchiectasis population by Angelina L.P. Pieters, Qianting Lv, Jennifer J. Meerburg, Tjeerd van der Veer, Eleni-Rosalina Andrinopoulou, Pierluigi Ciet, James D. Chalmers, Michael R. Loebinger, Charles S. Haworth, J. Stuart Elborn, Harm A.W.M. Tiddens

“…Methods Baseline CTs of BE patients who participated in a clinical trial were collected retrospectively. …”
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A relational approach to co-create Advance Care Planning with and for people living with dementia: a narrative study by Tharin Phenwan, Judith Sixsmith, Linda McSwiggan, Deans Buchanan

“…Methods Narrative online and telephone interviews were conducted with 13 PwD and 23 family carers. Participants were recruited via the Join Dementia Research (JDR) Platform. …”
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Factors associated with, and variations in, COVID-19 hospital death rates in England’s first two waves: observational study by Alex Bottle, Paul Aylin, Stephen Brett, Puji Faitna

“…To quantify the correlation between hospitals’ first and second wave death rates.Design Observational study using administrative data.Setting Acute non-specialist hospitals in England.Participants All patients admitted with a primary diagnosis of COVID-19.Primary and secondary outcomes In-hospital death.Results Hospital Episode Statistics (HES) data were extracted for all acute hospitals in England for COVID-19 admissions from March 2020 to March 2021. …”
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Assessing the Air Quality Impact of Train Operation at Tokyo Metro Shibuya Station from Portable Sensor Data by Deepanshu Agarwal, Xuan Truong Trinh, Wataru Takeuchi

“…Subways, as major public transportation modes in densely populated cities, can exhibit fine particulate matter (PM) levels that surpass safety limits, even in developed countries. …”
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Phase 1 study of novel anti-platelet agent to overcome pharmacogenomic limitations of clopidogrel by Anil Pareek, Nitin Chandurkar, Vivek Raut, Kumar Naidu

“…Therefore, we planned a study with an objective of evaluating safety, tolerability, pharmacodynamics and pharmacokinetics of a novel thienopyridine antiplatelet agent AT-10 in healthy Indian subjects compared with standard dosage regimen of clopidogrel based on their CYP2C19 genotyping.Methods Two CYP2C19 genotype–based groups were identified, that is, poor metabolisers and extensive metabolisers, with 20 subjects in each group (n=40) for participating in a randomised, two-period, crossover study. …”
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Smallholder farmers’ knowledge, attitudes and practices towards biological control of papaya mealybug in Kenya by Kate Constantine, Fernadis Makale, Idah Mugambi, Harrison Rware, Duncan Chacha, Alyssa Lowry, Ivan Rwomushana, Frances Williams

“…Conclusions Previously, poor attention has been paid to farmer perceptions and participation in biological control, which has resulted in limited success in developing countries. …”
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Implementation of the School as a Learning Organisation Approach in Vocational Education: The Case of Latvia by Gunta Siliņa-Jasjukeviča, Ilze Briška, Inese Lūsēna-Ezera, Agnese Lastovska, Inga Linde

“…For education policy makers: Since the features of SLO are only partially visible in vocational education documents in Latvia, the framework should be improved to cover all dimensions of the SLO, and norms and agreements on collective understanding should be harmonised in policy documents. …”
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