Integrated metabolome and transcriptome analysis reveals potential mechanism during the bud dormancy transition of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsi... by Huan Guan, Huan Guan, Yuhuan Zhao, Yuhuan Zhao, Qing Chen, Qianqian Zhang, Qianqian Zhang, Pengpeng Yang, Pengpeng Yang, Shuying Sun, Shuying Sun, Guilin Chen, Guilin Chen

“…A total of 1,069 differentially accumulated metabolites (DAMs) participated in amino acid and carbohydrate metabolism. …”
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Bridging animal models and humans: neuroimaging as intermediate phenotypes linking genetic or stress factors to anhedonia by Huiling Guo, Yao Xiao, Shuai Dong, Jingyu Yang, Pengfei Zhao, Tongtong Zhao, Aoling Cai, Lili Tang, Juan Liu, Hui Wang, Ruifang Hua, Rongxun Liu, Yange Wei, Dandan Sun, Zhongchun Liu, Mingrui Xia, Yong He, Yankun Wu, Tianmei Si, Fay Y. Womer, Fuqiang Xu, Yanqing Tang, Jie Wang, Weixiong Zhang, Xizhe Zhang, Fei Wang

“…The rodent studies included a genetic model (P11 knockout) and an environmental stress model (chronic unpredictable mild stress), while the human data comprised 748 participants from three cohorts. Using the amplitude of low-frequency fluctuations, we identified neuroimaging patterns in rodent models. …”
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Causes of admissions and in-hospital mortality among patients admitted to critical care units in primary and secondary hospitals in Vietnam in 2018: a multicentre retrospective stu... by Vu Quoc Dat, Bui Thi Khanh Linh, Giang Bao Kim

“…Objective The goal of this study was to describe the burden of disease and in-hospital mortality among patients admitted to the critical care units (CCUs) in Vietnam.Design Retrospective study.Setting The whole 1-year data of admissions to CCUs were collected from 34 hospitals from January to December 2018.Participants A total of 44 013 episodes of admission to CCUs were analysed.Primary outcome We used International Classification of Diseases-11 codes to assess the primary diagnosis associated with admissions and in-hospitals mortality. …”
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Effectiveness of deliberate practices versus conventional lecture in trauma training for medical students by Suksan Kanoksin, Bhapapak Na Songkhla, Amarit Tansawet, Issaree Laopeamthong, Pakkapol Sukhvibul, Suphakarn Techapongsatorn

“…Methods A randomized controlled trial was conducted with 48 first- to third-year medical students at the Faculty of Medicine Vajira Hospital at Navamindradhiraj University (Thailand). The participants were randomly assigned to either the deliberate practice group (n = 24) or the conventional lecture group (n = 24). …”
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A scoping review of strategies for the prevention of hip fracture in elderly nursing home residents. by Anna M Sawka, Nofisat Ismaila, Ann Cranney, Lehana Thabane, Monika Kastner, Amiram Gafni, Linda J Woodhouse, Richard Crilly, Angela M Cheung, Jonathan D Adachi, Robert G Josse, Alexandra Papaioannou

“…Data from 20 trials were included: 7--vitamin D (n = 12,875 participants), 2--sunlight exposure (n = 522), 1--alendronate (n = 327), 1--fluoride (n = 460), 4--exercise or multimodal interventions (n = 8,165), and 5--hip protectors (n = 2,594). …”
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Rapid diagnosis of bacterial vaginosis using machine-learning-assisted surface-enhanced Raman spectroscopy of human vaginal fluids by Xin-Ru Wen, Jia-Wei Tang, Jie Chen, Hui-Min Chen, Muhammad Usman, Quan Yuan, Yu-Rong Tang, Yu-Dong Zhang, Hui-Jin Chen, Liang Wang

“…Moreover, the CNN model was blindly tested on SERS spectra of vaginal fluid samples collected from 40 participants with unknown BV infection status, achieving a prediction accuracy of 90.75% compared with the results of the BVBlue Test combined with clinical microscopy. …”
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Assessment of blood lead and haemoglobin levels among battery technicians and local government office workers in South-western Nigeria by Ebenezer Adeiza Ozomata, Babatunde Ogunnowo

“…Results: A total of 150 battery technicians and 150 office workers participated in the study. The battery technicians were less educated and earned less but had more years of working experience (p≤0.001) when compared to office workers. …”
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Nudging in the nursing home: A qualitative interpretive study by Anne Helene Mortensen, Dagfinn Nåden, Dag Karterud, Vibeke Lohne

“…The study was conducted between December 7th. 2019 and July 2nd. 2020. Participants: Individuals involved in the units during the observation period. …”
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The effect of the use of omeprazole versus famotidine on the kidney transplant function: a randomized controlled study by Miłosz Miedziaszczyk, Marek Karczewski, Ilona Idasiak-Piechocka

“…Abstract Tacrolimus is metabolized in the liver with the participation of cytochrome P450 isoforms 3A4 and 3A5 (CYP3A4, CYP3A5). …”
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Efficacy in Japanese adults with growth hormone deficiency receiving weekly somapacitan or daily growth hormone: results from phase 3 REAL 1 trial by Fumio Otsuka, Michael Højby Rasmussen, Takaaki Endo, Claus Sværke, Shigeyuki Tahara, Gudmundur Johannsson

“…This study aimed to evaluate the efficacy and safety of somapacitan and daily GH in Japanese individuals with AGHD.MethodsThis subgroup study included the 34-week main period of the multinational, randomized, parallel-group, phase 3 trial, REAL 1 (NCT02229851). Participants received once-weekly somapacitan or daily GH (Norditropin®), both administered subcutaneously. …”
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Poor Nurses’ Work Environment Increases Quiet Quitting and Reduces Work Engagement: A Cross-Sectional Study in Greece by Ioannis Moisoglou, Aglaia Katsiroumpa, Aggeliki Katsapi, Olympia Konstantakopoulou, Petros Galanis

“…After controlling for confounders, we found that lower nurse participation in hospital affairs, less collegial nurse–physician relationships, worse nursing foundations for quality of care, and lower levels of nurse manager ability, leadership, and support were associated with higher levels of quiet quitting among nurses. …”
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Case for hospital nurse-to-patient ratio legislation in Queensland, Australia, hospitals: an observational study by Carol Windsor, Patsy Yates, Linda H Aiken, Clint Douglas, Matthew D McHugh

“…Objectives To determine whether there was variation in nurse staffing across hospitals in Queensland prior to implementation of nurse-to-patient ratio legislation targeting medical-surgical wards, and if so, the extent to which nurse staffing variation was associated with poor outcomes for patients and nurses.Design Analysis of cross-sectional data derived from nurse surveys linked with admitted patient outcomes data.Setting Public hospitals in Queensland.Participants 4372 medical-surgical nurses and 146 456 patients in 68 public hospitals.Main outcome measures 30-day mortality, quality and safety indicators, nurse outcomes including emotional exhaustion and job dissatisfaction.Results Medical-surgical nurse-to-patient ratios before implementation of ratio legislation varied significantly across hospitals (mean 5.52 patients per nurse; SD=2.03). …”
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A luta pela terra e a recriação dos espaços de vida de assentados na Campanha Gaúcha by Michele Lindner, Rosa Maria Vieira Medeiros

“…However, it became clear that the importance of the conquest of “new land”, or “new territory”, as well as the importance of participation in a social movement lastedthis whole process of repossession which involves a strong adaptation of individuals to their new territory. …”
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An explanatory model of suicidal ideation based on family functionality and mental health problems: A cross-sectional study of medical students by Leslie Aguilar-Sigueñas, David Villarreal-Zegarra

“…Results: A total of 480 participants were included. The prevalence of suicidal ideation was 39Poisson regression analysis adjusted identified that people with anxiety symptoms were more than four times more likely to have suicidal ideation (PR=4.89; 95% CI:1.90-12.64). …”
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Socioeconomic environment and survival in patients after ST-segment elevation myocardial infarction (STEMI): a longitudinal study for the City of Vienna by Christian Roth, Michael Kühn, Rudolf Berger, Sonja Spitzer, Vanessa di Lego

“…On weekends, it is the only hospital in charge of treating STEMIs and thus provides representative data for the Viennese population.Participants The study comprises a total of 1481 patients with STEMI, including women and men aged 24–94 years.Primary and secondary outcome measures Primary outcome measures are age at STEMI and age at death. …”
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East Midlands knee pain multiple randomised controlled trial cohort study: cohort establishment and feasibility study protocol by Michael Doherty, Roshan das Nair, Ana Valdes, Reuben Ogollah, Paul Greenhaff, Bonnie Millar, Michelle Hall, Amy Fuller, Polykarpos Angelos Nomikos, David A Walsh, A Abhishek

“…Qualitative interviews will be conducted with a sample of participants from each of the two active intervention arms.Ethics and dissemination This protocol was approved by the East Midlands-Derby Research Ethics Committee (18/EM/0288) and registered at ClinicalTrials.gov (protocol v4.0, 10/02/2020). …”
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Cytokines and Water Distribution in Anorexia Nervosa by Hubertus Himmerich, Bethan Dalton, Olivia Patsalos, Ulrike Schmidt, Iain C. Campbell

“…In the whole sample, GM-CSF, MCP-4, and IL-4 were positively, whereas IFN-γ, IL-6, and IL-10 were negatively associated with all three parameters of body water. In AN participants, we found a statistically significant negative correlation of IL-10 with ICW, ECW, and TBW. …”
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Estimating the Effect of Adhering to the Recommendations of the 2019 Canada’s Food Guide on Health Outcomes in Older Adults: Protocol for a Target Trial Emulation by Didier Brassard, Nancy Presse, Stéphanie Chevalier

“…In the hypothetical trial, participants will be instructed to meet sex-specific minimal intakes for vegetables and fruits, whole grains, animal- and plant-based protein foods, milk and plant-based beverages, and unsaturated fats. …”
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Optimizing haemodialysis outcomes: A pilot study on the effectiveness of multidisciplinary clinics in enhancing vascular access and improving patient outcomes by Boon Cheok Lai, Hui Boon Tay, Pei Shan Lee

“…Results The study analysed 53 and 92 participants in the multidisciplinary clinics and conventional groups, respectively. …”
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Longitudinal examination of young married women’s fertility and family planning intentions and how they relate to subsequent family planning use in Bihar and Uttar Pradesh India by Niranjan Saggurti, Lisa Calhoun, Priya Nanda, Ilene S Speizer, A J Francis Zavier, Gwyn Hainsworth

“…Objectives This study examines which fertility and family planning (FP) intentions are related to subsequent FP use in a sample of young, married women in India.Design We use 3-year longitudinal data from married women ages 15–19 in 2015–2016 (wave 1) who are not using contraception to examine factors associated with any use of FP in 2018–2019 (wave 2).Setting Data were collected in the states of Bihar and Uttar Pradesh, India.Participants A representative sample of 4893 young married women ages 15–19 was surveyed in 2015–2016 and 4000 of them were found and interviewed 3 years later. …”
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