RATIONAL DRUG DESIGN OF POTENT V600E-BRAF KINASE INHIBITORS THROUGH MOLECULAR DOCKING SIMULATION by Bello Abdullahi Umar, Adamu Uzairu, Gideion Adamu Shallangwa, Sani Uba

“…V600E-BRAF protein has lot potential for scientific investigation as the therapeutic target owing to its participation in melanoma cancer and is the molecular target of many anticancer compounds like quinolinylaminopyrimidines (QAP) derivatives. …”
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Case Report: Prenatal diagnosis of novel compound heterozygous variants in WDR35 gene causing short-rib thoracic dysplasia 7 with or without polydactyly by Jianlong Zhuang, Junyu Wang, Zhengping Huang, Yu’e Chen, Chunnuan Chen

“…In addition, two compound heterozygous variants NM_015102.5:c.[1196A>G(p.E399G)];[1972C>T(p.R658*)] in NPHP4 gene were also identified in the fetus, which may be partially responsible for fetal kidney hyperechogenicity and oligohydramnios.ConclusionThis is the first study reporting a novel deletion compound combined with a causative missense variant in WDR35 leading to SRTD7. …”
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Public Perception of Genetically Modified Organisms and the Implementation of Biosafety Measures in Kenya by Kunyanga Nkirote Catherine, B. Roy Mugiira, N. Josephat Muchiri

“…A cross-sectional survey was used with 216 participants sampled purposively and 16 key informants interviewed in a qualitative survey with triangulation of data from a scoping literature review. …”
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Effects of a foot-ankle strengthening programme on clinical aspects and gait biomechanics in people with knee osteoarthritis: protocol for a randomised controlled trial by Tania F Salvini, Glauko Dantas, Isabel C N Sacco, Ana F dos Santos, Ricky Watari, Alessandra B Matias, Paula R M S Serrao, Henrique Pott-Junior

“…Data will be analysed on intention-to-treat principles and a per protocol basis.Ethics and dissemination Investigators and sponsors will communicate trial results to participants and healthcare professionals through scientific databases and social media. …”
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Effects of postoperative physical exercise rehabilitation on cardiorespiratory fitness, functional capacity and quality of life in patients with colorectal, breast, and prostate ca... by Mailin Beyer, Christian Bischoff, Johannes Lässing, Ines Gockel, Roberto Falz

“…However, there is a lack of high-quality trials with a higher number of participants examining the effects of postoperative exercise in patients with colorectal, breast, and prostate cancer. …”
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Sleep as a mediator between chronic diseases and depression: a NHANES study (2005–2018) by Ming Tan, Ming Tan, Haihong Zhao, Haihong Zhao, Ruya Nie, Ruya Nie, Pingping Deng, Pingping Deng, Cuixiao Wang

“…ObjectiveThis article investigates the relationship between common chronic diseases and depression among US adults and examines the mediating role of sleep in this relationship, using a cross-sectional study to offer recommendations for depression prevention.MethodsThis study analyzed data from 10,710 participants collected from the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2018. …”
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High craving is associated with fewer abstinent days and lesser time to relapse during treatment in severe alcohol use disorder by Soundarya Soundararajan, Pratima Murthy

“…Methods: Among 264 treatment-seeking male participants (mean [SD] age = 36 [6.7] years) with severe AUD, craving was assessed according to the Penn Alcohol Craving Scale (PACS) at treatment initiation and two follow-up visits (median follow-up: 1, 2 weeks). …”
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Philosophical Ideas of Arne Næss in the Humanitarian Diplomacy of Norway by M. G. Zubov

“…The author of the arcticle makes it a point to show on separate examples to what extend the ideas of Næss A. are compatible with the basic principles of Norway's contemporary humanitarian diplomacy - humanity, neutrality, impartiality and independence, - as well as with the aims put forward by Norway in this respect which are to encure the needed with the necessery security and assistance; to finance humanitarian actions based on the international principles of humanity, neutrality, impartiality and independence; to prepare international community to responses to global humanitarian challenges of the future; to prevent and respond to humanitarian crises and participate in eleminating their aftermath. Norway - one of the few countries in the world allocating 1 % of their GNP for the aims of the UN Millennium Programme - works actively in such directions of humanitarian diplomacy as combating climate change, protecting the environment, facilitating international cooperation in the field of development, peace-building and humanitarian assistance. …”
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Advances in Therapy for Urothelial and Non-Urothelial Subtype Histologies of Advanced Bladder Cancer: From Etiology to Current Development by Whi-An Kwon, Ho Kyung Seo, Geehyun Song, Min-Kyung Lee, Weon Seo Park

“…For advanced-stage diseases, clinical trial participation is strongly recommended to address the lack of robust evidence. …”
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Cardiac Magnetic Resonance Imaging for Diagnosis of Cardiac Sarcoidosis: A Meta-Analysis by Jianxiong Zhang, Yunxiao Li, Qiufen Xu, Bo Xu, Haoyan Wang

“…Eight studies with a total of 649 participants met the inclusion criteria, and data were extracted. …”
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Influenza vaccination hesitancy and related factors among pregnant and breastfeeding women: A cross-sectional study by Dania Comparcini, Giancarlo Cicolini, Melania Totaro, Letizia Governatori, Francesco Pastore, Daniela Miniscalco, Maria Elena Flacco, Eustachio Cuscianna, Silvio Tafuri, Valentina Simonetti

“…A multicentre, cross-sectional study was conducted between February and June 2022 using structured phone interviews to assess: (1) socio-demographics and clinical history; (2) anti-flu vaccination status, previous anti-flu vaccination, and Sars-CoV-2 infection history; (3) insights into influenza vaccination during pregnancy; (4) attitudes toward anti-flu vaccination, using the Vaccination Attitudes Examination (VAX) Scale; (5) anxiety levels, measured by the Self-Rating Anxiety Scale (SAS). Among the 387 participants, 22.8% were already vaccinated or expressed willingness to be vaccinated against influenza, and 54% had an anxiety disorder. …”
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Integration of social work into specialist palliative home service by Janice Lee Wartchow, Stefan Bär, Bernd Alt-Epping, Christina Gerlach

“…Results: Four physicians and four nurses from the SAPV-team based at Heidelberg University Hospital participated. The medical staff’s attributions to SW significantly impact its integration into SAPV. …”
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EVALUATION OF AN INDUCTIVE STRATEGY OF TEACHING MUSIC AND PROGRAMMING TO PRIMARY SCHOOL STUDENTS by Marius Bănuț, Ion Albulescu

“…Thus, it was found that the percentage of results exceeding the 25th percentile, i.e. 75% of the sample of participants, produced variability at the upper limit of the scoring system. …”
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Enhancing diagnostic outcomes in kidney genetic disorders: the KidGen national kidney genomics study protocol by Amali Mallawaarachchi, Hugh McCarthy, Thomas A. Forbes, Kushani Jayasinghe, Chirag Patel, Stephen I. Alexander, Tiffany Boughtwood, Jeffrey Braithwaite, Aron Chakera, Sam Crafter, Ira W. Deveson, Randall Faull, Trudie Harris, Lilian Johnstone, Matthew Jose, Anna Leaver, Melissa H. Little, Daniel MacArthur, Tessa Mattiske, Christine Mincham, Kathy Nicholls, Catherine Quinlan, Michael C. J. Quinn, Gopala Rangan, Jessica Ryan, Cas Simons, Ian Smyth, Madhivanan Sundaram, Peter Trnka, Laura Wedd, Erik Biros, Zornitza Stark, Andrew Mallett

“…The program will seek to enrol up to 200 families from KidGen Collaborative kidney genetics clinics across Australia who have yet to receive conclusive diagnoses despite prior testing. Participants will undergo a personalised pathway of research genomic investigations. …”
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Exploring household water conservation behaviors in Saudi Arabia: A structural equation modeling approach by Abdulaziz I. Almulhim, Ismaila Rimi Abubakar

“…Public lectures and workshops were identified as the most preferred sources of information about water conservation practices (factor loading [λ] = 0.788). Participants indicate their support for public awareness campaigns for promoting water conservation, but they showed resistance to the idea of raising water tariffs (λ = 0.435) and implementing water conservation laws with fines for violators (λ = 0.318) as water conservation policies. …”
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Association of Biomarker Level with Cardiovascular Events: Results of a 4-Year Follow-Up Study by L. Turgunova, B. Baidildina, Y. Laryushina, B. Koichubekov, A. Turmukhambetova, L. Akhmaltdinova

“…We examined 363 people aged 30 to 65 who have been living permanently in the city of Saran, Karaganda region. The selected participants were people registered at a clinic at the city of Saran, who were screened between August and September 2014. …”
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Strategies for Gait Retraining in a Collegiate Runner with Transfemoral Amputation: A Case Report by Jillian Santer, Stephanie MacDonald, Katherine Rizzone, Shawn Biehler, Tanya Beiswenger

“…# Background More than fifty percent of people with limb amputations participate in sports or physical activity following amputation. …”
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Can a theory-based intervention lead primiparous women to decide to have a normal vaginal delivery? A randomized controlled trial by Rashin Pourashraf, Masoumeh Abbasi-Shavazi, Mahboubeh Valiani, Sara Jambarsang, Hossein Ali Sadeghian

“…In total, 112 primiparous pregnant women participating in childbirth preparation classes were divided into two intervention and control groups by nonrandom sampling method. …”
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Sunscreen Use among a Population of Saudi University Students by Mohammed I. AlJasser, Abdullah Aljumah, Mohannad Alzaydi, Abdullah Alassaf, Suliman Alassafi, Maha T. Alassafi, Mohammed Almedlej, Emad Masuadi

“…Eighty percent of participants used other methods of sun protection. Sunscreen with a sun protection factor (SPF) > 30 was used in 59% of students. …”
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Validation of chronic obstructive pulmonary disease recording in the Clinical Practice Research Datalink (CPRD-GOLD) by John R Hurst, Jennifer K Quint, Hana Müllerova, Liam Smeeth, Harriet Forbes, Susan Eaton, Rachael L DiSantostefano, Kourtney Davis

“…We assessed the accuracy of different approaches using the Clinical Practice Research Datalink, a UK electronic health record database.Setting 951 participants registered with a CPRD practice in the UK between 1 January 2004 and 31 December 2012. …”
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