Dysregulation of the NLRP3 Inflammasome and Promotion of Disease by IL-1β in a Murine Model of Sandhoff Disease by Nick Platt, Dawn Shepherd, David A. Smith, Claire Smith, Kerri-Lee Wallom, Raashid Luqmani, Grant C. Churchill, Antony Galione, Frances M. Platt

“…These data demonstrate that IL-1β actively participates in the disease process and provides proof-of-principle that blockade of the pro-inflammatory cytokine IL-1β may provide benefits to patients.…”
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The Effects of Eight-Week Regular Training in Amateur Amputee Football Team Athletes' Body Composition by Betül Akyol, Mehmet Ilkım, Burak Canpolat

“…The purpose of this study is to observe the effects of the 8 week regular training program on body composition of the amateur amputee sports club athletes. 12 amateur amputee athletes in the Malatya Ay Yildiz Amateur Amputee Football Team with ages ranging from 16 to 33 (X age: 24.33 ± 5.71 years, X length: 1.74 ± 8.07 meters, X weight: 75.09 ± 15.16 kg) voluntarily participated in this study. The training program consists of strength, strength, agility, speed, technique, tactics, coordination and flexibility.  …”
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The contribution of forest coffee certification program to household income and resource conservation: Empirical evidences from Southwest Ethiopia by Diriba Abdeta, Alemayehu N. Ayana

“…However, these programs have faced criticism, particularly regarding their impact on participants' livelihoods and resource conservation. …”
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Nostalgia, ideología y simbología franquista en ROJO: A Spanish Horror Experience by Sara Rebollo-Bueno, Antonio Francisco Campos-Méndez

“…Así, ROJO se erige como un videojuego de terror que utiliza la sátira para enviar un mensaje antifascista, utilizando símbolos que, hoy día, son parte de la imagen de partidos como Vox, pues los usan para su propia identificación. …”
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Telephone coaching supports exercise in people with prediabetes and diabetes: A mixed-methods study by Ana Paula Delgado Bomtempo, Gabriela Lima de Melo Ghisi, Mariana Balbi Seixas, Adriano Luiz Pereira, Paul Oh, Danielle Aparecida Gomes Pereira, Lilian Pinto da Silva

“…Conclusion: The telephone coaching intervention can support people with prediabetes and diabetes in adhering to exercise recommendations outlined in diabetes guidelines, especially after participating in programs focused on promoting lifestyle changes. …”
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Incentive Mechanism Design for Distributed Autonomous Organizations Based on the Mutual Insurance Scenario by Yiguang Pan, Xiaomei Deng

“…The rise of blockchain has led to discussions on new governance models and the cooperation of multiple participants. Due to the cognitive defects of the blockchain protocol in terms of intelligent contracts and decentralized autonomous organizations (DAOs), it is often unclear as to how to make decisions about the evolution of blockchain applications. …”
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Multicenter research in dialysis centers in Brazil: recruitment and implementation of the SARC-HD study by Marvery P. Duarte, Otávio T. Nóbrega, Barbara P. Vogt, Fábio A. Vieira, Dário R. Mondini, Maryanne Z.C. Silva, Henrique S. Disessa, Rodrigo R. Krug, Bruna R.M. Sant’Helena, Daiana C. Bundchen, Maristela Bohlke, Angélica N. Adamoli, Marco C. Uchida, Carla M. Avesani, Maycon M. Reboredo, Heitor S. Ribeiro

“…Results: 21 centers from three Brazilian regions consented to participate, with two dropping out. Ten principal investigators oversaw the 19 sites. …”
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Addressing the mental health needs of India’s aging population: Understanding depression prevalence and social risk factors in tertiary care outpatients by Joanne Lydia Rajkumar, Surekha Viggeswarapu, Suja Kurian, Munaf B. Nandyal, Mahasampath Gowri

“…Results: A total of 171 participants were recruited. The prevalence of depression was found to be 53.2% with PHQ-2 and 35.6% with GDS. …”
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Intermittent fasting as a treatment for obesity in young people: a scoping review by Jomanah Bakhsh, Sarah-Jeanne Salvy, Alaina P. Vidmar

“…The review included 34 studies (28 interventional studies and 6 observational studies) with 893 participants aged 12 to 25. Interventions varied with 9 studies in cohorts with obesity utilizing intermittent fasting as an obesity treatment. …”
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Crimean-Congo haemorrhagic fever virus screening among African individuals in Spain: Lessons to learn by Helena Miriam Lorenzo Juanes, Amparo López-Bernus, Belen Vicente, Montserrat Alonso-Sardón, Beatriz Rodríguez Alonso, Josue Pendones Ulerio, Pedro Fernandez Soto, Juan Luis Muñoz Bellido, Antonio Muro, Moncef Belhassen-García

“…Forty-seven percent of the immigrant participants were from Equatorial Guinea; thus, the IgG seroprevalence among the Equatorial Guinean immigrant population (13/228) was 5.70 %. …”
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Perceived Burden and Healthy Lifestyle Behavior in Family Caregivers of the Persons with Disabilities in Bukhara by Hülya YÜCEL, Nurhayat KORKMAZ

“…Methods: The sociodemographic characteristics of the participants were recorded. The number of children in the family, duration of care period, disability group of the one who is cared, duration and type of disability, age and gender of the young person were asked. …”
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Impact of Rs657152 Gene Polymorphisms on Inflammatory Markers in COVID-19 Patients With Type 2 Diabetes Mellitus by Ahmed Amshawee, Maryam A. Hussain

“…This study enrolled 91 participants, including 31 healthy individuals, 30 COVID-19 patients with T2DM, and 30 non-diabetic COVID-19 patients. …”
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The association between perceived neighborhood social cohesion and intimate partner violence in a refugee camp in Dollo Ado, Ethiopia by Rebecca Hailu Astatke, Theodros Woldegiorgis, Jennifer Scott, Ndola Prata, Kim G. Harley, Negussie Deyessa, Anne Bennett, Vandana Sharma

“…In total, 302 Somali refugees (147 women and 155 men), sampled using snowball sampling, participated in the data collection. Logistic regression was used to examine P-NSC and its association with IPV to inform an IPV and HIV prevention intervention. …”
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Health system barriers to hypertension care in Peru: Rapid assessment to inform organizational-level change. by Kendra N Williams, Janeth Tenorio-Mucha, Karina Campos-Blanco, Lindsay J Underhill, Armando Valdés-Velásquez, Antonia Fuentes Herbozo, Laura K Beres, Lisa de las Fuentes, Lucy Cordova-Ascona, Zoila Vela-Clavo, Gonzalo Mariano Cuentas-Canal, Juan Carlos Mendoza-Velasquez, Sonia Mercedes Paredes-Barriga, Raquel Hurtado La Rosa, Makeda Williams, Elvin H Geng, William Checkley, Joel Gittelsohn, Victor G Davila-Roman, Stella M Hartinger-Peña

“…., doctors, nurses, midwives, dentists, nutritionists), followed by a deductive qualitative analysis of transcripts and notes. Participating healthcare providers indicated that low prioritization and lack of national policies for hypertension care have resulted in limited funding and lack of societal-level prevention efforts. …”
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The Effect of Diaphragmatic Breathing as a Complementary Therapeutic Strategy in Stress of Children and Teenagers 6–18 Years Old by Pelagia Tsakona, Ioannis Kitsatis, Thomas Apostolou, Ourania Papadopoulou, Alexandra Hristara-Papadopoulou

“…The studies were based on DB, muscle relaxation, nutrition, counseling, music therapy, and slow breathing exercises. The participants in the intervention group improved in comparison to those in the control group in terms of stress and depression in most included studies, in terms of school performance in two studies, in terms of better family relationships in one study, and showed improvement in anthropometric indicators in two studies. …”
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Sequence Analysis-Enhanced AI: Transforming Interactive E-Book Data into Educational Insights for Teachers by Yaroslav Opanasenko, Emanuele Bardone, Margus Pedaste, Leo Aleksander Siiman

“…We specified the process for developing a chatbot for transferring teachers’ queries into sequence analysis results and gathered feedback from teachers, allowing us both to estimate current design solutions to make sequence analysis results available and to find potential vectors of its development. Participants provided explicit feedback on CustomGPT, appreciating its potential for group and individual analysis, while suggesting improvements in visualization clarity, legend design, descriptive explanations, and personalized tips to better meet their needs. …”
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Patterns of sensory and hedonic responses for salty and umami tastes and their impact on food familiarity, consumption, and nutritional status: A gender-based analysis from a large... by Camilla Cattaneo, Sara Spinelli, Caterina Dinnella, Cristina Proserpio, Erminio Monteleone, Ella Pagliarini, Monica Laureati

“…Associations among sensory-hedonic patterns, nutritional status, personality, and psycho-attitudinal traits, as well as food habits, were considered.Participants (n = 2878) rated their liking and intensity of salty, umami, and overall flavor sensations for bean purée with varying salt levels and provided anthropometric and food consumption data. …”
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Enhancing the research enterprise at a health sciences university: A call for an institutional paradigm shift by Bryan G. Beutel, Taryn Bissing, Aaditya Patel, Nicolette Duong, Jan Talley

“…Descriptive statistics quantitively analyzed factors that influence student participation in research, perceived benefits, and obstacles to performing research. …”
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Adaptatıon Of Sport Fanatıcısm Scale Into Turkısh by Erkan Faruk Şirin, Ali Erdoğan

“…The 5-point Likert type scale consisting of 12 items was applied to 528 participants who are supporters of Besiktas, Fenerbahce, Galatasaray and Trabzonspor clubs. …”
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Effects of Active Video Games Combined with Conventional Physical Therapy on Perceived Functionality in Older Adults with Knee or Hip Osteoarthritis: A Randomized Controlled Trial by Francisco Guede-Rojas, Cristhian Mendoza, Jorge Fuentes-Contreras, Cristian Alvarez, Bárbara Agurto Tarbes, Javiera Karina Muñoz-Gutiérrez, Adolfo Soto-Martínez, Claudio Carvajal-Parodi

“…This study aimed to evaluate the effectiveness of active video games (AVGs) as a complement to conventional physical therapy (CPT) in improving functional disability. Methods: Sixty participants were randomly assigned to an experimental group (EG, <i>n</i> = 30, 68.7 ± 5.4 years), which received CPT combined with AVGs, or to a control group (CG, <i>n</i> = 30, 69.0 ± 5.5 years), which received CPT alone. …”
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