Structural and functional analysis reveals the catalytic mechanism and substrate binding mode of the broad-spectrum endolysin Ply2741 by Shuang Wang, Xinxin Li, Jiahui Ma, Xiaochao Duan, Haiyan Wang, Linkang Wang, Dayue Hu, Wenwu Jiang, Xiangmin Li, Ping Qian

“…To the best of our knowledge, we found that residue Gln29 participated in the lytic activity of endolysin for the first time. …”
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Le territoire limnique, une alternative à la gouvernance des plans d’eau par masses d’eau ? by Pascal Bartout, Laurent Touchart

“…However, it proves unsatisfactory in its failure either to take into account limnological diversity or to integrate the lentic question within a codified approach which is preferentially and partially potamological. Hence, the question arises of the relevance of the spatial perimeters used. …”
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Effect of Covid-19 Pandemic on Recreational Awareness and Quality of Life by Mehmet Demirel, Alper Kaya, Davut Budak, Mustafa Sabır Bozoğlu, Yusuf Er

“…A total of 818 people participated in this study, in which the recreational awareness levels of university students and the effects of the Covid-19 pandemic on quality of life were discussed in terms of various variables. …”
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Obese Children with Metabolic Syndrome Have 3 Times Higher Risk to Have Nonalcoholic Fatty Liver Disease Compared with Those without Metabolic Syndrome by Dimitrios Papandreou, Mirey Karavetian, Zacharoula Karabouta, Eleni Andreou

“…One hundred and twenty-five subjects aged 11-12 years old participated in the study. Methods. Anthropometric and biochemical indices were measured, including lipid and liver profile, blood glucose, serum insulin, and liver ultrasound. …”
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FBXW7 Reduces the Cancer Stem Cell-Like Properties of Hepatocellular Carcinoma by Regulating the Ubiquitination and Degradation of ACTL6A by Xing Wang, Ying Li, Yongning Li, Peng Liu, Songbai Liu, Yaozhen Pan

“…In present study, we found that FBXW7 participates in the self-renewal, tumorigenicity, sorafenib therapy, and stem cell-like properties of HCC cells in vivo and in vitro. …”
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Narrative microstructure and macrostructure in adolescents with Down syndrome and Williams syndrome by Aitana Viejo, Maite Fernández-Urquiza, Eliseo Diez-Itza

“…The aim of the present study was to explore the linguistic profiles of 14 adolescents with DS and WS, and 14 typically developing controls (matched by chronological and verbal age) by comparing the microstructure and macrostructure of narratives and their possible dissociation. Participants watched an episode of the Tom and Jerry cartoon series and were asked to retell it. …”
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Does 5-minute training improve VO2max and agility? A study of situational game training in futsal by Agus Himawan, Haryo Mukti Widodo, Heni Yuli Handayani, Fajar Hidayatullah, Khoirul Anwar, Septyaningrum Putri Purwoto, Tutur Jatmiko, I Dewa Made Aryananda Wijaya Kusuma, Muhamad Syamsul Taufik

“…Methodology: The research design used in this study is experimental, employing a randomized controlled trial with a control group. The participants consisted of 16 futsal players divided into two groups: the experimental group undergoing situational game training with an additional 5-minute exercise load, and the control group undergoing regular training without additional load. …”
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Antiedemic Effect of the Myosin Light Chain Kinase Inhibitor PIK7 in the Rat Model of Myocardial Ischemia Reperfusion Injury by Dmitry L. Sonin, Mikhail S. Medved, Asker Y. Khapchaev, Maria V. Sidorova, Marina E. Palkeeva, Olga A. Kazakova, Garry V. Papayan, Daniil A. Mochalov, Sarkis M. Minasyan, Ilya E. Anufriev, Daria V. Mukhametdinova, Natalia M. Paramonova, Ksenia M. Balabanova, Anastasia S. Lopatina, Ilia V. Aleksandrov, Natalya Yu. Semenova, Anna A. Kordyukova, Kirill V. Zaichenko, Vladimir P. Shirinsky, Michael M. Galagudza

“…Electron microscopy has shown membrane-bound blebs of endotheliocytes, which partially or completely obturate the capillary lumen, and few capillaries with signs of intercellular gap formation in samples obtained from the center of the early no-reflow zone in control and PIK7-injected rats. …”
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Molecular mechanisms and therapeutic strategies in overcoming chemotherapy resistance in cancer by Yixiang Gu, Ruifeng Yang, Yang Zhang, Miaomiao Guo, Kyle Takehiro, Ming Zhan, Linhua Yang, Hui Wang

“…Abstract Cancer remains a leading cause of mortality globally and a major health burden, with chemotherapy often serving as the primary therapeutic option for patients with advanced-stage disease, partially compensating for the limitations of non-curative treatments. …”
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In-Service Teacher Professional Development: Challenges and Opportunities for Innovating the Trichronous Modality of Delivery in Vietnam’s EFL Education by Tuyen Van Nguyen, Helena Sit

“…Thirty volunteer EFL teachers from across Vietnam, representing the north, central, and south regions, participated in in-depth interviews. These teachers teach English at primary, secondary, and high schools. …”
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Apixaban in Comparison to Warfarin for Stroke Prevention in Nonvalvular Atrial Fibrillation: A Systematic Review and Meta-Analysis of Observational Studies by Muhammad U. Siddiqui, David Scalzitti, Zunaira Naeem

“…This systematic review aims to assess the efficacy and safety of apixaban compared to those of warfarin. Eligible participants were adults diagnosed with nonvalvular atrial fibrillation. …”
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Challenges and interventions in water resource management for horticultural crop production in rural and tribal communities in India by Muganyizi J. Bisheko, Rejikumar G

“…Employing a qualitative approach, the study used participant observations to obtain current information on farming practices and daily issues encountered by farmers, resource mapping and transect walks to understand the spatial challenges associated with water management and distribution of the village’s water sources, and focus group discussions (FGDs) to capture the collective perspectives of farmers. …”
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Research progress of GLP-1RAs in the treatment of type 2 diabetes mellitus by Xu He, Xu He, Xu He, Wei Zhao, Wei Zhao, PeiHang Li, PeiHang Li, YinJiang Zhang, YinJiang Zhang, GuoHua Li, HongYu Su, BiNan Lu, BiNan Lu, ZongRan Pang, ZongRan Pang

“…It plays a role through a specific GLP-1 receptor (GLP-1R) distributed in many organs or tissues and participates in the regulation of glucose homeostasis in the body. …”
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The SGLT-2 Inhibitor Dapagliflozin Has a Therapeutic Effect on Atherosclerosis in Diabetic ApoE−/− Mice by Weiling Leng, Xinshou Ouyang, Xiaotian Lei, Mingxia Wu, Liu Chen, Qinan Wu, Wuquan Deng, Ziwen Liang

“…Dapagliflozin treatment showed favorable effects on glucose and fat metabolism, partially reversed the formation of atherosclerosis, inhibited macrophage infiltration, and enhanced the stability of lesion. …”
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Research on the Collaborative Development of Marine Awareness Education Between Local Colleges and Primary and Secondary Schools Under the Symbiotic Theory by CHEN Anqi, XU Hongyu, QIU Fengyan, ZENG Jingyi, GU Mindong, HUANG Aiping

“…Therefore, in order to realize the cooperative development of marine awareness education between local colleges and primary and secondary schools in the three levels of symbiotic unit, symbiotic mode and symbiotic environment, we should build cooperative participation channels and exert the joint force of symbiotic unit. …”
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Investigating the consequences of urban creep in Shahrekord by ghorbanali karimi dehkordi, rahmatollah monshizadeh, bijan rahmani

“…The most important environmental-physical consequences are increased environmental pollution, destruction of traditional architecture, destruction of biodiversity; major economic consequences of stock markets and rising land and housing prices, diminishing villagers' reluctance to productive activities (agriculture and livestock), capital flight from villages And their savings in the city and the rising cost of living amidst the socio-cultural consequences of luxury and the tendency to consume luxury goods, reduce solidarity and participation, crowding and crowding in cities, modeling of life and urbanization culture. have been.…”
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Assessment of High-resolution Local Emissions and Land-use in Air Quality Forecasting at an Urban, Coastal, Desert Environment by Christos Fountoukis, Yasir Mohieldeen, Luis Pomares, Ivan Gladich, Azhar Siddique, Adam Skillern, Mohammed A. Ayoub

“…Abstract Fine particulate matter, ozone and nitrogen oxides are forecasted using a three-dimensional atmospheric meteorology-chemistry model (WRF-Chem) and a triple-nesting configuration over the Middle East and the Arabian Peninsula focusing on the hot desert climate of Qatar. …”
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Teacher support and secondary school students’ learning engagement: A moderated mediation model by Yanhong Shao, Yongna Feng, Xi Zhao, Gang Liu, Lili Zhang

“…The study involved 665 participants (M age = 14 years, SD = 0.790) randomly selected from four public secondary schools in Eastern China. …”
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Tumor-Associated Mast Cells in Thyroid Cancer by Carla Visciano, Nella Prevete, Federica Liotti, Gianni Marone

“…CXCL1/GRO-α and CXCL10/IP-10 appear to be involved in the stimulation of cell proliferation, while CXCL8/IL-8 participates in the acquisition of TC malignant traits through its ability to induce/enhance the EMT and stem-like features of TC cells. …”
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Epidemiological assessment of essential life skills and its determinants among adolescents in an urban slum area by Kritanjali Sahu Bose, Sujata Lavangare, Aritra Bose

“…The sociodemographic profile and life skills were assessed among the study participants. The questionnaire for the measurement of life skills consisted of five domains: Time management, communication, leadership, goal setting, and coping skills. …”
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