RET inhibition overcomes resistance to combined CDK4/6 inhibitor and endocrine therapy in ER+ breast cancer by Charlotte K. Kindt, Sidse Ehmsen, Sidse Ehmsen, Sidse Ehmsen, Sofie Traynor, Benedetta Policastro, Nikoline Nissen, Mie K. Jakobsen, Monique F. Hundebøl, Lene E. Johansen, Martin Bak, Elsa Arbajian, Johan Staaf, Henrik J. Ditzel, Henrik J. Ditzel, Henrik J. Ditzel, Carla L. Alves

“…The clinical relevance of RET expression in ER+ breast cancer was investigated by gene array analysis of primary tumors treated with endocrine therapy and by immunohistochemical scoring of metastatic lesions from patients who received combined CDK4/6i and endocrine therapy.ResultsWe show that RET is upregulated in ER+ breast cancer cell lines resistant to combined CDK4/6i and fulvestrant compared to isogenic cells resistant to fulvestrant alone. siRNA-mediated silence of RET in high RET-expressing, combined CDK4/6i- and fulvestrant-resistant cells reduced their growth partially by affecting cell cycle regulators of the G2-M phase and E2F targets. …”
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When Technology Meets Anxiety:The Moderating Role of AI Usage in the Relationship Between Social Anxiety, Learning Adaptability, and Behavioral Problems Among Chinese Primary Schoo... by Ma G, Tian S, Song Y, Chen Y, Shi H, Li J

“…Learning adaptability partially mediated this relationship, suggesting that social anxiety not only directly impacts behavioral problems but also indirectly heightens the risk by reducing learning adaptability. …”
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Sunlight exposure practice and its associated factors among infants in Ethiopia, systematic review and meta-analysis. by Fanos Yeshanew Ayele, Natnael Kebede, Asnakew Molla Mekonen, Mengistu Mera Mihiretu, Yawkal Tsega, Elsabeth Addisu, Niguss Cherie, Tesfaye Birhane, Chala Daba, Ahmed Hussien Asfaw, Zinet Abegaz, Abel Endawekie, Anissa Mohammed, Dagnachew Melak, Fekade Demeke Bayou, Husniya Yasin, Aregash Abebayehu Zerga, Fikre Bayu Gebeyehu, Birhanu Wagaye

“…<h4>Methods</h4>All articles were systematically searched by PubMed, Hinari, Global Health and CINAHL, Epistemonikos, African Journal of Online (AJOL), Google Scholar and Google. …”
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Le tourisme dans les paysages culturels des hauts plateaux du sud de la Chine by Zhe Wang, Nelson Graburn

“…Une approche des parties prenantes est appliquée pour comprendre les attitudes et les pratiques des différents agents envers les champs en terrasses et les villages traditionnels. …”
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Significance of Heparin-Binding Protein and D-dimers in the Early Diagnosis of Spontaneous Bacterial Peritonitis by Tomasz Mikuła, Mariusz Sapuła, Joanna Jabłońska, Joanna Kozłowska, Wojciech Stańczak, Dagny Krankowska, Alicja Wiercińska-Drapało

“…A total of 63 patients with decompensated liver cirrhosis and ascites participated in the study. The etiology of liver cirrhosis was varied (HCV: n=40, HBV: n=13, HCV/HBV: n=4, AIH: n=3, PBC: n=2, and haemochromatosis: n=1). …”
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Accuracy of algorithms to identify patients with a diagnosis of major cancers and cancer-related adverse events in an administrative database: a validation study in an acute care h... by Takashi Fujiwara, Yasuyuki Okumura, Hironobu Tokumasu, Takashi Kanemitsu, Kosei Tajima, Akinori Yuri, Masahiro Iwasaku

“…The sensitivity and positive predictive value (PPV) with 95% CIs were calculated.Participants The validation cohort included patients with lung (n=2257), breast (n=1121), colorectal (n=1773), ovarian (n=216) and bladder (n=575) cancer who visited the hospital between January 2014 and December 2018, and those with prostate cancer (n=3491) visiting between January 2009 and December 2018, who were identified using EMRs.Outcomes Key outcomes included primary diagnosis, deaths and AEs.Results For primary diagnosis, sensitivity and PPV for the respective cancers were as follows: lung, 100.0% (96.6 to 100.0) and 81.0% (74.9 to 86.2); breast, 100.0% (96.3 to 100.0) and 74.0% (67.3 to 79.9); colorectal, 100.0% (96.6 to 100.0) and 80.5% (74.3 to 85.8); ovarian, 89.8% (77.8 to 96.6) and 75.9% (62.8 to 86.1); bladder, 78.6% (63.2 to 89.7) and 67.3% (52.5 to 0.1); prostate, 100.0% (93.2 to 100.0) and 79.0% (69.7 to 86.5). …”
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Geography and age drive racial and ethnic disparities in hospital mortality for paediatric community-acquired pneumonia in the United States: a retrospective population based cohor... by Cody-Aaron L. Gathers, Nadir Yehya, Anireddy Reddy, Paula M. Magee, Vanessa C. Denny, Michelle R. Mayeda, Amanda O’Halloran, Sanjiv D. Mehta, Stephanie Wanamaker, Jessica C. Fowler, Garrett Keim

“…Joint associations of race, ethnicity, age, and geographic region may partially inform potential mechanisms underlying these disparities. …”
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Lower Kinetic Chain, Meet the Thinking Brain: A Scoping Review of Cognitive Function and Lower Extremity Injury Risk by Michaela A. Reyes, Mark O. Probasco, Trina N. Worby, Dylan E. Loertscher, Lyndsey K. Soderbeck, Wendy E. Huddleston

“… # Discussion Consistent across participant demographics, tasks, and dependent measures, fifty-one of fifty-six assessed articles concluded that decreased cognitive ability or increased cognitive load led to risky LE mechanics or a direct increase in non-contact LE injury risk…”
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Towards a cervical cancer-free future: women’s healthcare decision making and cervical cancer screening uptake in sub-Saharan Africa by Bright Opoku Ahinkorah, Abdul-Aziz Seidu, Richard Gyan Aboagye, Bernard Yeboah-Asiamah Asare, Joshua Okyere, Bupe Mwamba

“…We employed multilevel binary logistic regression modelling.Setting Sub-Saharan Africa.Participants Women aged 15–49 years in Benin (n=5282), Côte d’Ivoire (n=1925), Cameroon (n=7558), Kenya (n=6696), Namibia (n=1990) and Zimbabwe (n=5006).Primary outcome measures Cervical cancer screening uptake.Results The overall prevalence of cervical cancer screening across the six sub-Saharan African countries was 13.4%. …”
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Bienestar psicológico y satisfacción vital en adolescentes mexicanos tempranos y medios / Psychological well-being and life satisfaction in Mexicans at early and mid-adolescence by Blanca Barcelata-Eguiarte, Diego Rivas-Miranda

“…English Based on the Positive Development of Youth perspective, the aim of this study was to analyse the contribution of psychological well-being and its dimensions on life satisfaction in early and middle adolescence. Participants were 572 students, aged 13 to 18 years (Mage=15.39; SD=1.90), from public high and senior-high schools in the Mexico City Metropolitan Area. …”
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Phase IV adaptive randomised clinical trials evaluating efficacy and cost-efficacy of pre-emptive pharmacogenetic genotyping strategies in the Spanish National Health System: iPHAR... by Xandra García-González, Alberto M Borobia, Antonio J Carcas, Miriam Estébanez, Montserrat Carmona, Irene García García, Francisco Abad-Santos, Luis A López-Fernández, Esther Cubo, Iñaki Imaz-Iglesia, Alicia Marín-Candón, Miriam Saiz-Rodríguez, Irene Taladriz-Sender, Pedro Arias, Rocío Rosas-Alonso, Enrique Seco-Meseguer, Stefan Stewart, Elena Diago-Sempere, María del Mar García Saiz, Emilio J Laserna-Mendieta, Ana M Peiró, Magí Farré, Consuelo Rodriguez-Jimenez, Judith Sanabria-Cabrera, Lucia Pedrosa, Ignacio Bernardino, Javier Guiijarro-Eguinoa, Arturo Gómez López De Las Huertas, Susana Martín-López, Olga Hladun Alvaro, Vicente Arrate, Ana Fries, Daniel Rodriguez Díaz, Fernando Marqués García, Núria Alonso Pedrol, Modesto M Maestre Muñiz, Leticia Rodríguez Alcolado, Carlos Ortiz-Bautista, Angela Remesal-Doblado, María Isabel Lucena, Zaida Salmón González, Inmaculada Coca-Prieto

“…A total of 225 subjects will be recruited among the 10 participating centres if no futility/efficacy boundary is reached in the prespecified interim analyses. …”
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Spatial and temporal changes of breast-conserving surgery rates and its influential factors among Chinese patients with breast cancer from 2013 to 2019: a registry-based study by Pengpeng Ye, Yuan Yang, Wei Hu, Lingyan Dai, Erwei Song, Shunrong Li, Liling Zhu, Kai Chen, Yanjie Xu, Xiaoyu Wang, Jianli Zhao, Jianrong He, Queran Lin, Tongrui Shang, Xiujuan Gui, Ziliang Zhong, Qianru Chen, Qing Yan, Xiaoliang Huang, Zijian Liang

“…Objective Our study aims to evaluate the spatial and temporal changes of breast-conserving surgery (BCS) rates and influential factors of BCS in Guangdong Province, China.Design, setting and participants This registry-based cohort study analysed the data of patients of all age groups, from the medical record cover page, which was mandatorily collected for inpatients by the Health Administrative Department of Guangdong Province, China. …”
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Food groups, macronutrient intake and objective measures of total carotenoids and fatty acids in 16-to-24-year-olds following different plant-based diets compared to an omnivorous... by Synne Groufh-Jacobsen, Christel Larsson, Isabelle Mulkerrins, Dagfinn Aune, Anine Christine Medin

“…<h4>Methods</h4>Cross-sectional design, with healthy 16-to-24-year-olds (n = 165) recruited from the Agder area in Norway, following a vegan, lacto-ovo-vegetarian, pescatarian, flexitarian or omnivore diet. Participants completed an electronic questionnaire, a dietary screener, 24-hour dietary recalls and provided dried blood samples for analysis of carotenoids and fatty acids.…”
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Factors Influencing the Growth of Tourism in Uganda: A Case Study of Bwindi Impenetrable National Park. by Katwesigye, Jordan

“…-The findings of this research are expected to be useful to policy makers, academicians and other key players in the tourism industry and community development sector.Although the results have established that local communities participate in the tourism decision-making process through their leaders who are members of the decision-making bodies, overall the local people in Ruhija sub-county felt they were generally not involved. …”
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Enhance Research and Innovation in ICT products, Applications, and Services by Businge, Phelix Mbabazi

“…From the six schools, a sample of 332 students and 24 teachers were required to participate in the study. Data was collected by means of a questionnaire. …”
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Human Resource Practices and Employee Retention in Local Governments in Uganda: A Case of Kabale District Local Government. by Baingana, Alex

“…The study targeted 134 participants, but 119 managed to respond, including 117 who filled out the questionnaire and 02 who were interviewed. …”
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Human Resource Practices and Employee Retention in Local Governments in Uganda: A Case of Kabale District Local Government. by Baingana, Alex

“…The study targeted 134 participants, but 119 managed to respond, including 117 who filled out the questionnaire and 02 who were interviewed. …”
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Effects of Job Stress on Teachers Productivity in Primary Schools of Katuna Town Council in Kabale District. by Faida, Elias

“…Sampling will involve simple random sampling to select 108 participants from 127 target populations who were the teachers and Headteachers of Primary Schools in Kaduna Town Council. …”
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Factors Associated with Stunting in Children Under Five Years of Age: A Case of Buhara Sub County, Kabale District. by Namanya, Oliver

“…The study employed a cross-sectional descriptive design with qualitative and quantitative strategies in data collection from 380 participants drawn from a population of 5728 households. …”
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Presenting the indigenous model of organizational self-leadership with an emphasis on training in non-governmental organizations by Sajad Ghoreishi, abbas abbaspour, Mostafa Niknami, Morteza Taheri

“…This research is of a mixed type. Participants in the qualitative part are 32 people (7 women and 25 men). …”
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