The Effect of Diacerein on Type 2 Diabetic Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis by Shizhe Guo, Xianshan Guo, Hongya Zhang, Xuan’e Zhang, Zhen Li

“…Five RCTs with 278 participants were included. Compared with control, diacerein provided significant improvement on FBG (MD -0.52; 95% CI (-0.89~-0.14); P=0.007), but TSA showed that this positive effect required more support. …”
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Accuracy of screening tests for cervical precancer in women living with HIV in low-resource settings: a paired prospective study in Lusaka, Zambia by Nicola Low, Partha Basu, Andreas Limacher, Katayoun Taghavi, Misinzo Moono, Mulindi Mwanahamuntu, Herbert Kapesa, Albert Manasyan, Julia Bohlius, Marie Roumet, Thamsanqa Madliwa, Anne Rutjes

“…A sensitivity analysis considered disease when only visible lesions were biopsied.Results Women included in the study had well-controlled HIV infection (median CD4 count=542 cells/mm3) and all except one were on antiretroviral therapy. Among 371 participants with histopathological results, 27% (101/371) women had CIN2+ and 23% (23/101) were not detected by any index test. …”
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Multiple Myeloma and B Cell Lymphoma. Investigation of IL-6, IL-6 Receptor Antagonist (IL-6RA), and GP130 Antagonist (GP130A) Using Various Parameters in an In Vitro Model by Eva Kovacs

“…Our results showed that (1) all five MM cell lines (OPM-2, RPMI-8226, U-266, KMS-12-BM, MOLP-8) expressed surface IL-6R and gp130, the B cell lymphomas (WSU-1, DOHH-2, U-698) expressed only gp130; (2) exogenous IL-6 markedly up-regulated the expression of membrane IL-6R (up to 186%) and down-regulated the gp130 receptor (down to 4%) in MM cell lines, the membrane expression of gp130 in B cell lymphomas was not altered; (3) IL-6 markedly increased the spontaneous proliferation (up to 151%) in all MM cell lines, that of B cell lymphomas was not affected; (4) IL-6 increased the DNA synthesis in the S cell cycle phase of MM cells and arrested the stage G2/M, IL-6 was ineffective in any cell cycle phase of B cell lymphoma; (5) IL-6RA inhibited the membrane IL-6R partially, the proliferation was decreased only slightly; and (6) although gp130A inhibited the membrane gp130 completely, the proliferation was decreased 81—78% in MM and B cell lymphoma cell lines. …”
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“The Founder and Father of his Empire”: Voltaire on the Peace of Nystad and the Imperial Status of Russia by S. A. Mezin

“…The author finds out, why Voltaire, condemning fascination with the history of wars and kings, in his two works: «The History of Charles XII» and «The History of the Russian Empire under Peter the Great» paid great attention to the Northern War and Peter I’s participation in it.The reasons of the French historian interest to the named subject are viewed in terms of the modern methods of historical analysis, «philosophical» basis of his views on war and civilization, features of historical presentation.The paper shows Voltaire’s change in attitude on interpretation of the military historical subjects, first covered in «The History of Charles XII» and then in «The History of the Russian Empire under Peter the Great». …”
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Exosomal miR-141-3p from PDLSCs Alleviates High Glucose-Induced Senescence of PDLSCs by Activating the KEAP1-NRF2 Signaling Pathway by Min Liu, Rui Chen, Yunxuan Xu, Jiawen Zheng, Min Wang, Ping Wang

“…Stem cell-derived exosomes are important participants in intercellular information exchange and can help ameliorate senescence. …”
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Crisis response strategies of universities during the ongoing war: Beyond experience and responsibilities by Oleksandr Spivakovsky, Serhii Omelchuk, Daria Malchykova

“…The opinions expressed herein are the authors’ own and do not necessarily express the views of either the Bridge USA or American Councils.The authors express their gratitude to the vice-presidents, deans of faculties, and academic and non-academic staff of Kherson State University who participated in the development of institutional documents that implement crisis management decisions presented in this paper and form a crisis response strategy for the university during martial law.…”
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Altered brain functional network connectivity and topology in type 2 diabetes mellitus by Weiwei Ni, Weiyin Vivian Liu, Mingrui Li, Shouchao Wei, Xuanzi Xu, Shutong Huang, Lanhui Zhu, Jieru Wang, Fengling Wen, Hailing Zhou

“…This study aimed to investigate T2DM-driven alterations in brain functional network connectivity and topology.MethodsEighty-five T2DM patients and 67 healthy controls (HCs) were included. All participants underwent clinical, neuropsychological, and laboratory tests, followed by MRI examinations, including resting-state functional magnetic resonance imaging (rs-fMRI) and three-dimensional high-resolution T1-weighted imaging (3D-T1WI) on a 3.0 T MRI scanner. …”
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Development and effectiveness evaluation of an interactive e-learning environment to enhance digital health literacy in cancer patients: study protocol for a randomized controlled... by Lukas Lange-Drenth, Hellena Willemer, Mirjam Banse, Anke Ernst, Anne Daubmann, Anja Holz, Christiane Bleich, Susanne Weg-Remers, Holger Schulz

“…Two thirds of the 660 participants will be recruited through the German Cancer Information Service (CIS) and one third through non-CIS routes. …”
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Clinico-spirometrical correlation of newly detected COPD patients with known tobacco smoking exposure or biomass smoke exposure presenting to a teaching institution in Vadodara, Gu... by Bhavesh Patel, G Mothiganesh, Arti D. Shah, Chirag H. Chakravarti, Parshwa Naik, Princee Patel

“…The study comprised records of 50 participants, from September 2022 to January 2024. Along with the spirometry results, pertinent clinical data were gathered. …”
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Effect of Nutrition Education Based on Health Belief Model on Nutritional Knowledge and Dietary Practice of Pregnant Women in Dessie Town, Northeast Ethiopia: A Cluster Randomized... by Tona Zema Diddana, Gezahegn Nigusse Kelkay, Amanuel Nana Dola, Abinet Arega Sadore

“…A total of 138 pregnant women participated. Nutrition education was given using Health Belief Model (HBM) theory and general nutrition education for intervention and control group, respectively. …”
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Effect of long-term exercise on circulating ghrelin in overweight and obese individuals: a systematic review and meta-analysis by Xianyang Xin, Hai Wang, Yongqing Guo, Jun Xie

“…A total of 13 interventions involving 944 participants were included to systematically investigate the regulatory effects of exercise on ghrelin levels in obese and overweight individuals. …”
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Effects of group sports activities on physical activity and social interaction abilities of children with autism spectrum disorders by Yu Xing, Yu Xing, Shuaibin Huang, Yatong Zhao, Xueping Wu

“…In social interaction ability, the duration of loneliness was significantly reduced (t = −2.567, p < 0.017, Cohen d = 0.57), and the duration of joint participation (t = −3.009, p < 0.007, Cohen d = 0.02) and the regular game (t = −2.511, p < 0.026, Cohen d = 0.46) were significantly increased, respectively. 4 weeks after the intervention, the sedentary behavior and loneliness of the experimental group both continued to decrease. …”
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Real-world survival outcomes with immune checkpoint inhibitors in large-cell neuroendocrine tumors of lung by Samuel Kareff, Jair Bar, Amir Onn, Alona Zer, Chul Kim, Stephen V Liu, Elizabeth Dudnik, Mor Moskovitz, Anastasiya Lobachov, Teodor Gottfried, Damien Urban, Ofer Rotem, Mira Wollner

“…Background Little is known regarding the efficacy of immune checkpoint inhibitors (ICI) in patients with advanced large-cell neuroendocrine lung carcinoma (aLCNEC).Methods 125 consecutive patients with aLCNEC were identified in the electronic databases of 4 participating cancer centers. The patients were divided into group A (patients who received ICI, n=41) and group B (patients who did not receive ICI, n=84). …”
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Sensation seeking and risk adjustment: the role of reward sensitivity in dynamic risky decisions by Yin Qianlan, Chen Shou, Hou Tianya, Dong Wei, Taosheng Liu

“…We compared these distinctions concerning RA among participants exhibiting different levels of SS.ResultsIndividuals exhibiting higher levels of SS (HSS) in the study displayed a tendency to disregard past risks, potentially resulting in diminished behavioral adaptability. …”
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Attitudes Toward General Vaccination Mediate the Association Between Influenza Vaccination History and Pneumococcal Vaccination Intention Among Older Adults in China by Siwen Huang, Chi Ruan, Yan Jiang, Yudan Song, Yuhang Zhang, Zeying Qin, Xinyu Shi, Mengyue Zhang, Jingtao Zhou, Dingwan Chen, Yongkang Xiao, Liang Wang, Lili Tian, Rui Peng, Zongchao Peng, Sitong Luo

“…<b>Method:</b> A multi-center cross-sectional survey was conducted among 1031 older adults, and 658 participants (median age: 65.0 ± 9.0 years) who had not received pneumococcal vaccination were included in the analysis. …”
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Empagliflozin-Metformin Combination Has Antioxidative and Anti-Inflammatory Properties that Correlate with Vascular Protection in Adults with Type 1 Diabetes by Miodrag Janić, Matej Cankar, Jan Šmid, Alenka France Štiglic, Aleš Jerin, Mišo Šabovič, Andrej Janež, Mojca Lunder

“…Its antioxidative activity at least partially explains the improvement in arterial function. …”
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Reliability of the EasyAngle® for Assessing Hip Range of Motion in Healthy Children by Elana Duffy, Maria Wells, Alan Miller, Megan Tondra, Antonette Doty

“… # Study Design Descriptive Laboratory Study # Methods Passive hip ROM (flexion, abduction, extension, internal rotation, external rotation) was measured on each leg of healthy participants using the EasyAngle®. A total of 40 hip joints were measured. …”
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Healthcare utilization and related costs among older people seeking primary care due to back pain: findings from the BACE-N cohort study by Danielle van der Windt, Milada Cvancarova Småstuen, Kjersti Storheim, Margreth Grotle, Zinajda Zolic-Karlsson, Ørjan Nesse Vigdal, Rikke Munk Killingmo, Lise Kretz

“…Objectives To describe healthcare utilization and estimate associated costs during 1 year of follow-up among older people seeking primary care due to a new episode back pain and to describe healthcare utilization across patients with different risk profiles stratified using the StarT Back Screening Tool (SBST).Design Prospective cohort study.Participants and setting A total of 452 people aged ≥55 years seeking Norwegian primary care with a new episode of back pain were included.Outcome measures The primary outcome of this study was total cost of healthcare utilization aggregated for 1 year of follow-up. …”
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L-shaped association between dietary iron intake and HPV infection: a cross-sectional analysis based on national health and nutrition examination survey 2005–2016 by Xiaotong Chen, Haiwei Chen, Yuling Chen, Lixin Tang, Jiaqi Liu, Yu-Hua Ou

“…The objective of our study was to investigate the potential relationship between the consumption of dietary iron and HPV infection.MethodsOur investigation drew upon comprehensive datasets from 7,819 participants enrolled in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2016. …”
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Screen time among kindergarten children in the Australian Capital Territory (including a comparison of First Nations and non-Indigenous children) by Kathleen O’Brien, Clair Bannerman, Karen Ciszek, Kirsty A Douglas

“…Methods 5,516 children participated in the cross-sectional population-based ACT Kindergarten Health Check (KHC) survey, including 146 First Nations children. …”
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