Novel risk loci encompassing genes influencing STAT3, GPCR, and oxidative stress signaling are associated with co-morbid GERD and COPD. by Ava C Wilson, Alison Rocco, Joe Chiles, Vinodh Srinivasasainagendra, Wassim Labaki, Deborah Meyers, Bertha Hidalgo, Marguerite R Irvin, Surya P Bhatt, Hemant Tiwari, Merry-Lynn McDonald

“…We performed the first whole-genome sequence association analysis of comorbid GERD and COPD in 12,438 multi-ancestry participants. The co-heritability of GERD and COPD was 39.7% (h2 = 0.397, SE = 0.074) and we identified several ancestry-independent loci associated with co-morbid GERD and COPD (within LINC02493 and FRYL) known to be involved in oxidative stress and G protein-coupled receptor (GPCR) signaling mechanisms. …”
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What should be publicly funded in the Colombian health system? A mixed methods study of citizens’ perceptions by Juan Carlos Velasquez, Claudia Marcela Vélez, Diana Patricia Díaz-Hernández, Pamela Velázquez-Salazar, Gilma Hernández-Herrera, Daniel Felipe Patiño-Lugo, Olga Francisca Salazar-Blanco, Leydi Camila Rodríguez-Corredor, Viviana María Vélez-Marín, Anny Julieth Jaramillo-García

“…Prioritising which health technologies should be publicly funded is one decision that requires prudence and consideration of the values and expectations of the people who will be affected by it.Objective To identify and understand the citizens’ perceptions about which health technologies should be publicly funded in Colombia.Design Sequential exploratory mixed methods study; the first was a qualitative embedded case study, and the second was a Q methodology study.Participants 46 citizens were interviewed, and 30 citizens ordered a Q-sample of 45 statements.Analysis Interviews were content analysed. …”
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Serum Magnesium Level among Acute Myocardial Infarction Patients and Its Correlation with Intra-hospital Complications: A Cross-sectional Single-center Study among Sudanese Patient... by Mohammed Taha, Ayman Azhary, Nooh Mohamed Hajhamed, Waleed Azhary Sir Alkhatim, Salahdeen Ismail Mohammed, Abdullah M Bakheit, Abdallah Elssir Ahmed, Abubakar Abdelbagi

“…Serum Mg was measured for all participants, and hypomagnesemia was considered as a serum Mg level <1.6 mg/dl. …”
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Safety and effectiveness of an herbal decoction (modified Saengmaeksan) in hypertensive patients: Protocol for a real-world prospective observational study. by Nahyun Cho, Hobin Moon, Kyung-Min Shin, Byoung-Kab Kang, Jungtae Leem, Changsop Yang

“…<h4>Methods</h4>This single-arm, prospective, observational study will be conducted at Kyunghee Bichedam Korean Medicine Clinic from October 23, 2023 to August 30, 2024, enrolling 30 hypertensive patients. Over 12 weeks, participants will undergo 4 visits, receiving modified Saengmaeksan twice daily for 8 weeks, with a subsequent 4-week follow-up. …”
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OMERACT GCA phantom project: validation of a 3D-printed ultrasound training phantom for diagnosis of giant cell arteritis by Annamaria Iagnocco, Christian Dejaco, Richard J Wakefield, Stavros Chrysidis, Sara Monti, Thomas Daikeler, Esperanza Naredo, Lene Terslev, Wolfgang A Schmidt, Alojzija Hočevar, Christina Duftner, Chetan Mukhtyar, Valentin Sebastian Schäfer, Kate Smith, Eugenio De Miguel, Marcin Milchert, Andreas P Diamantopoulos, Pierluigi Macchioni, Uffe Møller Døhn, George A Bruyn, Verena Tischler, Wolfgang Hartung, Markus Aschwanden, Giuseppe Germanò, Aaron Juche, Rositsa Karalilova, Dennis Boumans, Kresten Krarup Keller, Luca Seitz, Berit Nielsen, Tobias Schremmer, Florian Recker, Cees Haagsma, Pantelis Karakostas, Borsha Sarker

“…This study tested the reliability of ultrasonography findings and measurements of the intima-media thickness (IMT) among ultrasonography experts by using phantoms of the axillary (AA) and temporal arteries (TA) created with high-resolution 3D printing.Methods Twenty-eight participants from 12 European countries received eight sets of phantoms of the AA and the superficial TA (including common, frontal and parietal branches), which were examined in a blinded fashion according to a predefined protocol and evaluated based on Outcome Measures in Rheumatology (OMERACT) GCA ultrasound definitions. …”
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Role of the regulator in enabling a just culture: a qualitative study in mental health and hospital care by Roland Bal, Ian Leistikow, Jan-Willem Weenink, Iris Wallenburg, Guy Widdershoven, Laura Hartman, Eva van Baarle

“…Transcripts and observation reports were thematically analysed.Setting Three mental healthcare providers, two hospitals and the healthcare inspectorate in the Netherlands.Participants We conducted 61 interviews and 7 focus groups with healthcare professionals, managers and other staff in healthcare organisations and with inspectors. …”
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Comparative efficacy and safety of 20 intravenous pharmaceutical intervention for prevention of etomidate-induced myoclonus: a systematic review and Bayesian network meta-analysis by Lu Chen, Lu Chen, Pengxiang Zhou, Pengxiang Zhou, Zhengqian Li, Ziyang Wu, Suodi Zhai, Suodi Zhai

“…We included randomized controlled trials (RCTs) comparing intravenous pharmaceutical interventions to prevent EIM with placebo, no intervention, or another pharmaceutical intervention.ResultsForty-eight RCTs involving 4,768 participants randomly assigned to 20 intravenous pharmaceutical interventions and normal saline were included. …”
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The current status and influencing factors of diabetes knowledge among non-endocrinology nurses of tertiary general hospitals: a cross-sectional survey study by Jia Song, Su Li, Chongcai Gu, Shiyan Zhao, Xing Li, Siqin Liu, Jinmei Tuo, Shiming Huang

“…We analyzed the data using SPSS 29.0. Results The participants’ self-assessment score for diabetes knowledge were (62.27 ± 16.80)(out of 100), objective score for diabetes knowledge were (57.33 ± 25.78)(out of 100). …”
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Association between social determinants of health and premature atherosclerotic cardiovascular disease and sex differences in US adults: A cross-sectional study by Chun Yang, Na Zhang, Tiankuo Gao, Yingxin Zhu, Chen Gong, Mingyue Xu, Cuicui Feng

“…Result: A total of 40,536 participants aged ≥18 years (19,548 men and 20,888 women) were included in the analysis. …”
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La participación activa como base fundamental para la mejora del lanzamiento en baloncesto de formación by Enrique Ortega Toro, Aurelio Olmedilla Zafra, David Cárdenas Vélez

“…Para la realización del presente trabajo se administró un cuestionario de autoeficacia específica al contexto y se analizaron todos los lanzamientos de un total de 22 partidos, con una muestra de 187 jugadores. Los resultados señalan que existe poco reparto en el número de lanzamientos a canasta, siendo unos pocos jugadores los que realizan la gran totalidad de lanzamientos. …”
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Les Intellectuels américains et l’idéal démocratique by Daniel Geary

“…Daniel Geary examine, à travers quatre figures marquantes, la manière dont les intellectuels américains ont interrogé, éprouvé et participé à la construction de la démocratie depuis la fin du xixe siècle, s’engageant sur le terrain public pour porter une critique sociale et culturelle centrée sur l’idéal démocratique. …”
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COVID-19 in Princess Marina Hospital, Botswana: An Outbreak Investigation by Keatlaretse Siamisang, Dineo Kebadiretse, Pamela Smith-Lawrence

“…Females accounted for 154 (79.8%) participants. Most of the wards were affected. The wards with the highest numbers of cases were female medical ward (39), emergency department (24), gynecology ward (17), and pediatric medical ward (10). …”
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Nuclear Factor I-C Regulates Stemness Genes and Proliferation of Stem Cells in Various Mineralized Tissue through Epithelial-Mesenchymal Interactions in Dental Epithelial Stem Cell... by Dong-Seol Lee, Yeo Joon Song, Hye Ri Gug, Ji-Hyun Lee, Hyun Sook Bae, Joo-Cheol Park

“…However, the question remains whether Nfic participates in the late stage of development, perpetuating the proliferation of stem cells. …”
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The relationship between maternal age, obesity and child mortality: a cross-sectional study using 2013–2014 Demographic and Health Survey in Democratic Republic of the Congo at nat... by Zacharie Tsala Dimbuene, Raphaël Muanza Nzuzi, Severin Mabanza Matondo

“…Setting: The most recent Demographic and Health Surveys from Democratic Republic of Congo (DRC). Participants: The final samples consisted of 7892 women of reproductive ages (15–49 years) and 19 003 children aged 0–59 months. …”
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An Improved Predictive Model for Determining the Permeability Coefficient of Artificial Clayey Soil Based on Double T2 Cut-Offs by Zhen Lu, Aimin Sha, Junfeng Gao, Meng Jia, Wentong Wang

“…The water evaporated in the CRS and FRS was defined as the absolute movable water and the partially movable water, respectively. The water that could not evaporate in the RS was defined as the immovable water. …”
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Understanding recruitment to a perioperative randomised controlled trial: protocol for a mixed-methods substudy nested within a feasibility trial of octreotide infusion during live... by Duncan Wagstaff, S Ramani Moonesinghe, Jez Fabes, Michael Spiro, Edgar Brodkin, Ee-Neng Loh, Vivienne Hannon

“…Qualitative methods offer insight into barriers and enablers to participation. This is a substudy within a feasibility randomised controlled trial of octreotide infusion during liver transplantation at two National Health Service hospitals, which will evaluate patient and staff experiences of trial processes. …”
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Level of fecal neopterin and calprotectin in asymptomatic and symptomatic norovirus-infected children with malnutrition in Indonesia by Anisa Lailatul Fitria, Zayyin Dinana, Aussie Tahta Maharani, Alinda Syifa Fumizuki, Faiz Nabila Mumtazya, Dominikus Raditya Atmaka, Laura Navika Yamani, Juniastuti, Maria Inge Lusida, Soetjipto, Septa Indra Puspikawati

“…Methods: In total 78 stool samples from children under five years old were analyzed in this comparative study. The 67 of the participants were malnourished children, with 24 had asymptomatic (ANV) and 18 had symptomatic norovirus infection (SNV), while 25 had no infections (Mal). …”
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Exploring knowledge gaps and research needs in respiratory therapy: A qualitative description study by Marco Zaccagnini, Andrew West, Esther Khor, Shirley Quach, Mika L. Nonoyama

“… # Discussion The findings establish a fundamental understanding of the current gaps and the specific needs of RTs that require further investigation. Participants strongly emphasized the significance of research priorities that consider the breadth and depth of the respiratory therapy profession, which underscores the complex nature of respiratory therapy and its application in practice…”
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Optimizing athletic engagement and performance of obese students: an adaptive approach through basketball in physical education by Oumayma Slimi, Oumayma Slimi, Antonella Muscella, Santo Marsigliante, Mourad Bahloul, Georgian Badicu, Abdullah F. Alghannam, Fatma Hilal Yagin

“…This study evaluated the effects of a 7-week adapted basketball program on the performance and athletic engagement of students with obesity.MethodsSixty-two students with obesity (23 boys, 39 girls, aged 15-17) were randomly assigned to an experimental group (EG, n = 30; 11 boys, 19 girls) participating in adapted basketball sessions or a control group (CG, n = 32; 12 boys, 20 girls) attending standard basketball lessons. …”
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Fecal Elastase Levels Predict Honeycombing in Pancreas Detected with Endoscopic Ultrasound by Sinan Akay, Burcu Şirin, Belkıs Ünsal

“…Fecal elastase measurements were performed after the patients were qualified to participate in the study according to endosonography findings. …”
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