Experimental medicine study with stabilised native-like HIV-1 Env immunogens drives long-term antibody responses, but lacks neutralising breadthResearch in context by Katrina M. Pollock, Hannah M. Cheeseman, Leon R. McFarlane, Suzanne Day, Monica Tolazzi, Hannah L. Turner, Jennifer Joypooranachandran, Katsiaryna Shramko, Stefania Dispinseri, Philipp Mundsperger, Ilja Bontjer, Nana-Marie Lemm, Sofia Coelho, Maniola Tanaka, Tom Cole, Bette Korber, Dietmar Katinger, Quentin J. Sattentau, Andrew B. Ward, Gabriella Scarlatti, Rogier W. Sanders, Robin J. Shattock

“…Findings: Fifty-one participants (men n = 23 and women n = 28) aged 18–55 were enrolled. …”
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A cross-sectional study on the association between physical activity and the risk of colon cancer based on NHANES 2007–2018 by Daoyang Zou, Xi Xin, Yunxian Xu, Huangzhen Xu, Tianwen Xu

“…Data related to the study were obtained from the NHANES database for participants aged 20 and above between 2007 and 2018. …”
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Undernutrition risk and obesity increase the risk of osteosarcopenia in Mexican adults aged 50 and over: a prospective cohort study by Isabel Omaña-Guzmán, Ashuin Kammar-García, Luis Miguel Gutierrez-Robledo, Oscar Rosas-Carrasco

“…The baseline mean age of participants was 69.6 years (SD 9.1), with ages ranging from 50 to 92 years. …”
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Effectiveness of direct patient outreach with a narrative naloxone and overdose prevention video to patients prescribed long-term opioid therapy in the USA: the Naloxone Navigator... by Jason M Glanz, Ingrid A Binswanger, Shane R Mueller, Komal J Narwaney, Nicole M Wagner, Stanley Xu, Courtney R Kraus, Kris Wain, Sheila Botts

“…Data were analysed with generalised linear mixed effects and log-binomial regression models.Results There were 519 participants in the intervention arm and 485 participants in the usual care arm. …”
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Clinical validation of an individualized auto-adaptative serious game for combined cognitive and upper limb motor robotic rehabilitation after stroke by Ioannis Doumas, Thierry Lejeune, Martin Edwards, Gaëtan Stoquart, Yves Vandermeeren, Bruno Dehez, Stephanie Dehem

“…Participants performed three consecutive ROBiGAME sessions during which overall task difficulty was determined through simultaneous DDA of motor and attentional parameters. …”
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Frailty in older adults admitted to hospital: outcomes from the Western Sydney Clinical Frailty Registry by Julee McDonagh, Richard I Lindley, Karen Byth, Reejamol John, Caleb Ferguson

“…Design Prospective observational cohort study. Setting and participants 592 adults admitted to an acute geriatric medicine service in NSW, Australia, were included in this study. …”
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Physical impairments in Adults with Developmental Dysplasia of the Hip (DDH) undergoing Periacetabular osteotomy (PAO): A Systematic Review and Meta-Analysis by Michael J M O'Brien, Julie S Jacobsen, Adam I Semciw, Inger Mechlenburg, Lisa U Tønning, Chris J W Stewart, Joshua Heerey, Joanne L Kemp

“… # Objective To investigate differences in physical impairments in adults with DDH undergoing PAO compared with asymptomatic participants, and to investigate pre- to post-PAO changes in physical impairments…”
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Effects of empathy mapping and mini-simulation on second-year nursing students’ empathy and communication self-confidence: a quasi-experimental study by Hsiang-Ping Huang, Yun Tien, Yung-Chang Lin, I-Chen Yu, Nai-Hui Chien

“…This deficiency also hampers participants’ or observers’ ability to engage in deep reflection, feedback, and learning. …”
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The effect of hindrance stressors on the emotional exhaustion among front-line healthcare workers in the recuperation period during the COVID-19 epidemic in China: a prospective cr... by Hua Zhang, Huan Wang, Junying Ye, Hao Wu, Xinyao Zhou, Caiping Song, Pengpeng Yin, Renzhong Shi, Yang Dan

“…Inclusion criteria included worked as front-line health workers and participated in the fight against COVID-19 in Hubei; age ≥18 years; normal cognitive and comprehension abilities under physical and mental health; volunteer to participate in this study. …”
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Assessment, Decision, Adaptation, Production, Topical Experts-Integration, Training, and Testing (ADAPT-ITT) Framework to Tailor Evidence-Based Posttraumatic Stress Disorder Treatm... by Cristina M Lopez, Angela D Moreland, Stephanie Amaya, Erin Bisca, Christin Mujica, Tayler Wilson, Nathaniel Baker, Lauren Richey, Allison Ross Eckard, Patricia A Resick, Steven A Safren, Carla Kmett Danielson

“…Theater testing was completed with 7 participants to evaluate acceptability of CPT-L for PWH. …”
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The outcome of trachomatous trichiasis surgery in Ethiopia: risk factors for recurrence. by Saul N Rajak, Esmael Habtamu, Helen A Weiss, Amir B Kello, Bayeh Abera, Mulat Zerihun, Teshome Gebre, Clare E Gilbert, Peng T Khaw, Paul M Emerson, Matthew J Burton

“…<h4>Methodology/principal findings</h4>We conducted a two-year follow-up study of 1300 participants who had PLTR surgery, conducted by one of five TT nurse surgeons. …”
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Examination of Business People’s Attitudes Towards Virtual Trade Fairs by Hakan Tunahan, Ayhan Bekar, Ayşegül Karataş

“…Determining the direction of attitudes of the business people, who participated in virtual fairs, will allow for having an idea about the future of these fairs. …”
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Different Approaches to requesting Consent for Routine data linkage in Neonatal follow-up (ACORN): protocol for a 2×2 factorial randomised trial by Jane E Harding, Barry Milne, Jenny Rogers, Greg Gamble, Jane Marie Alsweiler, Christopher McKinlay, Gavin Brown, Aakash Bajirao Rajay, Caroline Anne Crowther, Nike Franke, Trecia Wouldes

“…With at least 1136 participants, the ACORN trial would have 90% power to detect an absolute difference of 5% in the primary outcome for each factor, assuming a consent rate of 90% in the control groups and alpha 0.05. …”
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The Impact of Chronic Low-Back Pain on Quality of Life among Samples of Iraqi Patients: A Cross-Sectional Study by Nadia Ayad Mohammed Jawad, Mohammad Hadi Alosami, Zainab Fadhil Mahdi

“…Conclusion: Participants’ quality of life is significantly impacted by CLBP. …”
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Protocol for a feasibility study evaluating a supported self-management intervention for stroke survivors with aphasia (StarStep study) by Faye Wray, Madeline Cruice, Ian Kellar, Anne Forster

“…We aim to recruit 30 stroke survivors who have aphasia (and/or their family members) and who are ≤ 12-month post-stroke to participate in data collection for the study. Following informed consent, participants will complete a baseline data collection questionnaire which will include measures of quality of life, symptoms of depression and perceived communicative effectiveness. …”
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Identification of serum metabolite biomarkers in premature infants with bronchopulmonary dysplasia: protocol for a multicentre prospective observational cohort study by Ping Zhou, Jun Chen, Ying Liu, Cheng Chen, Xin Guo, Zhangbin Yu, Jiebo Liu, Yanping Guo, Dan Dan Rao, Shengnan He, Xudong Yan, Wanxiang He, Songzhou Xu, Ruolin Zhang

“…Additionally, a nested case-control study will be conducted, matching participants 1:1 with a control group sharing similar BPD risk factors.Ethics and dissemination Our protocol has been approved by the Medical Ethics Committees of all participating hospitals, including Peking University Shenzhen Hospital, Shenzhen People’s Hospital, Shenzhen Baoan Women’s and Children’s Hospital, Longgang District Maternity and Child Healthcare Hospital, Nanshan Maternity and Child Healthcare Hospital and Shenzhen Luohu People’s Hospital. …”
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Knowledge, attitude, perception, and preventative practices towards COVID-19 in sub-Saharan Africa: A scoping review. by Ugochinyere Ijeoma Nwagbara, Emmanuella Chinonso Osual, Rumbidzai Chireshe, Obasanjo Afolabi Bolarinwa, Balsam Qubais Saeed, Nelisiwe Khuzwayo, Khumbulani W Hlongwana

“…Eleven studies showed that participants had a positive attitude towards COVID-19, and fifteen studies showed that participants had good practices towards COVID-19.…”
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Young researchers’ reflections on workshops with youth to develop research recruitment materials by Zeba Khan, Hajar Seiyad, Kaiya Jacob, Ayla Arhinson, Aleyah Williams, Sarah Munro

“…Our strategies included the (i) Re-distribution of Power to Enable Youth Participation, (ii) Use of Technology to Promote Collaboration and Confidentiality and (iii) Emphasizing Reciprocal Knowledge Building, to facilitate meaningful youth participation. …”
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The Effect of Sleep Deprivation on Junior Physicians’ Cognitive Performance and Irritability in the Kingdom of Bahrain by Abdulla Almusalam, Israa Sinan

“…Methods: Following the recruitment of participants, they were asked to complete the Pittsburgh Sleep Quality Index (PSQI) to assess sleep quality and disturbances over 1 month. …”
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Analysis of Social Performance and Action Units During Social Skills Training: Focus Group Study of Adults With Autism Spectrum Disorder and Schizophrenia by Hiroki Tanaka, Kana Miyamoto, Jennifer Hamet Bagnou, Elise Prigent, Céline Clavel, Jean-Claude Martin, Satoshi Nakamura

“…We investigated the differences between roleplay tasks and participant groups (ASD, schizophrenia, and control). …”
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