The endocytic adaptor AP-2 maintains Purkinje cell function by balancing cerebellar parallel and climbing fiber synapses by Marianna Tolve, Janine Tutas, Ebru Özer-Yildiz, Ines Klein, Anne Petzold, Veronika J. Fritz, Melina Overhoff, Quinn Silverman, Ellie Koletsou, Filip Liebsch, Guenter Schwarz, Tatiana Korotkova, Silvana Valtcheva, Graziana Gatto, Natalia L. Kononenko

“…Using mouse genetics, viral tracing, calcium imaging, and kinematic analysis, we demonstrate that loss of the AP-2 μ subunit in Purkinje cells leads to early-onset ataxia and progressive degeneration. Synaptic dysfunction, marked by an overrepresentation of parallel fibers (PFs) over climbing fibers (CFs), precedes Purkinje cell loss. …”
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The Contribution of the Cerebellum to Cognition in Spinocerebellar Ataxia Type 6 by Freya E. Cooper, Manon Grube, Kelly J. Elsegood, John L. Welch, Thomas P. Kelly, Patrick F. Chinnery, Timothy D. Griffiths

“…This study sought evidence for a specific cerebellar contribution to cognition by characterising the cognitive phenotype of Spinocerebellar Ataxia Type 6 (SCA-6); an autosomal dominant genetic disease which causes a highly specific late-onset cerebellar degeneration. …”
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Integrated analysis of chromatin and transcriptomic profiling of the striatum after cerebral hypoperfusion in mice by Shijia Le, Fengyiyang Xu, Zhi Luo, Weihao Shi, Shuangshuang Lu, Zengyu Zhang, Zimin Guo, Wenshi Xu, Mingqi Yang, Tianyi Li, Xu Li, Kun Liang, Lei Zhu

“…Methods RNA-seq was utilized to identify differentially expressed genes (DEGs) associated with hypoperfusion. In parallel, ATAC-seq was used to assess changes in chromatin accessibility within the striatum, providing insight into the epigenome and potential regulatory mechanisms. …”
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Frequency Dependence of C-V Characteristics of MOS Capacitors Containing Nanosized High-κ Ta2O5 Dielectrics by Nenad Novkovski, Elena Atanassova

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Crystal structure, Hirshfeld surface analysis and crystal voids of 4-nitrobenzo[c][1,2,5]selenadiazole by Atash V. Gurbanov, Tuncer Hökelek, Gunay Z. Mammadova, Khudayar I. Hasanov, Tahir A. Javadzade, Alebel N. Belay

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Syntheses, crystal structures, Hirshfeld surface analyses and crystal voids of 1-(4-bromophenyl)-2,2-dichloroethan-1-one and 2,2-dibromo-1-(p-tolyl)ethan-1-one by Atash V. Gurbanov, Firudin I. Guseinov, Aida I. Samigullina, Tuncer Hökelek, Khudayar I. Hasanov, Tahir A. Javadzade, Alebel N. Belay

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Clinical Efficacy of Curcumin and Vitamin E on Inflammatory-Oxidative Stress Biomarkers and Primary Symptoms of Menopause in Healthy Postmenopausal Women: A Triple-Blind Randomized... by Azizeh Farshbaf-Khalili, Alireza Ostadrahimi, Mojgan Mirghafourvand, Khatereh Ataei-Almanghadim, Sara Dousti, Amir Mehdi Iranshahi

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Evaluation of efficacy and safety of generic tacrolimus (Suprotac®) compared to reference tacrolimus (Prograf^®) in kidney transplantation: a phase IV study by Behzad Einollahi, Mohsen Nafar, Mohammad Javanbakht, Amirhesam Alirezaei, Jalal Azmandian, Abbas Etminan, Mohammad Reza Ardalan, Jalal Etemadi, Roghayeh Akbari, Vahid Pourfarziani, Seyed Sadraddin Rasi Hashemi, Seyed Maryam Rahbar, Shahrzad Shahidi, Javid Safa, Hamid Tayyebi Khosroshahi, Sima Abedi Azar, Shahrzad Ossareh, Abdolamir Atapour, Bahareh Marghoob, Fatemeh Nazemian, Hamidreza Kafi, Araz Sabzvari

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Peningkatan Akurasi Mesin Penerjemah Bahasa Inggris - Indonesia dengan Memaksimalkan Kualitas dan Kuantitas Korpus Paralel by Herry Sujaini

“…Penelitian ini menggunakan metode bilingual evaluation understudy (BLEU) untuk mengklasifikasikan pasangan kalimat paralel sebagai kalimat berkualitas tinggi atau buruk. Metode ini diterapkan ke korpus paralel yang berisi 1,5 M pasangan kalimat Inggris-Indonesia paralel dan memperoleh 900K pasangan kalimat paralel berkualitas tinggi. …”
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Relieve apalachense en los Montes de Toledo (diciembre de 2017) by Jesús Santos

“…En la foto, hecha al atardecer de un día de invierno con el sol ya muy bajo, se pueden observar algunas de esas sierras paralelas, con altitudes que oscilan entre los 900 y los 1000 metros, separados por valles en los que se acumulan neblinas vespertinas.   …”
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Relieve apalachense en los Montes de Toledo (diciembre de 2017) by Jesús Santos

“…En la foto, hecha al atardecer de un día de invierno con el sol ya muy bajo, se pueden observar algunas de esas sierras paralelas, con altitudes que oscilan entre los 900 y los 1000 metros, separados por valles en los que se acumulan neblinas vespertinas.   …”
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Over-Response Correction of SNC 350p ROOS and PTW Markus Chambers in the Surface Dose and Build-Up Region Dosimetry of 6MV Photon Beam by Deepali Patil, Mukesh Zope, DINESH SAROJ, Aslam P. A., Basil George

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La lutte contre la piraterie au large de la Somalie by Vice-amiral Gérard Valin

“…The French means are now used under the European flag, within Atalanta Operation. In parallel, some other operations have been set up by the USA (Task Force 151), NATO and various other States. …”
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Biomechanical comparison of locking femoral neck plate versus cannulated screws with or without a medial buttress plate in Pauwels type 3 femoral neck fractures by Yilmaz Onder, Tugrul Bulut, Osman Nuri Eroglu, Samet Ciklacandir, Yalcin Isler

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Preparation of PEO/Clay Nanocomposites Using Organoclay Produced via Micellar Adsorption of CTAB by Ahmet Gürses, Mehtap Ejder-Korucu, Çetin Doğar

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Epistaksis dan Hipertensi : Adakah Hubungannya? by Bestari J. Budiman, Al Hafiz

“…Di ruang gawat darurat, pemberian obat anti hipertensi diberikan sebelum atau bersamaan dengan manajemen epistaksis itu sendiri. …”
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Energy-Efficient Compact Heat Exchangers Made of Porous Heat-Conducting Materials by S. N. Osipov, A. V. Zakharenko

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Morphometric Factors Controlling the Old and New Debris-Laden Floods in the South-Southwest Catchment Area of the Esence Mountains with the Example of Günebakan (Erzincan) Flood by Pınar Polat, İbrahim Kopar, Fatih Yalçın

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L’utilisation du bois dans les aménagements portuaires antiques de Narbonne/Narbo Martius (Aude) by Corinne Sanchez, Jean-Michel Fabre, Sophie Coadic, Julie Labussière, Benoit Favennec, Marie-Pierre Jézégou, Stéphanie Wicha

“…The Aude river, the ancient Atax, is mentioned by ancient authors as a major trade route. …”
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FNDC5/irisin mitigates the cardiotoxic impacts of cancer chemotherapeutics by modulating ROS-dependent and -independent mechanisms by Manish Kumar, Abhishek Singh Sengar, Anushree Lye, Pranesh Kumar, Sukhes Mukherjee, Dinesh Kumar, Priyadip Das, Suvro Chatterjee, Adele Stewart, Biswanath Maity

“…Intriguingly, we identified two parallel signaling cascades impacted by FNDC5 in cardiomyocytes: the ROS-driven intrinsic mitochondrial apoptosis pathway and the ROS-independent Ataxia Telangiectasia and Rad3-Related Protein (ATR)/Checkpoint Kinase 1 (Chk1) pathway. …”
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