Can smoking duration alone replace pack-years to predict the risk of smoking-related oncogenic mutations in non-small cell lung cancer? A cross-sectional study in Japan by Masahiko Ando, Yoshihiko Taniguchi, Akihiro Tamiya, Akihide Matsumura, Koichi Ogawa, Yasuhiro Koh, Hiroyasu Kaneda, Motohiro Izumi, Yoshiya Matsumoto, Kenji Sawa, Mitsuru Fukui, Naoki Yoshimoto, Akihito Kubo, Shun-ichi Isa, Hideo Saka, Tomoya Kawaguchi

“…Objective To investigate whether smoking duration alone can replace pack-years to predict the risk of oncogenic mutations in non-small cell lung cancer (NSCLC).Design A cross-sectional study using the baseline dataset from the Japan Molecular Epidemiology for Lung Cancer Study.Setting Forty-three medical institutions nationwide in Japan.Participants From July 2012 to December 2013, 957 patients with newly diagnosed stage I–IIIB NSCLC who underwent surgery were enrolled, and molecular analyses were performed on 876 samples (from 441 ever-smokers and 435 never-smokers).Main outcomes measured We calculated the area under the receiver operating characteristic curve (AUC) values using logistic regression to compare between the predictive values of smoking duration and pack-years for mutational frequencies in the v-Ki-ras2 Kirsten rat sarcoma (KRAS), tumour suppressor p53 (TP53), and epidermal growth factor receptor (EGFR) genes and for cytosine-to-adenine base substitution (C>A).Results For predicting KRAS mutations, the AUC values for smoking duration and pack-years were 0.746 (95% CI 0.682 to 0.800) and 0.759 (95% CI 0.700 to 0.810), respectively (p=0.058). …”
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Ultrasensitive interferons quantification reveals different cytokine profile secretion in inflammatory myopathies and can serve as biomarkers of activity in dermatomyositis by Loïs Bolko, Loïs Bolko, Loïs Bolko, Céline Anquetil, Céline Anquetil, Alba Llibre, Solène Maillard, Damien Amelin, Karim Dorgham, Vincent Bondet, Océane Landon-Cardinal, Océane Landon-Cardinal, Océane Landon-Cardinal, Ségolène Toquet, Ségolène Toquet, Kuberaka Mariampillai, Samuel Malatre, Alexandrine Mahoudeau, Baptiste Hervier, Mathieu Rodero, Guy Gorochov, Darragh Duffy, Olivier Benveniste, Olivier Benveniste, Yves Allenbach, Yves Allenbach

“…ObjectiveThe objective of this study was to evaluate the presence of different types of interferon in idiopathic inflammatory myopathies (IIM) and their subgroups using ultrasensitive cytokine detection techniques (SIMOA) and to assess their potential as activity biomarkers.MethodsDisease activity was measured at the time of serum collection and assessed by manual muscle testing eight (MMT8 score 0-150), muscle enzymes to calculate the Physician Global Assessment (PGA) (0-10). …”
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Increasing prevalence of thyroid autoimmunity in childhood type 1 diabetes in the pre-COVID but not during the COVID era by Vivien Herczeg, Eszter Muzslay, Diána Czipó, Lili Terkovics, Johanna Takács, Réka Garai, Réka Garai, Fanni Kovács, Andrea Luczay, Anna Körner, Péter Tóth-Heyn

“…Annual prevalence rates of TA and ultrasound-proven thyroiditis were calculated. Mean (± SD) follow-up period was 4.7 (± 2.8) years.ResultsThe overall prevalence of TA among our T1D children was 22.8% ([20.3;25.5], 310 cases) with significantly more girls affected (p<0.001). …”
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Experiences and opinions of adults with type 1 diabetes on the android-based open-source closed-loop system in China: a qualitative study by Chaofan Wang, Daizhi Yang, Jinhua Yan, Ping Ling, Mengyun Lei, Ying Ni, Xiaodi Guo, Qingying Huang

“…The scores of the questionnaire on AAPS satisfaction were calculated, and the Mann-Whitney U test was used to compare the results of different sections of the questionnaire.Setting Guangdong Province in China.Participants This study recruited patients with T1D from the Guangdong T1D translational medicine study and the ‘Tang Tang Quan’ T1D online community in China, who participated in a clinical trial on the efficacy and safety of AAPS.Results The study interviewed 20 adults with T1D aged 32±9.94 years. …”
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Effects of different-valent vaccines against human papillomavirus (HPV) to prevent persistent HPV16/18 infections and CIN2+ in women: a systematic review and network meta-analysis by Haiyue Wu, Lucia Li, Kun Fu, YuFei Shen, Yingnan Lu, Zexi Liao, Yingzhen Liu, Wenting Zha, Lisha Wu, Yu Zhang

“…Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to summarize the intervention effects. Results: Eighteen RCTs and one post hoc analysis of RCTs were included. …”
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The Minimum Dietary Diversity For Women Indicator Can Be Extended To Children And Adolescents aged 4-15 Years As A Proxy Population Indicator For Good Micronutrient Adequacy Of Die... by Loty Diop, Aulo Gelli, Lieven Huybregts, Joanne E Arsenault, Lilia Bliznashka, Erick Boy, Megan Deitchler, Carl Lachat, Mourad Moursi, Angelica M Ochoa-Avilés, Deanna K Olney, Elodie Becquey

“…On the basis of a food group score compiled from 10 food groups (FGS-10), the minimum dietary diversity for women, calculated as FGS-10 ≥ 5, is a validated proxy population indicator for better micronutrient intake adequacy for adult women in low- and middle-income countries (LMICs). …”
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Differentiation between glioblastoma and solitary brain metastases using perfusion and amide proton transfer weighted MRI by Malte Knutsson, Tim Salomonsson, Faris Durmo, Emelie Ryd Johansson, Anina Seidemo, Jimmy Lätt, Anna Rydelius, Sara Kinhult, Elisabet Englund, Johan Bengzon, Peter C. M. van Zijl, Peter C. M. van Zijl, Linda Knutsson, Linda Knutsson, Linda Knutsson, Pia C. Sundgren, Pia C. Sundgren, Pia C. Sundgren

“…Quantitative parameter maps were calculated, and regions-of-interest (ROIs) were placed in whole tumor, contrast-enhanced tumor (ET), edema, necrosis and normal-appearing white matter (NAWM). …”
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Lymphocyte-C-reactive protein ratio upon admission to predict disease progression and ICU admission in adult patients with diabetic ketoacidosis by Yi-Jia Hu, Shu-Xiao Qiu, Jian-Nan Zhang, Qi-Qi Lai, Yi-Lu Lin, Lin-Qiong Liu, Di Wu, Hui-Ying Liu, Huan Meng, Jia-Xi Xu, Jia-Ning Zhang, Bo-Wen Liu, Yan Gao, Kai Kang, Yang Gao

“…Subsequently, sequential organ failure assessment (SOFA) score and LCR were calculated based on relevant clinical parameters within 24 h of admission. …”
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Effect of drug interactions with apixaban on clinical outcomes in cancer patients with venous thromboembolism by Marte Svalastoga, Trine-Lise Larsen, Trine-Lise Larsen, Jorunn Brekke, Tone Enden, Hege Frøen, Herish Garresori, Eva Marie Jacobsen, Alina Carmen Porojnicu, Anne Hansen Ree, Anne Hansen Ree, Dag Torfoss, Elin Osvik Velle, Hilde Skuterud Wik, Waleed Ghanima, Waleed Ghanima, Per Morten Sandset, Per Morten Sandset, Anders Erik Astrup Dahm, Anders Erik Astrup Dahm

“…Odds ratios (OR) were calculated for recurrent VTE, clinically relevant non-major bleeding (CRNMB), and major bleeding during the 36-month follow-up period. …”
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Computational and in vitro evaluation of sumac-derived ©Rutan compounds towards Sars-CoV-2 Mpro inhibition by Muzaffar Kayumov, Parthiban Marimuthu, Parthiban Marimuthu, Jamoliddin Razzokov, Jamoliddin Razzokov, Jamoliddin Razzokov, Nurkhodja Mukhamedov, Nurkhodja Mukhamedov, Akmal Asrorov, Nodir S. Berdiev, Jamolitdin F. Ziyavitdinov, Ansor Yashinov, Ansor Yashinov, Yuliya Oshchepkova, Shavkat Salikhov, Sharafitdin Mirzaakhmedov

“…The binding free energy (BFE in kcal/mol) of components were calculated as follows: R8 (−104.636) > R6 (−93.754) > R7’ (−92.113) > R5 (−81.115) > R7 (−67.243). …”
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Dissolved Mn(III) is a key redox intermediate in sediments of a seasonally euxinic coastal basin by R. Klomp, R. Klomp, O. M. Żygadłowska, M. S. M. Jetten, V. E. Oldham, N. A. G. M. van Helmond, N. A. G. M. van Helmond, C. P. Slomp, C. P. Slomp, W. K. Lenstra, W. K. Lenstra

“…When bottom waters are euxinic in summer, model-calculated rates of sedimentary Mn cycling decrease strongly because of a lower supply of Mn oxides. …”
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Effect of different restorative design and materials on stress distribution in cracked teeth: a finite element analysis study by Ting Liu, Yinghao Huang, Yue Li, Jiali Meng, Yajing Liu, Yuan Wei, Yequan Huang, Qian Zhou, Weidong Yang, Fuhua Yan, Xiang Wang, Yanan Zhu

“…Stress distribution patterns and the maximum von Mises (VM) stresses were calculated and compared. Results Compared to the base model, all restorations showed that high-stress concentration moved from the lower margin of the crack area towards the top of the crack area. …”
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Gender differences in use of cigarette and non-cigarette tobacco products among adolescents aged 13–15 years in 20 African countries by Israel T. Agaku, Rose Sulentic, Adriana Dragicevic, Gibril Njie, Candace K. Jones, Satomi Odani, Tina Tsafa, Joy Gwar, Constantine I. Vardavas, Olalekan Ayo-Yusuf

“…Adjusted prevalence ratios (APRs) were calculated in a multivariable Poisson regression model to examine whether correlates of tobacco use differed between boys and girls. …”
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Olfactory mucosa-mesenchymal stem cells with overexpressed Nrf2 modulate angiogenesis and exert anti-inflammation effect in an in vitro traumatic brain injury model by Zigui Chen, Chunyuan Zhang, Yuhua Fang, He Zhang, Jiawei Luo, Changfeng Miao, Jiale Li, Jun Peng, Yingqi Qiu, Ying Xia, Qisheng Luo

“…The effects of OM-MSCsNrf2 on the survival and angiogenesis of PC12 cells were evaluated through cell counting kit-8 (CCK-8) and tube formation assay, and extracellular acidification rate (ECAR) and oxygen consumption rate (OCR) were calculated to reflect glycolysis. Immunofluorescence assay was applied to determine the effects of OM-MSCsNrf2 on microglial polarization, and the underlying molecular mechanisms were analyzed based on the quantification tests of RT-qPCR and immunoblotting. …”
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Temporal trends of the utilization patterns of sedative-hypnotic medications in children, adolescents and young adults: a 21-year population-based study with joinpoint regression a... by Carltin Chun Ting Kwok, Heidi Ka Ying Lo, Ching Yui Chan, Joe Kwun Nam Chan, Corine Sau Man Wong, Calvin Pak Wing Cheng, Chung Ho, Brian Man Ho Leung, Wilfred Shone Horn Wong, Zoe Hoi Shuen Yu, Edwin Ho Ming Lee, Wing Chung Chang

“…Methods This population-based study identified 60,660 individuals aged 4–24 years who had redeemed ≥ 1 BZRA prescription within 2000–2020, using data from medical-record database of Hong Kong public-healthcare-services. We calculated annual prescription prevalence (per 1,000 persons per year) for any BZRA, BZRA-subtypes (short- and long-acting benzodiazepines, Z-drugs) and individual BZRAs. …”
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Genetic and environmental contribution to phenotypic resemblance between Iranian couples: Tehran Cardiometabolic and Genetic Study (TCGS) by Parisa Riahi, Amir Hossein Saeidian, Albert Tenesa, Carolyn T. Hogan, Michael March, Kamran Guity, Mahmoud Amiri Roudbar, Asieh Zahedi, Maryam Zarkesh, Farideh Neshati, Mehdi Hedayati, Fereidoun Azizi, Hakon Hakonarson, Maryam S. Daneshpour, Mahdi Akbarzadeh

“…We used a recent GWAS meta-analysis of ∼5.4M individuals of height to calculate polygenic risk scores (PRS) for spouses’ height. …”
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Turning the Surface Electronic Effect Over Core‐Shell CoS2─FexCo1‐xS2 Nanooctahedra Toward Electrochemical Water Splitting in the Alkaline Medium by Lian‐Ming Lyu, Yu‐Chung Chang, Han‐Jung Li, Pei‐En Wang, Ruei‐Hung Juang, Ming‐Yen Lu, Cheng‐Shiuan Li, Chun‐Hong Kuo

“…From the predictions by density functional theory (DFT) calculations in reaction thermodynamics, the energy barriers in OER and HER both follow the order of Fe0.9Co0.1S2(111) < Fe0.25Co0.75S2(111) < CoS2(111). …”
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Right ventricular myocardial work: proof-of-concept for the assessment of pressure-strain loops of patients with pre-capillary pulmonary hypertension by Bárbara Lacerda Teixeira, Francisco Albuquerque, Raquel Santos, André Ferreira, Ricardo Carvalheiro, João Reis, Luis Almeida Morais, Tânia Mano, Pedro Rio, Ana Teresa Timoteo, Rui Cruz Ferreira, Ana Galrinho

“…RV global work index (RVGWI) was calculated as the area of the RV pressure-strain loops. …”
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Incidence, long-term predictors and progression of chronic kidney disease among African migrants and non-migrants: the transcontinental population-based prospective RODAM cohort st... by Charles Agyemang, Ellis Owusu-Dabo, Erik Beune, Karlijn Meeks, Bert-Jan H van den Born, Liffert Vogt, Felix P Chilunga, Charles F Hayfron-Benjamin, Sampson Twumasi-Ankrah, Muhulo Muhau Mungamba, Eva L van der Linden, Engwa A Godwill, Samuel N Darko, Benedicta N Chungag

“…CKD incidence and its progression to end-stage kidney disease (ESKD) were defined using Kidney Disease: Improving Global Outcomes (KDIGO) criteria. CKD incidence was calculated using age- and sex standardisation for those without CKD at baseline. …”
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Preparation Methods and Perceived Risk of Foodborne Illness Among Consumers of Prepackaged Frozen Vegetables – United States, September 2022 by Michelle Canning, Michael Ablan, Tamara N. Crawford, Amanda Conrad, Alexandra Busbee, Misha Robyn, Katherine E. Marshall

“…Point estimates and 95% CIs were calculated, and differences between respondents were determined using Wald chi square tests. …”
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