Anticonvulsant Effects of Synthetic <i>N</i>-(3-Methoxybenzyl)oleamide and <i>N</i>-(3-Methoxybenzyl)linoleamide Macamides: An In Silico and In Vivo Study by Karin Jannet Vera-López, Jorge Alberto Aguilar-Pineda, Rodrigo Martín Moscoso-Palacios, Gonzalo Davila-Del-Carpio, José Luis Manrique-Murillo, Badhin Gómez, Minerva González-Melchor, Rita Nieto-Montesinos

“…MD simulations, molecular docking, and MM/PBSA calculations were used for these purposes. Based on our results, we selected the two best macamides and performed an in vivo study to analyze their therapeutic effect in male Sprague Dawley rat models. …”
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Biomarker microRNA-371a-3p - expression in malignancies other than germ-cell tumours by Gazanfer Belge, Markus Klemke, Bendix Hansen, Cansu Dumlupinar, Aylin Igde, Dirk Arnold, Hans Salwender, Christian Wülfing, Armin Soave, Klaus-Peter Dieckmann

“…Median M371 serum levels and percentages of M371 level elevations were calculated for the entire NTM group and for entity-specific subgroups. …”
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Current and future burden of breast cancer in Asia: A GLOBOCAN data analysis for 2022 and 2050 by Mengxia Fu, Zhiming Peng, Min Wu, Dapeng Lv, Yanping Li, Shuzhen Lyu

“…Age-standardized rates for incidence and mortality per 100,000 person-years were calculated using direct age standardization with the Segi-Doll World standard population. …”
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Rebound Mechanism and Control of the Hard Main Roof in the Deep Mining Roadway in Huainan Mining Area by Denghong Chen, Chao Li, Xinzhu Hua, Xiaoyu Lu, Yongqiang Yuan, Chen Li

“…Taking the occurrence conditions of the hard main roof in the deep 13-1 coal mining roadway in Huainan mining area as the research object, based on the mechanical parameters of the surrounding rock and the stress state of the main roof obtained by numerical simulation, a simply supported beam calculation model was established based on the damage factor D, main roof support reaction RA, RB, and critical range C (9 m) and B (7 m) at the elastoplastic junction of the solid coal side and mining face side (hereinafter referred to as “junction”). …”
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Cost-effectiveness of selective digestive decontamination (SDD) versus selective oropharyngeal decontamination (SOD) in intensive care units with low levels of antimicrobial resist... by Marc J M Bonten, Denise van Hout, Nienke L Plantinga, Patricia C Bruijning-Verhagen, Evelien A N Oostdijk, Anne Marie G A de Smet, G Ardine de Wit, Cornelis H van Werkhoven

“…Objective To determine the cost-effectiveness of selective digestive decontamination (SDD) as compared to selective oropharyngeal decontamination (SOD) in intensive care units (ICUs) with low levels of antimicrobial resistance.Design Post-hoc analysis of a previously performed individual patient data meta-analysis of two cluster-randomised cross-over trials.Setting 24 ICUs in the Netherlands.Participants 12 952 ICU patients who were treated with ≥1 dose of SDD (n=6720) or SOD (n=6232).Interventions SDD versus SOD.Primary and secondary outcome measures The incremental cost-effectiveness ratio (ICER; ie, costs to prevent one in-hospital death) was calculated by comparing differences in direct healthcare costs and in-hospital mortality of patients treated with SDD versus SOD. …”
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Functional and Structural Investigation of Myenteric Neurons in the Human Colon by Kristin Elfers, Alina Sophia Sehnert, Alexander Wagner, Ulrich Zwirner, Helena Linge, Ulf Kulik, Daniel Poehnert, Markus Winny, Benjamin Gundert, Heiko Aselmann, Gemma Mazzuoli-Weber

“…Immunohistochemistry was performed to calculate the total neuronal numbers. Results: Stimulation with nicotine and 5-HT elicited reproducible action potential discharge in a proportion of human myenteric neurons. …”
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Contribution of Spatial Heterogeneity and Temporal-Spatial Change of Ecosystems to the Thermal Environment of Tourist Destinations: A Case Study of Sichuan-Chongqing Region, China by Dechao Chen, Xinliang Xu, Huailong Jiang, Zongyao Sun, Luo Liu, Zhi Qiao

“…Using the 2005–2015 moderate resolution imaging spectroradiometer (MODIS) data on the land surface temperature combined with the land use data, the urban thermal environment contribution index (CI) of prefecture-level cities and ecosystem types corresponding to the study area in Sichuan-Chongqing region were quantitatively calculated under various seasonal and diurnal conditions in terms of the scales of administrative divisions and ecosystem types. …”
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Structure and dynamics analysis of brain functional hypernetworks based on the null models by Chen Cheng, Yao Li, Chunyan Wang, Yanli Yang, Hao Guo

“…Then, the level of similarity and correlation between the topological attributes of the original brain functional hypernetwork and the topological attributes of the brain functional hypernetwork null model were calculated to analyze the dependencies between the features of interest. …”
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Comparison of ELISA and IFAT for Leishmania infantum by European and Middle Eastern diagnostic laboratories by Kurayi G. Mahachi, Marie Ozanne, Patrick Bourdeau, Juliana Sarquis, Eric Kontowicz, Laia Solano-Gallego, Luis Cardoso, Gaetano Oliva, Gad Baneth, Maria Grazia Pennisi, Angela M. Toepp, Guadalupe Miró, Margaret Carrel, Christine A. Petersen

“…True and false positives were calculated to determine the probability of identifying samples. …”
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Characterization of the Phosphotransferase from <i>Bacillus subtilis</i> 1101 That Is Responsible for the Biotransformation of Zearalenone by Yuzhuo Wu, Qiuyu Zhou, Junqiang Hu, Yunfan Shan, Jinyue Liu, Gang Wang, Yin-Won Lee, Jianrong Shi, Jianhong Xu

“…The maximum velocity (<i>V</i>_max), Michaelis constant (<i>K</i>_m), and catalytic constant (<i>k</i>_cat) were calculated through fitting to be 16.40 μM·s⁻¹·mg⁻¹, 18.18 μM, and 54.69 s⁻¹, respectively. …”
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The association between the dietary inflammatory index and multiple myeloma: a case–control study by Hoda Zahedi, Mohammad-Reza Jowshan, Hamid Rasekhi, Maryam Amini, Omid Sadeghi, Mahshid Mehdizadeh, Sayeh Parkhideh, Moloud Payab, Erfan Zamani, Mahdi Shadnoush, Abbas Hajifathali

“…Dietary assessment was conducted using a validated semi-quantitative food frequency questionnaire (FFQ) including 154 items, and energy-adjusted DII scores were calculated to determine the level of inflammatory properties in each individual’s diet using 29 dietary parameters. …”
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Global magnitude and temporal trends of stroke attributable to lead exposure from 1990 to 2021 by Ying Wang, Ran Liu, Wenxia Li, PengNan Bao, JinWei Zhang, Wei Yue

“…The estimated annual percentage change (EAPC) was calculated to evaluate trends from 1990 to 2021. Results: Between 1990 and 2021, the global burden of stroke attributable to lead exposure increased significantly, with deaths rising from 341,294 to 556,595 and DALYs from 8.52 million to 12.02 million. …”
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Nomogram based on dual-energy computed tomography to predict the response to induction chemotherapy in patients with nasopharyngeal carcinoma: a two-center study by Huanhuan Ren, Junhao Huang, Yao Huang, Bangyuan Long, Mei Zhang, Jing Zhang, Huarong Li, Tingting Huang, Daihong Liu, Ying Wang, Jiuquan Zhang

“…The clinical and DECT-derived parameters of tumor lesions were calculated to predict the response. We employed univariate and multivariate analysis to identify significant factors. …”
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Different nitrogen uptake patterns of plant and soil microorganisms in the forest-grassland transition zone on the Loess Plateau by Lina Wang, Xu Deng, Ying Zhou, Xueqi Geng, Zeling Zhang, Yakun Tang

“…IntroductionIt is unclear whether plants and microorganisms achieve niche complementarity by taking up different inorganic nitrogen (N) forms to alleviate N competition, particularly in N–limited regions.MethodsThis paper conducted a 15-day 15N tracer study (15NH4NO3 or 15NH4NO3) in situ to quantitatively calculate the uptake rates of plants and microorganisms in four stands (pure Hippophae rhamnoides L, pure Pinus tabuliformis Carrière, mixed H. rhamnoides–P. tabuliformis, and Artemisia gmelinii Weber ex Stechm grassland) in the forest–grassland transition zone on the Loess Plateau during the growing season. …”
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Influence of bleaching gels containing 45S5 Bioglass on enamel color, surface roughness, and microhardness by Rafael Dascanio, Camila Siqueira Silva Coelho, Marina Trevelin Souza, Edgar Dutra Zanotto, Vanessa Cavalli

“…The %SHL (surface hardness loss) was calculated at T1 and T2. Data were analyzed by ANOVA and Tukey tests (α = 0.05). …”
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Microstructural transformation of GO to rGO by ascorbate acid green-agent enhanced using sonication method by Masruroh, Freygieon Ogiek Rizal Sukma, Kormil Saputra, Nandang Mufti, Kusumandari, Anton Prasetyo, Rachmat T Tjahjanto, Dionysius J D H Santjojo

“…The increase in the intensity of the D band in the Raman spectrum indicated an increase in structural defects due to the reduction of oxygen groups. Crystallite size calculations from Raman and XRD revealed that rGO had a smaller crystallite size than GO, where rGO with a sonication duration of 120 min had a smaller crystallite size than rGO with 180 min, indicating an expansion of the sp ^2 domain. …”
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Analysis of codon usage bias in the mitochondrial genome of Pleurozia purpurea by Mengxue DU, Xin ZHANG, Jie GAO, Sheng BI, Jiewei HAO, Lina ZHANG

“…Then, CodonW and EMBOSS explorer were utilized to calculate various metrics for each gene, including GC content, effective number of codons (ENC), codon adaptation index (CAI), and relative synonymous codon usage (RSCU). …”
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Assessing Genetic Diversity and Population Structure of Western Honey Bees in the Czech Republic Using 22 Microsatellite Loci by Aleš Knoll, Martin Šotek, Jan Prouza, Lucie Langová, Antonín Přidal, Tomáš Urban

“…The genetic variation was calculated as 2% and 1% between populations, 8% and 6% between individuals within populations, and 91% and 93% between all individuals in samples from hives and flowers, respectively. …”
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Mechanism of dexmedetomidine protection against cisplatin induced acute kidney injury in rats by Zeng-lu Zheng, Jun-wei Ma, Yi Luo, Gui-jin Liang, Shi-jie Lei, Ke-jin Yan, Hai-bing Meng, Xiu-juan Liu

“…After weighing the kidneys of the rats, the kidney arterial resistive index was calculated, and CP-induced AKI was evaluated. In addition, four serum biochemical indices were measured: histopathological damage in rat kidneys was detected; levels of inflammatory factors, interleukin (IL)-1β, IL-18, IL-6, and tumor necrosis factor alpha, in kidney tissue homogenate of rats were assessed through enzyme-linked immunosorbent assay (ELISA); and levels of NLRP-3, caspase-1, cleaved caspase-1, gasdermin D (GSDMD), and GSDMD-N in kidney tissues of rats were determined via western blotting.Results Dex treatment reduced nephromegaly and serum clinical marker upregulation caused by CP-induced AKI. …”
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Joint exposure to multiple air pollutants and residual cardiovascular risk in hypertension by Yalan Li, Wei Hong, Jingjing Wu, Jie Wang, Shiqi Liu, Hong Yuan, Jingjing Cai, Rujia Miao, Jiangang Wang, Yao Lu

“…Using high-quality datasets from China, the ground-level air pollutants concentrations, including PM2.5, PM2.5–10, SO2, O3, CO and NO2, at each participant’s residence were calculated. The relationships between individual and multiple air pollutants with the residual cardiovascular risk were assessed by Cox proportional hazards models, air pollution score analyses and Bayesian Kernel Machine Regression model. …”
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