Extracellular vesicles-derived miR-21 as a biomarker for early diagnosis and tumor activity in breast cancer subtypes by Claudia Omarini, Virginia Catani, Ilenia Mastrolia, Angela Toss, Federico Banchelli, Chrystel Isca, Daniele Medici, Ornella Ponzoni, Marco Brucale, Francesco Valle, Maria Cristina Baschieri, Roberto D’Amico, Valentina Masciale, Chiara Chiavelli, Federica Caggia, Carlo Augusto Bortolotti, Federico Piacentini, Massimo Dominici

“…The levels of miR-21 in EVs was evaluated using real time PCR and compared between groups (EBC, MBC and FU vs. HD) by calculating the fold change and ΔΔCt statistic. EVs size and concentration did not differ significantly among patient groups. …”
Get full text

Supplementary oxygen efficacy for chronic pulmonary disorders and exertion desaturation by Paraschos Archontakis Barakakis, Adam Wolfe, Andrei Schwartz, Gabriel J. Hernandez Romero, Vipul Gidwani, Shaylika Chauhan, Shinichi Arizono, Ralph J. Panos, Spyridon Fortis

“…Means and standard deviations were extracted and standardised mean differences (SMDs), the difference in means between groups divided by the standard deviation, and 95% confidence intervals were calculated. Exercise capacity was the primary outcome; exercise dyspnoea, baseline dyspnoea and quality of life were secondary objectives. …”
Get full text

RAGE and its ligands in breast cancer progression and metastasis by Madalina Coser, Bogdan Mihai Neamtu, Bogdan Mihai Neamtu, Bogdan Pop, Bogdan Pop, Calin Remus Cipaian, Calin Remus Cipaian, Maria Crisan, Maria Crisan

“…We conducted a meta-analysis to assess the relationship between the RAGE rs1800624 polymorphism and breast cancer risk using fixed-effect or random-effect models to calculate odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs).ResultsRAGE upon activation by its ligands enhances downstream signaling pathways, contributing to breast cancer cells migration, growth, angiogenesis, metastasis, and drug resistance. …”
Get full text

The sarcoma ring trial: a case-based analysis of inter-center agreement across 21 German-speaking sarcoma centers by Siyer Roohani, Jolina Handtke, Kamal Hummedah, Markus Albertsmeier, Dimosthenis Andreou, Leonidas Apostolidis, Marinela Augustin, Sebastian Bauer, Moritz Billner, Florian Bösch, Christoph K. W. Deinzer, Niklas Deventer, Anna Duprée, Franziska Eckert, Lars Engel, Katja Fechner, Hagen Fritzsche, Verena Gaidzik, Saeed Ghani, Robert Grützmann, Wiebke K. Guder, Rainer Hamacher, Judith S. Hecker, Anne Hendricks, Axel Hillmann, Philipp Houben, Georg Hübner, Philipp Ivanyi, Christina Jentsch, Maren Jordan, Peter Kappl, Moritz Kaths, Torsten Kessler, Johanna Kirchberg, Carolin Knebel, Robert Krempien, Burkhard Lehner, Ulrich Lenze, Lars H. Lindner, Alisa Martina Lörsch, Nadia Maguire, Sophie Müller, Pompiliu Piso, Vlatko Potkrajcic, Peter Reichardt, Stephan Richter, Simone Schewe, Lars M. Schiffmann, Felicitas Scholten, Jana Käthe Striefler, Matthias Schwarzbach, Katharina Seidensaal, Sabine Semrau, Joanna Szkandera, Christoph J. Szuszies, Beate Timmermann, Armin Tuscherer, Armin Wiegering, Moritz T. Winkelmann, David Kaul, Jens Jakob

“…Agreement percentages were calculated, and consensus levels were rated on a scale of 1 to 10. …”
Get full text

Temporal Analysis of the Incidence, Mortality and Disability-Adjusted Life Years of Benign Gallbladder and Biliary Diseases in High-Income Nations, 1990–2019 by Dominic W. Proctor, BMBS, MSc, Richard Goodall, BSc, MBChB, MRCS, FHEA, Kim Borsky, MBBS, MMRCS, Justin D. Salciccioli, MBBS, MA, Dominic C. Marshall, MBBS, MRCP, BSc, Kumaran Shanmugarajah, MD, PhD, Joseph Shalhoub, BSc, MBBS, FHEA, PhD, DIC, MEd, FFSTEd, FRCS, FEBVS

“…A mortality-incidence index (MII) was also calculated. Joinpoint regression analysis was performed. …”
Get full text

Impact of mindfulness-based tri-modal prehabilitation on functional recovery and selected surgical outcomes of patients with colorectal cancer admitted to surgical hospital wards:... by Bawantha Gamage, Manori Nayanakantha Gamage, Nilushika Madushani Perera, Chadani Samararatna Kodikara, Jayamina Udhara Munasinghe Wijeratne, S M D P Seneviratne Alles, Thavendra Kumaran, J M Chandima Jeewandara, Sanath Thushara Chamakara Mahawithanage

“…This study investigates the effectiveness of mindfulness-based tri-modal prehabilitation in improving functional recovery and surgical outcomes for patients with CRC.Methods and analysis The sample size of this prospective, randomised controlled trial was calculated based on the primary outcome, which is the detection of the clinically significant difference in a 6 min walk test (6MWT). …”
Get full text

Unveiling Low-frequency Eclipses in Spider Millisecond Pulsars Using Wideband GMRT Observations by Sangita Kumari, Bhaswati Bhattacharyya, Devojyoti Kansabanik, Rahul Sharan, Ankita Ghosh, Jayanta Roy

“…No eclipses were detected for PSR J0751+1807, J1738+0333, and J1807–2459A at 300–500 MHz and 550–750 MHz. We calculated the mass-loss rate of the companion for PSR J1555–2908 and PSR J1810+1744 and found that these rates are insufficient to ablate the companion stars. …”
Get full text

Multi-generational adaptation to Solanum nigrum increases reproduction and decreases microbial diversity of Aphis gossypii by Peng Wang, Peng Wang, Yu-Xi Jing, Ya-Jie Ma, Ya-Jie Ma, Dan Wang, Yong-Pan Shan, Hongyan Hu, Changcai Wu, Xian-Peng Song, Xiangliang Ren, Xiangliang Ren, Xiangliang Ren, Yan Ma, Yan Ma, Yan Ma, Xiaoyan Ma, Xiaoyan Ma, Xiaoyan Ma

“…However, the potential mechanisms by which A. gossypii adapts to different hosts during the transition between crops, such as Gossypium hirsutum (Malvales: Malvaceae) and S. nigrum remain elusive. We calculated the life table parameters of A. gossypii after rearing on S. nigrum for ten generations. …”
Get full text

The impact of oxidative balance on all-cause and cause-specific mortality in US adults and cancer survivors: evidence from NHANES 2001–2018 by Juan Wu, Yingdong Han, Menghui Yao, He Zhao, Zhikai Li, Tiange Xie, Yun Zhang, Xuejun Zeng

“…Methods This study included 37,317 adults (52% female) from the National Health and Nutrition Examination Survey (2001–2018). OBS was calculated based on antioxidant and pro-oxidant exposures and categorized into quartiles. …”
Get full text

Optimal treatment approach for intracranial germinoma: a systematic review and meta-analysis by Zhirui Zhou, Jiabing Liu, Qi Yue, Lingxiao Chen, Xiwei Zhang, Xin Lin, Lin Zheng, Enmin Wang, Yang Wang, Ying Mao

“…Pooled risk ratio (RR) and 95% confidence interval (CI) were calculated. Subgroup analysis was applied according to radiotherapy (RT) alone or with chemotherapy (CTx). …”
Get full text

Association between weight-adjusted-waist index and the prevalence of gallstone disease in Minhang District, Shanghai: a cross-sectional study by Jian Wang, Zixuan Zheng, Hongyu Tan, Shan Wei, Yufeng Gu, Yingsheng Cheng, Chengyan Xu, Wei Wang

“…Methods We conducted a cross-sectional study involving 19,426 participants divided into stone (n = 4,398) and non-stone (n = 15,028) groups based on ultrasound-confirmed GSD. WWI was calculated, and its association with GSD was analyzed using logistic regression models, adjusting for confounders such as age, gender, and comorbid conditions. …”
Get full text

Ecological risk assessment and response prediction caused by LUCC in the central Yunnan Province by Yongdong Zhang, Zisheng Yang, Renyi Yang, Fuhua Liu, Yimei He, Linlin Cao, Jinrong Yang, Jiayi Zhang

“…Therefore, this study takes the central Yunnan Province (CYP) as an example, and uses the Patch-Generating Land Use Simulation (PLUS) model and the Integrated Valuation of Ecosystem Services and Trade-offs (InVEST) model to simulate the land use/land cover (LULC) in different scenarios in the future, calculate the ecosystem services (ESs) from 2000 to 2020 and the next 20 years, as well as ERs of various types of ESs caused by LUCC. …”
Get full text

Metabolomic approach to investigate <i>Dactylis glomerata</i> L. from the VIR collection by N. Yu. Malysheva, T. V. Shelenga, A. E. Solovyeva, T. B. Nagiev, N. V. Kovaleva, L. L. Malyshev

“…Statistical processing included the calculation of the main parameters of variability, factor analysis of the correlation system (Qand R-technique), cluster analysis by Ward’s method and discriminant analysis. …”
Get full text

Monocyte to High‐Density Lipoprotein Ratio Is Associated With Carotid Plaque: A Retrospective Cohort Study by Shuang Liu, Xinlei Miao, Manling Hu, Ziping Song, Xiaoling Xie, Yuting Sun, Meng Li, Guimin Tang, Song Leng

“…Multivariable‐adjusted Cox regression models were used to calculate the MHR‐associated risk of incident CP. The mean age of the population was 46.14 years and 58.8% (n=3093) of the participants were male. …”
Get full text

Accelerated aging as a mediator of the association between co-exposure to multiple air pollutants and risk of chronic kidney disease by Shuo Zhang, Yuxin Liu, Jike Qi, Yu Yan, Tongyu Gao, Xin Zhang, Dong Sun, Ting Wang, Ping Zeng

“…Methods: Using a cohort of 313,908 participants without CKD at baseline from the UK Biobank, we examined the potential association between co-exposure to multiple air pollutants, including PM2.5, PM10, PM2.5–10, NO2 and NOx, and the incidence of CKD by calculating an air pollution score. Mediation analyses were performed to examine the mediating role of accelerated aging (PhenoAgeAccel or KDM-BioAgeAccel) in this association. …”
Get full text

Design, Content and Ecological Validity and Reliability of the Physical Activity and Sport Habits Questionnaire for Children Aged 8–12 Years in the Province of Gipuzkoa (Spain) by Aduna Badiola-Lekue, Irantzu Ibañez, Maite Fuentes, Javier Yanci, Oidui Usabiaga, Aitor Iturricastillo

“…Statistical analyses included the Wilcoxon test to compare expert ratings, effect size and percentage change calculations for magnitude assessment, and McNemar, McN-Bowker or Wilcoxon tests to compare differences between initial and repeat responses. …”
Get full text

Spatiotemporal Variability of Channel Roughness and its Substantial Impacts on Flood Modeling Errors by Md Abdullah Al Mehedi, Shah Saki, Krutikkumar Patel, Chaopeng Shen, Sagy Cohen, Virginia Smith, Adnan Rajib, Emmanouil Anagnostou, Tadd Bindas, Kathryn Lawson

“…Here, we developed and analyzed a continental‐scale n dataset (along with alternative formulations) calculated from observed velocity, slope, and hydraulic radius in 200,000 surveys conducted over 5,000 U.S. sites. …”
Get full text

Prevalence and clinical correlates of Gardnerella spp., Fannyhessea vaginae, Lactobacillus crispatus and L. iners in pregnant women in Bukavu, Democratic Republic of the Congo by Lisa Himschoot, Guy Mulinganya, Guy Mulinganya, Guy Mulinganya, Tess Rogier, Ghislain Bisimwa, Ghislain Bisimwa, Freddy Kampara, Freddy Kampara, Yvette Kujirakwinja, Yvette Kujirakwinja, Jules Mongane, Jules Mongane, Innocent Mubalama, Steven Callens, Mario Vaneechoutte, Piet Cools

“…A logistic regression model and ROC curves were calculated to determine the best diagnostic marker for BV.ResultsHere, L. iners (75.8%) was the most prevalent species and G. vaginalis (36.0%) the most common Gardnerella species. …”
Get full text

Effects of Polymorphisms in Myc-Related Genes on Bleeding Complications in Patients with Stable Warfarin Responses by Jeong Yee, Woorim Kim, Byung Chul Chang, Jee Eun Chung, Kyung Eun Lee, Hye Sun Gwak

“…Attributable risk and the number needed to genotype (NNG) were also calculated to evaluate the potential clinical value of genotyping. …”
Get full text

Arsenic and Heavy Metals in Vietnamese Rice: Assessment of Human Exposure to These Elements through Rice Consumption by Dinh Binh Chu, Hung Tuan Duong, Minh Thi Nguyet Luu, Hong-An Vu-Thi, Bich-Thuy Ly, Vu Duc Loi

“…The estimated daily intake through rice consumption was calculated and compared with the level proposed by the Food and Agriculture Organization of the United Nations. …”
Get full text