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    Fitting and comparison of calcium-calmodulin kinetic schemes to a common data set using non-linear mixed effects modelling. by Domas Linkevicius, Angus Chadwick, Guido C Faas, Melanie I Stefan, David C Sterratt

    Published 2025-01-01
    “…To find good parameter fits, despite this uncertainty, we used non-linear mixed effects modelling as implemented in the Pumas.jl package. The Akaike information criterion values for our reaction rate constants were significantly lower than for the published parameters, indicating that the published parameters are suboptimal. …”
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