Complexed Crystal Structure of Saccharomyces cerevisiae Dihydroorotase with Inhibitor 5-Fluoroorotate Reveals a New Binding Mode by Hong-Hsiang Guan, Yen-Hua Huang, En-Shyh Lin, Chun-Jung Chen, Cheng-Yang Huang

“…Crystal structures of ligand-bound DHOase show that the flexible loop extends toward the active site when CA-asp is bound (loop-in mode) or moves away from the active site, facilitating the product DHO release (loop-out mode). …”
Get full text

Facile construction of polyoxometalate-modified polyaryletherketone-based hybrid membranes with enhanced proton conductivity by Bo Hu, Qiuchen Du, Yang Yang, Dengdeng Li, Jiawang Fu, Bailing Liu, Hong-Ying Zang, Yangguang Li, Haiming Xie, Zhongmin Su

“…Herein, the Keggin-type POM H3PW12O40·nH2O (PW12) was introduced into sulfonated polyaryletherketone (SPAEK) with closely packed and flexible side chains to construct hybrid membranes (SPAEK-PW12-x%, x = 5, 10, 13, 15). …”
Get full text

Performance Analysis of IRS-Assisted Multi-Link FSO System Under Pointing Errors by Takumi Ishida, Chedlia Ben Naila, Hiraku Okada, Masaaki Katayama

“…The integration of intelligent reflecting surfaces (IRS) into free-space optical (FSO) communication systems is considered as a promising and innovative approach to overcoming existing challenges due to the strict line-of-sight (LoS) requirements faced by conventional FSO setups, thereby ensuring more flexible and controllable links and expanding the communication coverage area. …”
Get full text

Evaluating the resilience of the drug supply chain based on SWARA and CoCoSo multi criteria decision making approach with type 1 and interval type 2 fuzzy data (case study: Bojnord... by Fatemeh Bahman, Alireza Shahraki, Sayyid Ali Banihashemi

“…Due to linguistic uncertainty, the weighting of the criteria was done with the fuzzy SWARA decision-making method and the ranking of the options for more accurate evaluation was performed by the interval type-2 fuzzy CoCoSo method in Excel software.Findings: The identified criteria in order of importance are knowledge management, agility, readiness and prediction, management method, supply chain design and structure, visibility and control, adaptability, collaboration, complementarity, innovation, complexity management, flexibility, uncertainty in the number of changes, and integration. …”
Get full text

Enhancing older adults’ gait: a systematic review of multicomponent exercises for fall prevention by Diego Brum Allendorf, Ana Júlia de Azevedo Ferrony, Sarah Giulia Bandeira Felipe, Rafael Reimann Baptista

“…The findings indicate that regular physical activity and muscle strength and flexibility enhancements can improve gait features, including speed, step length, and phases of foot-ground contact. …”
Get full text

Unveiling the Genetic Diversity and Demographic History of <i>Coffea stenophylla</i> in Sierra Leone Using Genotyping-By-Sequencing by Paul M. Lahai, Peter O. Aikpokpodion, Alieu Mohamed Bah, Mohamed T. Lahai, Lyndel W. Meinhardt, Seunghyun Lim, Ezekiel Ahn, Dapeng Zhang, Sunchung Park

“…Evidence of recent bottlenecks and small effective population size (118–140) was found across all three populations, reflecting the impact of recent anthropogenic disturbances on this species. Using a model-flexible inference approach, we unveiled a strong ancient bottleneck approximately 23,000 years ago, coinciding with the last glacial maximum (LGM), followed by post-glacial expansion and divergence into distinct genetic clusters. …”
Get full text

Influence of Vibration Isolator Failure on Vehicle Operation Performance and Floating Slab Track Structure Vibration Reduction Effectiveness by Caiyou Zhao, Dongya Liu, Xiaoming Zhang, Qiang Yi, Liuchong Wang, Ping Wang

“…In order to study the influence of vibration isolator failure on vehicle operation performance and floating slab track structure vibration reduction effectiveness, a rigid-flexible coupling dynamic model of vehicle-rail-floating slab track is established by multibody dynamics and finite element simulation, and the rationality of the model and its parameters is verified by comparing the theoretical calculation results with the measured data. …”
Get full text

Multiepitope Subunit Vaccine Design against COVID-19 Based on the Spike Protein of SARS-CoV-2: An In Silico Analysis by Hamza Arshad Dar, Yasir Waheed, Muzammil Hasan Najmi, Saba Ismail, Helal F. Hetta, Amjad Ali, Khalid Muhammad

“…These high-ranked epitopes were all connected to each other via flexible GPGPG linkers, and at the N-terminus side, the sequence of Cholera Toxin β subunit was attached via an EAAAK linker. …”
Get full text

Six Sigma Approach to Developing a Microgrid Station for Research and Teaching by Gabriel Nasser Doyle de Doile, Miguel Castilla, Pedro Paulo Balestrassi, Antonio Carlos Zambroni de Souza, Jaume Miret

“…The conclusion of this paper highlights the benefits of using the DFSS conceptual methodology to develop a microgrid station for research and teaching, such as adaptation to educational needs; enhancement of the learning experience; refutation of experimental errors; cost-effective, flexible, and modular design; collaborative learning environment; data-driven teaching; and continuous improvement. …”
Get full text

A Novel Two-Stage Deep Learning Model for Network Intrusion Detection: LSTM-AE by Vanlalruata Hnamte, Hong Nhung-Nguyen, Jamal Hussain, Yong Hwa-Kim

“…The deep neural network (DNN) and convolutional neural network (CNN) are examined in this article as types of deep learning models for developing a flexible and effective IDS capable of detecting and comparing them with the proposed model in detecting cyber-attacks. …”
Get full text

Quick Response Code Technology-based Contact Tracing Solutions to Mitigate Epidemic Outbreaks: A Review by Agburu O. Adikpe, Ezekiel E. Agbon, Abdulkadir M. Giwa, Habib T. Adeyemo, Moses A. Adegoke, Franklin C. Njoku

“…Quick response (QR) codes can be considered a lightweight technology as they provide environmentally friendly solutions with flexible applications across industries. They also enable contactless interactions and transactions, which is essential for the health and safety of users in the event of an epidemic. …”
Get full text

Strategic Planning of Rural Development Based on Foresight Methodologies by Rasul Gusmanov, Almir Askarov, Milyausha Lukyanova, Vitaliy Kovshov, Eugene Stovba

“…The paper states that modern foresight methodology is quite flexible and multifaceted. It can be widely applied at different hierarchical levels of management. …”
Get full text

Development of proactive mode of providing tax deductions for personal income tax by E. L. Gulkova, M. V. Karp, M. V. Tipalina

“…The authors concluded, firstly, that it is necessary to form prefilled applications not only while receiving tax deductions, but also when paying PIT, for example, when a person sells real estate, cars. …”
Get full text

Selection of an Effective Hand Sanitizer to Reduce COVID-19 Effects and Extension of TOPSIS Technique Based on Correlation Coefficient under Neutrosophic Hypersoft Set by Abdul Samad, Rana Muhammad Zulqarnain, Emre Sermutlu, Rifaqat Ali, Imran Siddique, Fahd Jarad, Thabet Abdeljawad

“…The practicality, effectivity, and flexibility of the current approach are proved through comparative analysis with the assistance of some existing studies.…”
Get full text

Engineering a phi15-based expression system for stringent gene expression in Pseudomonas putida by Eveline-Marie Lammens, Daniel C. Volke, Alison Kerremans, Yannick Aerts, Maarten Boon, Pablo I. Nikel, Rob Lavigne

“…Apart from creating four optimized platform P. putida hosts and a set of Golden Gate-compatible vectors, we demonstrate the extensive flexibility of the phi15 system. A proof-of-concept expression for industrially relevant fluorinase resulted in 2.5- and 5-fold increased yield compared to other widely-adopted expression systems. …”
Get full text

Highly Strained AlGaAs‐GaAsP Nanomembranes‐Based High‐Performance Diode by Haris Naeem Abbasi, Moheb Sheikhi, Donghyeok Kim, Ranveer Singh, Jiarui Gong, Jie Zhou, Qiming Zhang, Shuoyang Qiu, Carolina Adamo, Patrick Marshall, Clincy Cheung, Vincent Gambin, Zhenqiang Ma

“…Abstract Nanomembranes (NMs) made from single‐crystalline inorganic semiconductors offer unique properties, such as flexibility, transparency, and tunable bandgaps, making them suitable for complex device integration and next‐generation high‐power devices. …”
Get full text

Model-Oriented Training of Coordinators of the Decentralized Control System of Technological Facilities With Resource Interaction by Volodymyr M. Dubovoi, Maria S. Yukhimchuk, Viacheslav V. Kovtun, Krzysztof R. Grochla

“…For the implementation of coordination methods, learning systems have an advantage since they can flexibly adapt to the specifics of each facility control. …”
Get full text

A Comparative Study of the Effect of Sutureless Versus Multiple Sutures Technique on Complications following Third Molar Surgery in Nepalese Subpopulation by Arun Kr. Mahat, Ram Yadav, Anjani Kr. Yadav, Pradeep Acharya, Ashok Dongol, Alok Sagtani, Mehul R. Jaisani

“…Postoperative variables such as pain, swelling, and trismus were measured by a single concealed observer using a 10 cm Numerical Rating Scale (NRS), flexible plastic measuring tape, and vernier caliper preoperatively and on 1st, 2nd, and 7th postoperative days. …”
Get full text

Mobile base station site as a virtual power plant for grid stability by Jussi Laimio, Mika Keski-Heikkilä, Matti Pärssinen, Roope Lahti, Olli Salmela, Topi Volkov, Jari Collin, Petri Rannikko, Henri Koskela, Jukka Manner

“…Despite the substantial electrical consumption of mobile networks, they are yet to harness their inherent flexibility for aiding in the stability of the power grid. …”
Get full text

Nano-Perforated Silicon Membrane with Monolithically Integrated Buried Cavity by Sanjeev Vishal Kota, Anil Thilsted, Daniel Trimarco, Jesper Yue Pan, Ole Hansen, Jörg Hübner, Rafael Taboryski, Henri Jansen

“…Due to this architecture’s flexibility and process robustness, structural parameters such as membrane thickness, diameter, integrated support structures, and cavity height can be adjusted, allowing a wide range of NPM geometries. …”
Get full text