Potential and mechanisms of indigenous Indonesian medicinal plants in treating sexual dysfunction: A systematic review and pharmacological network overview by Sukardiman, Roihatul Mutiah, Rosita Handayani

“…The pharmacology network analysis demonstrated that the compounds present in Eurycoma longifolia, specifically stigmasterol, eurycomanone, and eurycomalactone, target 13 genes associated with erectile dysfunction (ED), which include BCL2, AKT1, SOAT1, PCSK9, ACHE, BDNF-AS, TMX2-CTNND1, GSK3B, LINCO1672, TP53, H19, HIF1A, and IL1B. …”
Get full text

HUMAN GENES CONTROLLING FEEDING BEHAVIOR OR BODY MASS AND THEIR FUNCTIONAL AND GENOMIC CHARACTERISTICS: A REVIEW by E. V. Ignatieva, D. A. Afonnikov, E. I. Rogaev, N. A. Kolchanov

“…Four genes (BDNF, MC4R, PCSK1, and POMC) were confirmed by all three data sources; thus, these genes have the highest priority (No. 1). …”
Get full text

Emotivity matters for mood licensing by Lena Baunaz, Joanna Blochowiak, Cristina Grisot

“…A recent approach sheds light on the importance of emotive contexts in the selection of subjunctive mood cross-linguistically (Baunaz & Pusks 2022, Baunaz & Lander 2024). Our hypothesis is that in cases where mood selection is optional (i.e., with alternating verbs), the subjunctive mood is licensed by the presence of the [Emo] feature, which is activated in emotive contexts. …”
Get full text

Parenting Styles and the Development of Socio-Emotional Regulation Skills in Preschool Children by Rahmatallahi Taiye Ojibara

“…Parenting Styles Questionnaire (PSQ) and a self-Constructed Rating Scale for preschool Children's Socio-Emotional Rating Scale (PCSRS) were used to elicit information about the preschool parents' parenting styles and the rate scale for evaluation about their Socio-Emotional Skills displayed in the classroom. …”
Get full text

Purslane: The Reigning Champion of Vitamins A and E among Vegetables and a Potential Crop for Home Gardens by Xueyan Zhang, Mary Dixon, Guodong Liu

“… Purslane is often labeled as a noxious weed in Florida; however, this seemingly pesky plant is perceived as a nutritional powerhouse in Asia and other continents. …”
Get full text

Quantitative Structure–Activity Relationship (QSAR) Modeling of Chiral CCR2 Antagonists with a Multidimensional Space of Novel Chirality Descriptors by Ramanathan Natarajan, Ganapathy S. Natarajan, Subhash C. Basak

“…The data reduction using principal component analysis resulted in the extraction of eight principal components (PCs). The linear regression using the principal component scores (PCSs) resulted in a three-predictor prediction model with good statistics: R² = 0.823; Adj R² = 0.790. …”
Get full text

Jere COVID-19: Pwodwi jaden ak izin anbalaj yo by Laurel Dunn, Michelle Danyluk, Emmanuel Duvalsaint

“… Pandan ke pa gen prèv ki asosye viris COVID-19 la a yon pwoblèm sekirite alimantè, li se yon pwoblèm sante pou travayè yo paske li pwopaje l pa kontak moun ak moun oswa lè w manyen yon sifas ki kontamine. …”
Get full text

Jere COVID-19: Pwodwi jaden ak izin anbalaj yo by Laurel Dunn, Michelle Danyluk, Emmanuel Duvalsaint

“… Pandan ke pa gen prèv ki asosye viris COVID-19 la a yon pwoblèm sekirite alimantè, li se yon pwoblèm sante pou travayè yo paske li pwopaje l pa kontak moun ak moun oswa lè w manyen yon sifas ki kontamine. …”
Get full text

The authority of the printed word in the Lithuanian village of the XIX century by Džiuljeta Maskoliūnienė

“…For example, already at the beginning of the century, the book as a significant tool of education was poetized in the texts by Dionizas Poška. In "Gramatoje pas Tadeušą Čackį," Dionizas Poška emphasizes the importance of the trilingual dictionary by K. …”
Get full text

Identification of a New m6A Regulator-Related Methylation Signature for Predicting the Prognosis and Immune Microenvironment of Patients with Pancreatic Cancer by Tianle Zou, Dan Shi, Weiwei Wang, Guoyong Chen, Xianbin Zhang, Yu Tian, Peng Gong

“…The multivariate Cox regression analysis identified four gene methylation (PCSK6, HSP90AA1, TPM3, and TTLL6) to construct a prognosis model. …”
Get full text

Therapeutic Potential of <i>Lappula patula</i> Extracts on Germline Development and DNA Damage Responses in <i>C. elegans</i> by Qinghao Meng, Anna Hu, Weiyu Xiao, Robert P. Borris, Hyun-Min Kim

“…The DNA damage response was evaluated through the expression of the <i>atm-1, atl-1</i> and <i>pCHK-1</i>. Apoptosis was quantified by monitoring cell death during the pachytene stage. …”
Get full text

Sequencing and Integration of Cervical Manual Therapy and Vestibulo-oculomotor Therapy for Concussion Symptoms: Retrospective Analysis by Christopher Kevin Wong, Lauren Ziaks, Samantha Vargas, Tessia DeMattos, Chelsea Brown

“… # Results After 10.4±4.8 sessions over 57.6±34.0 days, general symptoms improved on the PCSS (p=0.001, 95%CI=12.4-30.6); and specific symptoms on the DHI (p<0.001, 95%CI=14.5-33.2), CISS (p<0.002, 95%CI=7.1-18.3), ABC (p<0.024, 95%CI=-.3 - -.1), and BIVSS (p<0.001, 95%CI=13.4-28.0). …”
Get full text

Self-reported knowledge and difficulties towards palliative care among healthcare professionals in rural China: a cross-sectional study by Junwei Niu, Min Feng, Changhui Song, Hui Xie

“…PC knowledge and PC difficulties were assessed using the Palliative Care Knowledge Questionnaire-Chinese version (PCKQ-PCN) and the Palliative Care Difficulties Scale (PCDS). …”
Get full text

β-glucan attenuates intestinal ischemia-reperfusion injury in mice by promoting glucagon-like peptide-1 secretion by WANG Wei, HAN Ben, SUN Lihua

“…The effect of 0.1 mg/mL BG treatment on the GLP-1 level in the serum and intestinal tissues of normal mice was determined with ELISA and immunofluorescence assay, respectively, and RT-PCR for the molecules related to GLP-1 expression (Gcg, Pcsk1/2, GIP and Foxa2). The effects of LLT and Ex9-39 pretreatment on intestinal morphology and intestinal barrier damage were also determined by morphological observation and expression levels of related molecules. …”
Get full text

Combining In Vitro, In Vivo, and In Silico Approaches to Explore the Effect of <i>Ceratonia siliqua</i> and <i>Ocimum basilicum</i> Rich Phenolic Formula on Lipid Metabolism and Pl... by Mohammadine Moumou, Amani Tayebi, Abderrahmane Hadini, Omar M. Noman, Abdulsalam Alhalmi, Hamza Ahmoda, Souliman Amrani, Hicham Harnafi

“…This includes the HMG-CoA reductase, PPARα/γ, PCSK9, Cyp7a1, and ATP-citrate lyase. Conclusions: The CBF could be a good source of natural supplements, functional foods, and pharmaceuticals effective in managing hyperlipidemia and oxidative stress and preventing their related cardiovascular disorders.…”
Get full text

PfFBXO1 is essential for inner membrane complex formation in Plasmodium falciparum during both asexual and transmission stages by Sreelakshmi K. Sreenivasamurthy, Carlos Gustavo Baptista, Christopher M. West, Ira J. Blader, Jeffrey D. Dvorin

“…Proteomic analysis identified PfSKP1 as one of PfBXO1’s stable interacting partners, while other major proteins included multiple IMC pellicle and membrane proteins. …”
Get full text

Headache after pediatric traumatic brain injury: a comparison between a post-acute sample of children and adolescents and general population by Marina Zeldovich, Leonie Krol, Katrin Cunitz, Christian Auer, Daniel Pinggera, Victoria Schön, Philipp Geiger, Joachim Suss, Inga K. Koerte, Emilie Isager Howe, Nada Andelic, Anna Buchheim, Matthias Gondan, Nicole von Steinbüchel

“…The Postconcussion Symptom Inventory (PCSI) item assessing headache was used as the outcome variable. …”
Get full text

Development, optimization and application of a universal fluorescence multiplex PCR-based assay to detect BCOR genetic alterations in pediatric tumors by Meng Zhang, Xingfeng Yao, Nan Zhang, Yongbo Yu, Chao Jia, Xiaoxing Guan, Wenjian Xu, Xin Ni, Yongli Guo, Lejian He

“…Abstract Background A number of genetic aberrations are associated with the BCL6-correpresor gene (BCOR), including internal tandem duplications (ITDs) and gene fusions (BCOR::CCNB3 and BCOR::MAML3), as well as YWHAE::NUTM2, which are found in clear cell sarcoma of the kidney (CCSK), sarcoma with BCOR genetic alterations, primitive myxoid mesenchymal tumor of infancy, and high-grade neuroepithelial tumors in children. …”
Get full text

The Dialogical, The Ecological and Beyond by Jon Goodbun, Ben Sweeting

“…Prompted by the opening question referring to cybernetics as a general study of information processes, focusing on the production, exchange, and consumption of meaning, not limited to a focus on digital logic, Goodbun and Sweeting revisit a plethora of positions on dialogue including those of Gordon Pask, Gregory Bateson, Ranulph Glanville, David Bohm among others. …”
Get full text

Searching for new genes associated with the familial hypercholesterolemia phenotype using whole-genome sequencing and machine learning by D. E. Ivanoshchuk, A. B. Kolker, O. V. Timoshchenko, S. E. Semaev, E. V. Shakhtshneider

“…Rare pathogenic variants in the LDLR gene are present in 75–85 % of cases with an identified molecular genetic cause of the disease, and variants in other genes (APOB, PCSK9, LDLRAP1, ABCG5, ABCG8, and others) occur at a frequency of &lt; 5 % in this group of patients. …”
Get full text