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8861
Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes
Published 2021-09-01“…In synergy with the effect of anti-PD-1 Ab, Met boosts CD8TIL proliferation and IFN-γ secretion, resulting in decreased glycolysis and oxidative phosphorylation in tumor cells. Consequently, Glut-1 is elevated in CD8TILs, together with the expansion of activated dendritic cells. …”
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8862
Alpha-adrenergic receptor agonists in terms of modern views on glaucoma monitoring and treatment
Published 2019-07-01“…Brimonidine affects NMDA receptors, inhibits proapoptotic protein expression, activates neurotrophic processes, and normalizes oxidative phosphorylation thus preventing mitochondrial dysfunction.…”
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8863
Mineralization and metallogenic model of the Laurani high-sulfidation epithermal deposit in northeastern Bolivian Altiplano
Published 2024-12-01“…Stage IV is formed by supergene oxidation of earlier metalliferous minerals postdated the main mineralization. …”
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8864
Therapeutic Potential of <i>Cajanus cajan</i> (L.) <i>Millsp</i>. Leaf Extract in Modulating Gut Microbiota and Immune Response for the Treatment of Inflammatory Bowel Disease
Published 2025-01-01“…Additionally, the levels of tight junction proteins (ZO-1, Occludin) and oxidative stress enzymes (iNOS, SOD1, CAT) were investigated by qPCR. …”
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8865
Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins
Published 2025-02-01“…Fabp7 also improves mitochondrial function and fatty acid oxidation (FAO), enhancing cancer cell survival. Furthermore, cancer cells increase Fabp7 expression in CD8+ T cells, disrupting circadian clock gene expression and triggering apoptosis through p53 stabilization. …”
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8866
Annexin A8 deficiency delays atherosclerosis progression
Published 2025-01-01“…BMT showed that hematopoietic AnxA8 deficiency had no effect on atherosclerotic progression. Oxidized low‐density lipoprotein (ox‐LDL) increased AnxA8 expression in murine aortic endothelial cells (MAECs). …”
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8867
Preindustrial-to-present-day changes in atmospheric carbon monoxide: agreement and gaps between ice archives and global model reconstructions
Published 2025-01-01“…Over the 1980–2010 CE period (common era; all subsequent years in the paper are reported in CE), trends in ice archive and firn air observations and AerChemMIP outputs align remarkably well at northern and southern high latitudes, indicating improved quantification of anthropogenic CO emissions and the main CO sink (OH oxidation) compared to ACCMIP. From 1850 to 1980, AerChemMIP models and observations consistently show increasing [CO] in both the Northern Hemisphere (NH) and Southern Hemisphere (SH), suggesting a robust understanding of the CO budget evolution. …”
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8868
Crack of a helicopter main rotor actuator attachment: failure analysis and lessons learned
Published 2013-09-01“…Finite Element Analysis (FEA) located the highest tensile stress value, when the servo actuator is in its nominal working condition, at the same points where the corrosion products were more concentrated (i.e. in the part of the fracture exposed to oxidative air effect for the longest time). The good agreement between FEA and morphological evidences allowed to determine the progressive fracture origin area, though it was not possible to individuate the crack initiation point. …”
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8869
Effects of <i>Enterococcus faecalis</i> Supplementation on Growth Performance, Hepatic Lipid Metabolism, and mRNA Expression of Lipid Metabolism Genes and Intestinal Flora in Geese
Published 2025-01-01“…In conclusion, <i>E. faecalis</i> supplementation promoted fatty acid oxidation, reduced blood lipid levels, alleviated hepatic lipid accumulation, and improved ileal morphology and intestinal flora diversity, thereby enhancing growth performance and lipid metabolism in geese. …”
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8870
Exometabolomic exploration of culturable airborne microorganisms from an urban atmosphere
Published 2025-02-01“…This study provides new insights into the transformation and potential oxidative capacity of atmospheric microorganisms concerning organic matter at air–land/water interfaces. …”
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8871
A combined use of Panax ginseng extract and the probiotic, Lactobacillus plantarum in the diet of Asian seabass, Lates calcarifer: Effects on growth, immunity and survival after ba...
Published 2025-03-01“…Supplementation of fish with GINS alone or combined with LAC-P significantly mitigated oxidative stress, as malondialdehyde (MDA) levels decreased in these treatments (P < 0.01). …”
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8872
Crack of a helicopter main rotor actuator attachment: failure analysis and lessons learned
Published 2013-10-01“…Finite Element Analysis (FEA) located the highest tensile stress value, when the servo actuator is in its nominal working condition, at the same points where the corrosion products were more concentrated (i.e. in the part of the fracture exposed to oxidative air effect for the longest time). The good agreement between FEA and morphological evidences allowed to determine the progressive fracture origin area, though it was not possible to individuate the crack initiation point. …”
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8873
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8874
Effect of Simultaneous Use of Different Amounts of Biochar and Soil Application of Common Sulfur and Spraying of Nanosulfur on Yield and Yield Components and Some Phytochemical Cha...
Published 2025-09-01“…Biochar can reduce fertilizer and water use by increasing the soil CEC and water-holding capacity (WHC).Using sulfur (especially in soil with low sulfur content) improves soil properties and increases plant growth and yield. The biochemical oxidation of elemental sulfur produces sulfuric acid (H2SO4), which decreases soil pH and solubilizes CaCO3 in alkaline soils to make soil conditions more favorable for plant growth. …”
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8875
Does coenzyme Q10 improve semen quality and circulating testosterone level? a systematic review and meta-analysis of randomized controlled trials
Published 2025-01-01“…BackgroundSeminal oxidative stress has been shown to be a key factor in the development of male infertility. …”
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8876
Iconic Celebration of Charms and Friendship in Poetry: Fálétí’s “Adébímpé Ọ̀jẹ́dòkun”
Published 2021-12-01“…Exasperated, Adébímpé resorted back to the power of the word as he emitted precarious incantations that forced the fingernails of the leopard to sink back into their sockets; the tongue glue jammed into the roof of the mouth; the teeth withdrawing and hiding inside the gums of the clenched jaws. It was at this point that the great hunter, Adébímpé, choke-holding the leopard, called on the younger hunters and ordered them to come near and shoot the beast at close range. …”
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8877
The efficacy and safety of Ginkgo biloba L. leaves extract combined with ACEI/ARB on diabetic kidney disease: a systematic review and meta-analysis of 41 randomized controlled tria...
Published 2025-01-01“…It also seems beneficial for oxidative stress and inflammation but has minimal impact on glucose and blood pressure. …”
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8878
Effect of Berberine on the Inflammatory Response of ANA-1 Cells Induced by Angiotensin Ⅱ Based on TLR4 Signaling Pathway
Published 2022-04-01“…Compared with the control group, the expression of TLR4, p-p65 protein of the model group after intervention for 12 h was significantly increased, the expression of TLR4, p-p65 protein of the model + the high dose BBR group, the model group + the inhibitor group, the model group + the inhibitor group + the high dose BBR goup was significantly decreased. ⑥ Biochemical test results: compared with the control group, the content of MDA of the model group was significantly increased, SOD activity was significantly decreased, the difference was statistically significant (<italic>P</italic><0.05), the content of MDA in the model group + the low, medium and high dose BBR group was significantly down-regulated, SOD activity was significantly increased, the difference was statistically significant (<italic>P</italic><0.05).ConclusionBBR can regulate TLR4 signaling pathway and inhibit the abnormal activation of TLR4 signaling pathway induced by Ang Ⅱ and NF-κB, MAPK signal transduction, and reduce the content of proinflammatory factors and regulate inflammatory response; in addition, BBR can also improve the lipid peroxidation and antioxidant ability of ANA-1 cells induced by Ang Ⅱ, reduce the oxidative stress damage caused by Ang Ⅱ, and protect ANA-1 cells.…”
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8879
不同温度烫制红油辣椒的风味研究 Flavor of chili oil poured at different temperatures
Published 2025-01-01“…Raw spiciness of chili oil mainly came from the migration of volatile substances from the Capsicum annuum itself, cooked spiciness came from fat oxidation reaction, and burnt spiciness came from Maillard reaction. …”
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8880
Dacostaite, K(Mg<sub>2</sub>Al)[Mg(H<sub>2</sub>O)<sub>6</sub>]<sub>2</sub>(AsO<sub>4</sub>)<sub>2</sub>F<sub>6</sub>  ⋅  2H<sub>2</sub>O, a new fluoride–arsenate mi...
Published 2025-01-01“…Its genesis is related to the activity of oxidized (Al,F)-rich fluids during the late-stage evolution of the Sb ore deposit formerly exploited at the Cetine di Cotorniano Mine.…”
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