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    Phytochemical, Proximate, Anti-Oxidant, and Anti-Inflammatory Properties of Aqueous and Methanol Extracts of Dried Shell of Cajanus cajan seed collected from a Rural Community in Nsukka, Enugu State, Nigeria by S. I. Orjiocha, M. U. Ibezim-Ezeani, F. C. Otuu, C. O. Ugorji

    Published 2025-02-01
    “…Data obtained show that some of the analytical constituents were flavonoids (2,226.50 ± 47.350, Phenolics (6,294.65±117.35), Alkaloids (175.09±3.34), moisture (13.762%), ash (4.183%), and protein (9.01%). Some of the anti-oxidant properties - DPPH IC50 of 25.07 ± 0.09 µg/ml, nitric oxide scavenging activity equivalent to 20.0mM/g, and a Ferric Reduction Antioxidant Property (FRAP) value of 2.53 compared, favorably with ascorbic acid standard. …”
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    LDHA-mediated glycolysis in stria vascularis endothelial cells regulates macrophages function through CX3CL1-CX3CR1 pathway in noise-induced oxidative stress by Ying Yi, Min-Yu Wu, Kai-Tian Chen, An-Hai Chen, Lin-Qiu Li, Qin Xiong, Xian-Ren Wang, Wen-Bin Lei, Guan-Xia Xiong, Shu-Bin Fang

    Published 2025-02-01
    “…Abstract According to the World Health Organization, more than 12% of the world’s population suffers from noise-induced hearing loss (NIHL). Oxidative stress-mediated damage to the stria vascularis (SV) is one of the pathogenic mechanisms of NIHL. …”
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    Alkaloid-rich fraction from Luffa cylindrica Linn fruit enhances memory and mitigates oxidative stress in hippocampus of ozone-exposed sprague Dawley rat via LCMS and network pharmacology approach by Ankul Singh S, Chitra Vellapandian

    Published 2025-01-01
    “…Western blot analysis revealed altered expression of SOD2, Caspase 3, and Cytochrome C which play integral roles in oxidative stress, apoptosis, and mitochondrial function. …”
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    Fatty acid synthase inhibition improves hypertension-induced erectile dysfunction by suppressing oxidative stress and NLRP3 inflammasome-dependent pyroptosis through activating the Nrf2/HO-1 pathway by Jiaochen Luan, Mengchi Yu, Qi Gu, Xuan Zhou, Yunqiang Shao, Tong Chen, Jiayi Zhang, Zheng Zhu, Ninghong Song, Jie Yang

    Published 2025-01-01
    “…In vivo, C75 treatment restored endothelial function and reversed erectile dysfunction, accompanied by decreased oxidative stress and pyroptosis in the penile corpus cavernosum.ConclusionThese findings suggest that Fasn inhibition may offer a promising therapeutic strategy for hypertension-induced ED by alleviating oxidative stress and suppressing NLRP3 inflammasome-dependent endothelial cell pyroptosis via activation of the Nrf2/HO-1 pathway.…”
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