A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma by Torsten Diesinger, Alfred Lautwein, Sebastian Bergler, Dominik Buckert, Christian Renz, Radovan Dvorsky, Vyacheslav Buko, Siarhei Kirko, Edith Schneider, Florian Kuchenbauer, Mukesh Kumar, Cagatay Günes, Felicitas Genze, Berthold Büchele, Thomas Simmet, Martin Haslbeck, Kai Masur, Thomas Barth, Dieter Müller-Enoch, Thomas Wirth, Thomas Haehner

“…I-ol was not toxic to healthy tissues or organs. This study demonstrates for the first time the therapeutic effect of the specific CYP2E1 inhibitor I-ol on the tumorigenesis of HCC. …”
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Effects of Different Vegetation Restoration Measures on the Disintegration Characteristics of Eroded Degraded Land of Pinus massoniana in Red Soil Region by XI Jie, WU Zehua, LIN Qiang, WU Jieling, ZHANG Liu, ZHOU Shiqi, ZHOU Qin, SUN Lili, ZHA Xuan

“…The tree-shrub-grass furrow model (E3) was more suitable for the treatment of severely degraded P. massoniana land. (2) Soil organic carbon content, total phosphorus content, available phosphorus content, total potassium content, available potassium content, water content and aggregate characteristics were the main influencing factors of soil disintegration. (3) Among various factors affecting soil disintegration, soil geometric mean diameter (GMD) was the main direct influencing factor and played a dominant controlling role. …”
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Physical and Sensory Long-Term Disabilities from <i>Bothrops</i> Snakebite Envenomings in Manaus, Western Brazilian Amazon by Eduardo M. G. Fernández, Débora N. Oliveira, Alexandre V. Silva-Neto, Rafaela N. Dávila, Ligia Lengler, Marco A. Sartim, Altair S. Farias, Luiz C. L. Ferreira, Érica da Silva Carvalho, Fan H. Wen, Felipe Murta, Fernando Almeida-Val, Manuela B. Pucca, Jacqueline A. G. Sachett, Wuelton M. Monteiro

“…Assessment of disability was also performed using the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0). …”
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One Health interventions and challenges under rural African smallholder farmer settings: A scoping review by Evanson R. Omuse, Honest Machekano, Bonoukpoè M. Sokame, Daniel M. Mutyambai, Thomas Dubois, Sevgan Subramanian, Frank Chidawanyika

“…Most of the reported stakeholders of the OH initiatives were largely UN agencies, CGIAR centres, non-governmental organizations and universities. More than half of the studies focused on zoonotic and human-animal shared diseases. …”
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KEAP1 mutations as key crucial prognostic biomarkers for resistance to KRAS-G12C inhibitors by Linyan Tian, Chengming Liu, Sufei Zheng, Huiyang Shi, Fang Wei, Wenxin Jiang, Yucheng Dong, Haiyan Xu, Enzhi Yin, Nan Sun, Jie He, Yan Wang

“…Comparative analysis of differentially expressed genes in KEAP1 knockout cells versus controls, utilizing GO, KEGG, and Reactome pathway analyses, revealed substantial enrichment in pathways linked to extracellular matrix organization and cell adhesion processes. Although STK11 mutations and heightened PD-L1 expression indicated a trend toward poorer outcomes, these correlations lacked statistical significance. …”
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Comparative Ethics of Modern Payment Models by Jacob Riegler

“…Deciding what metrics to base healthcare prices on has become arduous. Whether organizations should charge a patient for healthcare in nations where it is considered a human right is a subject of debate. …”
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Karaparanın Aklanması Sorunu: Bir Türkiye Perspektifi by Bahadır Küçükuysal, Yasin Köse

“…Ancak, Asya ve Avrupa kıtalarıarasında bir köprü pozisyonunda bulunan ülkemizin coğrafi konumu, sınıraşan organize suç gruplarıiçin son derece elverişli bir zemin oluşturmaktadır. …”
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Professionalisation and governance in sports organisations: towards an integrated understanding by Raphael Stieger, Siegfried Nagel, Grazia Lang

“…Considering ongoing professionalization in sport organizations: A case study of the ACT Brumbies Super Rugby Club. …”
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Providing effective innovative strategies in the development of cosmetics industry with emphasis on international entrepreneurship by Ali Khabaz, Jamshid Edalatian shahryari, Heydar Amiran

“…Peter Drucker briefly states that every organization needs a core capability, and this important competency is innovation (Eidi et al, 2019). …”
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Presenting a model based on media and social networks in the management of intelligent electricity consumption by Ahmad shojaee arzaneee, Mohamad Hemati, Ali akbar Amin beydokhti

“…Extended Abstract                                           Introduction Social media is a strategic tool in the hands of resource owners to develop corporate brands, an environment that is very cost-effective with extensive communication and interaction with consumers and a small cost to introduce the product. Pages related to organizations in social media provide the possibility of two-way communication with consumers without time and place restrictions; whereas this communication has already been one-sided and from either the organization or consumers. …”
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Dépôts et pratiques symboliques dans l’établissement aristocratique gaulois de Varennes-sur-Seine, la Justice (Seine-et-Marne) by Jean-Marc Séguier, Ginette Auxiette, Fabien Pilon

“…Indeed, the occupations located in the heart of rural settlements, of oppida and of open-planned urban centers regularly provide organized and codified deposits of human and animal remains, as well as other material goods. …”
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Atmospheric Black Carbon Evaluation in Two Sites of San Luis Potosí City During the Years 2018–2020 by Valter Barrera, Cristian Guerrero, Guadalupe Galindo, Dara Salcedo, Andrés Ruiz, Carlos Contreras

“…Nevertheless, there is a lot to know about air pollutants in Mexico’s largest cities, like San Luis Potosi City, which is one of the 12 most crowded cities and is expected to grow in the next years; however, there is little information about air pollutant levels mainly particulate matter in their regulated size fractions (PM₁₀ or PM_2.5), and its main component of the Organic fraction: Black Carbon (BC), which is especially important because of its chemical properties and their effects on human health, air pollution, and climate change. …”
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Urban ozone formation and sensitivities to volatile chemical products, cooking emissions, and NO_<i>x</i> upwind of and within two Los Angeles Basin cities by C. E. Stockwell, M. M. Coggon, R. H. Schwantes, C. Harkins, C. Harkins, B. Verreyken, B. Verreyken, B. Verreyken, C. Lyu, C. Lyu, Q. Zhu, Q. Zhu, Q. Zhu, L. Xu, L. Xu, L. Xu, J. B. Gilman, A. Lamplugh, A. Lamplugh, A. Lamplugh, J. Peischl, J. Peischl, J. Peischl, M. A. Robinson, M. A. Robinson, P. R. Veres, P. R. Veres, M. Li, M. Li, A. W. Rollins, K. Zuraski, K. Zuraski, S. Baidar, S. Baidar, S. Liu, T. Kuwayama, S. S. Brown, B. C. McDonald, C. Warneke

“…<p><span id="page1122"/>Volatile chemical products (VCPs) and other non-traditional anthropogenic sources, such as cooking, contribute substantially to the volatile organic compound (VOC) budget in urban areas, but their impact on ozone formation is less certain. …”
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Efficient Hydrolysis of Sugar Beet Pulp Using Novel Enzyme Complexes by Maria I. Komarova, Margarita V. Semenova, Pavel V. Volkov, Igor A. Shashkov, Alexandra M. Rozhkova, Ivan N. Zorov, Sergei A. Kurzeev, Aidar D. Satrutdinov, Ekaterina A. Rubtsova, Arkady P. Sinitsyn

“…Through the process of enzymatic hydrolysis, these polysaccharides are converted into technical C6/C5 sugars, which can be further used as a substrate for the microbial synthesis of various substances, including biofuels, organic acids, and other green chemistry molecules. …”
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Impact of Additional Active Treatment for Prostate Cancer on Health-related Quality of Life of Men: Results from the EUPROMS 2.0 1-year Follow-up Survey by Lionne D.F. Venderbos, Sebastiaan Remmers, André Deschamps, John Dowling, Ernst-Günter Carl, Nuno Pereira-Azevedo, Monique J. Roobol

“…The EUPROMS 2.0 1yrFU survey included the validated European Quality of Life 5 Dimension 5 Level (EQ-5D-5L), European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ-C30), Expanded Prostate Cancer Index Composite Short Form (EPIC-26), and International Index of Erectile Function (IIEF)-15 overall satisfaction domains. …”
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Intention to use eLearning-based continuing professional development and its predictors among healthcare professionals in Amhara region referral hospitals, Ethiopia, 2023: using mo... by Jenberu Mekurianew Kelkay, Sisay Maru Wubante, Deje Sendek Anteneh, Mitiku Kassaw Takilo, Chernet Desalegn Gebeyehu, Temesgen Ayenew Alameraw, Kassahun Dessie Gashu

“…Abstract Background Continuing Professional Development (CPD) is provided through in-service programs organized based on competency development and lifelong learning for healthcare professionals to stay fit with the required knowledge and skills. …”
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Free fatty acids may regulate the expression of 11β-hydroxysteroid dehydrogenase type 1 in the liver of high-fat diet golden hamsters through the ERS-CHOP-C/EBPα signaling pathway... by Dandan Liu, Peipei Tian, Yilin Hou, Tingxue Zhang, Xiaoyu Hou, Lifang Liu, Xiaolong Li, Kunjie Zheng, Chao Wang, Guangyao Song

“…Abstract Objective Free fatty acids (FFA) can increase the expression of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in local tissues and organs. However, the mechanism underlying the effect of FFA on 11β-HSD1 expression remains unclear. …”
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Response mechanism of water status and photosynthetic characteristics of Cotoneaster multiflorus under drought stress and rehydrated conditions by Qiu-liang Huang, Miao-miao Zhang, Chang-shun Li, Chang-shun Li, Bo-yang Li, Sheng-lan Zhuo, Yu-shan Yang, Yu-da Chen, An-na Zhong, Hao-yang Liu, Wen-feng Lai, Zhen-bei Huang, Ming-hui Cao, Zong-sheng Yuan, Guo-fang Zhang

“…C. multiflorus responded to drought stress by avoiding or reducing water deficit in plant organs and tissues. Therefore, the shrub C. multiflorus is a drought-tolerant plant.DiscussionWe explored the response mechanisms of water status, photosynthetic characteristics, and chloroplast fluorescence parameters of C. multiflorus in drought and rehydrated after drought stress, especially the response mechanisms of nocturnal sap flow and nocturnal water refilling in response to drought stress, and identified the physiological coupling mechanisms, molecular mechanisms and drought types of C. multiflorus in response to drought.…”
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Negative effects of adverse childhood experiences and absence of positive childhood experiences on healthcare employees: survey findings built on 10 years of trauma-informed develo... by Laneita Williamson, Laneita Williamson, Stephanie S. Daniel, Jennifer Carter, Adam Ridenhour, Camila A. Pulgar, Yasmin Gay, Beata Debinski

“…These findings point to the value of a trauma-informed approach in healthcare, which offers healthcare organizations a framework for recognizing how trauma experiences affect wellbeing and intersect with the healthcare system, as well as how to create environments that are supportive of patients, staff, and providers.…”
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Covid-19 pandemic-related changes in teleworking, emotional exhaustion, and occupational burnout: a cross-sectional analysis of a cohort study by Anshu Uppal, Nick Pullen, Hélène Baysson, Stephanie Schrempft, Aminata Rosalie Bouhet, María-Eugenia Zaballa, Julien Lamour, Mayssam Nehme, Idris Guessous, Silvia Stringhini, Elsa Lorthe, Specchio-COVID19 study group

“…Conclusions Decreased teleworking frequency and not having the possibility of telework were associated with higher emotional exhaustion and diagnosed burnout. As organizations reconsider their telework policies in a post-pandemic era, they should consider the impact of such organizational changes on employee wellbeing.…”
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