Typical and atypical metabolic characteristics of three iridaceae isoflavone components: in vitro and in silico studies by Jifeng Gu, Jifeng Gu, Huishan Zhang, Mei Wang, Yuyang Zhou, Yuyang Zhou, Zhipeng Deng, Rong Shi

“…However, the metabolic characteristics of isoflavone aglycones remain unclear.MethodsIn this study, human liver microsomes (HLMs) and Cytochrome P450 (CYP) recombinant enzymes were used to study the metabolic stability, identify the metabolic pathways and enzyme kinetics of these three components, and elucidate their possible binding sites through molecular docking.ResultsWhen tectorigenin, irigenin, and irisflorentin were co-incubated with HLMs and CYP recombinant enzymes, hydroxylation metabolite for tectorigenin, demethylated metabolite for irigenin, and 6,7-dihydroxy-5,3′,4′,5′-tetramethoxy isoflavone originating from irisflorentin were identified. CYP2E1 and CYP3A4 have high metabolic rates for tectorigenin, whereas CYP2C19 and CYP1A2 are the most important metabolic enzymes for irigenin and irisflorentin, respectively. …”
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Skin autofluorescence as part of the comprehensive assessment of clinical and metabolic status of patients with end-stage chronic kidney disease by Darya Yu. Konovalova, Peter A. Lebedev, Olga V. Ushakova, Elena E. Potyakina, Dmitriy V. Kornilin, Vladimir N. Grishanov, Marina V. Komarova

“…The measurements were performed using the original SAF reader. RESULTS: SAF was significantly higher in TKR and patients receiving PHD. …”
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Metabolic syndrome and pancreatic lesions by O. S. Shifrin, I. A. Sokolina, A. E. Leonovich, M. A. Ashitko, T. L. Lemina, A. V. Korolyov

“…Of them steatosis of pancreas (SP) was diagnosed in 49 and in 290 – chronic pancreatitis. Original investigation algorithm was based on tasks of the study and included careful inquiry and physical investigation of patients. …”
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Spatial-temporal Variation and Local Source Identification of Air Pollutants in a Semi-urban Settlement in Nigeria Using Low-cost Sensors by Oyediran Kayode Owoade, Pelumi Olaitan Abiodun, Opeyemi R. Omokungbe, Olusegun Gabriel Fawole, Felix Samuel Olise, Olalekan O. M. Popoola, Roderic L. Jones, Philip K. Hopke

“…Most pollutants were of anthropogenic origins and exhibited the highest contributions from the southwest at most sampling locations. …”
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Investigation in blood-brain barrier integrity and susceptibility to immune cell penetration in a mouse model of Dravet syndrome by Cristina Alonso, Alicia García-Culebras, Valentina Satta, Inés Hernández-Fisac, Álvaro Sierra, José A. Guimaré, Ignacio Lizasoain, Javier Fernández-Ruiz, Onintza Sagredo

“…The elevated number of blood neutrophils did not apparently originate their infiltration into the hippocampus of DS mice as an immunofluorescence analysis indicated, and the same happened in B- and T-cells. …”
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ReliefF guided variable spiral tuna swarm optimization algorithm with somersault foraging for feature selection by Yu-Cai Wang, Jie-Sheng Wang, Min Zhang, Hao-Ming Song, Jia-Ning Hou, Yu-Liang Qi, Yu-Wei Song

“…Additionally, seven different mathematical spirals are employed to replace the original spiral foraging pattern in the TSO algorithm. …”
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Возможности применения Опросника «7х7» (7 симптомов за 7 дней) для оценки динамики симптомов функциональной диспепсии и синдрома раздраженного кишечника... by V. T. Ivashkin, A. A. Sheptulin, Ye. A. Poluektova, D. V. Reykhart, A. V. Belostotsky, A. A. Drozdova, V. S. Arnautov

“…Material and methods. Original study included 50 patients (36 men and 16 women) aged 18 to 64 years with confirmed diagnoses of IBS, FD and their combination. …”
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Mycotoxicological monitoring. Part 1. Complete mixed feed for pigs and poultry (2009–2018) by G. P. Kononenko, A. A. Burkin, Ye. V. Zotova

“…Special attention is paid to the importance of the projects for creation of common information resources that could become a unique scientific basis for innovations in feed poisoning prevention. Original monitoring data systematized and summarized in the paper are given in electronic format in section Additional materials.…”
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Phase I clinical trial testing the dose escalation and expansion of Pressurized IntraThoracic Hyperthermic Aerosol Cisplatin administration (PITHAC) for the management of pleural c... by Louis-Emmanuel Chriqui, Etienne Abdelnour-Berchtold, Edoardo Zanfrini, Severine Devesa-Perez, Michel Gonzalez, Thorsten Krueger, Kim Ellefsen, Alice Destaillats, David Bonnet, Martin Hübner, Hasna Bouchaab, Michal Bassani-Sternberg, Solange Peters, Sabrina Cavin, Jean Y Perentes

“…Background: Pleural carcinosis originates from various cancers. Its management consists in systemic therapies combined to dyspnea relief procedures. …”
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Analysis of a mouse germ cell tumor model establishes pluripotency-associated miRNAs as conserved serum biomarkers for germ cell cancer detection by Amanda R. Loehr, Dennis M. Timmerman, Michelle Liu, Ad J. M. Gillis, Melia Matthews, Jordana C. Bloom, Peter K. Nicholls, David C. Page, Andrew D. Miller, Leendert H. J. Looijenga, Robert S. Weiss

“…We previously developed a genetically engineered mouse model featuring malignant mixed TGCTs consisting of pluripotent embryonal carcinoma (EC) and differentiated teratoma that, like the corresponding human malignancies, originate in utero and are highly chemosensitive. Here, we report that miRNAs in the mouse miR-290-295 cluster, homologs of the human miR-371-373 cluster, were detectable in serum from mice with malignant TGCTs but not from tumor-free control mice or mice with benign teratomas. miR-291-293 were expressed and secreted specifically by pluripotent EC cells, and expression was lost following differentiation induced by the drug thioridazine. …”
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Late-time Optical and X-Ray Emission Evolution of the Oxygen-rich SN 1996cr by Daniel Patnaude, Kathryn E. Weil, Robert A. Fesen, Dan Milisavljevic, Ralph P. Kraft

“…The X-ray properties are consistent with what is expected from a shock breaking out into a lower-density environment. Though originally identified as a Type IIn SN, based upon late-time optical emission-line spectra, we argue that the SN 1996cr progenitor was partially or highly stripped, suggesting a Type IIb/Ib SN.…”
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Is global health truly global? A hashtag analysis of #GlobalHealth disparities on X by Zara Arshad, Pranav Sharma, Shweta Sharma, Mustafa Sajjad Cheema, Mustafa Sajjad Cheema, Charu Agarwal, Charu Agarwal, Tamara Tango, Tamara Tango, Farhan Bin Matin, Atanas G. Atanasov, Atanas G. Atanasov, Atanas G. Atanasov, Bodrun Naher Siddiquea, Maima Matin, Olga Adamska, Artur Stolarczyk, Rahul Kashyap, Rahul Kashyap, Faisal A. Nawaz, Faisal A. Nawaz

“…Among the top 25 most influential handles, a maximum (N = 09) were based in the United States—most profiles (N = 10) were categorized as international organizations followed by journals (N = 03).ConclusionThe study gives a glimpse into the discrepancies in global distribution and stakeholders of #GlobalHealth. Most posts originated from the global north, which hints at how the trend to #GlobalHealth is not perhaps as global as it is thought to be, and it also reflects upon the real-world scenarios in the context of Global Health Equity. …”
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A smartphone-guided secondary prevention digital health application reduces systolic blood pressure in patients with chronic coronary syndrome and insufficient blood pressure contr... by Philip Düsing, Stephan H. Schirmer, Sebastian Schäfer, Alexander Krogmann, Jan-Malte Sinning, Nikos Werner, Florian Bönner, Alexander Sedaghat, Cornelius Müller, Irina Eckardt, Georg Nickenig, Andreas Zietzer

“…The control group received standard care alone. From the original cohort, subgroups of patients with systolic BP ≥140 mmHg (n = 44), ≥130 mmHg (n = 89) and diastolic BP ≥90 mmHg (n = 28) were analyzed for BP reduction after 12 weeks.ResultsIn patients with systolic BP ≥140 mmHg, the intervention group showed a reduction in systolic BP by 15.5 mmHg (± 16.7 mmHg, p = 0.0001), which was greater compared to the control group (6.0 ± 13.0 mmHg, p = 0.058). …”
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Digital Literacy on SME Business Performance and The Mediating Role of Entrepreneurial Skills by Intan Novela Q.A, Hunik Sri Runing Sawitri, Asri Laksmi Riani, Suryandari Istiqomah, Anastasia Riani Suprapti, Mugi Harsono

“…Additionally, digital literacy is crucial for enhancing operational efficiency, product and service innovation, and customer communication. Originality/value (State of the art): The research broadens the understanding of digital literacy, positioning it as more than just a technical skill. …”
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Case report: an unusual long-term evolution of a diffuse midline glioma, H3K27 altered by Michael Griessmair, Michael Griessmair, Claire Delbridge, Claus Zimmer, Eva Mayr, Arthur Wagner, Julian Canisius, Marie-Christin Metz, Benedikt Wiestler, Benedikt Wiestler

“…Initial MRI showed an irregularly shaped, contrast-enhancing tumor around the third ventricle with central necrosis, most likely originating from the right thalamus. The patient underwent biopsy, followed by microsurgical resection with molecular analysis. …”
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Deep Learning-Based Feature Extraction Technique for Single Document Summarization Using Hybrid Optimization Technique by Jyotirmayee Rautaray, Sangram Panigrahi, Ajit Kumar Nayak, Premananda Sahu, Kaushik Mishra

“…However, traditional approaches that rely on directly extracting words often lead to redundancies and fail to establish a strong connection between the summary and the original document. This paper presents a novel Deep Learning (DL)-based text summarization approach incorporating the following phases: pre-processing, feature extraction, vectorization, and summarization using a hybrid Cat Swarm Optimization (CSO) and Harris Hawk Optimization (HHO) algorithm. …”
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T7 DNA polymerase treatment improves quantitative sequencing of both double-stranded and single-stranded DNA viruses by Billaud, Maud, Theodorou, Ilias, Lamy-Besnier, Quentin, Shah, Shiraz A., Lecointe, François, De Sordi, Luisa, De Paepe, Marianne, Petit, Marie-Agnès

“…It better represents the original synthetic mixtures compared to MDA or direct application of the xGen kit. …”
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Integrating biodiversity assessments into local conservation planning: the importance of assessing suitable data sources by Ferraille, Thibaut, Kerbiriou, Christian, Bigard, Charlotte, Claireau, Fabien, Thompson, John D.

“…Third, a data driven approach can lead to the use of notably different species communities to identify priority conservation areas when compared to the community in the original database. Finally, we propose a workflow to guide SEA stakeholders through the process of data rationalization and use in conservation planning. …”
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Constructing Identities: Amos Tutuola and the Ibadan Literary Elite in the wake of Nigerian Independence by Mackenzie Finley

“…They’re afraid to meet the ghosts from the dead” (emphasis in original).1 Amos Tutuola (1920–1997) was recognized globally for his perpetuation of Yoruba folklore tradition via novels and short stories written in unconventional English. …”
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Heterologous expression of SpsTAC2 in Arabidopsis affected branch angle and secondary vascular system development by Fangshu Niu, Mengru Yuan, Hongxia Zhao, Zhi Pang, Jie Yan, RuiXie Ning, Lin Shi, Fengqiang Yu, Dongshan Wei, Rong Yang, Runming Zhang, Haifeng Yang

“…The subcellular localization of SpsTAC2 was analyzed via Agrobacterium-mediated transient expression in onion (Allium cepa L.) epidermal cells. Phenotypic characterization of SpsTAC2 overexpressing Arabidopsis strains revealed that the branching angle of the transgenic strains was significantly greater than that of the wild type, and the anatomical structures of the stems and hypocotyls of the transgenic strains indicated that the vascular system of the transgenic strains developed more slowly than did that of the wild type. …”
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