Kinetics, modelling and optimization of Shea butter transesterification via clay doped ionic liquid catalyst by Nwosu-Obieogu Kenechi, Ude Callistus Nonso, Onukwuli Dominic Okechukwu, Ezeugo Joseph

“…Increase in the process parameters significantly affected the yield, with the highest yield of 89.45 % obtained at an agitation of 300rpm while other parameters were kept constant. After optimisation using response surface methodology (RSM), the second-order polynomial model was shown in the ANOVA with R2 values of 0.9952, Adj R2 (0.9862), and Pred R2 (0.8719), demonstrating model acceptability. …”
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Humanities education reform exploration and practice under outcomes-based education (OBE) by P. Yang

“…At present, the technology and tools of OBE, despite the criticism, remain relevant for the development and optimisation of the humanities education system.The aim of the present research is to study and analyse the theory of OBE and the practice on the application of pedagogical principles for modernisation of the humanities education in China.Results and scientific novelty. …”
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Association of Light’s Criteria with Pleural Fluid Procalcitonin Levels and Ultrasound Thorax with its Impact on the Management of Pleural Effusion: A Cross-sectional Study by BK Likhitha, Keertivardhan D Kulkarni, Madhav Mahawar

“…PCT measurement in pleural fluid further aids in distinguishing between transudative and exudative effusions and also in identifying infectious effusions from other types, optimising patient management.…”
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Keeping Active with Texting after Stroke (KATS): a single-arm feasibility and acceptability study of a behavioural intervention to promote community-based physical activity after s... by Gozde Ozakinci, Stephan U Dombrowski, Andrew Murphy, Albert Farre, Jenna Breckenridge, Jacqui H Morris, Linda A Irvine, Keith Jenkinson

“…Based on these findings, KATS will be further optimised before evaluating effectiveness in a randomised controlled trial.Trial registration number and protocol availability ISRCTN 13704805 https://www.hra.nhs.uk/planning-and-improving-research/application-summaries/research-summaries/keeping-active-with-texting-after-stroke-kats/Protocol available https://www.isrctn.com/ISRCTN13704805?…”
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The evolutionary history of Plasmodium falciparum from mitochondrial and apicoplast genomes of China-Myanmar border isolates by Yini Tian, Run Ye, Dongmei Zhang, Yilong Zhang

“…Additionally, by mapping global patterns of mt/apico genome polymorphism, we will gain valuable insights into the evolutionary history of P. falciparum and optimised strategies for controlling P. falciparum malaria at international borders. …”
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AI versus human-generated multiple-choice questions for medical education: a cohort study in a high-stakes examination by Alex KK Law, Jerome So, Chun Tat Lui, Yu Fai Choi, Koon Ho Cheung, Kevin Kei-ching Hung, Colin Alexander Graham

“…Combining AI efficiency with expert oversight could optimise question creation for high-stakes exams, offering a scalable model for medical education that balances time efficiency and content quality.…”
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Detectability of Emission from Exoplanet Outflows Calculated by pyTPCI, a New 1D Radiation-hydrodynamic Code by Riley Rosener, Michael Zhang, Jacob L. Bean

“…H α and Mg i 457 nm are moderately strong for some planets at some metallicities, but they are almost always optically thin, so some of their emission may not be from the outflow. …”
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The rapid infilling of a tide-dominated channel on the southern Yangtze Delta plain during the Medieval Climate Anomaly by Zhuoxuan Wu, Jianwen Wang, Xiaomei Nian, Fengyue Qiu, Zhanghua Wang, Zhanghua Wang

“…Three cores were drilled in the lower reaches of the palaeo-Wusong River, and surface sediment samples were collected from the Huangpu River in the southern plain of the Yangtze Delta. Using AMS 14C and optically stimulated luminescence (OSL) dating, sedimentological and alkaline earth metal analyses, this study explores the formation and silting history of the palaeo-Qinglong channel. …”
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Characterization of Seasonal Difference of HULIS-C Sources from Water Soluble PM2.5 in Seoul, Korea: Probing Secondary Processes by Hyung-Min Lee, Se Pyo Lee, Yugen Li, Jian Zhen Yu, Jin Young Kim, Yong Pyo Kim, Ji Yi Lee

“…Abstract HUmic-LIke Substances (HULIS) consists of a significant fraction of water-soluble organic carbon (WSOC) and optically active brown carbon. Understanding seasonality in their abundance and sources is an important step to quantifying their impacts on air quality and climate. …”
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Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Our Galaxy [version 2; peer review: 2 approved] by Pamela Klaassen, Maria Beltrán, Alessio Traficante, Mark Booth, Kate Pattle, Jonathan Marshall, Joshua Lovell, Brandt Gaches, Alvaro Hacar, Nicolas Peretto, Caroline Bot, Doris Arzoumanian, Thomas Stanke, Gaspard Duchêne, Ana Duarte Cabral, Antonio Hales, David Eden, Patricia Luppe, Jens Kauffmann, Elena Redaelli, Sebastian Marino, Álvaro Sánchez-Monge, Andrew Rigby, Dmitry Semenov, Eugenio Schisano, Mark Thompson, Silvia Spezzano, Claudia Cicone, Friedrich Wyrowski, Martin Cordiner, Tony Mroczkowski, Doug Johnstone, Luca Di Mascolo, Minju Lee, Eelco van Kampen, Thomas Maccarone, Daizhong Liu, Matthew Smith, Amélie Saintonge, Sven Wedemeyer, Alexander Thelen

“…Because we are deeply embedded in the plane of our Galaxy, it takes up a significant fraction of the sky, with complex dust lanes scattered throughout the optically recognizable bands of the Milky Way. These bands become bright at (sub-)millimetre wavelengths, where we can study dust thermal emission and the chemical and kinematic signatures of the gas. …”
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The Result of Timely Therapy for Whipple's Disease: a Clinical Case by S. N. Mekhtiev, O. A. Mekhtieva, E. Yu. Kalinina, V. E. Karev, A. V. Vanyan, O. M. Berko

“…The identified changes were represented by thickening of the villi and accumulations in the stroma of large macrophages (CD68+) with wide light cytoplasm containing abundant accumulations of PAS-positive, negative when stained with carbol fuchsin according to Ziehl — Nielsen and auramine-rhodamine (under microscopy in luminescence mode) short rods, as well as numerous optically empty small and larger cavities. Treatment with intravenous injections of ceftriaxone 2 g per day for 14 days and trimethoprim/sulfamethoxazole 1920 mg per day for 8 months led to improved health, normalization of laboratory parameters, endoscopic and morphological findings. …”
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Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Probing the transient and time-variable sky [version 2; peer review: 1 approved, 2 approved with reservations] by Pamela Klaassen, Mark Booth, Thomas Stanke, Evanthia Hatziminaoglou, Claudia Cicone, Martin Cordiner, Tony Mroczkowski, Doug Johnstone, Luca Di Mascolo, Minju Lee, Eelco van Kampen, Thomas Maccarone, Daizhong Liu, Matthew Smith, Amélie Saintonge, Sven Wedemeyer, Alexander Thelen, John Orlowski-Scherer, Tomasz Kamiński, Joe Bright, Atul Mohan, Michael Koss, Sigurd Næss, Francisco Miguel Montenegro-Montes, Paola Severgnini, Claudio Ricci, Jochen Greiner, Cristian Vignali

“…Submillimeter observations probe a variety of materials, such as optically thick dust, which are hard to study in other wavelengths. …”
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ALMA Spectral Survey of an Eruptive Young Star, V883 Ori (ASSAY). II. Freshly Sublimated Complex Organic Molecules in the Keplerian Disk by Jae-Hong Jeong, Jeong-Eun Lee, Seonjae Lee, Giseon Baek, Ji-Hyun Kang, Seokho Lee, Chul-Hwan Kim, Hyeong-Sik Yun, Yuri Aikawa, Gregory J. Herczeg, Doug Johnstone, Lucas Cieza

“…According to our analyses, using only optically thin lines is critical to deriving the reliable column densities of COMs. …”
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Implementing and evaluating the comprehensive integration of physical activity into a major health system: study design and protocol by Alex Ewing, Mark Stoutenberg, Jennifer L Trilk, Christopher Wichman, Paul A Estabrooks, John M Brooks, Meenu Jindal, James Rosemeyer, Leah M Schumacher, Lia K McNulty, Stephanie Eskuri, Frankie Bennett

“…Information gained from this study will lead to the refinement of a generalisable approach to inform future implementation strategies on optimising and scaling up the integration of comprehensive PA models in US health systems and be disseminated through conference presentations, publication in peer-reviewed journals and direct work with health systems.Trial registration number NCT06073041.…”
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Cost-effectiveness analysis of proactive home visits compared with site-based community health worker care on antenatal care outcomes in Mali: a cluster-randomised trial by Osondu Ogbuoji, Caroline Whidden, Emily Treleaven, Youssouf Keita, Kassoum Kayentao, Ari Johnson, Jenny X Liu, Minahil Shahid, Mohamed Berthé, Armand Zimmerman, David Charles Boettiger, Coumba Traoré, Mahamadou Sogoba, Saibou Doumbia, Amadou Beydi Cissé

“…However, despite the success of CHW programmes in various countries, WHO has called for additional research to develop evidence-based models that optimise CHW service delivery and that can be replicated across geographies.Methods The ProCCM Trial was a cluster-randomised controlled trial to compare proactive home visits by CHWs (intervention, 69 village clusters) to the provision of CHW care at community fixed sites only (control, 68 village clusters) in the Bankass health district in Central Mali. …”
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AICpred: Machine Learning-Based Prediction of Potential Anti-Inflammatory Compounds Targeting TLR4-MyD88 Binding Mechanism by Lucindah N. Fry-Nartey, Cyril Akafia, Ursula S. Nkonu, Spencer B. Baiden, Ignatus Nunana Dorvi, Kwasi Agyenkwa-Mawuli, Odame Agyapong, Claude Fiifi Hayford, Michael D. Wilson, Whelton A. Miller, Samuel K. Kwofie

“…These predictions must be consolidated with experimental screening to enhance further optimisation of the compounds. AICpred is the first of its kind targeting the inhibition of TLR4-MyD88 binding and is freely available at http://197.255.126.13:8080.…”
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Descemet Endothelial Thickness Comparison Trial 1 (DETECT 1): outcome masked, placebo-controlled trial comparing two types of corneal transplant surgeries and effect of rho kinase... by Thomas M Lietman, Jennifer Rose-Nussbaumer, Bennie H Jeng, Benjamin F Arnold, Winston Chamberlain, Charles C Lin, Jennifer Y Li, William Gensheimer, Jameson Clover, Nicole Varnado, Sarah Abdelrahman

“…The results of this trial will contribute to optimising corneal transplantation techniques and improving long-term graft survival, while also exploring the cost-effectiveness of these interventions. …”
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Meta-analysis of efficacy and safety of pembrolizumab for the treatment of advanced or recurrent cervical cancer by Xue Zhang, Wen-Jie Yin, Ai-Li Zhang, Xiao-Xiao Zhang, Li-Juan Ding, Jiao Zhang, Shu-Ting He, Jie-Ping Yan

“…Future research will primarily focus on optimising customised regiments that optimally integrate pembrolizumab into new therapies and combination strategies. …”
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Factors associated with non-response and nutritional status of non-responders at 6-month post-discharge: a cohort study nested in a MUAC-based nutrition programme for acutely malno... by Maguy Daures, Jérémie Hien, Cécile Cazes, Rodrigue Alitanou, Laure Saillet, Benjamin Séri, Ahmad Ag Mohamed Aly, Oumarou Maidadji, Atté Sanoussi, Aboubacar Mahamadou, Mathias Altmann, Kevin Phelan, Renaud Becquet, Susan Shepherd

“…As current research emphasizes ways to simplify and optimize treatment protocols, non-response emerges as a new issue to enhance program efficiency.MethodsA prospective cohort study was conducted from 2019 to 2020 at two health centres in Mirriah, Niger among children aged 6–59 months with uncomplicated AM treated under the Optimising treatment for Acute MAlnutrition (OptiMA) protocol. …”
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Importance of infarct topography in determination of stroke mechanism and recurrence risk: a post-hoc analysis of the dabigatran acute treatment of stroke trial by Michael D Hill, Ken Butcher, Kelvin Ng, Mukul Sharma, Shelagh B Coutts, Brian H Buck, Thalia Field, Erol Cimen, Laura C Gioia, Jodi Miller, Oscar R Benavente

“…The question is clinically relevant to optimise secondary stroke prevention investigations and treatment.Design We conducted a retrospective analysis of the dabigatran treatment of acute stroke II (DATAS II) trial (ClinicalTrials.gove NCT NCT02295826), in which patients underwent diffusion-weighted imaging (DWI) at baseline and 30 days after randomisation to one of two antithrombotic therapies. …”
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