Fluid balance and clinical outcomes in patients with aortic dissection: a retrospective case-control study based on ICU databases by Tao Chen, Peng Qiu, Yixuan Li, Xinwu Lu, Zhaoyu Wu, Zhijue Xu, Hongji Pu, Jiahao Lei, Zhuojing Zhang, Xinrui Yang, Ruihua Wang

“…A similar result was found for mean 24-hour fluid balance (OR 1.030, 95% CI (1.019, 1.042), p<0.001), and the cut-off was selected to be 5.12 dL (AUC=0.778, OR 3.066, 95% CI (1.634, 5.753), p<0.001).Conclusions This study stresses the importance of fluid balance in the clinical care of AD patients and provides new insights for optimising fluid management and monitoring strategies beyond the conventional focus on blood pressure and heart rate management.…”
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The multidisciplinary approach to the treatment of paediatric chronic pain: a qualitative analysis through focus groups by Aldana Paola Ercolano, Sabrina Galvan, Tessa Louise Marchesan, Alessia Gavioli, Gerardo Papa, Mariarita Todaro, Lidia Berforini D’Aquino, Alessia Zanatta, Andrea Vianello

“…Objectives: To explore healthcare professionals’ perceptions and expectations regarding the multidisciplinary approach to chronic pediatric pain, and identify areas for improvement to optimise rehabilitative practices. Methods: The study adopted a qualitative design, utilizing the Focus Group technique and unstructured interviews, following Consolidated Criteria for Reporting Qualitative Research (COREQ) guidelines. …”
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Development of a 3D-Printed Chest Phantom with Simulation of Lung Nodules for Studying Ultra-Low-Dose Computed Tomography Protocols by Jenna Silberstein, Steven Tran, Yin How Wong, Chai Hong Yeong, Zhonghua Sun

“…This study aimed to 3D print a patient-specific chest phantom simulating multiple lung nodules to optimise low-dose Computed Tomography (CT) protocols for lung cancer screening. …”
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DigiLoCS: A leap forward in predictive organ-on-chip simulations. by Manoja Rajalakshmi Aravindakshan, Chittaranjan Mandal, Alex Pothen, Stephan Schaller, Christian Maass

“…The developed tool, DigiLoCs, focuses explicitly on accurately describing complex biological processes within liver-chip systems. ODE-constrained optimisation is applied to estimate the clearance of compounds. …”
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Risk factors associated with human Mpox infection: a systematic review and meta-analysis by Nicola Luigi Bragazzi, Jianhong Wu, Jude Dzevela Kong, James Orbinski, Chigozie Louisa Jane Ugwu, Ali Asgary, Woldegebriel Assefa Woldegerima

“…Conversely, smallpox vaccination was associated with a significantly reduced risk of Mpox infection (OR=0.24, 95% CI 0.11, 0.55).Conclusion Identification of risk factors associated with Mpox provides insights for strategic public health planning, enabling targeted interventions for high-risk groups and optimising resource allocation to strengthen Mpox control efforts.…”
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Perspectives on which health settings geriatricians should staff: a qualitative study of patients, care providers and health administrators by Eric Kai-Chung Wong, Andrea C. Tricco, Wanrudee Isaranuwatchai, David M. J. Naimark, Sharon E. Straus, Joanna E. M. Sale

“…Abstract Background With a shortage of geriatricians and an aging population, strategies are needed to optimise the distribution of geriatricians across different healthcare settings (acute care, rehabilitation and community clinics). …”
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Digital-based emergency prevention and control system: enhancing infection control in psychiatric hospitals by Mi Yang, Xiaojun Zhu, Fei Yan, Xincheng Huang, Zhixue Wu, Xin Jiang, Yan Huang, Zezhi Li

“…Consequently, the system has the capacity to facilitate the emergency IPC response of psychiatric institutions to infectious diseases, while simultaneously optimising the training and educational methodologies employed in emergency prevention and control. …”
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Using Sequence Mining to Predict Complex Systems: A Case Study in Influenza Epidemics by Theyazn H. H. Aldhyani, Manish R. Joshi, Shahab A. AlMaaytah, Ahmed Abdullah Alqarni, Nizar Alsharif

“…This paper presents three adapting intelligence models: support vector machine regression (SVMR), artificial neural network using particle swarm optimisation (ANNPSO), and our intelligent time series (INTS) to predict influenza epidemics. …”
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Genetic trends and common BRCA1/2 pathogenic sequence variants in black African and Indian breast cancer patients presenting at Inkosi Albert Luthuli Central Hospital, KwaZulu-Nata... by M Makhetha, C Aldous, N Chabilal

“…For non-white patients, common variants are not well understood, and as such, all populations are offered the same test optimised for white patients. This carries a risk of misdiagnosis, the consequences of which include recurrence and increased mortality. …”
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COOL-LAMPS. VII. Quantifying Strong-lens Scaling Relations with 177 Cluster-scale Strong Gravitational Lenses in DECaLS by Simon D. Mork, Michael D. Gladders, Gourav Khullar, Keren Sharon, Nathalie Chicoine, Aidan P. Cloonan, Håkon Dahle, Diego Garza, Rowen Glusman, Katya Gozman, Gabriela Horwath, Benjamin C. Levine, Olina Liang, Daniel Mahronic, Viraj Manwadkar, Michael N. Martinez, Alexandra Masegian, Owen S. Matthews Acuña, Kaiya Merz, Yue Pan, Jorge A. Sanchez, Isaac Sierra, Daniel J. Kavin Stein, Ezra Sukay, Marcos Tamargo-Arizmendi, Kiyan Tavangar, Ruoyang Tu, Grace Wagner, Erik A. Zaborowski, Yunchong Zhang, (COOL-LAMPS Collaboration)

“…We estimate the Einstein-radius-enclosed total mass for 177 cluster-scale strong gravitational lenses identified by the ChicagO Optically selected Lenses Located At the Margins of Public Surveys (COOL-LAMPS) collaboration with lens redshifts ranging from 0.2 ⪅ z ⪅ 1.0 using the brightest-cluster-galaxy (BCG) redshift and an observable proxy for the Einstein radius. …”
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Molecular Distributions and Abundances in the Binary-shaped Outflow of V Hya by Mark A. Siebert, Raghvendra Sahai, Samantha Scibelli, Anthony J. Remijan

“…Employing LTE and non-LTE models of emission from the DUDE, we estimate the abundance distributions for optically thin species, and compare them with prototypical carbon-rich AGB envelopes. …”
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Two decades of recipient and donor referrals for heart transplantation to Groote Schuur Hospital, Cape Town, South Africa: A retrospective study by R Kanyongo, G Calligaro, B Cupido, J Scherman, A Brooks, C Ofoegbu, N Da Silva, A Ryan, M Mofamadi, K Seele, P Human, J Brink, P Zilla, T Pennel

“…There is an urgent need to analyse the current transplant referral pathway to optimise equitable access to transplantation. Objectives. …”
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Pairing regression and configurational analysis in health services research: modelling outcomes in an observational cohort using a split-sample design by Jason J Sico, Laura J Myers, Dawn M Bravata, Ying Zhang, Anthony J Perkins, Edward J Miech, Joanne Daggy

“…Configurational models optimise sensitivity with relatively few conditions. …”
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Impact of patient–family physician language concordance on healthcare utilisation and mortality: a retrospective cohort study of home care recipients in Ontario, Canada by Claire Kendall, Sharon Johnston, Michael Reaume, Peter Tanuseputro, Michael Pugliese, Douglas Manuel, Denis Prud'homme, Manish Sood, Ricardo Batista, Ewa Sucha, Rhiannon Roberts, Emily Rhodes, Emily Seale, Lise Bjerre, Louise Bouchard

“…For francophones, the risk of experiencing an ED visit, a hospitalisation or death was not impacted by the language of their family physician.Conclusions Patient–family physician language concordance is associated with a lower risk of adverse outcomes in non-English and non-French speakers. Optimising the delivery of language-concordant care could potentially result in significant decreases in the use of acute healthcare services and mortality at the population level.…”
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Web-based mindfulness and skills-based distress reduction for patients with cancer: study protocol of the multicentre, randomised, controlled confirmatory intervention trial Reduct by Dirk Schadendorf, Peter Martus, Stephan Zipfel, Yesim Erim, Alexander Bäuerle, Martin Teufel, Caterina Schug, Johanna Graf, Wolfgang Bethge, Andreas Dinkel, Anja Neumann, Jasmin Steinbach, Jana Heinen, Julia Barbara Krakowczyk, Mirjam Damerau, Sebastian Dries, Anja Mehnert-Theuerkauf, Mitra Tewes, Jörg Wiltink, Alexander Wünsch

“…We expect the Make It Training to be superior to treatment as usual optimised (TAU-O) in terms of reducing distress after completing the intervention (T1, primary endpoint).Methods and analysis The study comprises a multicentre, prospective, randomised controlled confirmatory interventional trial with two parallel arms. …”
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Efficacy and cost-effectiveness of an ACT and compassion-based intervention for women with breast cancer: study protocol of two randomised controlled trials {1} by Inês A. Trindade, Andreia Soares, David Skvarc, Diogo Carreiras, Joana Pereira, Óscar Lourenço, Filipa Sampaio, Bruno de Sousa, Teresa C. Martins, Paula Boaventura, Joana Marta-Simões, Mind Project Team, Helena Moreira

“…This paper presents the study protocol of two randomised controlled trials that aim to test the efficacy and cost-effectiveness of an optimised version of the Mind programme in women with breast cancer. …”
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Strategies adopted by men to deal with uncertainty and anxiety when following an active surveillance/monitoring protocol for localised prostate cancer and implications for care: a... by Chris Metcalfe, Jenny Donovan, Julia Wade, Vincent J Gnanapragasam, Michael Davis, David Neal, Richard Martin, Athene Lane, Edward Rowe, Freddie Hamdy, James Catto, Emma Turner, David Gillatt, Eleanor Walsh, Derek Rosario, Tim Peters, Roger Kockelbergh, Alan Paul, Peter Holding, Howard Kynaston, Owen Hughes, Prasad Bollina, Alan Doherty, Edgar Paez

“…This study investigated men’s strategies for coping with the uncertainties of active monitoring (AM, a surveillance strategy within the Prostate testing for cancer and Treatment, ProtecT trial) over the longer term and implications for optimising supportive care.Design Longitudinal serial in-depth qualitative interviews every 2–3 years for a median 7 (range 6–14) years following diagnosis.Setting Four centres within the UK Protect trial.Participants Purposive sample of 20 men with localised PCa: median age at diagnosis 64 years (range 52–68); 15 (75%) had low-risk PCa; 12 randomly allocated to, 8 choosing AM. …”
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Elevated blood glucose and unfavourable tuberculosis treatment outcomes in a low-income setting: findings from a prospective cohort study in Eswatini by Diederick E Grobbee, Kerstin Klipstein-Grobusch, Kennedy Otwombe, Victor Williams, Alinda G Vos-Seda, Marianne Calnan, Colani S Ngwenya, Samson Haumba, Lindiwe Mdluli-Dlamini

“…Hypertension (AOR 4.84; 95% CI: 1.48, 15.7), unemployment (AOR 2.01; 95% CI: 1.08, 3.71) and high school education (AOR 0.32; 95% CI: 0.16, 0.64) were associated with unfavourable treatment outcome.Conclusion Our study shows the need to optimise care for patients receiving treatment for tuberculosis by integrating screening for and treatment of diabetes and hypertension, prioritising males, those aged ≥55 years and those with a reactive HIV status to limit unfavourable outcomes and death.…”
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Neuroblastoma-derived hypoxic extracellular vesicles promote metastatic dissemination in a zebrafish model. by Anna Fietta, Pina Fusco, Giuseppe Germano, Sara Micheli, Marco Sorgato, Giovanni Lucchetta, Elisa Cimetta

“…The zebrafish (Danio rerio) is a valuable model organism for studying human biology due to its easy genetic manipulation and small size. It is optically transparent and shares genetic similarities with humans, making it ideal for studying developmental processes, diseases, and drug screening via imaging-based approaches. …”
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Incidence and Risk Factors of Lumbosacral Complications Following Long‐Segment Spinal Fusion in Adult Degenerative Scoliosis by Tinghua Jiang, Xinuo Zhang, Qingjun Su, Xianglong Meng, Aixing Pan, Hanwen Zhang, Yong Hai

“…These results will improve our ability to predict personal risk conditions and provide better medical optimisation for surgery.…”
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