Nutritional, phenolic and in vitro digestion characteristics of dried grape pomace processed with different micronization/air-classification protocols by Aristide Maggiolino, Roberta Greco, Federica Blando, Eleni Tsiplakou, Elisabetta Casalino, Pasquale De Palo

“…In conclusion, micronization and air-classification improved the protein content of finer grape pomace fractions but slightly reduced protein digestibility, likely due to interactions with phenolics or increased fibre. Overall, the optimised processing techniques show potential to make grape pomace a sustainable and functional feed ingredient for ruminants.…”
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Managerial thinking in neonatal care: a qualitative study of place of care decision-making for preterm babies born at 27–31 weeks gestation in England by Neena Modi, Elizabeth S Draper, Miaoqing Yang, Sarah E Seaton, Kelvin Dawson, Vasiliki Bountziouka, Oliver Rivero-Arias, Thillagavathie Pillay, Natalie Armstrong, Alexis Paton, Elaine Boyle, Victor L Banda, Caroline Cupit, Bradley Manktelow, Abdul Qader T Ismail

“…As part of a national project seeking to optimise service delivery for this group of babies (OPTI-PREM), we undertook qualitative research to better understand how decisions about place of birth and care are made and operationalised.Design Qualitative analysis of ethnographic observation data in neonatal units and semi-structured interviews with neonatal staff.Setting Six neonatal units across two neonatal networks in England. …”
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DepRescribing inapprOpriate Proton Pump InhibiTors (DROPIT): study protocol of a cluster-randomised controlled trial in Swiss primary care by Stefan Neuner-Jehle, Katharina Tabea Jungo, Sven Streit, Sven Trelle, Nicolas Rodondi, Carole Elodie Aubert, Kristie Rebecca Weir, Enriqueta Vallejo-Yagüe, Samantha Chan, Marie Roumet, Pascal Juillerat, Sofia Carolina Zambrano Ramos, Jennifer Inauen, Angela Edith Schulthess-Lisibach, Renata Vidonscky Lüthold, Clémentine Tombez, Martina Zangger, Flurina Jenal, Yvonne Mattmann, Christof Bieri, Michaela Barbier

“…Deprescribing strategies have emerged to safely reduce or substitute inappropriate PPIs and optimise patient care in an evidence-based manner. …”
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The development of a nurse-led preoperative anaesthesia screening tool by Delphi consensus by M B Nejthardt, P Alexandris, S Bechan, M F A Bijli, S Chetty, J M Dippenaar, M Gibbs, M Johnson, H Kluyts, R Llewellyn, M Motiang, P Mogane, P Motshabi, B Mrara, F Roodt, U Singh, S Spijkerman, E Turton, J van der Westhuizen, B Biccard

“…This would ensure adequate time for optimisation of high-risk patients preoperatively and limit avoidable day-of-surgery cancellations. …”
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Germ cell quantification in human fetal and prepubertal testis tissues: a comparison of current methodologies by Emma Kearney, David Greenald, Gabriele Matilionyte, Sheila Lane, Melissa D Tharmalingam, Jill Davies, Jan-Bernd Stukenborg, Grace Forsyth, Rod T Mitchell

“…Methods to quantify germ cell number in human immature testicular tissues are essential to evaluate the impact of chemotherapy exposures and to optimise cryopreservation protocols used in fertility preservation for prepubertal boys. …”
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Path analysis of factors influencing length of stay and hospitalisation expenses for oral cancer patients in tertiary hospitals in southeastern China: a cross-sectional study by Jing Wang, Chen Chen, Xiaoying Hu, Yi Fan, Yaping Wang, Yu Qiu, Qiujiao Yang, Mingming Xu, Yanfeng Weng, Yanni Li, Lisong Lin, Fa Chen, Baochang He, Fengqiong Liu

“…While prevention and early diagnosis remain critical, our findings underscore several modifiable factors, including improving oral hygiene and optimising surgical protocols, such as chemotherapy and lymph node dissection, that present opportunities to reduce costs and enhance cost-effectiveness. …”
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A deep learning algorithm to generate synthetic computed tomography images for brain treatments from 0.35 T magnetic resonance imaging by Luca Vellini, Flaviovincenzo Quaranta, Sebastiano Menna, Elisa Pilloni, Francesco Catucci, Jacopo Lenkowicz, Claudio Votta, Michele Aquilano, Andrea D’Aviero, Martina Iezzi, Francesco Preziosi, Alessia Re, Althea Boschetti, Danila Piccari, Antonio Piras, Carmela Di Dio, Alessandro Bombini, Gian Carlo Mattiucci, Davide Cusumano

“…Intensity Modulated Radiation Therapy (IMRT) plans were optimised on simulation MRI and calculated considering sCT and original CT as electron density (ED) map. …”
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Impact of quality of life on overall work productivity impairment and activity impairment of patients with systemic lupus erythematosus: the PEONY study by Yoshiya Tanaka, Shintaro Hirata, Shingo Nakayamada, Yusuke Miyazaki, Kazuyoshi Saito, Kunihiro Yamaoka, Shigeru Iwata, Yoshiyuki Yamaguchi, Keisuke Nakatsuka, Shunpei Kosaka, Katsuhide Kusaka, Toshiki Yabe-Wada, Masakazu Fujiwara, Yoshifumi Arita, Mitsuru Hoshino, Naoko Ozaki

“…Improving their quality of life and achieving social remission will require ongoing monitoring of PROs and tailoring treatments to optimise these outcomes.Trial registration number jRCT1030210647.…”
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Assessing water dependencies and risks in Dutch industries: Distribution, consumption and future challenges by C.J. Teo, J. Poinapen, J.A.M.H. Hofman, T. Wintgens

“…This study suggested areas for further exploration such as exploring different circular water strategies, industrial symbiosis, leveraging digital technology for optimising water management, and utilising alternative water sources.…”
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Interdisciplinary collaboration across secondary and primary care to improve medication safety in the elderly (IMMENSE study): study protocol for a randomised controlled trial by Liv Mathiesen, Jeanette Schultz Johansen, Kjerstin Havnes, Kjell H. Halvorsen, Stine Haustreis, Lillann Wilsgård Skaue, Elena Kamycheva, Kirsten K. Viktil, Anne Gerd Granås, Beate H. Garcia

“…The integrated medicines management (IMM) model is a multifactorial interdisciplinary methodology aiming to optimise individual medication therapy throughout the hospital stay. …”
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A retrospective analysis of outcomes and complications of living- and deceased-donor split-liver transplantation in Johannesburg, South Africa by R Crawford, J Loveland, P Gaylard, J Fabian, K Kinandu, B Bobat, A Mahomed, D Parbhoo, M Beretta, S Berkenfeld, S Rambarran, F van der Schyff, L Brannigan, B Strobele

“…The results of this study demonstrate comparable outcomes between DDSLT and LDLT, indicating that both methods are effective approaches to optimise organ utilisation for liver transplantation within our setting. …”
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Cultural humility strategies for recruitment and retention of minoritised participants: a scoping review protocol by Mireille Chehade, Kellie McLean, Samar Mohsen Ashmawi, Moroni Fernandez Cajavilca, Baomi T Phung, Maya N Clark-Cutaia, Brynne Campbell Rice

“…The objective of this scoping review is to understand the extent to which cultural humility practices are applied to health research and how they may be leveraged to optimise recruitment and retention among minoritised populations.Methods and analysis This scoping review will follow the Joanna Briggs Institute methodology for scoping reviews. …”
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Emergency interventions for cardiogenic shock due to decompensated aortic stenosis: a systematic review and meta-analysis by Mauro Chiarito, Dario Bongiovanni, Evaldas Girdauskas, Bastian Wein, Eva Harmel, Tamer Owais, Stephanie Gladys Kühne, Andrea Patrignani, Sebastien Elvinger, Damyan Penev, Philip W Raake

“…These findings offer critical insights for clinical decision-making optimising patient care in this critically ill population.…”
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Microscopic investigation of the occurring process of contact erosion by Yubo Li, Guo Yu, Lei He, Ying Cui

“…A visible seepage system packed with transparent sand optically matched oil, and a planar laser-induced fluorescence technique was used to visually study mechanisms during seepage-induced contact erosion. …”
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Theoretical understanding of water splitting by analyzing nanocatalyst photoabsorption spectra by Gollapalli Prince, Caspary Toroker Maytal

“…In a photoelectrochemical cell used for water splitting, the surface states of optically and chemically dominant species affect the catalysts’ performance. …”
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Immobilization of Paenibacillus polymyxa with biopolymers to enhance the production of 2,3-butanediol by Jnanada Joshi, Sarah Vanessa Langwald, Olaf Kruse, Anant Patel

“…Abstract Background Paenibacillus polymyxa, is a Gram-positive, plant growth promoting bacterium, known for producing 98% optically pure 2,3-butanediol, an industrially valuable chemical for solvents, plasticizers and resins. …”
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Bibliometric study of plastics microfluidic chip from 1994 to 2022: A review by Rhesa Muhammad Faisal, Olusola Olaitan Ayeleru, Helen Uchenna Modekwe, Ishmael Matala Ramatsa

“…The network of keywords was coupled and concluded that Polydimethylsiloxane (PDMS), Polymethyl methacrylate (PMMA), Polystyrene (PS), and Cyclic olefin copolymer (COC) benefitted the researchers of microfluidic chips owing to their biocompatibility, durability, optically transparent, and inexpensiveness. By identifying global trends, key materials, and leading contributors in plastic microfluidic chip research, this study offers valuable insights into the most influential countries, leading journals, and primary materials. …”
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Simulation of spectral bands of the MERIS sensor to estimate chlorophyll-a concentrations in a reservoir of the semi-arid region by Fernando Bezerra Lopes, Evlyn Márcia Leão de Moraes Novo, Cláudio Clemente Faria Barbosa, Eunice Maia de Andrade, Rafael Damiati Ferreira

“…The waters of the Orós reservoir were all classified as eutrophic. The main optically active component in modelling the shape of the spectra was chlorophyll-a. …”
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Remodeling of the brain angioarchitecture in experimental chronic neurodegeneration by Maj Schneider Thomsen, Serhii Kostrikov, Lisa Greve Routhe, Kasper Bendix Johnsen, Steinunn Sara Helgudóttir, Johann Mar Gudbergsson, Thomas Lars Andresen, Torben Moos

“…Brains were examined at 28 days (short-term neurodegeneration) and 91 days (long-term neurodegeneration) and analyzed for vascular remodeling taking both 2D and 3D approaches, the latter involving confocal microscopy of optically cleared samples combined with machine learning-based image analysis. …”
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Impact of Jupiter’s Heating and Self-shadowing on the Jovian Circumplanetary Disk Structure by Antoine Schneeberger, Olivier Mousis

“…Three-dimensional hydrodynamic simulations have shown that this disk was optically thick and significantly heated to very high temperatures owing to the intense radiation emitted by the hot, young planet. …”
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