Hubungan Kadar Profil Lipid dengan Kejadian Hipertensi pada Masyarakat Etnik Minangkabau di Kota Padang Tahun 2012 by Rahmat Feryadi, Delmi Sulastri, Husnil Kadri

“…Lipid profile can lead hypertension through a variety of mechanism, either directly or indirectly. This study aims to investigate the lipid profile relation with the incident of hypertension. …”
Get full text

Immune responses in children with secondary infection of mycoplasma pneumoniae after COVID-19: focus on eosinophils and IgE by Pingping Wang, Jin Yao, Yaqiong Li, Zhanjun Zhang, Ruiling Zhang, Shouting Lu, Meixia Sun, Xiaorong Huang

“…However, there is a lack of systematic research on the specific manifestations and mechanisms of eosinophils in secondary infection with Mycoplasma pneumoniae after SARS-CoV-2 infection. …”
Get full text

Non-small Cell Lung Cancer Cell Line PC-9 Drug-resistant Mutant Cell Line 
Establishment and Validation of Their Sensitivity to EGFR Inhibitors by Tao HU, Yang LOU, Mingbo SU

“…This study provides a clinically relevant cellular evaluation and mechanism validation system for the development of a new generation of innovative drugs targeting EGFR mutation resistance.…”
Get full text

Traditional herbal medicine legislative and regulatory framework: a cross-sectional quantitative study and archival review perspectives by Sileshi Dubale, Rashed Edris Usure, Yesuneh Tefera Mekasha, Gemmechu Hasen, Firdos Hafiz, Dereje Kebebe, Sultan Suleman

“…Key barriers to effective regulation included a lack of research on herbal medicines (90.3%) and insufficient regulatory mechanisms (87.8%). Additional challenges for regulatory offices included traditional healers’ reluctance to engage with scientific communities (56.5%), inadequate inspections (55.3%), and limited data on the safety, quality, and efficacy of certain medicinal plants (54.4%).ConclusionOverall, the Ethiopian Food and Drug Authority (EFDA) is significantly strengthening the legislative and regulatory framework for traditional herbal medicines (THM), although full implementation is still forthcoming. …”
Get full text

Myofibrillogenesis Regulator-1 in Smooth Muscle Cells Modulates Inflammation Signaling Pathways via Regulating ROCK1 Ubiquitination and Degradation to Impact Aortic Dissection by Yin H, Li X, Lu D, Zhao X, Yang Z, Wang Z, Xu F, Chen Y, Li C

“…Inflammation is a critical mechanism in the development of AD, and identifying specific molecular targets to regulate inflammation is crucial for stopping its progression. …”
Get full text

Hubungan antara Indeks Massa Tubuh dengan Kadar Nitrit Oksid pada Masyarakat Etnik Minangkabau di Kota Padang by Nidia Purwadianti, Fadil Oenzil, Delmi Sulastri

“…Obesity is strongly related to risk increase of many complications such as hypertension. One of the mechanisms that links obesity and hypertension is endhotelial disfunction due to nitric oxide (NO) level decrease. …”
Get full text

Four weeks of slow-paced breathing: a longitudinal, randomized, placebo-controlled study of the autonomic nervous system by Nicolas Bourdillon, Arnaud Rochat, Vanessa Hoop, Grégoire P. Millet

“…Further studies are required to better explore the underlying mechanisms. …”
Get full text

Kinetics of flocculation of kaolinite by chitosan-based flocculants and the floc structure by Ting XIAO, Wenjie ZOU, Kexin YU, Xuqin DUAN, Zhijun ZHANG, Ruijing XU

“…The adsorption morphology of Chi-g-CPAM on the SiO2 chip surface, floc structure, and flocculation mechanism are analyzed. The analysis reveals that long branched chains enhance Chi-g-CPAM’s bridging effect on kaolinite, accelerating settling. …”
Get full text

Asiaticoside Attenuates Chronic Restraint Stress-Induced Hippocampal CA1 Neuronal Ferroptosis via Activating BDNF/Nrf2/GPX4 Signaling Pathway by Zhou A, Feng HY, Fan CN, Wang J, Yuan ZY, Xu GH, Li CF, Huang WF, Yi LT

“…Our research aims to elucidate the potential antidepressant mechanisms of asiaticoside, a bioactive compound known for its neuroprotective and immunomodulatory properties.Methods: The antidepressant-like properties of asiaticoside in a model of chronic restraint stress (CRS)-induced depression in mice, with a particular focus on its interaction with ferroptosis-related pathways.Results: The behavioral results revealed that asiaticoside significantly ameliorated CRS-induced depressive symptoms, as evidenced by increased sucrose preference and reduced immobility time. …”
Get full text

Therapeutic Potential of Social Chatbots in Alleviating Loneliness and Social Anxiety: Quasi-Experimental Mixed Methods Study by Myungsung Kim, Seonmi Lee, Sieun Kim, Jeong-in Heo, Sangil Lee, Yu-Bin Shin, Chul-Hyun Cho, Dooyoung Jung

“…However, the specific effects and mechanisms through which these chatbots influence mental health remain underexplored. …”
Get full text

Damage of Green Synthetic Cement Slurry to Clastic Rock Reservoir by Meng Xu, Xin Tan, Libo Yang, Hanlie Cheng, David Cofell

“…XRD and SEM techniques were used to analyze the damage mechanism of cement slurry filtrate and solid phase particles to the reservoir. …”
Get full text

Intranasal Administration of the Combination of Dextro-Ketamine and Dexmedetomidine for Treatment of Diabetic Neuropathic Pain in Rats by Sudo SZ, Montagnoli TL, Dematté BE, Santos AD, Trachez MM, Gubert F, Mendez-Otero R, Zapata-Sudo G

“…Therefore, it is necessary to identify new therapeutic approaches to improve the quality of life of diabetic patients.Methods: This work evaluated the antinociceptive effect of intranasal administration of the combination of dextro-ketamine (keta), a non-competitive glutamatergic receptor antagonist, and dexmedetomidine (DEX), a selective alpha2-adrenergic agonist, in rats with neuropathic pain induced by streptozotocin-DM.Results: The thermal hyperalgesia and mechanical allodynia observed in DM model are reduced with the intranasal administration of the combination of keta and DEX (200 + 0.10 μg/kg) after 3 days of treatment. …”
Get full text

Theoretical and applied research on hydraulic slit-fracture joint roof control and pressure relief of hard roof in goaf roadway by Yongjiang ZHANG, Fei JI, Tongbin ZHAO, Ke YANG, Wenbin WU, Wangang JIANG

“…In order to improve the rock structure of roof plate, adjust the breaking and transporting law of hard rock layer, and then control the strong mine pressure in the adjacent roadway, this paper analyzes the distribution law of mine pressure in the mine roadway, adopts numerical simulation means to study the distribution of the support pressure in the adjacent roadway under the hard roof plate, investigates the mechanism of the peripheral rock structure transferring loads under the conditions of different roof-cutting parameters, and puts forward a joint method of cutting top plate to remove the pressure by the abrasive jet ultra-high pressure hydraulic cutting - hydraulic fracturing. …”
Get full text

Impact of protein intake from a caloric-restricted diet on liver lipid metabolism in overweight and obese rats of different sexes by Ying Tian, Jiawei Gong, Zhiyan He, Suwen Peng, Yuping Huan, Hongpeng Cao

“…The purpose of this study is to explore the effects and mechanisms of different protein intakes within a calorie-restricted diet on liver lipid metabolism, and to investigate whether these effects exhibit gender differences. …”
Get full text

Exosomes Derived from Apelin-Pretreated Mesenchymal Stem Cells Ameliorate Sepsis-Induced Myocardial Dysfunction by Alleviating Cardiomyocyte Pyroptosis via Delivery of miR-34a-5p by Li T, Zhao Y, Cao Z, Shen Y, Chen J, Huang X, Shao Z, Zeng Y, Chen Q, Yan X, Li X, Zhang Y, Hu B

“…This study aimed to determine whether EXOs sourced from Apelin-pretreated MSCs (Apelin-MSC-EXOs) would have potent cardioprotective effects against SMD and elucidate the underlying mechanisms.Methods: MSC-EXOs and Apelin-MSC-EXOs were isolated and identified. …”
Get full text

Reflections by a member of the Editorial Board by Kevin T. Smith

“…As an active researcher, I see Les/Wood as noteworthy because of the potential breadth of articles reporting on topics from wood mechanical properties to technologies and industrial processing to underlying anatomy and the biological processes that result in wood formation and preservation. …”
Get full text

DEFICIENCY OF DEMOCRACY IN THE EUROPEAN UNION: TO THE CONCEPT AND UNDERSTANDING OF PHENOMENOLOGY by Mykhaylo O. Baymuratov

“…Based on a systematic analysis of this phenomenology, it is concluded that the following features of this phenomenology can be distinguished: a) "democracy deficit" is a phenomenon that is not only inherent but also ordinary for modern democratic regimes (domestic level) or international organizations (international -subregional level) (subjective criterion); b) its characteristic feature is: insufficient level of democratic legitimacy (democratic recognition, recognition by the general population) of their institutions (functional- legitimate criterion); certain inconsistency of activities, mechanisms and procedures within such institutions with modern democratic standards (administrative-normative and procedural criteria). …”
Get full text

Smartphone-Based Intervention Targeting Norms and Risk Perception Among University Students with Unhealthy Alcohol Use: Secondary Mediation Analysis of a Randomized Controlled Tria... by Joseph Studer, John A Cunningham, Elodie Schmutz, Jacques Gaume, Angéline Adam, Jean-Bernard Daeppen, Nicolas Bertholet

“…ConclusionsPerceived drinking norms, but not perceived risks, partially mediated the intervention’s effect on alcohol use, confirming one of its hypothesized mechanisms of action. These findings lend support to using normative feedback interventions to discourage unhealthy alcohol use. …”
Get full text

Identifikasi Jenis Biji Kedelai (Glycine Max L) Menggunakan Gray Level Coocurance Matrix (GLCM) dan K-Means Clustering by Rahmat Robi Waliyansyah

“…Kacang kedelai merupakan tanaman pangan yang dapat diolah dalam berbagai olahan, seperti tempe & tahu. Indonesia mempunyai banyak varietas kedelai, varietas lokal atau impor. …”
Get full text

A novel arterial coupler with non-return snap-fit connection approach optimized arterial end-to-end anastomotic technique: An experimental study by Hong-Bo Guo, Mo-Fei Wang, Ren-Qi Yin, Kang-Kang Zhi

“…Its rationality was preliminarily tested through finite element analysis and related mechanical analysis methods. The isolated arteries were successfully anastomosed with the assistance of QAC in vitro testing, which showed good anti-traction properties. …”
Get full text