Utility of Pulse Oximetry Oxygen Saturation (SpO2) with Incorporation of Positive End-Expiratory Pressure (SpO2∗10/FiO2∗PEEP) for Classification and Prognostication of Patients wit... by Pratibha Todur, Anitha Nileshwar, Souvik Chaudhuri, Nitin Gupta, Srikant Natarajan, Shwethapriya Rao

“…Patients aged 18–80 years on invasive mechanical ventilation (MV) diagnosed with ARDS as defined by the Berlin definition were included. …”
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Safety and tolerability of the M2 muscarinic acetylcholine receptor modulator BAY 2413555 in heart failure with reduced ejection fraction in the REMOTE-HF study by Marat Fudim, Muhammad Shahzeb Khan, Dominik Linz, JoAnn Lindenfeld, Calum MacRae, Nina Kimmeskamp-Kirschbaum, Michaela Meyer, Thomas Mondritzki, Hanna Tinel, Wilfried Dinh, Robert J. Mentz

“…There were promising signs of target engagement, providing grounds for further exploration of the mechanism…”
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D-mannose alleviates chronic periodontitis in rats by regulating the functions of neutrophils by Xue Li, Xueting Chen, Qingyu Zhu, Pengye Zhang, Shunxue Nan, Lei Lv, Shengcai Qi

“…The study aimed to explore the protective effects of D-mannose on chronic periodontitis and determine whether its underlying mechanisms is related to neutrophils. Methods To explore the protective effects of D-mannose on chronic periodontitis, the eight-week-old Sprague Dawley rat model of lipopolysaccharide (LPS)-induced periodontitis was established, followed by D-mannose treatment by oral gavage. …”
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The Effect of Mulching on the Root Growth of Greenhouse Tomatoes Under Different Drip Irrigation Volumes and Its Distribution Model by Jiankun Ge, Yuhao Zhu, Xuewen Gong, Chuqi Yao, Xinyu Wu, Jiale Zhang, Yanbin Li

“…Despite the continuous development of greenhouse cultivation technology, the influence mechanism of covering conditions on the root distribution of greenhouse crops remains unclear, which is emerging as a significant research topic at present. …”
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Microplastic contamination in the gut and gills of commercial marine fish by . Nurhasanah, . Hasrianti, L. Hakim, E. Riani, M.Y. Iswari, M.R. Cordova

“…It is imperative to develop a standardized risk assessment mechanism utilizing advanced tools and methodologies to quantify the levels of microplastics in the environment and living organisms as the study moves forward. …”
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The shifting regulation and competition interface by Max Huffman

“…Their different strengths may also emerge independent of chronology: competition policy is a preferred market oversight mechanism when efficient outcomes are consistent with larger social, political, environmental – etc. – goals. …”
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Exosome‐derived long non‐coding RNA AC010789.1 modified by FTO and hnRNPA2B1 accelerates growth of hair follicle stem cells against androgen alopecia by activating S100A8/Wnt/β‐cat... by Shaojun Chu, Lingling Jia, Yulong Li, Jiachao Xiong, Yulin Sun, Qin Zhou, Dexiang Du, Zihan Li, Xin Huang, Hua Jiang, Baojin Wu, Yufei Li

“…However, the molecular mechanism of HFSCs against AGA remains elusive. Methods The expression and prognosis of lncRNA AC010789.1 in AGA hair follicle tissues were assessed by qRT‐PCR analysis. …”
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Growth performance of neonatal Holstein heifers fed acidified waste milk containing essential oil blend and encapsulated butyrate alone or in combination by Ting Liu, Zhihao Luo, Peng Li, Shuru Cheng, Jianping Zhu, David.P. Casper

“…The possibility exists that these technologies may be additive based on their individual mechanisms of action. The study objective was to evaluate EO and C4 alone or in combination when fed to Holstein heifers raised on a commercial Chinese dairy operation. …”
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Effect of miR-144-3p-Targeted Regulation of PTEN on Proliferation, Apoptosis, and Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells under Stretch by Shiyong Ling, Xi Luo, Bo Lv, Hua Wang, Mengzhi Xie, Kai Huang, Jingchuan Sun

“…The BMSCs were then continuously stimulated for 24 h using a Flexercell in vitro cellular mechanics loading device, applying a draft force at a frequency of 1 Hz and a deformation rate of 18%. …”
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Ekspresi Gen Family Bcl-2 dan Ekspresi Gen Protein Kanal Ion Vdac1 pada Oligozoospermia by Arni Amir

“…Pada penelitian ini dapat disimpulkan bahwa overekspresi VDAC dan BAC berkaitan dengan kejadian oligozoospermia<br />Kata kunci: Oligozoospermia, VDAC, Bax, Bcl-2, ekspresi gen</p><p>Abstract<br />One form of infertility in men is the number of spermatozoa which is less than normal (Oligozoospermia). Various mechanisms though have a role in the occurrence of oligozoospermia, it can be from physical factors, stress, food and molecular.This research is a molecular study of gen expression, Bax, Bcl2 and VDAC influence of the oligozoospermia’s occurrence.The research is conducted on 40 samples of oligozoospermia and as a control is normozoospermia class with a lot of number. …”
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Treatment of autonomous intestinal neuropathy in critical care by prucalopride and multistrain probiotic by A. L. Kovaleva, A. I. Ulyanin, O. Yu. Kiselyova, Ye. A. Poluektova, O. S. Shifrin, A. S. Tertychny, V. T. Ivashkin

“…The most likely cause for development of ileus in this case is development of autonomous intestinal neuropathy associated to severe intoxication. Basic mechanisms for development of autonomous intestinal neuropathy are discussed: suppression of smooth muscular contractility by C. difficile toxins A and B (in the first of presented cases) and combined autoimmune neuronal damage by immune cells due to expression of proteins by neoplastic cells (in the second case). …”
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Comparison of Clinical Characteristics and Mortality Outcome in Critical COVID-19 Patients Infected with Alpha and Omicron Variants by Cheng HI, Chang KW, Wu BC, Teo MY, Hung WS, Wu HM, Huang ACC, Lin CW, Lin TY, Lin HC, Chiu CH, Lin SM

“…Critically ill patients who had confirmed SARS-CoV-2 infection and were on mechanical ventilation (MV) were enrolled. Demographic data, laboratory results, and treatment information were collected and analyzed. …”
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Six MicroRNA Prognostic Models for Overall Survival of Lung Adenocarcinoma by Juan Li, Xuyu Gu, Chanchan Gao, Jun Zhang

“…To gain a deeper understanding of the underlying mechanism behind the model, the two most important miRNAs in the model, miR-195-3p and miR-5571-5p, were selected for HPA database validation and ceRNA network construction. …”
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Comprehensive Analysis of m5C RNA Methylation Regulator Genes in Clear Cell Renal Cell Carcinoma by Jiajin Wu, Chao Hou, Yuhao Wang, Zhongyuan Wang, Pu Li, Zengjun Wang

“…However, the function and mechanism of m5C RNA methylation regulators in clear cell renal cell carcinoma (ccRCC) remains undiscovered. …”
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Positively charged polysilsesquioxane/iodide lonic liquid as a quasi solid-state redox electrolyte for dye-sensitized photo electrochemical cells: infrared, <mml:math alttext="$^{{...

“…The addition of iodine increased the specific conductivity of the hydrolyzed and nonhydrolyzed MTMSPI<mml:math alttext="$^+I^-$"> <mml:mrow> <mml:msup> <mml:mi></mml:mi> <mml:mtext>+</mml:mtext> </mml:msup> <mml:msup> <mml:mtext>I</mml:mtext> <mml:mo>&#x2212;</mml:mo> </mml:msup> </mml:mrow> </mml:math>, which we attributed to the formation of triiodide ions contributed to the conductivity via the Grotthus mechanism. DSPEC cells based on a titania-dye system with MTMSPI<mml:math alttext="$^+I^-$"> <mml:mrow> <mml:msup> <mml:mi></mml:mi> <mml:mtext>+</mml:mtext> </mml:msup> <mml:msup> <mml:mtext>I</mml:mtext> <mml:mo>&#x2212;</mml:mo> </mml:msup> </mml:mrow> </mml:math> electrolyte containing iodine (0.1 M) reached an overall efficiency between 3.3&#8211;3.7%.…”
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Clinical outcome changes in sarcopenic obesity: a meta-analysis of exercise training methods by Lei Chen, Haojing Zhou, Yichen Gong, Yi Tang, Hai Su, Zhongyi Zhang, Peijian Tong, Guoqian Chen

“…This underscores the clinical significance of exercise intervention in treating muscle-reducing obesity, suggesting future studies explore exercise intervention’s role and mechanism, particularly related to IGF-1, IL-6, and other cytokines.…”
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Pola Infeksi Oportunistik yang Menyebabkan Kematian pada Penyandang AIDS di RS Dr. M. Djamil Padang Tahun 2010-2012 by Aghnia Jolanda Putri, Eryati Darwin, Efrida .

“…Septic shock is the leading mechanism of cause of death among all.<br />Keywords: opportunistic infections, AIDS, death</p>…”
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The Multifaceted Roles of Myrrha in the Treatment of Breast Cancer: Potential Therapeutic Targets and Promises by Anwar Shams MD, MSc, PhD, Abdullah Ahmed Alzahrani, Taghreed A Ayash MSc, PhD, Shadi Tamur MD, FRCPC, FAAP, Majed AL-Mourgi MD, FRCS, FCCP, FACS

“…Nonetheless, myrrh’s precise rudimentary mechanisms of action in regulating genes involved in breast cancer evolution and progression remain elusive. …”
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Hyaluronic Acid-Based Hybrid Nanoparticles as Promising Carriers for the Intranasal Administration of Dimethyl Fumarate by Serri C, Piccioni M, Guarino V, Santonicola P, Cruz-Maya I, Crispi S, Di Cagno MP, Ferraro L, Dalpiaz A, Botti G, Giunchedi P, Rassu G, Gavini E

“…Lipid-polymer hybrid nanoparticles (LPNs) were developed to improve DMF stability, limiting gastrointestinal side effects and increasing brain bioavailability by nose-to-brain targeting application.Methods: DMF-loaded and unloaded LPNs with or without hyaluronic acid (HA) were prepared using the nanoprecipitation via magnetic/mechanical stirring technique. Particle morphology and surface properties were evaluated; drug content, viscosity, and mucoadhesion were determined. …”
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New Insights into the Role of Inflammatory Pathways and Immune Cell Infiltration in Sleep Deprivation-Induced Atrial Fibrillation: An Integrated Bioinformatics and Experimental Stu... by Liang J, Tang B, Shen J, Rejiepu M, Guo Y, Wang X, Shao S, Guo F, Wang Q, Zhang L

“…Analyses focusing on functional enrichment, such as Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), were conducted to pinpoint crucial biological mechanisms and pathways. Furthermore, we utilized immunofluorescence and Western blot techniques to evaluate YBX1 expression and its role in activating NLRP3 inflammasomes in a rat model induced by SD.Results: A total of 540 common DEGs were precisely identified between the AF and SD data collections. …”
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