Assessment of Convergence Angle of Tooth Preparations for Complete Crowns Among Dental Students: Typodont vs Simulator by Meriem Amine, Hafsa Oumayma Wahid, Saliha Fahi, Safaa Lehmouddi, Mouna Hamza, Samira Elarabi

“…Retention is one of the mechanical fundamental principles of preparation of cemented fixed prostheses. …”
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Anticancer Activity of Asiatic Acid from Centella Asiatica: A Comprehensive Systematic Review of In Vitro and In Vivo Studies by Fiki Muhammad Ridho, Panggih Fahrudin, Andika Julyanto Syachputra, Iren Angelia Aruan, Kamailiya Ulfah, Alfi Syahri

“…Based on the findings in the reviewed articles, we report that AsA, a triterpene derived from C. asiatica, exhibits anticancer effects demonstrated both in various cancer cell lines and in cancer cell-induced animal model, through several mechanisms, including anti-inflammatory effects, antioxidant effects, inhibition of cell proliferation, inhibition of invasion and migration, and induction of apoptosis and autophagy. …”
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The two-component system ArlRS is essential for wall teichoic acid glycoswitching in Staphylococcus aureus by Marieke M. Kuijk, Emma Tusveld, Esther Lehmann, Rob van Dalen, Iñigo Lasa, Hanne Ingmer, Yvonne Pannekoek, Nina M. van Sorge

“…To identify regulatory mechanisms underlying WTA glycoswitching, we screened 1,920 S. aureus mutants (Nebraska Transposon Mutant Library) by immunoblotting for differential expression of WTA-linked α1,4- or β1,4-GlcNAc using specific monoclonal antibody Fab fragments. …”
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Loss of histone H3K27me3 up-regulates SLC7A11 in diffuse gastric cancer cells by REN Yuanfeng, LIU Wenkang, CHU Zhaole

“…Objective‍　‍To map the genome-wide distribution profile of histone H3K27me3 modification in diffuse gastric cancer tissues， identify target genes regulated by H3K27me3， and primarily explore the potential mechanism of its modification reprogramming in the occurrence and development of the tumor. …”
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Rhein Mitigates Lung Injury in Severe Acute Pancreatitis Through the Inhibition of MARK4-Mediated Microtubule Destabilization by Sun Z, Liu J, Ge P, Cao Y, Liu J, Wen H, Luo X, Pei B, Jin Z, Li H, Xun L, Luo Y, Yang Q, Chen H

“…Zhenxuan Sun,1– 3,* Jie Liu,1– 3,* Peng Ge,1– 3,* Yinan Cao,4 Jin Liu,1– 3 Haiyun Wen,1– 3 Xinyu Luo,1– 3 Boliang Pei,1– 3 Zuocang Jin,1,3 Huijuan Li,3 Lu Xun,1– 3 Yalan Luo,5 Qi Yang,6 Hailong Chen1– 3 1Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 2Institute (College) of Integrative Medicine, Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 3Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 4Day Surgery Center, Dalian Municipal Central Hospital, Dalian, Liaoning, 116033, People’s Republic of China; 5Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 6Department of Traditional Chinese Medicine, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116023, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hailong Chen, Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Zhongshan Road 222, Dalian, Liaoning, 116011, People’s Republic of China, Tel +86 411 83635963, Fax +86 411 83622844, Email chenhailong@dmu.edu.cnPurpose: Explore the therapeutic effect and molecular mechanism of rhein on severe acute pancreatitis associated acute lung injury (SAP-ALI).Methods: The SAP-ALI rat model was constructed by retrograde injection of 5% sodium taurocholate into the pancreaticobiliary duct, and pulmonary microvascular endothelial cell (PMVEC) injury model was induced by LPS. …”
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ŽINOJIMO SOCIALUMO PROBLEMA ŠIUOLAIKINĖJE SOCIALINĖJE EPISTEMOLOGIJOJE: DU POŽIŪRIAI by Audronė Rimkutė

“…In other words, his knowing agent is an individual “cognitive mechanism”, and only his received “input” is social. …”
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Remote Continuous Microinjury-Triggered Cytokines Facilitate Severe Diabetic Foot Ulcer Healing via the Ras/Raf/MEK/ERK Pathway by Huang X, Liu J, Wu X, Mo Y, Luo X, Yang Y, Yang C, Liang X, Liang R, Chen Y, Fan Z, Lu W, Chen Y, Hua Q

“…However, the underlying mechanism remains largely unknown.Methods: We divided 72 Sprague-Dawley rats with DFUs into the control, sham, and TTT groups. …”
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Modulation of Acupuncture at Quchi (LI 11) and Waiguan (SJ 5) acupoints on LTP-like Plasticity by Qianqian SUN, Guo YU, Huitian ZHANG, Xiaokuo HE

“…Fix the coil, Once the optimal scalp site was found, the coil was securely fixed in place by an appropriate mechanical device. We used three laser pens to locate and mark with a soft-tipped pen to assure a constant placement of the coil throughout the session.②Detection of resting motor threshold (rMT): The response resting motor threshold (rMT) was defined as the stimulus intensity at which 5/10 consecutive single stimuli at the optimal sclap site evoked a MEP of at least 50 μV amplitude in the relaxed muscle.③Investigate the short-latency somatosensory-evoked potentials (SLSEP): Monophasic electrical stimulation adjusted to produce visible thumb twitch was delivered at points overlying the ulnar nerve at the right of FDI, through a bipolar electrode (cathode proximal) with intensity 5-10 mA.④Brain plasticity induced by PAS-LTP: The LTP-like plasticity induced by paired associative stimulation (PAS) consisted of 200 stimulus pairs of electrical stimulation followed by TMS. …”
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GPR87 promotes invasion and migration through the RHO/ROCK pathway in non-small cell lung cancer by LIU Chenxi, HAN Lin, YANG Yi, ZHOU Han, LIU Yayun, SHENG Deqiao

“…Objective·To explore the role and molecular mechanism of GPR87 in regulating the invasion and migration of non-small cell lung cancer (NSCLC).Methods·Bioinformatics methods, including GEO, UALCAN, KM Plotter and other public database analysis platforms, were used to screen candidate genes related to NSCLC invasion and predict their clinical relevance to NSCLC. …”
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Effect of Auditory Recognition on the Vocabulary Knowledge of Children with Functional Articulation Disorder by YAN Jiajian, WANG Chengdong, LU Jianliang, LI Yuchang, SHEN Longbin, OU Jianlin, CHEN Zhuoming

“…ObjectiveTo Observe the impact of auditory recognition function on vocabulary knowledge in children with functional articulation disorder (FAD) and to explore the mechanism of working memory (mainly auditory working memory and visual working memory) in the relationship between the two.MethodsA total of 113 children with FAD who were treated at the Rehabilitation Center of the First Affiliated Hospital of Jinan University from November 2019 to January 2022 were selected, with 2 cases dropped out. …”
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AiGPro: a multi-tasks model for profiling of GPCRs for agonist and antagonist by Rahul Brahma, Sunghyun Moon, Jae-Min Shin, Kwang-Hwi Cho

“…Leveraging multi-scale context aggregation and bidirectional multi-head cross-attention mechanisms, our approach demonstrates that ensemble models may not be necessary for predicting complex GPCR states and small molecule interactions. …”
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"INCREASING THE WELFARE OF THE "WORKING POOR" IN THE REPUBLIC OF MOLDOVA", CHALLENGES, CONSEQUENCES, SOLUTIONS by Dorin VACULOVSCHI

“…There is a strong decrease in occupational indicators, and a degradation of the human potential in the Republic of Moldova, thus undermining the functioning mechanism of the national economy for a longer perspective. …”
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Progress of research on aviation kerosene preparation using bioethanol by Pan LI, Yu ZHAO, Xingguo WU, Lulu ZHANG, Junhao HU, Wei CHEN, Jing BAI, Chun CHANG, Shuqi FANG

“…This study introduces the carbon–carbon coupling of ethanol and hydrodeoxidation for the production of aviation kerosene, including discussions on reaction mechanisms and catalysts for the preparation of high-carbon alcohol. …”
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Early embryonic developmental toxicity of TPhP and CDP: Roles of PPARγ by Jing HUANG, Yunuo ZHAI, Boyang LI, Jing JI, Chuanhai LI, Shixin LIU, Yiman LIU, Junhua YUAN, Qixiao JIANG

“…It is necessary to elucidate these developmental toxicological effects and underlying mechanisms to improve risk assessments and better protect sensitive populations. …”
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Efficacy and Safety of Recombinant Human Thrombopoietin (rhTPO) on Coagulation Function and Inflammatory Factors in the Treatment of Patients with Sepsis-Related Thrombocytopenia by Huijuan Wang MD, Dong Chen MD, Ming He MD

“…No significant differences were found between the groups in terms of mechanical ventilation time, intensive care unit (ICU) length of stay, and total hospital stay ( P  > 0.05). …”
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LGR4 is essential for maintaining β-cell homeostasis through suppression of RANK by Joanna Filipowska, Zelda Cisneros, Sneha S. Varghese, Nancy Leon-Rivera, Peng Wang, Randy Kang, Geming Lu, Yate-Ching Yuan, Hung-Ping Shih, Supriyo Bhattacharya, Sangeeta Dhawan, Adolfo Garcia-Ocaña, Nagesha Guthalu Kondegowda, Rupangi C. Vasavada

“…To determine the role of LGR4 we employed in vitro Lgr4 loss and gain of function in primary rodent and human β-cells and examined its mechanism of action in the rodent INS1 cell line. Using Lgr4fl/fl and Lgr4fl/fl/Rankfl/fl × Ins1-Cre mice we generated β-cell-specific conditional knockout (cko) mice to test the role of LGR4 and its interaction with RANK in vivo under basal and stress-induced conditions. …”
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Subtyping Social Determinants of Health in the "All of Us" Program: Network Analysis and Visualization Study by Suresh K Bhavnani, Weibin Zhang, Daniel Bao, Mukaila Raji, Veronica Ajewole, Rodney Hunter, Yong-Fang Kuo, Susanne Schmidt, Monique R Pappadis, Elise Smith, Alex Bokov, Timothy Reistetter, Shyam Visweswaran, Brian Downer

“…Finally, the expert panel inferred the subtype labels, potential mechanisms, and targeted interventions. …”
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Evaluation of Machine Learning Algorithms for Classification of Visual Stimulation-Induced EEG Signals in 2D and 3D VR Videos by Mingliang Zuo, Xiaoyu Chen, Li Sui

“…By analyzing EEG signals, researchers can explore the neural mechanisms underlying cognitive and emotional responses to VR stimuli. …”
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Lower incidence of hepatocellular carcinoma with tenofovir alafenamide in chronic hepatitis B: Evidence from a large-scale cohort by Hye-Jin Yoo, Jae-Young Kim, Jeong-Ju Yoo, Hye Won Lee, Sang Gyune Kim, Young Seok Kim

“…From a practical perspective, these findings can guide physicians in prescribing more effective treatments, assist researchers in designing further studies to explore the mechanisms behind the effectiveness of TAF, and inform policymakers to craft healthcare policies that optimize patient outcomes while considering potential limitations, such as the observational nature of the study and residual confounding factors.…”
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Cross-sectional Study of EMG and EMG Rise During Fast and Slow Hamstring Exercises by Kasper Krommes, Markus Due Jakobsen, Thomas Bandholm, Lars Louis Andersen, Mette Zebis, Anthony Shield, Per Hölmich, Kristian Thorborg

“… # Conclusion The Nordic Hamstring displayed the highest level muscle activity and most explosive recruitment characteristics with early and high rate of electromyographic rise, compared to even high velocity exercises, thus providing a possible mechanism by which it may increase performance and reduce injuries…”
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