Elucidating the Role of HIF-1α/YAP Signaling Pathway in Regulating Inflammation in Human Periodontal Stem Cells: An in vitro Study by Zhao HW, Liu ST, Wang XJ, Zhang XM, Ma X

“…Hui-Wei Zhao,1 Shu-Tai Liu,2 Xiang-Jin Wang,1 Xue-Mei Zhang,1 Xiang Ma1 1Department of Periodontology, The Affiliated Yantai Stomatological Hospital, Binzhou Medical University, Yantai, 264000, People’s Republic of China; 2Department of Periodontology, Shenzhen Stomatology Hospital, Shenzhen, 518000, People’s Republic of ChinaCorrespondence: Xiang Ma, Department of Periodontology, The Affiliated Yantai Stomatological Hospital, Binzhou Medical University, 148 North Road, YanTai, People’s Republic of China, Email MaXiang900218@163.comBackground and Objective: Periodontitis is a chronic inflammatory disease caused by dental plaque accumulation, leading to damage of periodontal tissues and potential tooth loss. Understanding the mechanisms of periodontitis, particularly the role of hypoxia in inflammation, is critical for identifying novel therapeutic strategies. …”
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Breeding and genetic aspects of creating productive forms of fast-developing spring bread wheat by B. V. Rigin, E. V. Zuev, V. A. Tyunin, E. R. Shreyder, Z. S. Pyzhenkova, I. I. Matvienko

“…The present work was aimed at analyzing special features of genetic and physiological mechanisms of early maturity in spring wheat (Triticum aestivum L.) and at determining possibilities of creating recombinants with high development rate and plant productivity.Materials and methods. …”
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MSC-exosomes pretreated by Danshensu extracts pretreating to target the hsa-miR-27a-5p and STAT3-SHANK2 to enhanced antifibrotic therapy by Jiabin Liang, Jingxiu Zhao, Lin Yang, Qian Wang, Jing Liao, Jianhao Li, Weizhao Zhuang, Fanghong Li, Jinxian He, Yukuan Tang, Hanwei Chen, Chen Huang

“…The identification of the hsa-miR-27a-5p_R-1-STAT3-SHANK2 axis may reveal new molecular mechanisms underlying fibrosis, further research is needed to fully elucidate its impact on PF. …”
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Research on Material Design of Medical Products for Elderly Families Based on Artificial Intelligence by Jinjin Rong, Xu Ji, Xin Fang, Moon-Hwan Jee

“…In such cases, it could help in expecting and, subsequently, forestalling any conceivable hypertension or unpredictable heart rate. Essentially, mechanical ‘pets’ are likewise assisting with fighting off feelings of loneliness, while additionally assisting with upgrading patient consideration simultaneously. …”
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The Prognostic Value and Overexpression of Cyclin A Is Correlated with Gene Amplification of both Cyclin A and Cyclin E in Breast Cancer Patient by A. Husdal, G. Bukholm, I. R. K. Bukholm

“…In this study we wanted to evaluate the mechanisms behinde overexpression of cyclin A, as well as the impact of other cyclins, both at the gene level and at the protein level, on prognosis of breast cancer patients. …”
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Combination Fractional Carbon Dioxide Laser Treatment and Bone Marrow Mesenchymal Stem Cell Therapy Enhances the Treatment of Skin Photoaging in a Murine Model System by Li L, He Z, Yu C, Zhang C, Yu Y, Li Y, Xu X

“…Li Li,1– 3,* Zeyu He,3– 5,* Chengqian Yu,3– 5 Chao Zhang,3– 5 Yanqiu Yu,6 Yuanhong Li,3– 5 Xuegang Xu3– 5 1ShanXi Medical University, Taiyuan, People’s Republic of China; 2Department of Dermatology, The First Hospital of ShanXi Medical University, Taiyuan, 030001, People’s Republic of China; 3Department of Dermatology, The First Hospital of China Medical University, Shenyang, 030001, People’s Republic of China; 4Key Laboratory of Immunodermatology (China Medical University), Ministry of Education, Shenyang, 110001, People’s Republic of China; 5NHC Key Laboratory of Immunodermatology (China Medical University), Shenyang, 110001, People’s Republic of China; 6Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, 110122, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xuegang Xu, Department of Dermatology, The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning Province, 110001, People’s Republic of China, Email xuxuegang2749290@163.com Li Li, Department of Dermatology, The First Hospital of ShanXi Medical University, No. 85 South Jiefang Road, Yingze District, Taiyuan, Shanxi Province, 030001, People’s Republic of China, Email lilizaimu0807@163.comBackground: Fractional carbon dioxide lasers and bone marrow mesenchymal stem cells (BMSCs) are commonly employed in the treatment of skin photoaging.Objective: This study was developed to explore the effects of combination carbon dioxide laser treatment and BMSC injection on skin photoaging and the underlying molecular mechanisms.Methods & Materials: In total, 24 mice with experimentally photoaged skin were separated into control, carbon dioxide fractional laser treatment, combination therapy, and BMSC injection groups. …”
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Factors Affecting Negative Symptoms in Schizophrenia and Their Relationship with Anxiety and Depression by Zeng G, Liang R, Xiao L, Cao W, Zhou W, Wang W, Liu C, Zhou H, Shi X, Chen B, Chen W

“…Meanwhile, these symptoms are closely linked to anxiety and depression, further complicating prognosis. The mechanisms underlying these relationships remain unclear. …”
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Specifically blocking αvβ8-mediated TGF-β signaling to reverse immunosuppression by modulating macrophage polarization by Cuicui Guo, Hui Sun, Yulei Du, Xiaodong Dai, Yu Pang, Zhen Han, Xinhui Xiong, Shaowei Li, Junhua Zhang, Qingbing Zheng, Xun Gui

“…Nevertheless, the expression profile of αvβ8 remains a subject of debate, and the precise mechanisms underlying the anti-tumor effects of anti-αvβ8 antibodies are not yet fully elucidated. …”
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TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles by Dorival Mendes Rodrigues-Junior, Chrysoula Tsirigoti, Konstantina Psatha, Dimitris Kletsas, Michalis Aivaliotis, Carl-Henrik Heldin, Aristidis Moustakas

“…Conclusion Hence, we delineated a novel signaling cascade that leads to high rates of EV generation by cancer cells in response to TGF-β, with cholesterol being a key intermediate step in this mechanism. Graphical Abstract • TGF-β increases EV release by activating a MEK-ERK1/2-SREBP2-DHCR7 signaling and transcriptional pathway. • TGF-β-induced DHCR7 expression raises cholesterol abundance that promotes EV release. • EVs carry surface latent TGF-β and MMP9 that can activate TGF-β receptor signaling on the surface of recipient cells.…”
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Chemical Composition and Larvicidal Activity of Flower Extracts from Clitoria ternatea against Aedes (Diptera: Culicidae) by Darvin R. Ravindran, Madhuri Bharathithasan, Patmani Ramaiah, Mohd Sukhairi Mat Rasat, Dinesh Rajendran, Shakila Srikumar, Intan H. Ishak, Abd Rahman Said, Rajiv Ravi, Mohamad Faiz Mohd Amin

“…Hence, the major focus of this study is to identify the larvicidal mechanisms, metabolite, antioxidants, and chemical compounds and elucidate their structures from C. ternatea flower and to test their efficacies against early 4th instar larvae of Aedes aegypti and Aedes albopictus. …”
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Whole-genome resequencing landscape of adaptive evolution in Relict gull (Larus relictus) by Chao Yang, Qingxiong Wang, Kuo Sun, Lei Luo, Hao Yuan, Xuejuan Li, Yuan Huang, Hong Xiao

“…The findings identified several genes associated with the correlated changed life-history traits of L. relictus, including BMP4 involved in beak adaptation; HAND2, NEUROG1, COL11A2, and EDNRB involved in the evolution of the palate, soft palate, and tongue; PIGR and PLCB2 involved in an enhanced response to bitter taste by sensing chemical secretions released by staple food substrate insects to activate protective mechanisms. Furthermore, thirty-four genes related to sperm development and activity, including KLHL10 and TEKT3, were identified in the expanded gene family. …”
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29 m6A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 Transcriptomic Dataset... by Ming Liu, Keman Xu, Fatma Saaoud, Ying Shao, Ruijing Zhang, Yifan Lu, Yu Sun, Charles Drummer, Li Li, Sheng Wu, Satya P. Kunapuli, Gerard J. Criner, Jianxin Sun, Huimin Shan, Xiaohua Jiang, Hong Wang, Xiaofeng Yang

“…Our findings shed new light on the functions of upregulated m6A-RMRs in 41 diseases and cancers, nine cellular and molecular mechanisms, novel therapeutic targets for inflammatory disorders, metabolic cardiovascular diseases, autoimmune diseases, organ failures, and cancers.…”
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Effect of L-Citrulline on Creatine Kinase MM (CK-MM) Isoenzymes in Mice: An In Vivo Study Focusing on Immunohistochemistry Analysis by Dhoni Akbar Ghozali, Annisa Aghnia Rahma, Shafira Nur Hanifa, Muhana Fawwazy Ilyas

“…This study contributes valuable insights into the multifaceted benefits of L-citrulline supplementation for supporting overall muscle health and performance by identifying its protective effects under different mechanisms, including improved blood flow, antioxidant activity, enhanced mitochondrial function, and promotion of muscle protein synthesis.   …”
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Innovative Model of Socio-Professional Development of a Student’s Personality by E. F. Zeer, V. S. Tretyakova, M. V. Zinnatova

“…The content of each module is focused on the final result of educational activity: professional, diagnostic, competence, technological, functional. The mechanism of the model implementation is to build an individual student professional perspective aimed at practical action in order to improve the level of qualification, ability to work, enrichment of professional and personal qualities and behavioural patterns.Scientific novelty of the present research consists in the formation of interdisciplinary scientific knowledge (at the intersection of psychology, pedagogy, philosophy, occupational studies) on the methodology of the modelling, organisation and content of professional education taking into account modern challenges and demands of the digital economy. …”
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Performance of sewage sludge reuse in the manufacturing of fired bricks by K. Moulato, M. Ammari, L. Ben Allal

“…This paper studies the physicochemical, geotechnical, mineralogical, mechanical, and environmental characterizations of earth bricks with the objective of evaluating the performance of the sewage sludge and eventually studying its consistency with natural clay to produce brick samples. …”
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4-Octyl itaconate inhibits synovitis in the mouse model of post-traumatic osteoarthritis and alleviates pain by Yu-Zhen Tang, Wan Chen, Bao-Yun Xu, Gang He, Xiu-Cheng Fan, Kang-Lai Tang

“…Finally, we utilized network pharmacology analysis to predict the mechanism of 4-OI in treating PTOA synovitis and conducted preliminary validation. …”
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Effects of combining sensory-motor exercises with transcranial direct current stimulation on cortical processing and clinical symptoms in patients with lumbosacral radiculopathy: A... by Soheila Qanbari, Roya Khanmohammadi, Gholamreza Olyaei, Zohreh Hosseini, Hanie Sadat Hejazi

“…This combined approach aligns with the neurophysiological mechanisms underlying CLBP and may target the neuroplastic changes induced by low back pain. …”
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Rock breaking regularity of layered rock mass blasting under the influence of different resistance lines by Jianxin YU, Pengzhan MENG, Xin ZHANG, Zhenzhen LI

“…The research results contribute to a deeper understanding of the mechanism of layered rock blasting in underground engineering.…”
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FGF21 and APOA1 mRNA-based therapies for the treatment of experimental acute pancreatitis by Amaya Lopez-Pascual, Eva Santamaria, Nuria Ardaiz, Iker Uriarte, Tiffany Palmer, Anne-Renee Graham, Celia Gomar, Roberto C. Barbero, M. Ujue Latasa, Maria Arechederra, Jesus M. Urman, Carmen Berasain, Antonio Fontanellas, Carlos L. del Rio, Maite G. Fernandez-Barrena, Paolo G.V. Martini, Joshua R. Schultz, Pedro Berraondo, Matias A. Avila

“…Further research is warranted to elucidate the mechanisms underlying their therapeutic efficacy and optimize treatment regimens for clinical translation.…”
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Unveiling Cuproptosis-Driven Molecular Clusters and Immune Dysregulation in Ankylosing Spondylitis by Wei B, Wang S, Li S, Gu Q, Yue Q, Tang Z, Zhang J, Liu W

“…Cuproptosis is a newly recognized copper-induced cell death mechanism. Our study explored the novel role of cuproptosis-related genes (CRGs) in AS, focusing on immune cell infiltration and molecular clustering.Methods: By analyzing the peripheral blood gene expression datasets obtained from GSE73754, GSE25101, and GSE11886, we identified the expression patterns of cellular factors and immune infiltration cell related to cuproptosis. …”
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