Identification of the Granule-Bound Starch Synthase (GBSS) Genes Involved in Amylose Biosynthesis in Tartary Buckwheat (<i>Fagopyrum tataricum</i> (L.) Gaertn.) by Juan Huang, Fei Liu, Jieqiong Zhang, Bin Tang, Jiao Deng, Taoxiong Shi, Liwei Zhu, Hongyou Li, Qingfu Chen

“…Overall, this research not only deepens our understanding of the molecular mechanisms of amylose synthesis in Tartary buckwheat, but also provides scientific insights for enhancing crop amylose content and quality through molecular breeding.…”
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Biomechanical Performance of Mandibular Molars with Deep Mesio-Occlusal-Distal Cavities Rehabilitated with Horizontal Posts: A 3D Finite Element Analysis by Sonali Sharma, Sindhu Ramesh, Jasmine Rayapudi

“…Based on the evidence-based scientific data and on the mechanical properties of materials, i.e., Young’s modulus and Poisson ratio, the model of a mandible and mandibular first molar was replicated. …”
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Value Propositions for Digital Shared Medication Plans to Boost Patient–Health Care Professional Partnerships: Co-Design Study by Benjamin Bugnon, Francesca Bosisio, Alain Kaufmann, Pascal Bonnabry, Antoine Geissbuhler, Christian von Plessen

“…A qualitative, participatory methodology was used to iteratively explore collaborative medication management experiences and identify barriers and enabling mechanisms, including technology. We conducted a thematic analysis of participant interviews to develop value propositions for digital SMPs. …”
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Exploring the Effects of Sleep Deprivation on Physical Performance: An EEG Study in the Context of High-Intensity Endurance by Shanguang Zhao, Majed M. Alhumaid, Hai Li, Xin Wei, Steve SHYH-Ching Chen, Hongke Jiang, Yuwu Gong, Yun Gu, Haiquan Qin

“…Abstract Background While the effects of sleep deprivation on cognitive function are well-documented, its impact on high-intensity endurance performance and underlying neural mechanisms remains underexplored, especially in the context of search and rescue operations where both physical and mental performance are essential. …”
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New pneumococcal serotype 20C is a WciG O-acetyltransferase deficient variant of canonical serotype 20B by Jigui Yu, Neil Ravenscroft, Peter Davey, Roshan Liyanage, Oliver Lorenz, Michelle M. Kuttel, Stephanie W. Lo, Feroze A. Ganaie, Moon H. Nahm

“…Pneumococci may evade host or vaccine-induced immunity as a result of variation in capsule structure mediated via multiple mechanisms, such as the loss or gain of O-acetylation. …”
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The Role of Mature Brain-Derived Neurotrophic Factor and Its Precursor in Predicting Early-Onset Insomnia in Stroke Patients Experiencing Early Neurological Deterioration by Shi G, Yu P, Wang Z, Xu M, Guo M, Wang X, Zhou R

“…Brain-derived neurotrophic factor (mBDNF) and its precursor, proBDNF, play essential roles in neuroplasticity and may be involved in the pathophysiological mechanisms underlying EOI. This study aimed to investigate the associations of serum mBDNF, proBDNF, and the mBDNF/proBDNF ratio with EOI in stroke patients experiencing END.Methods: In a prospective cohort study from October 2021 to December 2023, 232 stroke patients with END and 56 healthy controls (HCs) were enrolled. …”
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Serological Evidence of Hepatitis B and E and Dengue Coinfection in Chadian Patients and Impact on Lipidemia Profile by Alexandre Kanga Djasrabe, Borris Rosnay Tietcheu Galani, Moussa Mahamat Ali, Fissou Henry Yandai, Bessimbaye Nadlaou, Mayann Habkreo, Nicolas Yanou Njintang

“…Further research is required to elucidate the mechanism of action.…”
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Awake prone positioning and ventilation distribution as assessed by electric impedance tomography in patients with non-COVID-19 acute hypoxemic respiratory failure: A prospective p... by Jingjing Wang, Changxing Chen, Zhanqi Zhao, Puyu Deng, Chenchen Zhang, Yu Zhang, Hui Lv, Daonan Chen, Hui Xie, Ruilan Wang

“…However, its physiological mechanism remains unclear. In this study, we evaluated the effect of APP on lung ventilation in patients with moderate-to-severe AHRF to better understand the effects on ventilation distribution and to prevent intubation in non-intubated patients. …”
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Effect of Acupuncture at ST36 on Signal Transduction Pathways of BDNF-CREB in Dentate Gyrus of Telomerase Knockout Mice by Xiaoting YANG, Shiyi QI, Shen LIN, Dong LIN

“…Objective:To explore the effect of acupuncture on BDNF-CREB related signaling pathway in hippocampal dentate gyrus of Telomerase knockout mice (Terc-/-mice) and its neuro protective mechanism, in order to promote hippocampal neurogenesis, delay aging, improve learn cognitive skills, and provide possible pathways and experimental evidence.Methods:The phenotype was identified by polymerase chain reaction, and eighteen telomerase knockout mice with a length of 350 bp were selected, weighing (20±5) g. …”
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The Role of Prosocial (Politicized) Identity and Prejudice in Collective Action Intentions to Help Women and Men Suffered from Domestic Violence by O.A. Ananyeva, I.S. Prusova

“…A study of predictors of willingness to participate in collective action to help domestic violence survivors will help to clarify psychological mechanisms and barriers to the realisation of the prosocial potential of Russians, as well as develop recommendations for social campaigns aimed at helping violence survivors. …”
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High-fat diet-induced liver injury in Channa argus through lipid metabolism, anti-oxidative status, apoptosis, and inflammation by Jiaxin Tian, Ying Li, Jiwu Wan, Zhinan Yang, Guiqin Wang

“…Channa argus, a valuable fish species in southern Chinese aquaculture, is susceptible to fatty liver disease. To investigate the mechanism of liver injury in C. argus caused by a high-fat diet, fish were fed diets with varying fat levels: control (CK, 11 % fat), L16 (16 % fat), and L22 (22 % fat) for 90 days. …”
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Effect analysis of radiofrequency catheter ablation in the treatment of 7 children with atrial tachycardia-induced cardiomyopathy by Min Zhang, Xiaoxiao Cao, Suqiong Ji, Mohammadreza Kosari, Yong Zhang

“…RFCA and combined atrial appendectomy can effectively stop tachycardia, eliminate the mechanism of tachycardia, and allow complete recovery of cardiac function.…”
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Development of machine learning models for diagnostic biomarker identification and immune cell infiltration analysis in PCOS by Wenxiu Chen, Jianliang Miao, Jingfei Chen, Jianlin Chen

“…These findings shed light on potential mechanisms underlying PCOS pathogenesis and provide valuable insights for future research and therapeutic interventions.…”
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Construction of a Novel Necroptosis-Related Signature in Rat DRG for Neuropathic Pain by Liu Y, Hao S, Hao H, Zheng G, Bing J, Kang L, Li J, Zhao H, Hao H

“…Significantly enriched KEGG and GO pathways, drug target prediction and non-coding RNAs related to the signature holded promise for advancing our understanding of potential avenues for treatment and the mechanisms underlying neuropathic pain. Immune infiltration analysis revealed which types of immune cells related to the NRDEGs signature played an important role in the occurrence and development of neuropathic pain. …”
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Features of pancreatic parenchyma fibrosis in the comorbid course of chronic pancreatitis and chronic obstructive pulmonary disease by I.V. Dudka, O.S. Khukhlina, T.V. Dudka, O.Y. Hryniuk, V.O. Pavliuk

“…Correlation relationship between the parameter of ultrasonographic histography of the pancreas – L, which indicates the degree of the pancreas fibrosis, and the content of type IV collagen in the blood (r=0.54, p<0.05), the content of PBOP in the blood (r=0.46, p<0.05), hexosamines (r=0.38, p<0.05) points to the biochemical mechanisms of the pancreas fibrosis and opens up prospects for developing the ways of pathogenetic correction and prevention of CP progression in comorbidity with COPD.…”
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Inflammatory Monocyte Subsets Correlation with Iron Levels in Low Vitamin D Pediatric Transfusion-Dependent Thalassemia by Ghozali M, Matahari M, Cahyadi AI, Agustini SD, Ghrahani R, Reniarti L, Setiabudiawan B, Panigoro R

“…Blood monocytes, identified by their CD14 and CD16 expression, show functional diversity during injury or inflammation. Considering the mechanisms of vitamin D activation and its potential interaction with monocytes, further investigation of its immunomodulatory role in transfusion-dependent thalassemia is essential.Purpose: This study evaluated monocyte subsets, population, and surface receptor expression (CD14, CD16, and HLA-DR), and their association with iron status and vitamin D levels in patients with transfusion-dependent thalassemia.Patients and Methods: Fifty lysed erythrocyte-heparinized whole blood samples from transfusion-dependent thalassemia patients were analyzed by flow cytometry and classified into three monocyte subsets: CD14++CD16- (classical), CD14++CD16+ (intermediate), and CD14+CD16++ (non-classical). …”
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THE PROSPECTS OF THE RUSSIAN-CHINESE HUMANITARIAN COOPERATION IN FRAMEWORK OF “ONE BELT, ONE ROAD” INITIATIVE IMPLEMENTATION by D. A. Smaliakou

“…The author proposed to involve the humanitarian sphere as the mechanism of the start of transcontinental infrastructure projects in order to normalize the social and economic situation in these regions, to overcome socio-cultural barriers and to achieve integration of economics of various states for the sake of their steady growth and effectivization. …”
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A meta-analysis of MHC diversity in Pan troglodytes verus by Christelle Vangenot, Alicia Sanchez‑Mazas

“…This gives us an original focus on MHC evolution and its mechanisms and helps us to understand the specificities of the human and chimpanzee lineages, respectively.…”
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Functional Remediation Improves Serum BDNF and TrkB Levels in Euthymic Patients with Bipolar Disorder: A Randomized Trial Study by Li R, Li J, Ji SS, Li D, Chu L, Zhang J, Sun X, Luo X, Zhang Y

“…In terms of cognition, the change in serum BDNF levels was negatively correlated with changes in Mazes test, and the improved TrKB levels were associated with improved Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT) in the FR group (all p’s< 0.05).Conclusion: The changes in serum BDNF and TrkB levels may be implicated in the mechanisms underlying FR intervention in euthymic patients with BD.Limitation: A longer follow-up period than 12 weeks and set up healthy controls may make the results more convincing, and the sample size of this study is still insufficient.Keywords: functional remediation, TAU, serum BDNF/TrkB levels, neurocognitive functioning, bipolar disorder…”
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Ginsenoside Rd protects against acute liver injury by regulating the autophagy NLRP3 inflammasome pathway by Xiaomei Zhong, Yibin Sun, Yanxiang Lin, Shan Deng, Huan Wang, Xian Zhou, Jinjian Lu, Yanfang Zheng, Ruoyin Luo, Mingqing Huang, Jianyuan Song

“…To investigate the protective effect of Rd against thioacetamide (TAA)-induced acute liver injury and assess its underlying regulatory mechanisms related to autophagy and inflammation. Forty-eight 8 weeks old C57BL/6 mice were treated with saline (control or model group), Rd (12.5 mg/kg, 25 mg/kg or 50 mg/kg), and diammonium glycyrrhizinate (DG, 30 mg/kg) for three days. …”
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