Nutrient cycling characteristics along a chronosequence of forest primary succession in the Hailuogou Glacier retreat area, eastern Tibetan Plateau by Danli Yang, Ji Luo, Shumiao Shu, Yan Hu, Hongsong Tang, Xuemei Li

“…Coniferous forests’ nutrient cycling mechanisms offer a competitive edge in nutrient-poor environments, enhancing ecosystem stability.…”
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Mesenchymal stem cells from perinatal tissues promote diabetic wound healing via PI3K/AKT activation by Jiawei Huang, Qingwen Deng, Lai Ling Tsang, Guozhu Chang, Jinghui Guo, Ye Chun Ruan, Chi Chiu Wang, Gang Li, Hon Fai Chan, Xiaohu Zhang, Xiaohua Jiang

“…The PEGDA/SA/Col-I hydrogel demonstrated a unique balance of mechanical and biological properties and an optimal environment for MSC viability and function. …”
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Engineered Perfluorochemical Cancer-Derived Exosomes Loaded with Indocyanine Green and Camptothecin Provide Targeted Photochemotherapy for Effective Cancer Treatment by Lee YH, Huang CY

“…Moreover, tumor growth was significantly arrested by ICFESs containing 40/40 μM [ICG]/[CPT] in combination with 30 sec of NIR exposure without systemic toxicity, and the resulting tumors were approximately 15-fold smaller than those treated for 14 days with 40 μM free CPT alone.Conclusion: We suggest that the aforementioned anticancer efficacy was achieved via a dual-stage mechanism, phototherapy followed by chemotherapy. Taken together, the developed ICFESs are anticipated to be highly applicable for clinical cancer treatment. …”
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Genome-wide association study identifies candidate genes affecting body conformation traits of Zhongwei goat by Mingxuan Han, Xinbo Wang, Haidong Du, Yanlong Cao, Zhanqiang Zhao, Shuran Niu, Xuxu Bao, Youjun Rong, Xiaofang Ao, Furong Guo, Qincheng Xia, Fangzheng Shang, Ruijun Wang, Yanjun Zhang

“…Conclution It is the first GWAS study to analyze genomic data from 40d and 6 m of Zhongwei goats to understand the molecular genetic mechanisms of growth. Our research identified a series of SNPs and candidate genes associated with growth traits, which could assist us in developing the meat production trait in Zhongwei goats.…”
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Barriers and Facilitators to the Preadoption of a Computer-Aided Diagnosis Tool for Cervical Cancer: Qualitative Study on Health Care Providers’ Perspectives in Western Cameroon by Magali Jonnalagedda-Cattin, Alida Manoëla Moukam Datchoua, Virginie Flore Yakam, Bruno Kenfack, Patrick Petignat, Jean-Philippe Thiran, Klaus Schönenberger, Nicole C Schmidt

“…The HCPs emphasized the importance of clinical validation, usability testing, and iterative feedback mechanisms to build trust in the CAD tool’s accuracy and utility. …”
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Antibiotic resistance genotype, phenotype, and clinical outcomes in patients with Gram-negative infections at Rabin Medical Center in Israel by Rachelle E. Koch, Jackson Barth, Andrew E. Clark, Dhara Desai, Jiwoong Kim, Christine A. Pybus, Xiaowei Zhan, Leonard Leibovici, Dafna Yahav, David E. Greenberg

“…RJX84154 may play a role in multidrug-resistance.IMPORTANCEWhile there have been several studies that attempt to find clinical predictors of outcomes in patients hospitalized with bacterial infections, less has been done to combine clinical data with genomic mechanisms of antibiotic resistance. This study focused on a hospitalized patient population in Israel with infections due to medically important bacterial pathogens as a way to build a framework that would unite clinical data with both bacterial antibiotic susceptibility and genomic data. …”
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Integrated Impacts of Urban Spatial Form on Thermal Environment and Zonal Regulation under the Perspective of Spatial Heterogeneity by Yan Jinlong, Yin Chaohui, An Zihao, Zhang Simin, Wen Qian, Chen Weiqiang

“…This study takes the main urban area of Wuhan as an example, based on multi-source spatial data such as Landsat-8 remote sensing images, urban land classification, and buildings, integrates geodetectors and a geographically weighted regression model (MGWR) to investigate the mechanism of the influence of the urban form on the thermal environment under the control unit at the global and local levels, and finally utilizes the K-mean clustering approach to perform impact zoning. …”
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Activity of trypsin inhibitors in common bean seeds (Phaseolus vulgaris L.) from the VIR collection: variability and source material for breeding by T. V. Buravtseva, G. P. Egorova, M. O. Burlyaeva, M. A. Nikishkina

“…The search for samples with high content of inhibitors is also relevant, since inhibitors play a crucial role in the functioning of the basic biochemical mechanisms that determine and regulate the physiological state of the cell.Materials and methods. …”
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miR-424-5p Promotes Proliferation, Migration and Invasion of Colorectal Cancer Cells via the Targeting TXNIP/Hippo Axi by Zhang F, Zhu KL, Chen R, Su F

“…It also suppressed the malignant behavior of the CRC cells promoted by miR-424-5p. Mechanically, TXNIP overexpression significantly inhibited YAP/TAZ transcriptional activity, and the highly expressed miR-424-5p in CRC targeted TXNIP mRNA.Conclusion: The study clarify a novel miR-424-5p/TXNIP/Hippo signaling pathway that facilitated CRC cells proliferation, migration and invasion. …”
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Regional Differences of Digital Rural Construction in China and Driving Factors by Zeng Yongming, Zhong Zikang

“…In addition, the four sub-dimensional indexes—rural digital infrastructure, rural economic digitalization, rural governance digitalization, and rural life digitalization—show evident spatial differentiation characteristics, with the "Hu Huanyong Line" as the boundary. 3) Regarding mechanism, the spatial panel model was used to verify that government functions, economic foundations, digital foundations, and human capital were important driving factors for the construction of county-level digital rural areas. …”
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OXA β-lactamases from Acinetobacter spp. are membrane bound and secreted into outer membrane vesicles by Lucia Capodimonte, Fernando Teixeira Pinto Meireles, Guillermo Bahr, Robert A. Bonomo, Matteo Dal Peraro, Carolina López, Alejandro J. Vila

“…This advantage could be crucial in polymicrobial infections, in which Acinetobacter spp. are usually involved, and underscore the relevance of identifying the cellular localization of lactamases to better understand their physiology and target them.IMPORTANCEβ-lactamases represent the main mechanism of antimicrobial resistance in Gram-negative pathogens. …”
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Effect of short inter-pregnancy interval on perinatal and maternal outcomes among pregnant women in SSA 2023: Systematic review and meta-analysis. by Fentahun Yenealem Beyene, Kihinetu Gelaye Wudineh, Simachew Animen Bantie, Azimeraw Arega Tesfu

“…<h4>Methods</h4>A systematic and a comprehensive literature searching mechanism were used without any restriction, through Google scholar, PubMed, Scopus, Web of Sciences, and Grey literature databases for reporting the effect of short inter pregnancy interval. …”
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Cardio-metabolic-related plasma proteins reveal biological links between cardiovascular diseases and fragility fractures: a cohort and Mendelian randomisation investigationResearch... by Karl Michaëlsson, Rui Zheng, John A. Baron, Tove Fall, Alicja Wolk, Lars Lind, Jonas Höijer, Carl Brunius, Eva Warensjö Lemming, Olga E. Titova, Bodil Svennblad, Susanna C. Larsson, Shuai Yuan, Håkan Melhus, Liisa Byberg, Hannah L. Brooke

“…Methods: We used proteomics and a cohort design combined with Mendelian randomisation analysis to understand shared mechanisms for developing CVD and fragility fractures, two significant sources of disease burden and health expenditure. …”
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ELABELA promotes the migration and homing of bone marrow mesenchymal stem cells to myocardial injury sites through the ERK1/2/miR-299a-5p/Exo70 pathway by Jing-Yu Hou, Hao Wu, Shuang-Mei Li, Xiao-Jing Li, Shu-Jun Yang, Xu-Xiang Chen, Chang-Qing Zhou, Hui-Bao Long, Hai-Dong Wu, Jia-Ying Fu, Ya-Jie Guo, Tong Wang

“…Transcriptome sequencing and bioinformatics analysis were employed to identify and validate the mechanisms by which ELA promoted the migration of BMSCs. …”
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Effect of operational parameters on droplet deposition characteristics using an unmanned aerial vehicle for banana canopy by Jiaxiang Yu, Jiaxiang Yu, Xing Xu, Jieli Duan, Jieli Duan, Yinlong Jiang, Yinlong Jiang, Haotian Yuan, Haotian Yuan, Huazimo Liang, Shuaijie Jing, Shuaijie Jing, Zhou Yang, Zhou Yang, Zhou Yang

“…Banana, as a typical large broad-leaved crop, has high requirements for pests and diseases control. The mechanization degree of plant protection management in banana orchard is low. …”
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Iron deficiency in endure athletes by Michał Rogulski, Yauheniya Patarocha, Aleksandra Ślusarska, Jolanta Mędyk, Paulina Błasiak, Małgorzata Wirkijowska, Patryk Mikołajec, Ruslan Huk, Barbara Bilecka, Jakub Wirkijowski

“…Especially in marathon and half-marathon runners - these groups of endurance athletes are at high risk for iron deficiency via several mechanisms, such as sweating, gastrointestinal bleeding, urinary-tract blood loss, hemolysis, and others.   …”
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Treatment of Vascular Dementia by Using Fuyuan Capsule Combined with "Xingnao Kaiqiao" Acupuncture by LI Hongmei, WANG Xiaoqin, GUO Yang, SHI Hongxing, GUO Xiao, WANG Xue

“…ObjectiveTo observe the clinical effect of Fuyuan capsule combined with "Xingnao Kaiqiao" acupuncture on vascular dementia (VD) and explore its mechanism.MethodsA total of 150 VD patients with deficiency of spleen and kidney and blood stasis were enrolled in the Hengshui Traditional Chinese Medicine Hospital of Hebei Province from May 2020 to September 2021. …”
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Spatiotemporal evolution and driving force analysis of drought characteristics in the Yellow River Basin by Meiying Wang, Yangbo Chen, Jingyu Li, Yanjun Zhao

“…Understanding the time-domain abrupt changes and evolutionary mechanisms of drought events is crucial for comprehending the water resource dynamics in the basin. …”
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Assessing the Impact of a Virtual Reality Cognitive Intervention on Tennis Performance in Junior Tennis Players: Pilot Study by Joaquin A Anguera, Aleem Choudhry, Michael Seaman, Dominick Fedele

“…However, many questions remain unanswered, and further work is needed to better understand the potential utility and mechanisms underlying potential effects of such a platform.…”
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High-fat diet promotes gestational diabetes mellitus through modulating gut microbiota and bile acid metabolism by Lei Yao, Xuefei Zhou, Xianqi Jiang, Hao Chen, Yuanliang Li, Xiao Xiong, Yan Tang, Haogang Zhang, Pengfei Qiao

“…Fecal microbiota transplantation (FMT) further confirmed that gut microbiota contributed to bile acids (BAs) metabolic dysfunction during HFD-associated GDM development. Mechanically, HFD-FMT administration activated Fxr, Shp, and Fgf15 activity, disturbed the glucose metabolism and aggravated insulin resistance but not in HFD-FMT Fxr−/− mice and ND-FMT Fxr−/− mice. …”
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