Global Trends in the Incidence and Primary Causes of Femoral Fractures, Excluding Femoral Neck Fractures: A Global Epidemiological Study by Fu F, Liu B, Pu H, Wang Y, Zhang P, Wei S, Gu H, Zhang Q, Ye H

“…Leading causes were mechanical forces, motor vehicle injuries, and pedestrian injuries, with notable regional disparities.Conclusion: Although the global incidence rate of femoral shaft fractures has declined, it has risen significantly among older adults, increasing their burden. …”
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Stress distribution in endodontically treated external cervical resorption lesions restored with MTA and biodentine – A finite element analysis by Mudita Manaktala, Sonali Taneja, Vidhi Kiran Bhalla

“…Both materials exhibit similar stress distribution patterns and offer adequate reinforcement against mechanical forces. Clinicians can confidently utilize MTA or Biodentine in the management of ECR, considering their favorable biomechanical properties and clinical outcomes. …”
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Association Between Dietary Inflammatory Index and Triglyceride Glucose-Body Mass Index with Iron Deficiency in Reproductive Age Women: Evidence from NHANES 2005-2018 by Ding J, Xu Z, Liang R, Xie S

“…Jia Ding,1,* Zhehao Xu,2,* Ruiyun Liang,3 Shuangfeng Xie1 1Department of Hematopathology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China; 2Department of General Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China; 3Department of Respiratory Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shuangfeng Xie, Email xiesf@163.comBackground & Aims: There is a growing focus on the role of dietary factors and metabolic conditions in the evolution and progression of iron deficiency (ID), yet few studies have examined the underlying mechanisms. Dietary Inflammatory Index (DII) is a metric that gauges the inflammatory potential of an overall diet. …”
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Systemic and mammary inflammation and mammary gland development of Holstein dairy cows around dry-off and calving by J. Gao, T.N. Marins, J.O.S. Calix, Z. Qi, C.G. Savegnago, A.M. Roper, M.W. Woldemeskel, J.K. Bernard, S. Tao

“…Our data also suggested that the increased mammary growth during the late gestation and early dry periods was mediated by different mechanisms. The concurrent increases in immune cell infiltration and mammary cell proliferation in the mammary gland following dry-off suggest an association between mammary immune responses and growth during the early dry period.…”
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The protein composition of human adenovirus replication compartments by Paloma Hidalgo, Amada Torres, Pierre M. Jean Beltran, Gamaliel López-Leal, Luca D. Bertzbach, Thomas Dobner, S. J. Flint, Ileana M. Cristea, Ramón A. González

“…We conducted quantitative proteome analyses of RC-enriched subnuclear fractions at different times post-infection with human adenovirus species C type 5, revealing a multifaceted network of proteins that participate in the regulation of gene expression, DNA damage response, RNA metabolism, innate immunity, and other cellular antiviral defense mechanisms. Furthermore, we validated the localization of several host proteins to viral RCs using immunofluorescence microscopy and immunoblotting and identified cellular HMGB1 as a proviral factor late during infection. …”
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Resveratrol contributes to NK cell-mediated breast cancer cytotoxicity by upregulating ULBP2 through miR-17-5p downmodulation and activation of MINK1/JNK/c-Jun signaling by Bisha Ding, Jie Li, Jia-Lin Yan, Chun-Yan Jiang, Ling-Bo Qian, Jie Pan

“…This study aims to investigate how RES affects the expression of ULBP2 and the sensitivity of breast cancer (BC) cells to NK cell cytotoxicity, along with the underlying mechanisms.MethodsThe effects of RES on ULBP2 expression were detected with qRT-PCR, western blot, flow cytometry analysis and immunohistochemistry. …”
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The prevalence of conjunctivitis in patients with novel coronavirus (COVID-19) and preventive measures by I.R. Gazizova, Yu.A. Desheva, T.V. Gavrilova, V.A. Chereshnev

“…This paper reviews a few studies on the possible involvement of SARS-CoV-2 in ocular surface diseases and ocular defence mechanisms against viruses.</i> </p> <p> <i>More research is needed to describe the presence of viral RNA in tears and to determine whether SARS-CoV-2 is transmitted by the contact with conjunctiva and/or through secrets although conjunctivitis was diagnosed in only a few patients with COVID-19 and only a few patients were positive for SARS-CoV-2 by conjunctival polymerase chain reaction (PCR).…”
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Shared Genes and Pathways in Ulcerative Colitis and Ankylosing Spondylitis: Functional Validation and Implications for Diagnosis by Li L, An G, Li F, Zhang D, Zhu X, Liang C, Zhao Y, Xie K, Zhou P, Zhu H, Jin X, Du L

“…Thus, in the current study, we aimed to investigate the shared genes and relevant mechanisms in UC and AS.Methods: Using datasets for UC (GSE113079) and AS (GSE1797879), we initially identified differentially expressed genes (DEGs) through differential expression analysis. …”
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The relationship between social support and psychological crisis vulnerability among family impoverished undergraduates: the intermediary role of psychological resilience by Weimin Yuan, Jinhui Ning, Mengke Huo, Yiwei Feng

“…Finally, we employed a structural equation modeling approach to analyze the underlying mechanisms between social support and psychological crisis vulnerability and to test the conspicuousness of the mediating role of psychological resilience in the process by which social support affects psychological crisis vulnerability.ResultsAnalysis of 1,549 valid questionnaires revealed that the overall level of psychological crisis vulnerability among family impoverished undergraduates was moderate. …”
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Emodin protects against severe acute pancreatitis-associated acute lung injury by activating Nrf2/HO-1/GPX4 signal and inhibiting ferroptosis in vivo and in vitro by Gang Shen, Haiyun Wen, Huijuan Li, Xuetao Zhang, Bowen Lan, Xuanchi Dong, Peng Ge, Yalan Luo, Hailong Chen

“…However, its protection mechanism in SAP-ALI needs to be further clarified. …”
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Evolutionary and functional divergence of Sfx, a plasmid-encoded H-NS homolog, underlies the regulation of IncX plasmid conjugation by Avril Wang, Martha Cordova, William Wiley Navarre

“…Therefore, studying the molecular mechanisms underlying conjugation regulation is essential for understanding antimicrobial resistance and pathogen evolution. …”
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Association between normal weight obesity and comorbidities and events of cardiovascular diseases among adults in South China. by Miaomiao Ma, Deliang Lv, Xiaobing Wu, Yuqing Chen, Shimiao Dai, Yutian Luo, Hui Yang, Wei Xie, Fengzhu Xie, Qinggang Shang, Ziyang Zhang, Zhiguang Zhao, Ji-Chang Zhou

“…The current study provides a ground to conduct further studies on whether body fat affects the risk of occurrence of CVD events and the underlying mechanisms in the future.…”
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Apoptotic Vesicles Attenuate Acute Lung Injury via CD73-Mediated Inhibition of Platelet Activation and NETosis by Tan L, Zhang C, Kou X, Zhao L, Wu D, Li J, Yu C, Xu T, Gao L, Mao X, Zhao C

“…In this study, our aim was to investigate the therapeutic effects and underlying mechanisms of apoVs in ALI.Methods: ALI was induced in mice through intratracheal instillation of lipopolysaccharide (LPS). …”
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Immunological and autonomic profile of ischemic stroke in lowlands by Nargiza T. Chekeeva, Svetalana G. Shleifer, Bolot B. Kulov, Begimai B. Kadyrova, Asel T. Jusupova, Elena V. Andrianova

“…Research objective was to study immunological and autonomic parameters in patients with primary IS of varying severity in low-mountain conditions and clarify the pathogenesis and mechanisms underlying stroke severity. Methods: An observational cohort study was conducted involving 52 patients with primary IS divided into three groups: mild stroke (n = 12), moderate stroke (n = 28), and severe stroke (n = 12). …”
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A novel approach to regulate glucose uptake in an anaplastic thyroid cancer cell line by Shabnam Heydarzadeh, Ali Asghar Moshtaghie, Maryam Daneshpour, Mehdi Hedayati

“…We anticipate that this study’s findings will contribute to a better understanding of the mechanism underlying curcumin’s anti-cancer properties, providing a theoretical foundation for the future clinical application of curcumin-related medications.…”
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Treatment-related Hypertension as a Prognostic Factor for De Novo Metastatic Hormone-sensitive Prostate Cancer: A Retrospective Real-world Evidence Study by Giuseppe Salfi, Martino Pedrani, Selin Candan, Vasile Urechie, Sara Merler, Lorenzo Ruinelli, Amos Colombo, Luis Castelo-Branco, Irene Testi, Fabio Turco, Luigi Tortola, Ursula Vogl, Luca Gabutti, Silke Gillessen, Ricardo Pereira Mestre

“…Larger studies are needed to validate these findings and explore the potential underlying mechanisms. Patient summary: In this report, we examined the outcomes of patients with metastatic hormone-sensitive prostate cancer and their correlation with hypertension toxicities. …”
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Identification of Potential miRNA-mRNA Regulatory Network Contributing to Parkinson’s Disease by Xi Yin, Miao Wang, Wei Wang, Tong Chen, Ge Song, Yixuan Niu, Ziying Jiang, Zhongbao Gao, Zhenfu Wang

“…Parkinson’s disease (PD) is a common neurodegenerative disease, and the mechanism underlying PD pathogenesis is not completely understood. …”
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MicroRNA Regulation of Endothelial Junction Proteins and Clinical Consequence by Yugang Zhuang, Hu Peng, Victoria Mastej, Weiguo Chen

“…Elucidation of these regulatory mechanisms will become a new alternative therapy for many diseases, such as cancers and inflammatory diseases.…”
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Prevalence and associated factors of multidimensional poverty among rural households in East Gojjam zone, Northern Ethiopia: a community-based cross-sectional study by Amare Wubishet Ayele, Yeshiwas Ewinetu, Asefa Delesho, Yirsie Alemayehu, Hayimro Edemealem

“…To address this issue, stakeholders should prioritize to promote climate-resilient agriculture and strengthening drought coping mechanisms. Furthermore, it is essential to account for the variations in poverty levels across different administrative units and ecological zones to effectively eradicate poverty among rural households.…”
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Intricate interplay of CRISPR-Cas systems, anti-CRISPR proteins, and antimicrobial resistance genes in a globally successful multi-drug resistant Klebsiella pneumoniae clone by Jianping Jiang, Astrid V. Cienfuegos-Galletd, Tengfei Long, Gisele Peirano, Tingyu Chu, Johann D. D. Pitout, Barry N. Kreiswirth, Liang Chen

“…Our findings advance the understanding of multi-drug resistance mechanisms and will aid in preventing the emergence of future MDR clones.…”
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