Potential diagnostic tools for intensive care unit acquired weakness: A systematic review by Chen Xin, Yubiao Gai, Lili Wei, Yanqiu Wang, Yuhong Luo, Binru Han

“…Background: Intensive care unit-acquired weakness is a prevalent complication among critically ill patients, associated with heightened mortality rates, extended durations of mechanical ventilation and hospital stays, as well as diminished mobility and unfavorable prognoses. …”
Get full text

Social vulnerability and genetic service utilization among unaffected BRIDGE trial patients with inherited cancer susceptibility by Jemar R. Bather, Melody S. Goodman, Adrian Harris, Guilherme Del Fiol, Rachel Hess, David W. Wetter, Daniel Chavez-Yenter, Lingzi Zhong, Lauren Kaiser-Jackson, Rachelle Chambers, Richard Bradshaw, Wendy Kohlmann, Sarah Colonna, Whitney Espinel, Rachel Monahan, Saundra S. Buys, Ophira Ginsburg, Kensaku Kawamoto, Kimberly A. Kaphingst, on behalf of the BRIDGE research team

“…Conclusions These results underscore the importance of investigating social and structural mechanisms as potential pathways to increasing genetic testing uptake among patients with increased inherited risk of cancer. …”
Get full text

Integrating bulk and single-cell RNA sequencing data: unveiling RNA methylation and autophagy-related signatures in chronic obstructive pulmonary disease patients by Shi-Xia Liao, Lan-Ying Zhang, Ling-Mei Shi, Huai-Yu Hu, Yan-Hui Gu, Ting-Hua Wang, Yao Ouyang, Peng-Peng Sun

“…These findings provide novel genetic insights into the epigenetic mechanisms of COPD and suggest potential avenues for developing diagnostic and therapeutic strategies.…”
Get full text

Enteric-Coated Aspirin Induces Small Intestinal Injury via the Nrf2/Gpx4 Pathway: A Promising Model for Chronic Enteropathy by Zhang M, Xia S, Feng L, Han X, Zhang Y, Huang Y, Liu Y, Zhao K, Guan J, Tian D, Liao J, Yu Y

“…This study aimed to establish a chronic model of aspirin-associated enteropathy, investigate the effect of enteric-coated aspirin on the intestinal flora, and explore the specific molecular mechanism of small intestinal damage.Methods: C57BL/6J mice were given aspirin for 45 days to induce chronic small intestinal injury. …”
Get full text

Sustainable development of the company on the basis of soft total quality management by Yuliia Prus

“…It is appropriate to deepen the case studies to identify the mechanisms by which TQM practices contribute to both environmental and social sustainability.…”
Get full text

The Effects of Mesenchymal Stem Cells on Antimelanoma Immunity Depend on the Timing of Their Administration by Dragana Miloradovic, Dragica Miloradovic, Bojana Simovic Markovic, Aleksandar Acovic, Carl Randall Harrell, Valentin Djonov, Nebojsa Arsenijevic, Vladislav Volarevic

“…Although several possible explanations have been proposed, including different numbers of injected and engrafted MSCs, heterogeneity in phenotype, and function of tumor cells, the exact molecular mechanisms responsible for opposite effects of MSCs in modulation of antitumor immunity are still unknown. …”
Get full text

Reservoir water level decline accelerates ground subsidence: InSAR monitoring and machine learning prediction of surface deformation in the Three Gorges Reservoir area by Jiaer Yang, Jiaer Yang, Pinglang Kou, Pinglang Kou, Xu Dong, Xu Dong, Ying Xia, Qinchuan Gu, Yuxiang Tao, Jiangfan Feng, Qin Ji, Weizao Wang, Ram Avtar

“…Despite existing studies, systematic exploration of long-term deformation characteristics and their driving mechanisms remains limited. This study combines SBAS-InSAR technology and machine learning to analyze and predict surface deformation in Fengjie County, Chongqing, China, between 2020 and 2022, focusing on riverside urban ground, riverside road slopes, and ancient landslides in the reservoir area.MethodsSBAS-InSAR technology was applied to 36 Sentinel-1A images to monitor surface deformation, complemented by hydrological and meteorological data. …”
Get full text

Fracture Line Morphology and a Novel Classification of Pilon Fractures by Jichao Liu, Chengdong Piao, Guanlu Cui, Haipeng Sun, Zhengwei Li

“…The new classification not only exhibits greater consistency, facilitating accurate communication of fracture characteristics among surgeons, but also aids in understanding the mechanisms of injury and formulating surgical strategies.…”
Get full text

Bioinformatics insights into mitochondrial and immune gene regulation in Alzheimer's disease by Tian Meng, Yazhou Zhang, Yuan Ye, Hui Li, Yongsheng He

“…Subsequently, we further analyzed the signaling pathways and potential biological mechanisms of the biomarkers through gene set enrichment analysis, prediction of transcription factors (TFs), miRNAs, and drug prediction. …”
Get full text

Patients admitted in an Intensive Care Unit with severe clinical manifestations of Influenza, october-december 2009 by Yenisey Quintero Mendez, Jorge Luis Ulloa Capestani, Rudis Monzón Rodríguez, Francisco García Valdés, Ramón E Álvarez Cepero, Jaime Geroy Gómez, Pablo Rodríguez Díaz, Alfredo Dario Espinosa Brito, Yanli Vázquez Villazón, Diley Moreno Ruiz, Octavio Rivero Rodríguez

“…The complications verified with more frequency were the cardiovascular ones (left ventricular failure and diverse types of arrhythmias) in 15 sick persons (13,4%), the multiple failure of organs in 14 (12,8%), the bacterial infection in 6 (5,6%) and the adult respiratory distress syndrome in 2 (1,9%). 19 patients required mechanic ventilation (17,4%). We only confirmed the diagnosis by RCP-TR in 8 cases (7,3%). …”
Get full text

The Frequency Dependence of Poisson’s Ratio in Fluid-Saturated Rocks by Liming Zhao, Tongjun Chen, Xin Zhang, Tao Xing

“…Based on one dominant fluid flow mechanism at each condition, we theoretically summarized that (1) when a rock is partially saturated or transits from drained state to undrained state at full saturation, ν increases monotonously with frequency, and the associated attenuation 1/Qν is positive with one peak. (2) When the rock transits from undrained state to unrelaxed state at full saturation, there are three cases: 1) ν increases monotonously with frequency and has positive 1/Qν with one peak, 2) ν keeps constant with frequency and has no attenuation, 3) and ν decreases monotonously with frequency and has negative 1/Qν with one peak. …”
Get full text

Spatial Distribution Characteristics of Micronutrients and Their Deficiency Effect on the Root Morphology and Architecture in Citrus Rootstock by Gaofeng Zhou, Yiping Fu, Mei Yang, Yanhong Li, Jing Zhang

“…To clarify the spatial distribution characteristics of essential nutrients in citrus roots and the influence mechanism of micronutrient deficiency on citrus root morphology and architecture, especially the effects on lateral root (LR) growth and development, two commonly used citrus rootstocks, trifoliate orange (<i>Poncirus trifoliata</i> L. …”
Get full text

Kangtaizhi Granule Alleviated Nonalcoholic Fatty Liver Disease in High-Fat Diet-Fed Rats and HepG2 Cells via AMPK/mTOR Signaling Pathway by Jiaxin Zhang, Haixia Du, Menglan Shen, Zhengqi Zhao, Xinmiao Ye

“…However, the underlying mechanisms under this efficacy are rather elusive. In the present study, network pharmacology and HPLC analysis were performed to identify the chemicals of KTZG and related target pathways for NAFLD treatment. …”
Get full text

Reciprocal regulation between DNMT3A/3B and microRNAs miRs-299-3p/-30e is a causal factor for the downregulation of microRNAs targeting androgen receptor in prostate cancer by Kavya Ganapathy, Christian F. Harrs, Samuel Harris, Stephen J. Staklinski, Ayman Khatib, Jong Y. Park, Ratna Chakrabarti

“…This study establishes a feedback regulation between AR targeting miRNAs and DNMTs in PCa cells and provides an insight into the mechanism of the aberrant expression of AR in advanced PCa that is potentially mediated through the downregulation of miRs-299-3p, −34c and −30e and stabilization of expression and activities of DNMTs.…”
Get full text

Comparative assessment of antibacterial effect of two types of laser and their effect on morphology and mineral content of dentin by Soha Adel Abdou, Haythem S Moharrum, Elsayed Abdallah Eltayeb

“…They were collected from the Dental Department of the Research Institute of Ophthalmology, Egypt. Mechanical preparation was done to all teeth after their crowns were removed. …”
Get full text

End-to-End Stroke Imaging Analysis Using Effective Connectivity and Interpretable Artificial Intelligence by Wojciech Ciezobka, Joan Falco-Roget, Cemal Koba, Alessandro Crimi

“…This elucidates the effective connectivity biomarker&#x2019;s contribution to stroke classification, fostering insights into disease mechanisms and treatment responses. This transparent analytical framework not only enhances clinical interpretability but also instills confidence in decision-making processes, crucial for translating research findings into clinical practice. …”
Get full text

Analysis of Fatigue Crack Propagation of an Orthotropic Bridge Deck Based on the Extended Finite Element Method by Ying Wang, Zhen Wang, Yuqian Zheng

“…As one of the most fatigue-sensitive parts of an orthotropic steel bridge deck, the weld between the U-rib and the top deck is prone to fatigue cracking under the actions of the stress concentration, welding residual stress, and vehicle load. To investigate the mechanism of fatigue crack propagation and the influence of the welding residual stress on the propagation patterns of fatigue cracks, a multiscale modeling method was proposed, and the static analysis and the dynamic propagation analysis of fatigue crack were carried out in this paper. …”
Get full text

Atmospheric oxidation of 1,3-butadiene: influence of seed aerosol acidity and relative humidity on SOA composition and the production of air toxic compounds by M. Jaoui, K. Nestorowicz, K. Nestorowicz, K. J. Rudzinski, M. Lewandowski, T. E. Kleindienst, J. Torres, E. Bulska, W. Danikiewicz, R. Szmigielski

“…Although the terms “acidified” and “non-acidified” are true for the solutions from which the seeds were atomized, there are far more fundamental differences between the phase states in which species partition to or from (aqueous/solid), which considerably affects their partitioning and formation mechanisms. SOA mass and most SOA products (i) were higher under acidified seed conditions, where the aerosol particles were deliquescent, than under non-acidified seed conditions, where the aerosol particles did not contain any aqueous phase; (ii) increased with the acidity of the aerosol aqueous phase in the experiments under acidified seed conditions; and (iii) decreased with increasing RH. …”
Get full text

Relationships between the Planetary Health Diet Index, its food groups, and polygenic risk of obesity in the CARTaGENE cohort by Guiomar Masip, Daiva E. Nielsen

“…Some components of a plant-based diet could be implicated in mechanisms underlying genetic susceptibility to obesity.…”
Get full text

Relationship Between ABO Blood Groups and Mental Disorders by Ajdacic-Gross V, Buadze A, Wagner EYN, Müller M, Seifritz E, Ranjbar S, Glaus J, Castelao E, Strippoli MPF, Vandeleur CL, Preisig M, von Känel R

“…The findings point to an unknown immunological mechanism that may play a role in the development of neurodevelopmental and substance use disorders.Keywords: ABO blood groups, neurodevelopmental disorders, substance use disorders, familial aggregation…”
Get full text