Shaping a low-carbon future: Uncovering the spatial-temporal effect of population aging on carbon emissions in China. by Zhuoqun Li, Haohao Li, Xueqiang Ji, Yuesong Zhang

“…Finally, this study explores the regional heterogeneity of the impact of aging on carbon emissions and its mechanism of action.<h4>Conclusion</h4>This study is instructive: first, the complex impact of population aging on carbon emissions should be fully recognized to formulate a comprehensive low-carbon development strategy; second, attention should be paid to the spatial spillover effect of aging on carbon emissions to strengthen inter-regional cooperation and coordination; and lastly, differentiated low-carbon policies should be formulated to address the characteristics of aging in different regions and stages in order to promote the synergistic development of a low-carbon society and an aging society.…”
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Natural Product Identification and Molecular Docking Studies of Leishmania Major Pteridine Reductase Inhibitors by Moses N. Arthur, George Hanson, Emmanuel Broni, Patrick O. Sakyi, Henrietta Mensah-Brown, Whelton A. Miller, Samuel K. Kwofie

“…A 100 ns MD combined with molecular mechanics Poisson–Boltzmann surface area (MM/PBSA) calculations confirmed the robust binding interactions and provided insights into the dynamics and stability of the protein–ligand complexes.…”
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Assessment of phytochemical screening, antibacterial, analgesic, and antipyretic potentials of Litsea glutinosa (L.) leaves extracts in a mice model. by Zubair Khalid Labu, Samira Karim, Md Tarekur Rahman, Md Imran Hossain, Sarder Arifuzzaman, Md Shakil

“…Future research is warranted to isolate the specific bioactive compounds and elucidate their mechanisms of action to further support the development of new treatments and contributing to modern medicinal practices based on this plant leaves.…”
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The Origin of the Large-Scale Industry in Klaipėda's Region in the end of the 19th - beginning of the 20th century by Julius Žukas

“…The rail freight and the system of factories based on heavy mechanical production and hired labor started and developed there. …”
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Proof of concept for multirotor systems with vortex-generating modes for regenerative wind energy: a study based on numerical simulations and experimental data by F. Avila Correia Martins, A. van Zuijlen, A. van Zuijlen, C. Simão Ferreira

“…The results indicate that, when the ABL-control strategy is employed, vertical momentum flux may become the dominant mechanism for wake recovery. In configurations with two or four ABL-control wings, the total wind power in the wake recovers to 95 % of the free-stream value at positions as early as <span class="inline-formula"><math xmlns="http://www.w3.org/1998/Math/MathML" id="M1" display="inline" overflow="scroll" dspmath="mathml"><mrow><mi>x</mi><mo>/</mo><mi>D</mi><mo>≈</mo><mn mathvariant="normal">6</mn></mrow></math><span><svg:svg xmlns:svg="http://www.w3.org/2000/svg" width="42pt" height="14pt" class="svg-formula" dspmath="mathimg" md5hash="f1f50c65a676d34319b7e018d39c81d7"><svg:image xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="wes-10-41-2025-ie00001.svg" width="42pt" height="14pt" src="wes-10-41-2025-ie00001.png"/></svg:svg></span></span> downstream of the multirotor system, representing a recovery rate that is approximately an order of magnitude faster than that observed in the baseline wake without ABL-control capabilities. …”
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Prevalence and molecular characteristics of colistin-resistant isolates among carbapenem-resistant Klebsiella pneumoniae in Central South China: a multicenter study by Zijuan Jian, Yanjun Liu, Zhiqian Wang, Peilin Liu, Jiahui Wang, Qun Yan, Wenen Liu

“…Conclusions This study highlights the presence of different colistin resistance mechanisms in isolates belonging to the same clone and identified multiple clonal transmission clusters in colistin resistant isolates, including the globally high-risk ST11 and ST307 clones, of which a significant proportion exhibited high virulence. …”
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Activation of Delta-Opioid Receptor Protects ARPE19 Cells against Oxygen-Glucose Deprivation/Reoxygenation-Induced Necroptosis and Apoptosis by Inhibiting the Release of TNF-α by Runjie Guo, Ping Chen, Tiantian Fu, Ren Zhang, Yuan Zhu, Nange Jin, Hong Xu, Yong Xia, Xuesong Tian

“…Here, we explored the mechanisms of TNF-α and DOR in necroptosis and apoptosis using an oxygen-glucose deprivation/reoxygenation (OGD/R) model of adult retinal pigment epithelial cell line-19 (ARPE19) cells. …”
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RECK as a Potential Crucial Molecule for the Targeted Treatment of Sepsis by Qin Y, Liao S, Sun J, Ye H, Li J, Pan J, He J, Xia Z, Shao Y

“…To better understand the roles of RECK and the related mechanisms, we make here a systematic and in-depth review of RECK. …”
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Imaging and Clinical Characteristics of 8 Cases of COVID-19 Complicated with Pneumomediastinum in Children by FU Qiang, REN Zuolei, LIN Zhiqiang, GONG Jianfeng, WANG Changzheng, WANG Ting, HU Yalan, TAN Jufang

“…IVIG and glucocorticoids may have positive effects, and if necessary, a mechanical ventilation should also be used.…”
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Integrated bioinformatics analysis to explore potential therapeutic targets and drugs for small cell carcinoma of the esophagus by Maofei Zhu, Maofei Zhu, Yueming Chu, Yueming Chu, Qiang Yuan, Qiang Yuan, Junfeng Li, Silin Chen, Lin Li, Lin Li, Lin Li

“…Therefore, a deeper understanding of the therapeutic targets and the mechanisms underlying its occurrence and development is of great importance for early diagnosis, identification of potential therapeutic agents and improvement of the prognosis for patients.MethodsFirstly, the dataset of SCCE was downloaded from the GEO database and GEO2R tool was employed for the analysis of differentially expressed genes (DEGs). …”
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Risk factors associated with in-hospital mortality during yellow fever outbreak in Brazil by Max McClure, Izabela Maurício de Rezende, Leonardo Soares Pereira, Maria Rita Teixeira Dutra, Jordana Rodrigues Barbosa Fradico, Rodrigo Macedo, Marcelle Cardoso Marçal, Lívia Soares Coelho Fonte Boa, Alexandre Maurício Castro Bragato, Flávio Augusto de Almeida Faria, Livia Pamplona, Rodrigo Fabiano do Carmo Said, Carlos Eduardo Calzavara-Silva, Dario Brock Ramalho, Cintia Lopes de Brito Magalhães, Pedro Augusto Alves, Thaysa Drummond Palmeira Gama, Gláucia Fernandes Cota, Thomas P. Monath, Olindo Assis Martins-Filho, Marcelo Antônio Pascoal-Xavier, Andrea Teixeira-Carvalho, Betânia Paiva Drumond, A. Desiree LaBeaud, Yellow Fever Collaborative Group, Argus Leão Araújo, Barbara Lenoir, Bruno Dala Vedova Gomes Beato, Carolina Lins Rodrigues Vieira, Daniel Vitor de Vasconcelos Santos, Flavia Mansur Starling, Gabriela Miana de Mattos Paixão, Indiara Penido, Izabela Aparecida Coelho, Leandro Henrique Malta Cunha, Letícia Menezes, Livia Frota Rabelo, Letícia Lemos Jardim, Lívia Fulgêncio da Cunha Melo, Lívia Zignago Moreira dos Santos, Ludmila de Paula, Luísa Lages de Abre Paladino, Natalia Soares Albuquerque, Simone Lopes Oliveira Lemos, Tayrine Araújo

“…In-hospital mortality (hypothesis formulated after data collection), demographic factors and clinical and laboratory assessments were used.ResultsStudy patients were mainly men (87.6%), with a median age of 46.0 (IQR 36.5, 57.0). 131 (46.3%) patients were admitted to the ICU, and 62 (22.0%) used invasive mechanical ventilation for a median of 2 days (IQR 1, 3). …”
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Effect of colloidal particle size on physicochemical properties and aggregation behaviors of two alkaline soils by Y. Yan, X. Zhang, C. Xu, C. Xu, J. Liu, F. Hu, F. Hu, Z. Geng, Z. Geng

“…The purposes of the present study are to clarify how particle size affects the physicochemical properties and aggregation kinetics of soil colloids and to further reveal the underlying mechanisms. Soil colloidal fractions, from two alkaline soils – Anthrosol and Calcisol – were subdivided into three ranges: <span class="inline-formula"><i>d</i>&lt;2</span> <span class="inline-formula">µ</span>m, <span class="inline-formula"><i>d</i>&lt;1</span> <span class="inline-formula">µ</span>m and <span class="inline-formula"><i>d</i>&lt;100</span> nm. …”
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Prevalence and determinants of faecal carriage of carbapenem- and third-generation cephalosporin-resistant Enterobacterales: a cross-sectional household survey in northern VietnamR... by Max van Wijk, Hoang Huy Tran, Bich Ngoc Thi Vu, Costanza Tacoli, Tu Cam Thi Nguyen, Quynh Dieu Pham, Thương Hong Thi Nguyen, Trang Thu Nguyen, Hien Anh Thi Nguyen, Tung Son Trinh, Thai Duy Pham, Huong Kieu Thi Tran, Dung Tien Viet Vu, Duc Anh Dang, Tien Dac Tran, Duong Thanh Nguyen, H. Rogier van Doorn, Thomas Kesteman, Sonia Lewycka

“…Further research is required to understand the mechanisms behind these associations. Funding: This work was supported by Oxford University Clinical Research Unit internal grants in Vietnam from the Wellcome Trust Africa Asia Programme core grants (2015-2022—106680/Z/14/Z, and 2022-2029—225167/Z/22/Z).…”
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Different rs-fMRI Data Processing Methods in the Study of Vascular Cognitive Impairment by Ying GUAN, Luwen ZHU, Feng WANG, Danna CAO, Xiaoling LI, Qiang TANG

“…As a sensitive auxiliary examination method, rs-fMRI has been widely used in the neurological mechanism and diagnosis and treatment of VCI.In clinical application, there are many methods of rs-fMRI data processing for VCI, such as amplitude of low-frequency fluctuation(ALFF), regional homogeneity(ReHo), functional connectivity(FC), brain network, etc. …”
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PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way by Wei Huang, Ji Zhou, Jia Li, Yakun Wan, Chao Hu, Meng Liu, Pan Xu, Feng Tang, Jianhua Sun, Xiaolu Yu, Yiru Long, Binfan Chen, Yongliang Tong, Mengwen Shan, Xiaomin Jia, Henglei Lu, Runqiu Chen, Jin Ren, Guangyi Jin, Likun Gong

“…Immunophenotyping, immune cell depletion, tumor rechallenge, RNA sequencing and PD-L1-deficient models were combined to determine the mechanism for NDCs function. The dynamics of the in vivo behaviors of NDCs were assessed based on multiorgan changes in PD-L1 levels.Results The screened PD-L1 nanobodies were characterized as tumor-targeting and alleviated T-cell immunosuppression. …”
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m6A demethylase CpALKBH regulates CpZap1 mRNA stability to modulate the development and virulence of chestnut blight fungus by Lijiu Zhao, Xiangyu Wei, Fengyue Chen, Baoshan Chen, Ru Li

“…Collectively, our findings highlight the essential role of CpALKBH as an m6A demethylase in the development and virulence of C. parasitica, while also elucidating the molecular mechanisms through which m6A modification impacts CpZap1 mRNA stability.IMPORTANCEN6-methyladenosine (m6A) is the most abundant eukaryotic mRNA modification and is involved in various biological processes. …”
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Sdd3 regulates the biofilm formation of Candida albicans via the Rho1-PKC-MAPK pathway by Li Mei Pang, Guisheng Zeng, Eve Wai Ling Chow, Xiaoli Xu, Ning Li, Yee Jiun Kok, Shu Chen Chong, Xuezhi Bi, Jiaxin Gao, Chaminda Jayampath Seneviratne, Yue Wang

“…Understanding the molecular mechanisms governing biofilm formation is crucial for developing anti-biofilm therapies. …”
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Efficacy of Endoscopic Radiofrequency Ablation for Treatment of Reflux Hypersensitivity: A Study Based on Rome IV Criteria by Yuan-Xi Jiang, Zhi-Yu Dong, Jun-Wen Wang, Ying Chen, Hui-Hui Sun, Shu-Chang Xu

“…The aim of this study is to assess the effectiveness and possible mechanisms of endoscopic radiofrequency ablation in reflux hypersensitivity patients. …”
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A rare intersection: squamous cell carcinoma of the tonsil and the anti-TIF1 syndrome masquerade by Manush Sondhi, Megan Lear, Saleha Dar, Madiha Tariq

“…Conclusions TIF1 dermatomyositis is a unique subset of dermatomyositis with a strong association with malignancy, particularly squamous cell carcinoma (SCC). Mechanisms connecting TIF1 dermatomyositis and cancer involve gene expression dysregulation and chronic inflammation. …”
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Mineralized Granitic Porphyry of the Yangla Copper Deposit, Western Yunnan, China: Geochemistry of Fluid Inclusions and H-O, S, and Pb Isotopes by Xinfu Wang, Bo Li, ShenJin Guan, Olivier Nadeau, Guo Tang

“…It is demonstrated that the evolution of ore-forming fluid is continuous from the skarn ore body (SOB) stage to the porphyritic ore body stage and belong to the products of the same ore-forming fluid system, and the unisothermal mixing and cooling actions were maybe the main mechanism at the metallic minerals precipitation in mineralized granitic porphyry (MGP). …”
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