Walnut oil prevents hyperlipidemia induced by high-fat diet and regulates intestinal flora and liver metabolism by Rui Yang, Dan Chen, Yanling Chen, Yage Ma, Chaoyin Chen, Shenglan Zhao

“…Metabonomics analysis identified that a total of 19 potential biomarkers were screened out from the differential metabolites with |log2FC| > 1, VIP > 1 and p < 0.05.ConclusionWalnut oil can significantly prevent hyperlipidemia caused by high-fat diet. The mechanism is mainly through significantly reducing the content of MDA and the activities of ALT and AST, significantly increasing the activity of GSH-PX, and improving intestinal flora and liver metabolism.…”
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Calcitonin Gene-Related Peptide (Cgrp), Adrenomedullin (Am), Amylin, And Calcitonin (Ct) Receptors And Overlapping Biological Actions by J.A. Fischer, W. Born, R. Muff

“…The structure of a CT receptor was elucidated by the group of Goldring in 1991 through molecular cloning, and of a 60% homologous human CT receptor-like receptor (CRLR) shortly thereafter here. The latter was an orphan receptor until the discovery of the receptor-activity-modifying proteins (RAMP) by Foord which upon coexpression yield a CGRP receptor with RAMP1 and an AM receptor with RAMP2. …”
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Resting-State Functional Magnetic Resonance Imaging Study on the Functional Connectivity of Amygdalar Subregions in Patients with Chronic Non-Specific Low Back Pain by CHEN Xiaolin, LIU Hong, GAO Zhen, WU Mengjiao, FAN Cheng, JIANG Zheng

“…Amygdalar subregion may play an important role in CNLBP neuropathological mechanisms.…”
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Mechanistic insights into chloride‐related heart failure progression according to the plasma volume status by Hajime Kataoka

“…The present study evaluated the mechanisms of HF progression to a different type according to changes in the estimated plasma volume status (ePVS). …”
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Echoes of Strain: A Two-Year Longitudinal Study on the Impact of China’s Zero-COVID Policy on College Students’ Insomnia and Depressive Symptoms by Wang S, Zou X, Tang Q, Zhang L, Liu X, Liu G, Tao Y

“…“Difficulty initiating sleep” bridged the two disorders, while “anhedonia” played a pivotal role in triggering and sustaining other symptoms.Conclusion: This study underscores the lasting impact of the evolving zero-COVID policy on depressive and insomnia symptoms among college students, elucidating the underlying interaction mechanisms. There is a pressing need for a more comprehensive evaluation of the implementation of restrictive public policies, taking into account their potential long-term consequences.Keywords: insomnia, depression, dynamic zero-COVID policy, network analysis…”
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4-1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor models by Ignacio Melero, Alvaro Teijeira, Christian Klein, Maria E Rodriguez-Ruiz, Christina Claus, Pablo Umana, Tamara Tanos, Carlos E De Andrea, Carlos Luri-Rey, Paloma Sanchez-Mateos, Leticia Fernández-Rubio, María Collantes, Irantzu Serrano-Mendioroz, Celia Barrio-Alonso, Antonio Rullan, Jon Ander Simon, Eneko Garate-Soraluze, Claudia del Pilar Herrero

“…Selective monoclonal antibody (mAb)-mediated depletions of immune cell populations, neutralizing interferon alpha/beta receptor 1 (IFNAR-I) IFNAR and interferon (IFN)-γ mAbs and gene-modified mice (4-1BB−/−) were used to delineate the immune cell subsets and mechanisms required for efficacy. 67Ga labeled muFAP-4-1BBL tracked by SPECT-CT was used to study biodistribution. …”
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Target Groups for a Short Dexamethasone Course among Critically Ill COVID-19 Patients by Armen Oganesyan, Ruslan Menzulin, Yury Surovoy, Andrei Nikiforchin, Kirill Zykov

“…Subgroup analysis was performed to assess the impact of dexamethasone on mortality in patients with invasive mechanical ventilation (IMV). Results. Of 233 patients, 220 (median age: 65 years, 38% female) were included: 83 patients received dexamethasone and 137 received usual care. …”
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The CeHRes Roadmap 2.0: Update of a Holistic Framework for Development, Implementation, and Evaluation of eHealth Technologies by Hanneke Kip, Nienke Beerlage-de Jong, Lisette J E W C van Gemert-Pijnen, Saskia M Kelders

“…In the Summative Evaluation phase, the impact, uptake, and working mechanisms are evaluated using a multimethod approach. …”
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Relationship between internet gaming disorder, interpersonal needs, loneliness, and depression among adolescents using a chain mediation model by GAO-QU Yige, MUZAI Baier, DONG Jingwen, ZHAO Yuxi, ZHU Pengyu, GU Xicheng, LIU Shangbin, CAI Yong, YUAN Dong, WANG Ying

“…ObjectiveTo explore the relationships between internet gaming disorder (IGD), interpersonal needs, loneliness, and depression in adolescents through the construction of a chain mediation model, to clarify the underlying mechanisms of these associations, and to provid a theoretical basis for depression prevention and intervention.MethodsBased on the data of the 7th Population Census, using convenient sampling method 1 106 adolescents aged between 10‒19 years in South China (176), North China (147), Central China (332), and East China (451) were selected to conduct a cross-sectional survey, with a ratio of 1∶1∶1.5∶2.5. …”
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Mamá Empoderada: study protocol for a pilot trial of a novel parenting and mental health prevention intervention for migrant mothers with young children at the Mexico-US border by Gudelia Rangel, Shira M Goldenberg, Eileen Pitpitan, Kaylee Ramage, Ietza Bojorquez-Chapela, Cecilia Martinez-Torteya, Katherine Rosenblum, Chelsie Hernandez, Monica Alvarez

“…The aim of this study is to pilot-test a novel parenting and mental health prevention intervention for migrant mothers with young children (MMC) in Tijuana, Mexico, including (a) assessing acceptability; (b) estimating effect sizes on symptoms of depression, anxiety, and parenting stress; (c) identifying which theory-based mechanisms of action predict changes in outcomes; and (d) identifying factors associated with differential intervention response.Methods and analysis ‘Mamá Empoderada’ (Mom Power) is a theory-based, trauma-informed group intervention to promote mental health and responsive parenting among mothers with young children (0–5 years). …”
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AGD1/USP10/METTL13 complexes enhance cancer stem cells proliferation and diminish the therapeutic effect of docetaxel via CD44 m6A modification in castration resistant prostate can... by Hong Wang, Chunli Cui, Weiyi Li, Hui Wu, Jianjun Sha, Jiahua Pan, Wei Xue

“…To uncover the underlying mechanisms of AGD1, RNA pull-down assay, RIP, co-Immunoprecipitation (co-IP), mass spectrometry (MS), Methylated RNA immunoprecipitation (MeRIP) and single-base elongation and ligation-based qPCR amplification method (SELECT) were performed. …”
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Positional embeddings and zero-shot learning using BERT for molecular-property prediction by Medard Edmund Mswahili, JunHa Hwang, Jagath C. Rajapakse, Kyuri Jo, Young-Seob Jeong

“…Integrating position information within transformer architectures has emerged as a promising approach. This encoding mechanism provides essential supervision for modeling dependencies among elements situated at different positions within a given sequence. …”
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MAZ-mediated tumor progression and immune evasion in hormone receptor-positive breast cancer: Targeting tumor microenvironment and PCLAF+ subtype-specific therapy by Gaofeng Ni, Yuwei Sun, Hongling Jia, Zhikai Xiahou, Yumeng Li, Fu Zhao, Hongyan Zang

“…Understanding the molecular mechanisms behind this resistance, including tumor heterogeneity and changes in the tumor microenvironment, was crucial for overcoming resistance, identifying new therapeutic targets, and developing more effective personalized treatments. …”
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Species Diversity, Biomass Production and Carbon Sequestration Potential in the Protected Area of Uttarakhand, India by Geetanjali Upadhyay, Lalit M. Tewari, Ashish Tewari, Naveen Chandra Pandey, Sheetal Koranga, Zishan Ahmad Wani, Geeta Tewari, Ravi K. Chaturvedi

“…Further, comprehending the carbon storage mechanisms of these forests will be critical for developing environmental management strategies aimed at alleviating the impacts of climate change in the years to come.…”
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Inhibitory potential of probiotic spore formers grown as mono- and mix-cultures under conditions of different nutrient availability by O. V. Knysh, A. V. Martynov, T. P. Osolodchenko

“…The demonstrated effect of increasing the inhibitory potential of probiotic spore-forming bacteria by co-cultivation and application of nutrient depletion conditions requires further study and clarification of the underlying molecular mechanisms.…”
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Preventing epileptogenesis by interaction between inositol isomers and proteins by Lia Tsverava, Luka Kharkhelauri, Vincenzo Lagani, Giorgi Gamkrelidze, Veriko Bokuchava, Tamar Kiguradze, Merab Kokaia, Revaz Solomonia

“…Our previous investigations have highlighted MI's potential antiepileptogenic effects, although its exact mechanisms of action during epileptogenesis remain unclear. …”
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Canopy structure modulates the sensitivity of subalpine forest stands to interannual snowpack and precipitation variability by M. Berkelhammer, G. F. M. Page, G. F. M. Page, F. Zurek, C. Still, C. Still, M. S. Carbone, M. S. Carbone, W. Talavera, L. Hildebrand, J. Byron, K. Inthabandith, A. Kucinski, M. Carlson, K. Foss, W. Brown, R. W. H. Carroll, A. Simonpietri, M. Worsham, I. Breckheimer, I. Breckheimer, A. Ryken, R. Maxwell, R. Maxwell, D. Gochis, M. S. Raleigh, E. Small, K. H. Williams, K. H. Williams

“…Using the sap velocity data along with supporting measurements of soil moisture and snow depth, we propose three mechanisms that lead to stand density modulating the tree-level response to changing seasonality of precipitation: </p><ol><li> <p id="d2e396"><span id="page702"/>Topographically mediated convergence zones have consistent access to recharge from snowmelt which supports denser stands with high water demands that are more reliant and sensitive to changing snow.…”
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The impact of teacher emotional support on learning engagement among college students mediated by academic self-efficacy and academic resilience by Wenjing Guo, Juan Wang, Na Li, Luxin Wang

“…This study aims to explore the mechanisms behind the relationship between teachers’ emotional support and college students’ learning engagement, with a focus on the mediating roles of academic self-efficacy and academic resilience. …”
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Exploring the Kidney-Brain Crosstalk: Biomarkers for Early Detection of Kidney Injury-Related Alzheimer&rsquo;s Disease by Cai Y, Huang G, Ren M, Chai Y, Fu Y, Yan T, Zhu L

“…Nonetheless, the precise interactions and shared mechanisms between KI and AD have yet to be fully investigated. …”
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Prevalence of carbapenemase-encoding genes carriage in patients admitted to multidisciplinary hospital in Moscow by Ni O.G., Shifman E.M., Yakovlev S.V., Bykov A.O., Gorbacheva A.A., Kruglov A.N., Belotserkovskiy B.Z., Matyushkov N.S., Galata A.A., Protsenko D.N.

“…Additional lower respiratory tract samples were collected from patients who were undergoing mechanical ventilation. The collected samples were tested by polymerase chain reaction using AmpliSens reagent kits to identify crabapenemase-encoding genes: blaOXA-58, blaOXA-51, blaOXA-40, blaOXA-23, blaVIM, blaIMP, blaOXA-48, blaNDM and blaKPC. …”
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