SCIENTIFIC PARADIGM SHIFT AS THE BACKGROUND OF LANGUAGE EDUCATION by V. D. Tabanakova

“…Semantic information processing is carried out by linguists «manually»; therefore, fundamental linguistic knowledge is required in the fields of semantics, syntactics, pragmatics of the language sign, laws of linguistic nominations, laws of references, regularities of perception and reproduction, mechanisms of understanding and interpretation, etc.Practical significance. …”
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Management of Irritable Bowel Syndrome: Novel Approaches to the Pharmacology of Gut Motility by Carmelo Scarpignato, Iva Pelosini

“…Among the motor- inhibiting drugs, gut selective muscarinic antagonists (such as zamifenacin and darifenacin), neurokinin2 antagonists (such as MEN-10627 and MEN-11420), beta3-adrenoreceptor agonists (eg, SR-58611A) and GI-selective calcium channel blockers (eg, pinaverium bromide and octylonium) are able to decrease painful contractile activity in the gut (antispasmodic effect), without significantly affecting other body functions. Novel mechanisms to stimulate GI motility and transit include blockade of cholecystokinin (CCK)A receptors and stimulation of motilin receptors. …”
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SARS-COV-2 re-infection and incidence of post-acute sequelae of COVID-19 (PASC) among essential workers in New York: a retrospective cohort studyResearch in context by Tesleem K. Babalola, Sean A.P. Clouston, Zennur Sekendiz, Devi Chowdhury, Nicola Soriolo, Joseph Kawuki, Jaymie Meliker, Melissa Carr, Bruno R. Valenti, Ashley Fontana, Onix A. Melendez, Olga Morozova, Benjamin J. Luft

“…Interpretation: Although the pathogenetic mechanism for PASC remains unclear, identifying risk factors such as lack of vaccination or re-infection can assist in better understanding and managing the condition. …”
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A STUDY OF THE INFLUENCE OF EXTRACELLULAR VESICLES ON THE MORPHOFUNCTIONAL STATE OF THE ENDOMETRIUM IN VITRO by Оксана Александровна Мелкозерова, Ирина Викторовна Крутинь, Александра Юрьевна Храмцова, Мария Валерьевна Улитко, Алсу Фармутовна Мустафина

“…The resulting tissue fragments were placed in a phosphate-saline solution with the addition of penicillin-streptomycin, gentamicin and amphotericin for transportation. A combination of mechanical and chemical methods was used to isolate primary cells. …”
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Machine Learning–Based Risk Factor Analysis and Prediction Model Construction for the Occurrence of Chronic Heart Failure: Health Ecologic Study by Qian Xu, Xue Cai, Ruicong Yu, Yueyue Zheng, Guanjie Chen, Hui Sun, Tianyun Gao, Cuirong Xu, Jing Sun

“…With the abundance of medical data and the rapid development of machine learning (ML) technologies, new opportunities are provided for in-depth investigation of the mechanisms of CHF and the construction of predictive models. …”
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Patterns of self-harm presentations at a Tertiary Urban Hospital in Kenya: A retrospective 5-year study (2018-2022). by Willie Njoroge, Catherine Gitau, Everline Onchari, Linnet Ongeri, Linda Khakali, Murad Khan, Zul Merali, Lukoye Atwoli, Jasmit Shah

“…A national registry of self-harm behavior would also help further elucidate the occurrence and mechanisms of self-harm in the population, improving the possibility for early interventions and prevention.…”
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Phase I study of pembrolizumab in combination with ibrutinib for the treatment of unresectable or metastatic melanoma by Yuan Yao, Yiyi Yan, Vera J. Suman, Allan B. Dietz, Courtney L. Erskine, Anastasios Dimou, Svetomir N. Markovic, Svetomir N. Markovic, Robert R. McWilliams, Heather N. Montane, Matthew S. Block, Matthew S. Block

“…BackgroundImmune checkpoint inhibitors (ICIs) have been transformative in the treatment of patients with metastatic melanoma, but primary and secondary resistance to ICI treatment is common. One key mechanism for ICI resistance is the skewing of the immune response from a cytotoxic (Th1) to a chronic inflammatory (Th2) profile. …”
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Exhaustion of CD8pos central memory regulatory T cell differentiation is involved in renal allograft rejection by Florian Kälble, Jonas Leonhard, Jonas Leonhard, Martin Zeier, Oliver Zivanovic, Matthias Schaier, Andrea Steinborn

“…The pathogenesis of graft deterioration in case of rejection involves the exhaustive differentiation of both CD8pos T cell subsets, but the causal mechanisms have not yet been identified.MethodsIn this study, we separately investigated the differentiation of CD8posTregs/Tresps in 134 stable KTR with no evidence of renal graft rejection, in 41 KTR diagnosed with biopsy-confirmed rejection at enrolment and in 5 patients who were unremarkable at enrolment, but developed rejection within three years of enrolment. …”
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Application of iron-rich slag to capture carbon dioxide gas through direct gas-solid carbonation by F. Abdul, R.F. Rahman, K.A. Purwanto, F.I. Ma'ruf, Y. Setiyorini, V.A. Setyowati, S. Pintowantoro

“…The kinetics analysis was also carried out using several models, such as mass transport, chemical reaction, and diffusion-controlled model to estimate the carbón dioxide capture mechanism that occurs.FINDING: The carbon dioxide capture capacity of the iron-rich slag from the ferronickel industry is somewhat limited, albeit still relatively modest. …”
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Risk factors and prognosis analysis of dysphagia after occipitocervical fusion surgery: a retrospective study of 43 cases by Yufan Chen, Weihong Xu

“…Abstract Objectives To analyze the risk factors for developing dysphagia after occipitocervical fusion (OCF) and investigate possible mechanisms and prognosis. Methods The case data of 43 patients who underwent OCF were retrospectively reviewed. …”
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Uridine-cytidine kinase 2 is correlated with immune, DNA damage repair and promotion of cancer stemness in pan-cancer by Jinlong Tian, Yanlei Li, Yu Tong, Yuan Zhang, Tingxiao Zhao, Yao Kang, Qing Bi

“…This study aims to shed light on the role and possible mechanism of UCK2 in pan-cancer.MethodsWe used the R programming language for pan-cancer bulk sequencing data analysis, which were obtained from the University of California, Santa Cruz (UCSC) datasets. …”
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The Legionella pneumophila effector PieF modulates mRNA stability through association with eukaryotic CCR4−NOT by Harley O'Connor Mount, Malene L. Urbanus, Francesco Zangari, Anne-Claude Gingras, Alexander W. Ensminger

“…Collectively, this work reveals a new, highly conserved target of L. pneumophila effectors and suggests a mechanism by which the pathogen may be modulating host mRNA stability and expression during infection.IMPORTANCEThe intracellular bacterial pathogen Legionella pneumophila targets conserved eukaryotic pathways to establish a replicative niche inside host cells. …”
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The Efficacy of Conversational AI in Rectifying the Theory-of-Mind and Autonomy Biases: Comparative Analysis by Marcin Rządeczka, Anna Sterna, Julia Stolińska, Paulina Kaczyńska, Marcin Moskalewicz

“…Future research should focus on enhancing affective response mechanisms and addressing ethical concerns such as bias mitigation and data privacy to ensure safe, effective AI-based mental health support.…”
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Possible linking and treatment between Parkinson’s disease and inflammatory bowel disease: a study of Mendelian randomization based on gut–brain axis by Beiming Wang, Xiaoyin Bai, Yingmai Yang, Hong Yang

“…Thus, we aimed to identify the causal relationships and novel therapeutic targets shared between them based on their common pathophysiological mechanisms in gut–brain-axis (GBA). Methods A meta-analysis on bidirectional Mendelian randomization (MR) utilizing various datasets was performed to estimate their causal relationship. …”
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Comparative Evaluation of Intra-articular Ozone and Steroid Treatments in Patients with Coxarthrosis under Ultrasound Guidance: A Retrospective Study by Yilmaz Karaduman, Arzu Muz, Azize Serçe, Servi Yildirim, Ismail Eren Durmus, Suna Akin Takmaz

“…On the other hand, ozone therapy accelerates anabolic mechanisms, provides vascularisation of cartilage and bone, and slows down the degenerative process. …”
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<i>Cichorium intybus</i> L. Oligo-Polysaccharides (CIO) Exerts Antianxiety and Antidepressant Effects on Mice Experiencing Behavioral Despair and Chronic Unpredicted Mild Stress by Yanqin Luo, Xueyi Bei, Yiwen Zhang, Xinran Sun, Yongzhi Zhao, Fang Chen, Ruile Pan, Qi Chang, Qinghu He, Xinmin Liu, Ning Jiang

“…This study explores the antianxiety and antidepressant effects and mechanisms of CIOs by using acute behavioral despair and chronic unpredictable mild stress mice models and measuring the levels of 5-HT and the expression of proteins related to the BDNF/ERK and PI3K/Akt/mTOR pathways. …”
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Magnetic hybrid chitin-horse manure humic acid for optimized Cd(II) and Pb(II) adsorption from aquatic environment by Rahmat Basuki, Yusuf Bramastya Apriliyanto, Elva Stiawan, Adya Rizky Pradipta, Bambang Rusdiarso, Budi Riza Putra

“…Four isotherm (Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich (DR)) and six kinetic models (Lagergren, Ho, Santosa, Rusdiarso-Basuki-Santosa (RBS), Elovich, and Intraparticle Diffusion) were conducted to investigate the mechanism of Pb(II) and Cd(II) adsorption on HMHA-Ch-Fe3O4. …”
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Long-Term Therapeutic Effects of ²²⁵Ac-DOTA-E[c(RGDfK)]₂ Induced by Radiosensitization via G2/M Arrest in Pancreatic Ductal Adenocarcinoma by Mitsuyoshi Yoshimoto, Kohshin Washiyama, Kazunobu Ohnuki, Ayano Doi, Miki Inokuchi, Motohiro Kojima, Brian W. Miller, Yukie Yoshii, Anri Inaki, Hirofumi Fujii

“…Furthermore, to clarify the mechanism of successful tumor growth inhibition for a long duration in vivo, we investigated whether short-term high radiation exposure enhances radiation sensitivity. …”
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Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8+ T cell immunity to reject ‘cold’ tumors by Laetitia Fend, Eric Quemeneur, Monika Semmrich, Jean-Baptiste Marchand, Matilda Rehn, Nathalie Silvestre, Linda Mårtensson, Johann Foloppe, Ingrid Teige, Björn Frendeus, Petra Holmkvist, Carolin Svensson, Christelle Remy, Patricia Kleinpeter, Jules Deforges, Fred Junghus, Kirstie L Cleary, Mimoza Bodén

“…At a mechanistic level, accumulating preclinical and clinical data indicate dual mechanisms for αCTLA-4; ICB and regulatory T cell (Treg) depletion are both thought to contribute efficacy and toxicity in available, systemic, αCTLA-4 regimens. …”
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EZH2/miR-142-3p/HMGB1 axis mediates chondrocyte pyroptosis by regulating endoplasmic reticulum stress in knee osteoarthritis by Yang Chen, Shanshan Dong, Xin Zeng, Qing Xu, Mingwei Liang, Guangneng Liao, Lan Li, Bin Shen, Yanrong Lu, Haibo Si, Peifang Wei

“…This study aims to investigate the effect of ER stress on chondrocyte pyroptosis and the upstream regulatory mechanisms, which have rarely been reported. Methods:. …”
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